专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050049274A1 Quinolinone derivatives as inhibitors of c-fms kinase 有权
标题翻译：喹啉酮衍生物作为c-fms激酶的抑制剂
公开(公告)号：US20050049274A1
公开(公告)日：2005-03-03
申请号：US10894940
申请日：2004-07-20
申请人： Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
发明人： Mark Wall , Mark Player , Raymond Patch , Sanath Meegalla , Jian Liu , Carl Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
IPC分类号： A61P35/00 , C07D215/22 , C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/02 , A61K31/47 , C07D215/36
CPC分类号： C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译：本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5，R 6，Y 1，Y 2， 3>，Y 4和X在说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

2. 发明授权

US07326788B2 Quinolinone derivatives as inhibitors of c-fms kinase 有权
标题翻译：喹啉酮衍生物作为c-fms激酶的抑制剂
公开(公告)号：US07326788B2
公开(公告)日：2008-02-05
申请号：US10894940
申请日：2004-07-20
申请人： Mark J. Wall , Mark R. Player , Raymond Joseph Patch , Sanath Meegalla , Jian Liu , Carl R. Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
发明人： Mark J. Wall , Mark R. Player , Raymond Joseph Patch , Sanath Meegalla , Jian Liu , Carl R. Illig , Wing Cheung , Jinsheng Chen , Davoud Asgari
IPC分类号： C07D215/38 , C07D215/44
CPC分类号： C07D215/227 , C07D401/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.
摘要翻译：本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5，其中，R 6，R 6，Y 1，Y 2，Y 3，Y 4， SUP＆amp; X和X在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

3. 发明授权

US08796256B2 Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-α modulators 有权
标题翻译：取代的噻唑烷二酮吲唑，吲哚和苯并三唑作为雌激素相关受体α调节剂
公开(公告)号：US08796256B2
公开(公告)日：2014-08-05
申请号：US13114084
申请日：2011-05-24
申请人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
发明人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
IPC分类号： C07D417/06
CPC分类号： C07D417/06
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

4. 发明申请

US20110294780A1 SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS 有权
标题翻译：作为雌激素相关受体 - 调节剂的替扎唑啉衍生物，吲哚酚和苯并噻唑
公开(公告)号：US20110294780A1
公开(公告)日：2011-12-01
申请号：US13114084
申请日：2011-05-24
申请人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
发明人： Gilles Bignan , Wing Cheung , Micheal Gaul , Hui Huang , Xun Li , Raymond Patch , Sharmila Patel , Mark Player , Guozhang Xu , Bao-Ping Zhao , Jian Liu
IPC分类号： A61K31/427 , C07D413/14 , C07D401/14 , C07D453/02 , C07D451/04 , C07D498/04 , C07D455/02 , C07D419/14 , A61K31/5377 , A61K31/454 , A61K31/496 , A61K31/46 , A61K31/439 , A61K31/55 , A61K31/541 , A61K31/551 , A61K31/4439 , A61K31/5383 , A61K31/433 , A61K31/4245 , A61K31/41 , A61P19/08 , A61P19/06 , A61P19/10 , A61P35/04 , A61P19/04 , A61P35/00 , A61P19/02 , A61P29/00 , A61P11/00 , A61P11/08 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P3/06 , A61P9/00 , A61P9/10 , A61P5/48 , C07D417/14
CPC分类号： C07D417/06
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

5. 发明申请

US20060116368A1 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor 审中-公开
标题翻译：香草素VR1受体的4-哌啶甲酰胺调节剂
公开(公告)号：US20060116368A1
公开(公告)日：2006-06-01
申请号：US11288624
申请日：2005-11-29
申请人： Raul Calvo , Wing Cheung , Mark Player
发明人： Raul Calvo , Wing Cheung , Mark Player
IPC分类号： C07D279/16 , C07D265/36 , A61K31/5415 , A61K31/538
CPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
摘要翻译：本发明涉及香草素受体VR1配体。更具体地，本发明涉及作为VR1的有效调节剂的异异构酰胺，其可用于治疗和预防哺乳动物的疾病状况。

