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1. 发明申请

US20070142721A1 Monitoring of physiological analytes 有权
标题翻译：生理分析物的监测
公开(公告)号：US20070142721A1
公开(公告)日：2007-06-21
申请号：US11699850
申请日：2007-01-30
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
摘要翻译：提供了用于测量生物系统中存在的目标化学分析物浓度的方法和装置。采用器件配置和/或测量技术来降低干扰物质对传感器灵敏度的影响。本发明的一个重要应用涉及用于监测血糖值的方法和装置。

2. 发明申请

US20060092273A1 Stereo imaging system and method for use in telerobotic systems 有权
标题翻译：立体成像系统和用于远程遥控系统的方法
公开(公告)号：US20060092273A1
公开(公告)日：2006-05-04
申请号：US10795963
申请日：2004-03-07
申请人： David Gere , Christopher Burns , John Stern , Michael Tierney
发明人： David Gere , Christopher Burns , John Stern , Michael Tierney
IPC分类号： H04N13/00 , H04N15/00 , A61B1/04
CPC分类号： G02B23/2415 , A61B1/00183 , A61B1/00193 , H04N13/10 , H04N13/239 , H04N13/246 , H04N13/296 , H04N13/327 , H04N2005/2255
摘要： This invention relates to a stereo imaging system for use in telerobotic systems. A method of imaging a target site in a stereo imaging system is provided. The method typically includes capturing a right and a left optical image of the target site and transforming the right and the left optical images preferably into digital information. The method further includes converting the digital information into opposed images of the target site displayed on a stereo display of the stereo imaging system, one of the opposed images being associated with the right optical image and the other of the opposed images being associated with the left optical image. The method further includes regulating the digital information to cause the positions of the target site displayed on the opposed images to change relative to each other. The invention further provides for a method of aligning the opposed images, to a method of adjusting the stereo working distance of an image capture device, such as an endoscope and to a stereo imaging system.
摘要翻译：本发明涉及一种用于远程遥控系统的立体成像系统。提供了一种在立体成像系统中成像目标部位的方法。该方法通常包括捕获目标站点的右光学图像和左光学图像，并将左右光学图像优选地变换为数字信息。该方法还包括将数字信息转换为立体成像系统的立体显示器上显示的目标站点的相对图像，相对图像中的一个与右光学图像相关联，另一个相对的图像与左侧光学图像。所述方法还包括调节所述数字信息以使所述相对图像上显示的所述目标站点的位置相对于彼此改变。本发明还提供了一种将相对图像对准的方法，一种调整诸如内窥镜和立体成像系统的图像捕获装置的立体声工作距离的方法。

3. 发明申请

US20050069925A1 Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
标题翻译：用于监测生理分析物的微处理器，装置和方法
公开(公告)号：US20050069925A1
公开(公告)日：2005-03-31
申请号：US10903672
申请日：2004-07-30
申请人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
发明人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC分类号： A61B5/4283 , A61B5/14532 , A61B5/4266 , A61B5/4881 , A61B5/7267 , A61B2560/0252 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

4. 发明申请

US20050027179A1 Biosensor and methods of use thereof 有权
标题翻译：生物传感器及其使用方法
公开(公告)号：US20050027179A1
公开(公告)日：2005-02-03
申请号：US10936095
申请日：2004-09-08
申请人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/28 , G01N27/30 , G01N27/416 , G01N33/487 , G01N33/66 , A61B5/05
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61N1/30
摘要： An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.
摘要翻译：提供了一种用于连续透皮提取生物系统中存在的分析物的自动化系统。该系统可用于使用电化学生物传感器检测装置来检测和/或测量分析物的浓度。该系统可选择使用反向离子电渗法进行分析物的连续经皮提取。

5. 发明授权

US6141573A Chemical signal-impermeable mask 有权
公开(公告)号：US6141573A
公开(公告)日：2000-10-31
申请号：US128891
申请日：1998-08-04
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61N1/30 , C12Q1/00 , G01N27/416
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

6. 发明申请

US20070038053A1 Signal processing for measurement of physiological analytes 审中-公开
标题翻译：用于测量生理分析物的信号处理
公开(公告)号：US20070038053A1
公开(公告)日：2007-02-15
申请号：US11583407
申请日：2006-10-19
申请人： Bret Berner , Timothy Dunn , Kathleen Farinas , Michael Garrison , Ronald Kurnik , Matthew Lesho , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Timothy Dunn , Kathleen Farinas , Michael Garrison , Ronald Kurnik , Matthew Lesho , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1477 , A61B5/14532 , A61B5/14542 , A61B5/1486
摘要： A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
摘要翻译：提供了用于连续或连续地测量存在于生物系统中的目标化学分析物的浓度的方法，并且处理分析物特异性信号以获得与生物系统中的目标化学分析物的浓度密切相关的测量值。本发明的一个重要应用涉及用于监测血糖值的系统中的信号处理方法。

