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1. 发明授权

US08962880B2 Amorphous asiatic tromethamine salt and preparation method thereof 有权
标题翻译：无定形亚洲氨丁三醇盐及其制备方法
公开(公告)号：US08962880B2
公开(公告)日：2015-02-24
申请号：US14006198
申请日：2012-03-21
申请人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
发明人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
IPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/00
CPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/008
摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
摘要翻译：一种无定形亚洲氨丁三醇盐及其制备方法。该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

2. 发明授权

US10428013B2 Amide compound, preparation method and uses thereof 有权
公开(公告)号：US10428013B2
公开(公告)日：2019-10-01
申请号：US14129000
申请日：2012-06-25
申请人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
发明人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
IPC分类号： C07C235/84 , A61K31/165 , A61K31/166 , A61K31/222 , C07C325/02 , C07C235/20 , C07C235/26 , C07C251/24 , C07C231/02
摘要： Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

3. 发明申请

US20140243553A1 AMORPHOUS ASIATIC TROMETHAMINE SALT AND PREPARATION METHOD THEREOF 有权
标题翻译：非晶亚硫胺盐及其制备方法
公开(公告)号：US20140243553A1
公开(公告)日：2014-08-28
申请号：US14006198
申请日：2012-03-21
申请人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
发明人： Guobin Ren , Ying Liu , Jinyao Chen , Xiaoling Huang , Lin Xiao , Li Cai , Zhen Zhang , Xuejun Wu , Haiyan Sun , Quanhai Liu , Liling Jin , Minyu Liu , Yifang Deng , Zhiru Xu , Renhai Chen , Chungang Li , Xiangduan Tan , Yan Qin
IPC分类号： C07C227/14 , C07C229/38
CPC分类号： C07C227/14 , C07C215/10 , C07C229/38 , C07J63/008
摘要： An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.
摘要翻译：一种无定形亚洲氨丁三醇盐及其制备方法。该方法包括以下步骤：（1）将积雪草酸溶解在有机溶剂中; 步骤（2）与氨丁三醇混合; 步骤（3）搅拌并使其成盐，然后除去有机溶剂。无定形亚洲氨基丁三醇盐的制备方法容易有效，与现有技术相比，所得到的亚稳氨基甲基胺盐的水溶性和生物利用度大大降低。

4. 发明授权

US08261352B2 Hybrid representation for deterministic finite automata 有权
标题翻译：确定性有限自动机的混合表示
公开(公告)号：US08261352B2
公开(公告)日：2012-09-04
申请号：US12468454
申请日：2009-05-19
申请人： Qingming Ma , Bryan Burns , Sheng Li , Na Liu , Xuejun Wu , Shan Yu , Li Zheng
发明人： Qingming Ma , Bryan Burns , Sheng Li , Na Liu , Xuejun Wu , Shan Yu , Li Zheng
IPC分类号： G06F21/06
CPC分类号： H04L63/1416
摘要： A method includes receiving a data unit, determining whether a current state, associated with a deterministic finite automata (DFA) that includes a portion of states in a bitmap and a remaining portion of states in a DFA table, is a bitmap state or not, and determining whether a value corresponding to the data unit is greater than a threshold value, when it is determined that the current state is not a bitmap state. The method further includes determining whether the current state is insensitive, when it is determined that the value corresponding to the data unit is greater than the threshold value, where insensitive means that each next state is a same state for the current state, and selecting a default state, as a next state for the current, when it is determined that the current state is insensitive.
摘要翻译：一种方法包括接收数据单元，确定与包括位图中的状态的一部分和DFA表中的剩余部分状态的确定性有限自动机（DFA）相关联的当前状态是否为位图状态，以及当确定当前状态不是位图状态时，确定对应于所述数据单元的值是否大于阈值。该方法还包括当确定对应于数据单元的值大于阈值时确定当前状态是否不敏感，其中不确定意味着每个下一状态对于当前状态是相同的状态，并且选择默认状态，作为当前的下一状态，当确定当前状态不敏感时。

5. 发明授权

US06867194B2 Enzyme activated nitric oxide donors 失效
标题翻译：酶活化一氧化氮供体
公开(公告)号：US06867194B2
公开(公告)日：2005-03-15
申请号：US09925816
申请日：2001-08-09
申请人： Peng George Wang , Xuejun Wu , Xiaoping Tang
发明人： Peng George Wang , Xuejun Wu , Xiaoping Tang
IPC分类号： A61K31/706 , C07H13/12 , A61K3/785
CPC分类号： C07H13/12 , A61K31/706
摘要： Sugar-modified SIN-1 compositions are provided. The compositions are useful for generating NO in response to hydrolytic activity of a glycosidase specific for the O-glycosidic bond between the sugar and SIN-1 moieties. Pharmaceutical compositions containing the sugar-modified SIN-1 compositions and methods of using the compositions are also provided.
摘要翻译：提供了糖改性的SIN-1组合物。该组合物可用于响应糖和SIN-1部分之间的O-糖苷键特异的糖苷酶的水解活性产生NO。还提供了含有糖修饰的SIN-1组合物的药物组合物和使用该组合物的方法。

