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    • 3. 发明申请
    • Composite Flash-Precipitated Nanoparticles
    • 复合闪烁沉淀纳米颗粒
    • US20100330368A1
    • 2010-12-30
    • US12265206
    • 2008-11-05
    • Robert K. Prud'hommeMarian GindyYing Liu
    • Robert K. Prud'hommeMarian GindyYing Liu
    • B32B15/04
    • A61K9/5153A61K49/0019A61K49/0065A61K49/0093A61K49/1857Y10T428/2991
    • The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.
    • 本文描述的本发明涉及包含预先形成的包封在聚合物壳内的胶体颗粒的空间稳定的胶体构造物。 可控制尺寸的构造体是包含疏水性元素的纳米颗粒,具有疏水表面的带静电荷的颗粒,疏水性无机纳米结构和具有疏水域和亲水结构域的两亲共聚物。 构建体通过允许预先形成的胶体剂以及在聚合物纳米颗粒的核心内的溶解的疏水性活性物质同时包封的方法制备。 在各种实施方案中引入的活性物质是用于组合荧光,光学和磁共振成像应用的有机荧光染料,金属纳米结构和超顺磁性材料,以及用于治疗应用的疏水性药物。