7. 发明申请

US20060105420A1 Compositions and methods for enhancement of transdermal analyte flux 审中-公开
标题翻译：用于增强透皮分析物通量的组合物和方法
公开(公告)号：US20060105420A1
公开(公告)日：2006-05-18
申请号：US11329610
申请日：2006-01-11
申请人： Janet Tamada , Michael Tierney , Stephen Williams
发明人： Janet Tamada , Michael Tierney , Stephen Williams
IPC分类号： C12Q1/26
CPC分类号： A61B5/1486 , A61N1/0436 , A61N1/044 , A61N1/325 , C08J3/075
摘要： The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
摘要翻译：本发明涉及用于分析物监测设备的组合物。这些组合物可用于增加分析物通过皮肤，组织或粘膜表面的通量。组合物包括包含离子导电材料的水凝胶和收集储存器系统。本发明还包括制造/制造水凝胶或收集储存器系统的方法，包括水凝胶的收集组件，与水凝胶或收集储存器系统组合的电极组件及其使用方法。

8. 发明申请

US20050119540A1 Methods and devices for prediction of hypoglycemic events 审中-公开
标题翻译：用于预测低血糖事件的方法和装置
公开(公告)号：US20050119540A1
公开(公告)日：2005-06-02
申请号：US10982148
申请日：2004-11-05
申请人： Russell Potts , Michael Tierney
发明人： Russell Potts , Michael Tierney
IPC分类号： G01N21/35 , A61B5/00 , A61B5/05 , A61B5/145 , A61B5/1455 , A61B5/1468 , G01N33/487 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： A61B5/14532 , A61B5/7267 , G01N27/3271
摘要： Described herein are methods, devices, and microprocessors useful for predicting a hypoglycemic event in a subject. The hypoglycemic predictive approach described herein utilizes information obtained from a data stream, e.g., frequently obtained glucose values (current and/or predicted), body temperature, and/or skin conductance, to predict incipient hypoglycemic events and to alert the user.
摘要翻译：这里描述了可用于预测受试者中的低血糖事件的方法，装置和微处理器。本文描述的低血糖预测方法利用从数据流获得的信息，例如经常获得的葡萄糖值（当前和/或预测），体温和/或皮肤电导，以预测初始低血糖事件并提醒用户。

9. 发明授权

US06771995B2 Chemical signal-impermeable mask 失效
标题翻译：化学信号不透水面罩
公开(公告)号：US06771995B2
公开(公告)日：2004-08-03
申请号：US10324818
申请日：2002-12-20
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B500
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.
摘要翻译：化学信号不可渗透的掩模位于电解质流中，使得掩模位于化学信号源和感测从源传输的化学信号（例如通过扩散）的工作电极之间。掩模的配置使得掩模基本上防止具有相对于掩模的平面和工作电极的催化面的径向矢量分量的化学信号源的所有化学信号传输，因此主要仅允许化学信号传输基本上垂直于掩模的位置和工作电极的催化表面。通过减少或消除朝向工作电极的化学信号径向传输，掩模因此显着地减少或消除了边缘效应。通过显着降低由化学信号的径向传输产生的边缘效应，可以获得从源材料的给定区域输送的化学信号的量（例如，浓度）的更准确的测量。

10. 发明授权

US06659939B2 Cooperative minimally invasive telesurgical system 有权
公开(公告)号：US06659939B2
公开(公告)日：2003-12-09
申请号：US09433120
申请日：1999-11-03
申请人： Frederic H. Moll , David J. Rosa , Andris D. Ramans , Steven J. Blumenkranz , Gary S. Guthart , Gunter D. Niemeyer , William C. Nowlin , J. Kenneth Salisbury , Michael Tierney
发明人： Frederic H. Moll , David J. Rosa , Andris D. Ramans , Steven J. Blumenkranz , Gary S. Guthart , Gunter D. Niemeyer , William C. Nowlin , J. Kenneth Salisbury , Michael Tierney
IPC分类号： A61B100
CPC分类号： A61B19/2203 , A61B34/30 , A61B34/35 , A61B34/37 , A61B34/76 , A61B90/361 , A61B2017/00199 , A61B2034/305 , A61B2034/742 , A61B2090/506 , G06F19/00 , G09B23/285
摘要： Improved robotic surgical systems, devices, and methods include selectably associatable master/slave pairs, often having more manipulator arms than will be moved simultaneously by the two hands of a surgeon. Four manipulator arms can support an image capture device, a left hand tissue manipulation tool, a right hand tissue manipulation tool, and a fourth surgical instrument, particularly for stabilizing, retracting, tool change, or other functions benefiting from intermittent movement. The four or more arms may sequentially be controlled by left and right master input control devices. The fourth arm may be used to support another image capture device, and control of some or all of the arms may be transferred back-and-forth between the operator and an assistant. Two or more robotic systems each having master controls and slave manipulators may be coupled to enable cooperative surgery between two or more operators.

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