6. 发明申请

US20140128463A1 AMIDE COMPOUND, PREPARATION METHOD AND USES THEREOF 审中-公开
标题翻译：酰胺化合物，制备方法及其用途
公开(公告)号：US20140128463A1
公开(公告)日：2014-05-08
申请号：US14129000
申请日：2012-06-25
申请人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
发明人： Zhenpeng Yu , Gouping Wang , Zhen Zhang , Minyu Liu , Xiaoling Huang , Ying Liu , Lin Xiao , Li Cai , Xuejun Wu , Yifang Deng , Mianli Pan , Renhai Chen , Shenrong Tang , Quanhai Liu
IPC分类号： C07C235/84 , C07C231/02
CPC分类号： C07C235/84 , A61K31/165 , A61K31/166 , A61K31/222 , C07C231/02 , C07C235/20 , C07C235/26 , C07C251/24 , C07C325/02 , C07C2601/02 , C07C2601/14
摘要： Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.
摘要翻译：公开了酰胺化合物，其制备方法和用途，具体地，由式I表示的化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，Q，X和n如描述中所定义。还公开了制备式I化合物的方法，含有该化合物的组合物及其在制备用于调节血脂和/或预防胆结石的药物中的用途。本发明公开的式I化合物在体外具有稳定性，在药用有机溶剂中的溶解性好，动物中具有良好的生物利用度。

7. 发明授权

US09712374B1 Network services resource management 有权
公开(公告)号：US09712374B1
公开(公告)日：2017-07-18
申请号：US12859090
申请日：2010-08-18
申请人： Wei Cao , Xia Zhu , Xuejun Wu
发明人： Wei Cao , Xia Zhu , Xuejun Wu
IPC分类号： G06F15/16 , H04L29/08
CPC分类号： H04L29/08072 , H04L29/08135 , H04L49/9005 , H04L63/0227 , H04L63/0263 , H04L63/0281 , H04L63/1408 , H04L69/14
摘要： In general, the invention is directed to techniques for scheduling resource access within an intermediate network device. For example, as described herein, a device receives packets for a plurality of sessions that include application-layer data for the sessions. The device determines a weight for each of the plurality of sessions and, during periods of resource congestion, selects one or more sessions for additional resource allocation based on the respective weights of the sessions. The device allocates additional memory resources to selected sessions to enable further buffering of application-layer data such that the device may apply the service to multiple sessions concurrently despite the resource congestion.

8. 发明授权

US08258176B2 Dithiolopyrrolone compounds, the preparation and the use thereof 有权
标题翻译：二硫代罗环酮化合物，其制备及其应用
公开(公告)号：US08258176B2
公开(公告)日：2012-09-04
申请号：US12676470
申请日：2008-08-29
申请人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
发明人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
IPC分类号： A61K31/407 , C07D487/04 , C07D487/02
CPC分类号： C07D495/04
摘要： The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.
摘要翻译：本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。

9. 发明申请

US20100229238A1 HYBRID REPRESENTATION FOR DETERMINISTIC FINITE AUTOMATA 有权
标题翻译：用于确定有限自动机的混合代表
公开(公告)号：US20100229238A1
公开(公告)日：2010-09-09
申请号：US12468454
申请日：2009-05-19
申请人： Qingming Ma , Bryan Burns , Sheng Li , Na Liu , Xuejun Wu , Shan Yu , Li Zheng
发明人： Qingming Ma , Bryan Burns , Sheng Li , Na Liu , Xuejun Wu , Shan Yu , Li Zheng
IPC分类号： G06F21/06
CPC分类号： H04L63/1416
摘要： A method includes receiving a data unit, determining whether a current state, associated with a deterministic finite automata (DFA) that includes a portion of states in a bitmap and a remaining portion of states in a DFA table, is a bitmap state or not, and determining whether a value corresponding to the data unit is greater than a threshold value, when it is determined that the current state is not a bitmap state. The method further includes determining whether the current state is insensitive, when it is determined that the value corresponding to the data unit is greater than the threshold value, where insensitive means that each next state is a same state for the current state, and selecting a default state, as a next state for the current, when it is determined that the current state is insensitive.
摘要翻译：一种方法包括接收数据单元，确定与包括位图中的状态的一部分和DFA表中的剩余部分状态的确定性有限自动机（DFA）相关联的当前状态是否为位图状态，以及当确定当前状态不是位图状态时，确定对应于所述数据单元的值是否大于阈值。该方法还包括当确定对应于数据单元的值大于阈值时确定当前状态是否不敏感，其中不确定意味着每个下一状态对于当前状态是相同的状态，并且选择默认状态，作为当前的下一状态，当确定当前状态不敏感时。

10. 发明申请

US20100210856A1 DITHIOLOPYRROLONE COMPOUNDS, THE PREPARATION AND THE USE THEREOF 有权
标题翻译：二羟基吡咯烷酮化合物，其制备及其用途
公开(公告)号：US20100210856A1
公开(公告)日：2010-08-19
申请号：US12676470
申请日：2008-08-29
申请人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
发明人： Guoping Wang , Quanhai Liu , Haiyan Sun , Wei Wu , Jian Hou , Lin Yao , Chungang Li , Minyu Liu , Fei Li , Xuejun Wu , Shuai Zhao
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X1, R1, R2, R3, R4 are defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.
摘要翻译：本发明公开了由式I表示的二硫代环吡咯酮化合物或其药学上可接受的盐，其中X1，R1，R2，R3，R4如描述中所定义。本发明还公开了这样的化合物的制备，以及这些化合物在制备用于增加外周白细胞的药物中的用途以及用于抑制放射治疗或化学疗法中外周白细胞减少的辅助药物。

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