6. 发明申请

US20130031077A1 Longest Prefix Match Scheme 有权
标题翻译：最长前缀匹配方案
公开(公告)号：US20130031077A1
公开(公告)日：2013-01-31
申请号：US13284829
申请日：2011-10-28
申请人： Jian Liu , Philip Lynn Leichty , How Tung Lim , John Michael Terry , Mahesh Srinivasa Maddury , Wing Cheung , Kung Ling Ko
发明人： Jian Liu , Philip Lynn Leichty , How Tung Lim , John Michael Terry , Mahesh Srinivasa Maddury , Wing Cheung , Kung Ling Ko
IPC分类号： G06F17/30
CPC分类号： G06F7/02 , H04L45/7457 , H04L45/748
摘要： A LPM search engine includes a plurality of exact match (EXM) engines and a moderately sized TCAM. Each EXM engine uses a prefix bitmap scheme that allows the EXM engine to cover multiple consecutive prefix lengths. Thus, instead of covering one prefix length L per EXM engine, the prefix bitmap scheme enables each EXM engine to cover entries having prefix lengths of L, L+1, L+2 and L+3, for example. As a result, fewer EXM engines are potentially underutilized, which effectively reduces quantization loss. Each EXM engine provides a search result with a determined fixed latency when using the prefix bitmap scheme. The results of multiple EXM engines and the moderately sized TCAM are combined to provide a single search result, representative of the longest prefix match. In one embodiment, the LPM search engine supports 32-bit IPv4 (or 128-bit IPv6) search keys, each having associated 15-bit level 3 VPN identification values.
摘要翻译： LPM搜索引擎包括多个精确匹配（EXM）引擎和中等大小的TCAM。每个EXM引擎使用前缀位图方案，允许EXM引擎涵盖多个连续的前缀长度。因此，代替覆盖每个EXM引擎的一个前缀长度L，例如，前缀位图方案使得每个EXM引擎能够覆盖具有前缀长度为L，L + 1，L + 2和L + 3的条目。因此，较少的EXM引擎潜在地未充分利用，这有效地减少了量化损失。当使用前缀位图方案时，每个EXM引擎提供具有确定的固定延迟的搜索结果。多个EXM引擎和中等大小的TCAM的结果被组合以提供单个搜索结果，代表最长的前缀匹配。在一个实施例中，LPM搜索引擎支持32位IPv4（或128位IPv6）搜索密钥，每个具有关联的15位3级VPN标识值。

7. 发明授权

US08880494B2 Longest prefix match scheme 有权
标题翻译：最长前缀匹配方案
公开(公告)号：US08880494B2
公开(公告)日：2014-11-04
申请号：US13284829
申请日：2011-10-28
申请人： Jian Liu , Philip Lynn Leichty , How Tung Lim , John Michael Terry , Mahesh Srinivasa Maddury , Wing Cheung , Kung Ling Ko
发明人： Jian Liu , Philip Lynn Leichty , How Tung Lim , John Michael Terry , Mahesh Srinivasa Maddury , Wing Cheung , Kung Ling Ko
IPC分类号： G06F17/30 , H04L12/743 , G06F7/02 , H04L12/745
CPC分类号： G06F7/02 , H04L45/7457 , H04L45/748
摘要： A LPM search engine includes a plurality of exact match (EXM) engines and a moderately sized TCAM. Each EXM engine uses a prefix bitmap scheme that allows the EXM engine to cover multiple consecutive prefix lengths. Thus, instead of covering one prefix length L per EXM engine, the prefix bitmap scheme enables each EXM engine to cover entries having prefix lengths of L, L+1, L+2 and L+3, for example. As a result, fewer EXM engines are potentially underutilized, which effectively reduces quantization loss. Each EXM engine provides a search result with a determined fixed latency when using the prefix bitmap scheme. The results of multiple EXM engines and the moderately sized TCAM are combined to provide a single search result, representative of the longest prefix match. In one embodiment, the LPM search engine supports 32-bit IPv4 (or 128-bit IPv6) search keys, each having associated 15-bit level 3 VPN identification values.
摘要翻译： LPM搜索引擎包括多个精确匹配（EXM）引擎和中等大小的TCAM。每个EXM引擎使用前缀位图方案，允许EXM引擎涵盖多个连续的前缀长度。因此，代替覆盖每个EXM引擎的一个前缀长度L，例如，前缀位图方案使每个EXM引擎能够覆盖具有前缀长度为L，L + 1，L + 2和L + 3的条目。因此，较少的EXM引擎潜在地未充分利用，这有效地减少了量化损失。当使用前缀位图方案时，每个EXM引擎提供具有确定的固定延迟的搜索结果。多个EXM引擎和中等大小的TCAM的结果被组合以提供单个搜索结果，代表最长的前缀匹配。在一个实施例中，LPM搜索引擎支持32位IPv4（或128位IPv6）搜索密钥，每个具有关联的15位3级VPN标识值。

