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1. 发明申请

US20200230117A1 NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE 审中-公开
公开(公告)号：US20200230117A1
公开(公告)日：2020-07-23
申请号：US16088873
申请日：2017-04-24
申请人： Phillip M. COWLEY , Meredeth Ann MCGOWAN , Thomas J. BROWN , WISE Alan , Hua ZHOU , Yongxin HAN , Kun LIU , Qinglin PU , Hongjun ZHANG , IOMet Pharma Ltd.
发明人： Phillip M. Cowley , Meredeth Ann McGowan , Thomas J. Brown , Yongxin Han , Kun Liu , Qinglin Pu , Alan Wise , Hongjun Zhang , Hua Zhou
IPC分类号： A61K31/438 , C07D519/00
摘要： Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.

2. 发明授权

US09584617B2 Allocating cache request in distributed cache system based upon cache object and marker identifying mission critical data 有权
标题翻译：基于高速缓存对象和标识符来识别任务关键数据，在分布式缓存系统中分配高速缓存请求
公开(公告)号：US09584617B2
公开(公告)日：2017-02-28
申请号：US14144948
申请日：2013-12-31
申请人： Xiao Han , Kun Liu , Peter Zhao , Edward Lu , Jessica Yang , Tim Ke
发明人： Xiao Han , Kun Liu , Peter Zhao , Edward Lu , Jessica Yang , Tim Ke
IPC分类号： G06F15/16 , H04L29/08
CPC分类号： H04L67/2842 , H04L67/288
摘要： Various embodiments of the present disclosure provide improved systems and techniques for intelligently allocating cache requests to caches based upon the nature of the cache objects associated with the cache requests, and/or the condition of the caches in the distributed cache system, to facilitate cache system utilization and performance. In some embodiments, an allocation of cache requests may be performed in response to detection of a problem at one of a group of cache servers. For example, in some embodiments, a particular cache server may be entered into a safe mode of operations when the cache's ability to service cache requests is impaired. In other embodiments, an allocation of cache requests may be performed based on an cache object data type associated with the cache requests.
摘要翻译：本公开的各种实施例提供了用于基于与高速缓存请求相关联的高速缓存对象的性质和/或分布式高速缓存系统中的高速缓存的状况来智能地将缓存请求分配到高速缓存的改进的系统和技术，以便于缓存系统利用率和业绩。在一些实施例中，响应于检测到一组缓存服务器中的问题，可以执行高速缓存请求的分配。例如，在一些实施例中，当高速缓存服务高速缓存请求的能力受损时，可以将特定高速缓存服务器输入到安全操作模式。在其他实施例中，可以基于与高速缓存请求相关联的高速缓存对象数据类型来执行高速缓存请求的分配。

3. 发明授权

US09444602B2 Control signaling transmission method, control signaling processing device, and terminal 有权
标题翻译：控制信令传输方式，控制信令处理设备和终端
公开(公告)号：US09444602B2
公开(公告)日：2016-09-13
申请号：US14382433
申请日：2012-06-20
申请人： Zhaohua Lu , Xiaodan Zhang , Kun Liu , Dihao Ning
发明人： Zhaohua Lu , Xiaodan Zhang , Kun Liu , Dihao Ning
IPC分类号： H04J11/00 , H04B7/204 , H04B7/208 , H04J1/00 , H04L5/00 , H04W72/04
CPC分类号： H04L5/0053 , H04W72/0406 , Y02D70/1262
摘要： A method for transmitting control signaling, an apparatus for processing control signaling and a terminal are provided. A base station transmits evolved control signaling to an evolved terminal on M downlink subframes in a radio frame, wherein M is an integer greater than or equal to 1 and less than N, and N is the number of the downlink subframes in the radio frame. The above technical solution enhances basic control signaling of an LTE-series standard, reduces system overhead and terminal energy consumption, meets demands for future development of the industry, solves the problem of large system overhead and high terminal energy consumption due to the wireless communication standards, and meanwhile also gives sufficient consideration to backward compatibility of the system, and better meets demands of data users rapidly developing and future development of the wireless communications industry.
摘要翻译：提供了用于发送控制信令的方法，用于处理控制信令的装置和终端。基站在无线帧中的M个下行链路子帧上向演进终端发送演进控制信令，其中M是大于或等于1且小于N的整数，N是无线帧中的下行链路子帧的数量。上述技术方案增强了LTE系列标准的基本控制信令，降低系统开销和终端能耗，满足行业未来发展的需求，解决了无线通信标准引起的系统开销大，终端能耗高的问题同时也充分考虑到系统的向后兼容性，更好地满足了数据用户快速发展和未来无线通信行业发展的需求。

