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1. 发明申请

US20070027383A1 Patches, systems, and methods for non-invasive glucose measurement 审中-公开
公开(公告)号：US20070027383A1
公开(公告)日：2007-02-01
申请号：US11451738
申请日：2006-06-12
申请人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir , Robert Blair
发明人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir , Robert Blair
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B10/0064 , A61B2560/0412 , A61B2562/0295
摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.

2. 发明申请

US20070179371A1 Patches, systems, and methods for non-invasive glucose measurement 审中-公开
标题翻译：用于非侵入性葡萄糖测量的补片，系统和方法
公开(公告)号：US20070179371A1
公开(公告)日：2007-08-02
申请号：US11528750
申请日：2006-09-27
申请人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir , Robert Blair
发明人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir , Robert Blair
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B10/0064 , A61B2560/0412 , A61B2562/0295
摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要翻译：这里描述了用于测量葡萄糖的补丁，系统和方法。通常，贴片包括微流体收集层和检测器，并且系统包括贴片和测量装置。用于测量葡萄糖的一些方法包括清洁皮肤表面，使用微流体收集装置从皮肤表面收集汗液，以及测量收集的葡萄糖。其他方法包括清洁皮肤表面，在包含微量收集层的贴片中收集汗液，以及测量在贴片中收集的葡萄糖。还有其它方法包括清洁皮肤表面，在包括微量收集层和检测器层的贴片中从皮肤表面收集第一汗液样品，将第一汗液样品从收集层转移到检测器层，测量第一汗液样品中的葡萄糖汗液样品，并重复收集，转移和测量步骤至少一次。

3. 发明申请

US20060004271A1 Devices, methods, and kits for non-invasive glucose measurement 失效
标题翻译：用于非侵入性葡萄糖测量的装置，方法和试剂盒
公开(公告)号：US20060004271A1
公开(公告)日：2006-01-05
申请号：US11159587
申请日：2005-06-22
申请人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir
发明人： Thomas Peyser , Russell Potts , Herbert Berman , James Moyer , Mikhail Kouchnir
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14521 , A61B5/14532 , A61B2562/0295 , G01N33/66 , G06F19/00
摘要： Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
摘要翻译：描述了用于非侵入性测量葡萄糖的装置，方法和试剂盒。通常，这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。贴剂可以包括粘合剂材料，收集层，界面层和汗液渗透膜。透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。以这种方式，不能测量不相关的皮肤表面葡萄糖。补片还可以包括诱发局部汗水反应的组件。测量装置通常包括显示器，处理器和测量机构。所述方法通常包括以下步骤：用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面，将贴片放置在皮肤表面上，以及测量在贴剂中收集的葡萄糖。还描述了包括贴剂和测量装置的试剂盒。

4. 发明申请

US20050137469A1 Single detector infrared ATR glucose measurement system 审中-公开
标题翻译：单探测器红外ATR葡萄糖测量系统
公开(公告)号：US20050137469A1
公开(公告)日：2005-06-23
申请号：US10739657
申请日：2003-12-17
申请人： Herbert Berman , Thomas Peyser
发明人： Herbert Berman , Thomas Peyser
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A single detector infrared ATR glucose measurement system is disclosed herein. The device uses attenuated total reflection infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. A single IR detector is utilized along with an alternating filter. This device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.
摘要翻译：本文公开了单个检测器红外ATR葡萄糖测量系统。该设备使用衰减的全反射红外光谱。优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。单个IR检测器与交替滤波器一起使用。该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

5. 发明申请

US20080069904A1 Inhibition of angiogenesis through nitric oxide tachyphylaxis 审中-公开
标题翻译：通过一氧化氮快速抑制血管生成
公开(公告)号：US20080069904A1
公开(公告)日：2008-03-20
申请号：US11827487
申请日：2007-07-11
申请人： Bryan Oronsky , John Sliwa , Herbert Berman , Carol Tosaya , Neil Oronsky , Robin Martin
发明人： Bryan Oronsky , John Sliwa , Herbert Berman , Carol Tosaya , Neil Oronsky , Robin Martin
IPC分类号： A61K33/04 , A61K31/04 , A61P35/00
CPC分类号： A61K31/04 , A61K33/04 , A61K45/06 , A61K2300/00
摘要： A method is provided for treating cancer in a mammalian subject by inhibiting angiogenesis through the administration to the subject of a therapeutically effective amount of a nitrate-containing compound and a therapeutically effective amount of an inorganic selenium-containing compound. Kits and systems are also disclosed for practicing the subject methods.
摘要翻译：提供了一种通过向受检者施用治疗有效量的含硝酸盐化合物和治疗有效量的无机硒化合物来抑制血管发生来治疗哺乳动物受试者中的癌症的方法。还披露了用于实践主题方法的套件和系统。

6. 发明申请

US20060187010A1 Vehicle motion warning device 审中-公开
标题翻译：车辆运动警告装置
公开(公告)号：US20060187010A1
公开(公告)日：2006-08-24
申请号：US11061808
申请日：2005-02-18
申请人： Herbert Berman
发明人： Herbert Berman
IPC分类号： B60Q1/00 , G01S13/00 , B60T7/16 , G08G1/14
CPC分类号： B60T7/22 , B60Q1/50 , B60Q1/525 , B60Q2400/50
摘要： A device is disclosed which is adapted to be mounted on a vehicle to generate a warning pattern on the pavement near the vehicle. An intense, narrow light beam from a laser is directed downward from the device to generate a distinctly visible illuminated warning pattern on the pavement to warn of, for example, the backing-up of the vehicle or, when the vehicle is moving forward, to provide an indication of a safe clearance distance for a following vehicle. Also disclosed is such a device for providing a warning pattern in front of or beside the vehicle.
摘要翻译：公开了一种适于安装在车辆上以在车辆附近的路面上产生警告图案的装置。来自激光器的强烈的，窄的光束从装置向下指向以在路面上产生明显可见的照明警告图案，以警告例如车辆的后退，或者当车辆向前移动时，向提供后续车辆的安全距离的指示。还公开了用于在车辆前方或旁边提供警告模式的这种装置。

