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1. 发明申请

US20070142721A1 Monitoring of physiological analytes 有权
标题翻译：生理分析物的监测
公开(公告)号：US20070142721A1
公开(公告)日：2007-06-21
申请号：US11699850
申请日：2007-01-30
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
摘要翻译：提供了用于测量生物系统中存在的目标化学分析物浓度的方法和装置。采用器件配置和/或测量技术来降低干扰物质对传感器灵敏度的影响。本发明的一个重要应用涉及用于监测血糖值的方法和装置。

2. 发明申请

US20050027179A1 Biosensor and methods of use thereof 有权
标题翻译：生物传感器及其使用方法
公开(公告)号：US20050027179A1
公开(公告)日：2005-02-03
申请号：US10936095
申请日：2004-09-08
申请人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/28 , G01N27/30 , G01N27/416 , G01N33/487 , G01N33/66 , A61B5/05
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61N1/30
摘要： An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.
摘要翻译：提供了一种用于连续透皮提取生物系统中存在的分析物的自动化系统。该系统可用于使用电化学生物传感器检测装置来检测和/或测量分析物的浓度。该系统可选择使用反向离子电渗法进行分析物的连续经皮提取。

3. 发明申请

US20050215872A1 Monitoring of physiological analytes 有权
公开(公告)号：US20050215872A1
公开(公告)日：2005-09-29
申请号：US10982166
申请日：2004-11-05
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/327 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

4. 发明申请

US20050130249A1 Methods for measuring analyte in a subject and/or compensating for incomplete reaction involving detection of the analyte 有权
标题翻译：用于测量受试者中的分析物和/或补偿涉及检测分析物的不完全反应的方法
公开(公告)号：US20050130249A1
公开(公告)日：2005-06-16
申请号：US11042865
申请日：2005-01-24
申请人： Norman Parris , Russell Potts , Michael Tierney , Christopher Uhegbu
发明人： Norman Parris , Russell Potts , Michael Tierney , Christopher Uhegbu
IPC分类号： A61B5/00 , C12Q1/54 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1486
摘要： The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.
摘要翻译：本发明涉及一种用于传感器生成信号的数据处理的预测动力学方法，以及采用这种预测动力学方法的微处理器和监视系统。来自信号的瞬态区域的数据与合适的模型和曲线拟合方法一起使用以预测在反应完成时将对系统测量的信号。使用本发明的方法的传感器响应的数据处理产生的值对测量变量较不敏感。

5. 发明申请

US20050010093A1 Formulation and manipulation of databases of analyte and associated values 有权
标题翻译：分析物和相关值的数据库的制备和操作
公开(公告)号：US20050010093A1
公开(公告)日：2005-01-13
申请号：US10821055
申请日：2004-04-08
申请人： Russell Ford , Matthew Lesho , Russell Potts , Michael Tierney , Charles Wei
发明人： Russell Ford , Matthew Lesho , Russell Potts , Michael Tierney , Charles Wei
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G16H10/40 , G06F19/00 , G06F19/3456 , G16H10/60 , G16H40/63 , Y10S707/99945 , Y10S707/99948
摘要： The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
摘要翻译：本发明涉及配制分析物数据数据库的方法，数据库本身及其操作方法。一方面，本发明包括分析物数据点，派生数据和数据属性数据库的配方，其包括使用能够频繁地监测分析物浓度或量的分析物监测装置收集的数据点。这样的数据点可以包括获取的数据（例如，对应于由所述分析物监测装置测量的分析物浓度或量的值）。然后将这些数据点与一个或多个相关数据属性相关联。可以操纵生成的数据库以确定数据库的组件之间的关系。

6. 发明申请

US20070038053A1 Signal processing for measurement of physiological analytes 审中-公开
标题翻译：用于测量生理分析物的信号处理
公开(公告)号：US20070038053A1
公开(公告)日：2007-02-15
申请号：US11583407
申请日：2006-10-19
申请人： Bret Berner , Timothy Dunn , Kathleen Farinas , Michael Garrison , Ronald Kurnik , Matthew Lesho , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Timothy Dunn , Kathleen Farinas , Michael Garrison , Ronald Kurnik , Matthew Lesho , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1477 , A61B5/14532 , A61B5/14542 , A61B5/1486
摘要： A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
摘要翻译：提供了用于连续或连续地测量存在于生物系统中的目标化学分析物的浓度的方法，并且处理分析物特异性信号以获得与生物系统中的目标化学分析物的浓度密切相关的测量值。本发明的一个重要应用涉及用于监测血糖值的系统中的信号处理方法。