4. 发明申请

US20150270596A1 POWER DIVIDER AND METHOD OF FABRICATING THE SAME 有权
标题翻译：功率分配器及其制造方法
公开(公告)号：US20150270596A1
公开(公告)日：2015-09-24
申请号：US14436940
申请日：2012-10-25
申请人： Bo ZHOU , Kun LIU , Junyou CHEN , TELEFONAKTIEBOLAGET L M ERICSSON (PUBL)
发明人： Bo Zhou , Kun Liu , Junyou Chen
IPC分类号： H01P5/12 , H01P11/00
CPC分类号： H01P5/12 , H01P5/16 , H01P11/003 , H01P11/006
摘要： The invention provides a power divider, comprising: a plurality of transmission stages and a plurality of ground layers alternately arranged on respective ones of a plurality of dielectric layers, a first transmission stage being arranged on a first dielectric layer, and a last transmission stage being arranged below a last dielectric layer; wherein the plurality of transmission stages are arrayed vertically, each consisting of a loop formed by a transmission line; the first transmission stage has a first opening connected by a resistor, and each of the remaining transmission stages has the first opening connected by the resistor and a second opening without a resistor; two ends of the first opening of one of the adjacent transmission stages are connected to two ends of the second opening of the other one of the adjacent transmission stages by via transitions, in a top-to-bottom direction; and each ground layer has clearances through which the via transitions pass. The invention also provides a method of fabricating the power divider.
摘要翻译：本发明提供了一种功率分配器，包括：交替布置在多个电介质层中的多个电介质层上的多个发射级和多个接地层，第一传输级布置在第一介电层上，最后的传输级为布置在最后的介电层下面; 其中所述多个传输级垂直排列，每个由传输线形成的环路组成; 第一传输级具有由电阻器连接的第一开口，并且每个剩余的传输级具有通过电阻器连接的第一开口和没有电阻器的第二开口; 一个相邻传动级的第一开口的两端通过上下方向的过渡而连接到另一个相邻传动级的第二开口的两端; 并且每个接地层具有通孔经过的间隙。本发明还提供一种制造功率分配器的方法。

5. 发明授权

US09120781B2 Selective glycosidase inhibitors and uses thereof 有权
标题翻译：选择性糖苷酶抑制剂及其用途
公开(公告)号：US09120781B2
公开(公告)日：2015-09-01
申请号：US13697179
申请日：2011-05-10
申请人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
发明人： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
IPC分类号： C07D263/56 , C07D263/58 , C07D277/82 , C07D413/04 , C07D417/04 , C07D277/64 , C07D263/52 , C07D277/60
CPC分类号： C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
摘要： The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译：本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。

6. 发明申请

US20150189033A1 Distributed Cache System 有权
标题翻译：分布式缓存系统
公开(公告)号：US20150189033A1
公开(公告)日：2015-07-02
申请号：US14144948
申请日：2013-12-31
申请人： XIAO HAN , KUN LIU , PETER ZHAO , EDWARD LU , JESSICA YANG , TIM KE
发明人： XIAO HAN , KUN LIU , PETER ZHAO , EDWARD LU , JESSICA YANG , TIM KE
IPC分类号： H04L29/08
CPC分类号： H04L67/2842 , H04L67/288
摘要： Various embodiments of the present disclosure provide improved systems and techniques for intelligently allocating cache requests to caches based upon the nature of the cache objects associated with the cache requests, and/or the condition of the caches in the distributed cache system, to facilitate cache system utilization and performance. In some embodiments, an allocation of cache requests may be performed in response to detection of a problem at one of a group of cache servers. For example, in some embodiments, a particular cache server may be entered into a safe mode of operations when the cache's ability to service cache requests is impaired. In other embodiments, an allocation of cache requests may be performed based on an cache object data type associated with the cache requests.
摘要翻译：本公开的各种实施例提供了用于基于与高速缓存请求相关联的高速缓存对象的性质和/或分布式高速缓存系统中的高速缓存的状况来智能地将缓存请求分配到高速缓存的改进的系统和技术，以便于缓存系统利用率和业绩。在一些实施例中，响应于检测到一组缓存服务器中的问题，可以执行高速缓存请求的分配。例如，在一些实施例中，当高速缓存服务高速缓存请求的能力受损时，可以将特定高速缓存服务器输入到安全操作模式。在其他实施例中，可以基于与高速缓存请求相关联的高速缓存对象数据类型来执行高速缓存请求的分配。

