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1. 发明申请

US20060116368A1 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor 审中-公开
标题翻译：香草素VR1受体的4-哌啶甲酰胺调节剂
公开(公告)号：US20060116368A1
公开(公告)日：2006-06-01
申请号：US11288624
申请日：2005-11-29
申请人： Raul Calvo , Wing Cheung , Mark Player
发明人： Raul Calvo , Wing Cheung , Mark Player
IPC分类号： C07D279/16 , C07D265/36 , A61K31/5415 , A61K31/538
CPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
摘要翻译：本发明涉及香草素受体VR1配体。更具体地，本发明涉及作为VR1的有效调节剂的异异构酰胺，其可用于治疗和预防哺乳动物的疾病状况。

2. 发明授权

US08796256B2 Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-α modulators 有权
标题翻译：取代的噻唑烷二酮吲唑，吲哚和苯并三唑作为雌激素相关受体α调节剂
公开(公告)号：US08796256B2
公开(公告)日：2014-08-05
申请号：US13114084
申请日：2011-05-24
申请人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
发明人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
IPC分类号： C07D417/06
CPC分类号： C07D417/06
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

3. 发明申请

US20050049274A1 Quinolinone derivatives as inhibitors of c-fms kinase 有权
标题翻译：喹啉酮衍生物作为c-fms激酶的抑制剂
公开(公告)号：US20050049274A1
公开(公告)日：2005-03-03
申请号：US10894940
申请日：2004-07-20
申请人： Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
发明人： Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
IPC分类号： A61P35/00 , C07D215/22 , C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/02 , A61K31/47 , C07D215/36
CPC分类号： C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译：本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5，R 6，Y 1，Y 2， 3>，Y 4和X在说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

4. 发明申请

US20110294780A1 SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS 有权
标题翻译：作为雌激素相关受体 - 调节剂的替扎唑啉衍生物，吲哚酚和苯并噻唑
公开(公告)号：US20110294780A1
公开(公告)日：2011-12-01
申请号：US13114084
申请日：2011-05-24
申请人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
发明人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
IPC分类号： A61K31/427 , C07D413/14 , C07D401/14 , C07D453/02 , C07D451/04 , C07D498/04 , C07D455/02 , C07D419/14 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/46 , A61K31/439 , A61K31/55 , A61K31/541 , A61K31/551 , A61K31/4439 , A61K31/5383 , A61K31/433 , A61K31/4245 , A61K31/41 , A61P19/08 , A61P19/06 , A61P19/10 , A61P35/04 , A61P19/04 , A61P35/00 , A61P19/02 , A61P29/00 , A61P11/00 , A61P11/08 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P3/06 , A61P9/00 , A61P9/10 , A61P5/48 , C07D417/14
CPC分类号： C07D417/06
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

5. 发明授权

US07314971B2 Nuclear fertility restorer genes and methods of use in plants 失效
标题翻译：核生育恢复基因和植物中的使用方法
公开(公告)号：US07314971B2
公开(公告)日：2008-01-01
申请号：US10345072
申请日：2003-01-15
申请人： Gregory G. Brown , Charles Dendy , Benoit S. Landry , Wing Cheung , Hua Jin , Fang-Ming Lai , Natasa Formanova , Martin LaForest
发明人： Gregory G. Brown , Charles Dendy , Benoit S. Landry , Wing Cheung , Hua Jin , Fang-Ming Lai , Natasa Formanova , Martin LaForest
IPC分类号： C12N15/82 , C12N15/29 , A01H1/02 , A01H5/00
CPC分类号： C12N15/8287 , C07K14/415 , C12N15/1034 , C12N15/821 , C12N15/8289
摘要： The present invention includes nuclear fertility restorer genes, proteins encoded by those genes and transgenic plants and plant cells containing those genes. More particularly, the nuclear fertility restorer genes can be used to restore fertility in cytoplasmic male-sterile plants such as Brassica napus. Preferably, the nuclear fertility restorer genes are used with the Ogura (ogu) CMS system in Brassica napus.
摘要翻译：本发明包括核能恢复基因，由这些基因编码的蛋白质和转基因植物以及含有这些基因的植物细胞。更具体地说，核生育恢复基因可用于恢复细胞质雄性不育植物如甘蓝型油菜中的生育力。优选地，