7. 发明申请

US20060187449A1 Pesticide detector and method 有权
标题翻译：农药检测仪及方法
公开(公告)号：US20060187449A1
公开(公告)日：2006-08-24
申请号：US11062048
申请日：2005-02-18
申请人： Darius Sadeghi , Herbert Berman
发明人： Darius Sadeghi , Herbert Berman
IPC分类号： G01J3/42
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/4406 , G01J2001/4242 , G01J2003/1217 , G01N21/645 , G01N2021/6471 , G01N2021/6484 , G01N2201/0221
摘要： Highly portable, handheld instrument which can be pointed at the produce to be checked. Light from a source within the instrument is directed onto the produce to induce fluorescent emission from the produce, and fluorescent emissions from the produce are monitored with a detector within the instrument to detect the presence of pesticide residue on the produce. The light from the source is filtered to selectively pass light of a wavelength which induces maximum fluorescent emission from the pesticide to be detected, and the emissions from the produce are filtered to selectively pass emissions having a spectral content characteristic of the pesticide to be detected.
摘要翻译：高度便携的手持式仪器，可以指向要检查的产品。来自仪器内的源的光被引导到产品上以诱导来自产品的荧光发射，并且用仪器内的检测器监测来自产物的荧光发射以检测产物上农药残留的存在。来自源的光被过滤以选择性地通过从被检测的农药引起最大荧光发射的波长的光，并且过滤来自产物的排放物以选择性地通过具有要检测的农药的谱含量特征的发射。

8. 再颁专利

USRE30356E Hand drilling 失效
标题翻译：手钻
公开(公告)号：USRE30356E
公开(公告)日：1980-08-05
申请号：US915912
申请日：1978-06-16
申请人： Herbert Berman , Harvey L. Pastan
发明人： Herbert Berman , Harvey L. Pastan
IPC分类号： A61C1/00 , A61C1/06
CPC分类号： A61C1/06 , A61C1/0007
摘要： .Iadd.A hand drill includes an induction motor energized by a multi-phase electrical power source with the angle between consecutive phase maintained substantially constant over a wide frequency range by energizing logical circuitry comprising a number of flip-flops intercoupled by AND GATES. .Iaddend.

9. 发明申请

US20070213617A1 Infrared detection of cancerous tumors and other subsurface anomalies in the human breast and in other body parts 审中-公开
标题翻译：人乳腺癌和其他身体部位的癌性肿瘤和其他地下异常的红外检测
公开(公告)号：US20070213617A1
公开(公告)日：2007-09-13
申请号：US11706120
申请日：2007-02-14
申请人： Herbert Berman , Carol Tosaya , John Sliwa
发明人： Herbert Berman , Carol Tosaya , John Sliwa
IPC分类号： A61B6/00
CPC分类号： A61B5/015 , A61B5/0091 , A61B5/4312 , A61B5/6843
摘要： Apparatus and methods to further improve the performance of breast IR-imaging are provided, employing a combination of near-IR and mid-IR frequencies for detection of cancer and other types of subsurface defects. In addition, an IR transmissive or transparent window that can be IR-imaged through is disclosed that may also be utilized to one or both of distort the breast and/or manipulate an artificial heat-flow into or out of the breast.
摘要翻译：提供了进一步提高乳房IR成像性能的装置和方法，采用近红外和中红外频率的组合来检测癌症和其他类型的地下缺陷。此外，公开了可以被IR成像通过的IR透射或透明窗口，其也可用于使乳房变形和/或操纵进入或离开乳房的人造热流中的一者或两者。

10. 发明申请

US20060244962A1 Pesticide Detector and Method 有权
标题翻译：农药检测仪及方法
公开(公告)号：US20060244962A1
公开(公告)日：2006-11-02
申请号：US11456292
申请日：2006-07-10
申请人： Darius Sadeghi , Herbert Berman
发明人： Darius Sadeghi , Herbert Berman
IPC分类号： G01J3/42
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/4406 , G01J2001/4242 , G01J2003/1217 , G01N21/645 , G01N2021/6471 , G01N2021/6484 , G01N2201/0221
摘要： Highly portable, handheld instrument which can be pointed at the produce to be checked. Light from a source within the instrument is directed onto the produce to induce fluorescent emission from the produce, and fluorescent emissions from the produce are monitored with a detector within the instrument to detect the presence of pesticide residue on the produce. The light from the source is filtered to selectively pass light of a wavelength which induces maximum fluorescent emission from the pesticide to be detected, and the emissions from the produce are filtered to selectively pass emissions having a spectral content characteristic of the pesticide to be detected.
摘要翻译：高度便携的手持式仪器，可以指向要检查的产品。来自仪器内的源的光被引导到产品上以诱导来自产品的荧光发射，并且用仪器内的检测器监测来自产物的荧光发射以检测产物上农药残留的存在。来自源的光被过滤以选择性地通过从被检测的农药引起最大荧光发射的波长的光，并且过滤来自产物的排放物以选择性地通过具有要检测的农药的谱含量特征的发射。

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