7. 发明申请

US20150098399A1 CONTROL SIGNALING TRANSMISSION METHOD, CONTROL SIGNALING PROCESSING DEVICE, AND TERMINAL 有权
标题翻译：控制信号传输方法，控制信令处理装置和终端
公开(公告)号：US20150098399A1
公开(公告)日：2015-04-09
申请号：US14382433
申请日：2012-06-20
申请人： Zhaohua Lu , Xiaodan Zhang , Kun Liu , Dihao Ning
发明人： Zhaohua Lu , Xiaodan Zhang , Kun Liu , Dihao Ning
IPC分类号： H04L5/00
CPC分类号： H04L5/0053 , H04W72/0406 , Y02D70/1262
摘要： A method for transmitting control signaling, an apparatus for processing control signaling and a terminal are provided. A base station transmits evolved control signaling to an evolved terminal on M downlink subframes in a radio frame, wherein M is an integer greater than or equal to 1 and less than N, and N is the number of the downlink subframes in the radio frame. The above technical solution enhances basic control signaling of an LTE-series standard, reduces system overhead and terminal energy consumption, meets demands for future development of the industry, solves the problem of large system overhead and high terminal energy consumption due to the wireless communication standards, and meanwhile also gives sufficient consideration to backward compatibility of the system, and better meets demands of data users rapidly developing and future development of the wireless communications industry.
摘要翻译：提供了用于发送控制信令的方法，用于处理控制信令的装置和终端。基站在无线帧中的M个下行链路子帧上向演进终端发送演进控制信令，其中M是大于或等于1且小于N的整数，N是无线帧中的下行链路子帧的数量。上述技术方案增强了LTE系列标准的基本控制信令，降低系统开销和终端能耗，满足行业未来发展的需求，解决了无线通信标准引起的系统开销大，终端能耗高的问题同时也充分考虑了系统的向后兼容性，更好地满足了数据用户快速发展和未来无线通信行业发展的需求。

8. 发明授权

US08977253B2 Method for sending auxiliary detection signaling 有权
标题翻译：发送辅助检测信号的方法
公开(公告)号：US08977253B2
公开(公告)日：2015-03-10
申请号：US13143198
申请日：2009-12-24
申请人： Kun Liu , Zhaohua Lu , Ying Liu , Feng Xie , Yang Liu , Hongyun Qu
发明人： Kun Liu , Zhaohua Lu , Ying Liu , Feng Xie , Yang Liu , Hongyun Qu
IPC分类号： H04W24/00 , H04W48/12 , H04W4/08
CPC分类号： H04W48/12 , H04W4/08 , Y02D70/00
摘要： The present invention discloses a method for sending auxiliary detection signaling, comprising: for each base station in a base station group, that is, a first base station, the other base stations in the base station group except the first base station respectively send auxiliary detection signaling at the carrier frequency of the first base station. The technical solution saves both signaling overhead and power and reduces the complexity of a search carried out by an MS.
摘要翻译：本发明公开了一种发送辅助检测信令的方法，包括：对于基站组中的每个基站，即第一基站，基站组除第一基站之外的其他基站分别发送辅助检测在第一基站的载波频率处的信令。技术解决方案节省了信令开销和功率，并降低了MS进行的搜索的复杂性。

9. 发明授权

US08933113B2 Mineralocorticoid receptor antagonists 有权
标题翻译：盐皮质激素受体拮抗剂
公开(公告)号：US08933113B2
公开(公告)日：2015-01-13
申请号：US13979875
申请日：2012-01-19
申请人： Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
发明人： Alejandro Crespo , Ping Lan , Rudrajit Mal , Anthony Ogawa , Hong Shen , Peter J. Sinclair , Zhongxiang Sun , Ellen K. Vande Bunte , Zhicai Wu , Kun Liu , Robert J. DeVita , Dong-Ming Shen , Min Shu , John Qiang Tan , Changhe Qi , Yuguang Wang , Richard Beresis
IPC分类号： A61K31/416 , C07D231/56 , A61K31/405 , A61K31/404 , C07D403/06 , C07D209/08 , C07D209/10 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D413/06
CPC分类号： C07D413/06 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/416 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D209/08 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06
摘要： Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐，其可用于治疗醛固酮介导的疾病。还公开了制备式（I）化合物，用于治疗和预防上述疾病和用于制备用于此目的的药物的方法和包含式（I）化合物的药物组合物。

10. 发明授权

US08927507B2 Selective glycosidase inhibitors and uses thereof 有权
公开(公告)号：US08927507B2
公开(公告)日：2015-01-06
申请号：US14006888
申请日：2012-03-16
申请人： Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Craig A. Coburn , Kun Liu , Harold G. Selnick
发明人： Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Craig A. Coburn , Kun Liu , Harold G. Selnick
IPC分类号： C08B37/00 , C07D487/02 , A61K31/70 , A61K31/425 , C12Q1/34 , C07H13/04 , C07H9/06
CPC分类号： C07H9/06 , C07H13/04 , C12Q1/34 , G01N2333/924 , G01N2500/04
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

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