6. 发明申请

US20050267026A1 Combination dosing regimen for erythropoietin 审中-公开
标题翻译：红细胞生成素联合给药方案
公开(公告)号：US20050267026A1
公开(公告)日：2005-12-01
申请号：US11088284
申请日：2005-03-24
申请人： Wing Cheung
发明人： Wing Cheung
IPC分类号： A61K38/18
CPC分类号： A61K38/1816
摘要： The present invention provides a combination dosing regimen for erythropoietin (EPO). More particularly, the present dosing regimen includes administration of at least a first dosing segment comprising a first exposure to EPO capable of stimulating the production of reticulocytes followed by a second exposure to EPO capable of sustaining the maturation of the reticulocytes into neocytes, and ultimately, red blood cells. Advantageously, the dosing segment may be cycled or repeated, any number of times and according to any desired time scheme, in order to provide or maintain any desired total red blood cell count and/or hemoglobin concentration. Methods of treatment employing the combination dosing regimen, as well as kits are also provided.
摘要翻译：本发明提供促红细胞生成素（EPO）的组合给药方案。更具体地，本发明的给药方案包括施用至少第一给药段，其包含能够刺激网织红细胞生成的EPO的第一次暴露，然后第二次暴露于能够维持网织红细胞成熟为新细胞的EPO，红细胞。有利地，给药段可以循环或重复任意次数，并且根据任何期望的时间方案，以便提供或维持任何期望的总红细胞计数和/或血红蛋白浓度。还提供了使用联合给药方案的治疗方法以及试剂盒。

7. 发明授权

US6067563A Method and apparatus for avoiding control reads in a network node 有权
标题翻译：用于避免网络节点中的控制读取的方法和装置
公开(公告)号：US6067563A
公开(公告)日：2000-05-23
申请号：US306588
申请日：1999-05-06
申请人： Robert E. Thomas , Douglas M. Washabaugh , Peter J. Roman , Wing Cheung
发明人： Robert E. Thomas , Douglas M. Washabaugh , Peter J. Roman , Wing Cheung
IPC分类号： G06F11/30 , H04L12/56 , H04L29/06 , H04Q11/04 , G06F13/00
CPC分类号： H04L47/522 , G06F11/3006 , G06F11/3027 , G06F11/3055 , G06F11/3096 , H04L29/06 , H04L47/521 , H04L49/90 , H04L49/901 , H04L49/9036 , H04Q11/0478 , H04L2012/5616 , H04L2012/5635 , H04L2012/5658 , H04L2012/5679 , H04L2012/5681
摘要： A mechanism for avoiding an initiation of control read transactions on a system bus coupling a host system having a host memory and an interface connected to a peripheral unit as data is moved between the host system and the peripheral unit is presented. Control information associated with data memory portions in host memory is written to the interface for data memory portions storing outgoing data and data memory portions to receive incoming data. The interface includes a controller to move data between the host memory and the interface by first obtaining the control information for the associated data portions. The interface writes status reports in association with the movement of data between the interface and the host memory via the system bus. The mechanism thus enables data transfers to occur via the system without the initiation of control reads in absence of an exception condition.
摘要翻译：提出了一种用于避免在系统总线上启动控制读取事务的机制，该系统总线耦合具有主机存储器的主机系统和连接到外围单元的接口，因为数据在主机系统和外围设备之间移动。将与主机存储器中的数据存储器部分相关联的控制信息写入存储输出数据和数据存储器部分的数据存储器部分的接口以接收输入数据。该接口包括控制器，用于通过首先获得相关联的数据部分的控制信息来在主机存储器和接口之间移动数据。该接口通过系统总线写入与接口和主机存储器之间的数据移动相关联的状态报告。因此，该机制使得能够在没有异常条件的情况下通过系统进行数据传输而不启动控制读取。

8. 发明授权

US5970229A Apparatus and method for performing look-ahead scheduling of DMA transfers of data from a host memory to a transmit buffer memory 失效
标题翻译：用于执行从主机存储器到发送缓冲存储器的数据DMA传输的预先调度的装置和方法
公开(公告)号：US5970229A
公开(公告)日：1999-10-19
申请号：US707896
申请日：1996-09-12
申请人： Robert E. Thomas , Peter J. Roman , Wing Cheung
发明人： Robert E. Thomas , Peter J. Roman , Wing Cheung
IPC分类号： G06F13/38 , G06F13/00
CPC分类号： G06F13/387
摘要： An apparatus and method for transferring data from a source memory (e.g. a host memory) to a peripheral interface via a bus utilizes a transmit buffer memory coupled to the peripheral interface, and a current time counter advancing at the rate at which data is to be transferred from the transmit buffer memory to the peripheral interface. A schedule table data structure stores entries in some or all of its locations, where each location corresponds to a point in time at which data is to be transferred from the transmit buffer memory to the peripheral interface. A schedule table pointer is used for pointing to successive locations in the schedule table. The schedule table pointer advances at a rate faster than the current time counter advances so that the schedule table pointer represents a point in time which is ahead of the point in time currently output by the current time counter. A data transfer is initiated from the source memory to the transmit buffer memory via the bus when a valid entry is stored at the location in the schedule table pointed to by the schedule table pointer. The data is then transferred out of the transmit buffer memory to the peripheral interface when the current time counter reaches the value representing at least the same point in time that was represented by the schedule table pointer when the data transfer was initiated. Data transfers from the transmit buffer memory are thereby synchronized in time with their corresponding entries in the schedule table.
摘要翻译：用于经由总线将数据从源存储器（例如，主机存储器）传送到外围接口的装置和方法利用耦合到外围接口的发送缓冲存储器和以数据的速率前进的当前时间计数器从发送缓冲存储器传送到外设接口。调度表数据结构存储其部分或全部位置中的条目，其中每个位置对应于将数据从发送缓冲存储器传送到外围接口的时间点。调度表指针用于指向调度表中的连续位置。调度表指针以比当前时间计数器更快的速率前进，使得调度表指针表示在当前时间计数器当前输出的时间点之前的时间点。当有效条目存储在调度表指针指向的调度表中的位置时，通过总线从源存储器发送到发送缓冲存储器的数据传输。然后，当当前时间计数器达到表示数据传输启动时由调度表指针表示的至少相同的时间点的值时，将数据传送到发送缓冲存储器中的外设接口。因此，从发送缓冲存储器的数据传输在时间上与其在调度表中的相应条目同步。