7. 发明申请

US20050119540A1 Methods and devices for prediction of hypoglycemic events 审中-公开
标题翻译：用于预测低血糖事件的方法和装置
公开(公告)号：US20050119540A1
公开(公告)日：2005-06-02
申请号：US10982148
申请日：2004-11-05
申请人： Russell Potts , Michael Tierney
发明人： Russell Potts , Michael Tierney
IPC分类号： G01N21/35 , A61B5/00 , A61B5/05 , A61B5/145 , A61B5/1455 , A61B5/1468 , G01N33/487 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/14532 , A61B5/7267 , G01N27/3271
摘要： Described herein are methods, devices, and microprocessors useful for predicting a hypoglycemic event in a subject. The hypoglycemic predictive approach described herein utilizes information obtained from a data stream, e.g., frequently obtained glucose values (current and/or predicted), body temperature, and/or skin conductance, to predict incipient hypoglycemic events and to alert the user.
摘要翻译：这里描述了可用于预测受试者中的低血糖事件的方法，装置和微处理器。本文描述的低血糖预测方法利用从数据流获得的信息，例如经常获得的葡萄糖值（当前和/或预测），体温和/或皮肤电导，以预测初始低血糖事件并提醒用户。

8. 发明申请

US20070179371A1 Patches, systems, and methods for non-invasive glucose measurement 审中-公开
标题翻译：用于非侵入性葡萄糖测量的补片，系统和方法
公开(公告)号：US20070179371A1
公开(公告)日：2007-08-02
申请号：US11528750
申请日：2006-09-27
申请人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir , Robert Blair
发明人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir , Robert Blair
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B10/0064 , A61B2560/0412 , A61B2562/0295
摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要翻译：这里描述了用于测量葡萄糖的补丁，系统和方法。通常，贴片包括微流体收集层和检测器，并且系统包括贴片和测量装置。用于测量葡萄糖的一些方法包括清洁皮肤表面，使用微流体收集装置从皮肤表面收集汗液，以及测量收集的葡萄糖。其他方法包括清洁皮肤表面，在包含微量收集层的贴片中收集汗液，以及测量在贴片中收集的葡萄糖。还有其它方法包括清洁皮肤表面，在包括微量收集层和检测器层的贴片中从皮肤表面收集第一汗液样品，将第一汗液样品从收集层转移到检测器层，测量第一汗液样品中的葡萄糖汗液样品，并重复收集，转移和测量步骤至少一次。

9. 发明申请

US20060004271A1 Devices, methods, and kits for non-invasive glucose measurement 失效
标题翻译：用于非侵入性葡萄糖测量的装置，方法和试剂盒
公开(公告)号：US20060004271A1
公开(公告)日：2006-01-05
申请号：US11159587
申请日：2005-06-22
申请人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir
发明人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14521 , A61B5/14532 , A61B2562/0295 , G01N33/66 , G06F19/00
摘要： Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
摘要翻译：描述了用于非侵入性测量葡萄糖的装置，方法和试剂盒。通常，这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。贴剂可以包括粘合剂材料，收集层，界面层和汗液渗透膜。透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。以这种方式，不能测量不相关的皮肤表面葡萄糖。补片还可以包括诱发局部汗水反应的组件。测量装置通常包括显示器，处理器和测量机构。所述方法通常包括以下步骤：用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面，将贴片放置在皮肤表面上，以及测量在贴剂中收集的葡萄糖。还描述了包括贴剂和测量装置的试剂盒。

10. 发明申请

US20050049473A1 Methods for estimating analyte-related signals, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods 有权
标题翻译：用于估计分析物相关信号的方法，包括用于控制方法性能的编程的微处理器以及采用该方法的分析物监测装置
公开(公告)号：US20050049473A1
公开(公告)日：2005-03-03
申请号：US10963853
申请日：2004-10-13
申请人： Shashi Desai , Timothy Dunn , Matthew Lesho , Russell Potts , Janet Tamada , Charles Wei
发明人： Shashi Desai , Timothy Dunn , Matthew Lesho , Russell Potts , Janet Tamada , Charles Wei
IPC分类号： A61B5/00 , A61N1/30 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1477 , A61N1/30
摘要： The present invention relates to methods to increase the number of analyte-related signals used to provide analyte measurement values, e.g., when two or more analyte-related signals are used to obtain a single analyte measurement value a “rolling” value based on the two or more signals can be employed. In another aspect, interpolation and/or extrapolation methods are used to estimate unusable, missing or error-associated analyte-related signals. Further, interpolation and extrapolation of values are employed in another aspect of the invention that reduces the incident of failed calibrations. Further, the invention relates to methods, which employ gradients and/or predictive algorithms, to provide an alert related to analyte values exceeding predetermined thresholds. The invention includes the above-described methods, one or more microprocessors programmed to execute the methods, one or more microprocessors programmed to execute the methods and control at least one sensing and/or sampling device, and monitoring systems employing the methods described herein.
摘要翻译：本发明涉及增加用于提供分析物测量值的分析物相关信号的数量的方法，例如当使用两个或更多个与分析物相关的信号来获得单个分析物测量值时，基于两个分析物相关信号的“滚动”值或更多的信号。在另一方面，内插和/或外插方法用于估计不可用，缺失或与误差相关的分析物相关信号。此外，在本发明的另一方面，采用了内插和外推值来减少校准失败的事件。此外，本发明涉及采用梯度和/或预测算法来提供与超过预定阈值的分析物值相关的警报的方法。本发明包括上述方法，被编程为执行方法的一个或多个微处理器，被编程为执行方法和控制至少一个感测和/或采样装置的一个或多个微处理器，以及采用本文描述的方法的监视系统。

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