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    • 3. 发明申请
    • Devices, methods, and kits for non-invasive glucose measurement
    • 用于非侵入性葡萄糖测量的装置,方法和试剂盒
    • US20060004271A1
    • 2006-01-05
    • US11159587
    • 2005-06-22
    • Thomas PeyserRussell PottsHerbert BermanJames MoyerMikhail Kouchnir
    • Thomas PeyserRussell PottsHerbert BermanJames MoyerMikhail Kouchnir
    • A61B5/00
    • A61B5/1455A61B5/14521A61B5/14532A61B2562/0295G01N33/66G06F19/00
    • Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
    • 描述了用于非侵入性测量葡萄糖的装置,方法和试剂盒。 通常,这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。 贴剂可以包括粘合剂材料,收集层,界面层和汗液渗透膜。 透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。 以这种方式,不能测量不相关的皮肤表面葡萄糖。 补片还可以包括诱发局部汗水反应的组件。 测量装置通常包括显示器,处理器和测量机构。 所述方法通常包括以下步骤:用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面,将贴片放置在皮肤表面上,以及测量在贴剂中收集的葡萄糖。 还描述了包括贴剂和测量装置的试剂盒。
    • 5. 发明授权
    • Method and apparatus for detection, analysis and identification of
particles
    • 用于颗粒检测,分析和识别的方法和装置
    • US5515163A
    • 1996-05-07
    • US299896
    • 1994-09-01
    • Vladimir KupershmidtMikhail Kouchnir
    • Vladimir KupershmidtMikhail Kouchnir
    • G01N15/02G01N21/41G01N21/00
    • G01N15/0205G01N2015/0238G01N2021/1757G01N2021/4792G01N21/41
    • A method and an apparatus for the analysis of particles contained in a material, such as particles in a fluid or on a surface, such as the surface of a semiconductor, by two orthogonally polarized, intensity and phase modulated laser beams, wherein the detected scattered light is synchronously demodulated. The apparatus comprises a laser source producing a polarized laser beam, a state of polarization modulator, and a photoreceiver for detecting light scattered by particles at an angle to the incident light. A synchronous demodulator, such as a dual channel lock-in amplifier, separates the intensity and phase modulated portions of the scattered signals. A reference unit for detecting a non-scattered light produced by the sample to provide a reference is preferably provided, as well. The size, index of refraction and identity, of the particles, for example, can be determined.
    • 通过两个正交极化的强度和相位调制的激光束分析包含在流体或表面上的诸如半导体的表面的材料中的颗粒所包含的颗粒的方法和装置,其中所检测的散射 光被同步解调。 该装置包括产生偏振激光束的激光源,偏振调制器的状态和用于检测与入射光成角度的颗粒散射的光的光接收器。 诸如双通道锁相放大器的同步解调器分离散射信号的强度和相位调制部分。 也优选提供用于检测由样品产生的非散射光以提供参考的参考单元。 例如,可以确定颗粒的尺寸,折射率和身份。