9. 发明授权

US5941952A Apparatus and method for transferring data from a transmit buffer memory at a particular rate 失效
标题翻译：用于以特定速率从发送缓冲存储器传送数据的装置和方法
公开(公告)号：US5941952A
公开(公告)日：1999-08-24
申请号：US712687
申请日：1996-09-12
申请人： Robert E. Thomas , Peter J. Roman , Wing Cheung
发明人： Robert E. Thomas , Peter J. Roman , Wing Cheung
IPC分类号： H04L12/56 , H04Q11/04 , G06F13/38 , G06F15/17
CPC分类号： H04Q11/0478 , H04L2012/5616 , H04L2012/5635 , H04L2012/5658 , H04L2012/5664 , H04L2012/5667 , H04L2012/5679 , H04L2012/5681
摘要： An apparatus and method for transferring data from a source memory to a transmit buffer memory and then from the transmit buffer memory at a particular rate. A current time counter advances at the rate at which data is to be transmitted from the transmit buffer memory to the interface. A schedule memory stores entries, each valid entry being associated with data that is to be transmitted from the transmit buffer memory to the interface. A timestamp is associated with each valid entry in the schedule memory. Circuitry is then operative on each valid entry read from the schedule table to generate a request for a data transfer between the source memory and the transmit buffer memory; perform a data transfer from the source memory to the transmit buffer memory in response to the request; and transfer the data from the transmit buffer memory when the current time circuitry output reaches a value representing at least the same point in time that is represented by the timestamp associated with the entry for which the request was generated.
摘要翻译：一种用于将数据从源存储器传送到发送缓冲存储器然后以特定速率从发送缓冲存储器传送的装置和方法。当前时间计数器以数据从发送缓冲存储器发送到接口的速率前进。调度存储器存储条目，每个有效条目与要从发送缓冲存储器发送到接口的数据相关联。时间戳与调度存储器中的每个有效条目相关联。然后对从调度表读取的每个有效条目进行电路以产生对源存储器和发送缓冲存储器之间的数据传输的请求; 响应于该请求，执行从源存储器到发送缓冲存储器的数据传输; 并且当当前时间电路输出达到表示与由生成请求的条目相关联的时间戳表示的至少相同的时间点的值时，传送来自发送缓冲存储器的数据。

10. 发明授权

US10033650B2 Preserving quality of service across trill networks 有权
公开(公告)号：US10033650B2
公开(公告)日：2018-07-24
申请号：US13048817
申请日：2011-03-15
申请人： Shunjia Yu , Anoop Ghanwani , Phanidhar Koganti , John Michael Terry , Wing Cheung , Joseph Juh-En Cheng , Surya P. Varanasi
发明人： Shunjia Yu , Anoop Ghanwani , Phanidhar Koganti , John Michael Terry , Wing Cheung , Joseph Juh-En Cheng , Surya P. Varanasi
IPC分类号： H04L12/723 , H04L12/66 , H04J1/16 , H04L12/857 , H04L12/46 , H04L12/701 , H04L12/721
摘要： Systems and techniques for processing and/or forwarding packets are described. An ingress switch can use a QoS mapping mechanism to map a first set of Quality of Service (QoS) bits in a packet received from a customer to a second set of QoS bits for use in a Transparent Interconnection of Lots of Links (TRILL) packet which encapsulates the packet. The first set of QoS bits can be different from the second set of QoS bits. The TRILL packet can be processed and/or forwarded in the network based on the second set of QoS bits. At the egress switch, the TRILL packet can be decapsulated and the original packet with the original QoS bits (or QoS bits that are different from the original QoS bits) can be forwarded to the customer's network. In this manner, some embodiments of the present invention can preserve the QoS bits across a TRILL network.

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