8. 发明授权

US07314971B2 Nuclear fertility restorer genes and methods of use in plants 失效
标题翻译：核生育恢复基因和植物中的使用方法
公开(公告)号：US07314971B2
公开(公告)日：2008-01-01
申请号：US10345072
申请日：2003-01-15
申请人： Gregory G. Brown , Charles Dendy , Benoit S. Landry , Wing Cheung , Hua Jin , Fang-Ming Lai , Natasa Formanova , Martin LaForest
发明人： Gregory G. Brown , Charles Dendy , Benoit S. Landry , Wing Cheung , Hua Jin , Fang-Ming Lai , Natasa Formanova , Martin LaForest
IPC分类号： C12N15/82 , C12N15/29 , A01H1/02 , A01H5/00
CPC分类号： C12N15/8287 , C07K14/415 , C12N15/1034 , C12N15/821 , C12N15/8289
摘要： The present invention includes nuclear fertility restorer genes, proteins encoded by those genes and transgenic plants and plant cells containing those genes. More particularly, the nuclear fertility restorer genes can be used to restore fertility in cytoplasmic male-sterile plants such as Brassica napus. Preferably, the nuclear fertility restorer genes are used with the Ogura (ogu) CMS system in Brassica napus.
摘要翻译：本发明包括核能恢复基因，由这些基因编码的蛋白质和转基因植物以及含有这些基因的植物细胞。更具体地说，核生育恢复基因可用于恢复细胞质雄性不育植物如甘蓝型油菜中的生育力。优选地，

9. 发明申请

US20050267026A1 Combination dosing regimen for erythropoietin 审中-公开
标题翻译：红细胞生成素联合给药方案
公开(公告)号：US20050267026A1
公开(公告)日：2005-12-01
申请号：US11088284
申请日：2005-03-24
申请人： Wing Cheung
发明人： Wing Cheung
IPC分类号： A61K38/18
CPC分类号： A61K38/1816
摘要： The present invention provides a combination dosing regimen for erythropoietin (EPO). More particularly, the present dosing regimen includes administration of at least a first dosing segment comprising a first exposure to EPO capable of stimulating the production of reticulocytes followed by a second exposure to EPO capable of sustaining the maturation of the reticulocytes into neocytes, and ultimately, red blood cells. Advantageously, the dosing segment may be cycled or repeated, any number of times and according to any desired time scheme, in order to provide or maintain any desired total red blood cell count and/or hemoglobin concentration. Methods of treatment employing the combination dosing regimen, as well as kits are also provided.
摘要翻译：本发明提供促红细胞生成素（EPO）的组合给药方案。更具体地，本发明的给药方案包括施用至少第一给药段，其包含能够刺激网织红细胞生成的EPO的第一次暴露，然后第二次暴露于能够维持网织红细胞成熟为新细胞的EPO，红细胞。有利地，给药段可以循环或重复任意次数，并且根据任何期望的时间方案，以便提供或维持任何期望的总红细胞计数和/或血红蛋白浓度。还提供了使用联合给药方案的治疗方法以及试剂盒。

10. 发明授权

US6067563A Method and apparatus for avoiding control reads in a network node 有权
标题翻译：用于避免网络节点中的控制读取的方法和装置
公开(公告)号：US6067563A
公开(公告)日：2000-05-23
申请号：US306588
申请日：1999-05-06
申请人： Robert E. Thomas , Douglas M. Washabaugh , Peter J. Roman , Wing Cheung
发明人： Robert E. Thomas , Douglas M. Washabaugh , Peter J. Roman , Wing Cheung
IPC分类号： G06F11/30 , H04L12/56 , H04L29/06 , H04Q11/04 , G06F13/00
CPC分类号： H04L47/522 , G06F11/3006 , G06F11/3027 , G06F11/3055 , G06F11/3096 , H04L29/06 , H04L47/521 , H04L49/90 , H04L49/901 , H04L49/9036 , H04Q11/0478 , H04L2012/5616 , H04L2012/5635 , H04L2012/5658 , H04L2012/5679 , H04L2012/5681
摘要： A mechanism for avoiding an initiation of control read transactions on a system bus coupling a host system having a host memory and an interface connected to a peripheral unit as data is moved between the host system and the peripheral unit is presented. Control information associated with data memory portions in host memory is written to the interface for data memory portions storing outgoing data and data memory portions to receive incoming data. The interface includes a controller to move data between the host memory and the interface by first obtaining the control information for the associated data portions. The interface writes status reports in association with the movement of data between the interface and the host memory via the system bus. The mechanism thus enables data transfers to occur via the system without the initiation of control reads in absence of an exception condition.
摘要翻译：提出了一种用于避免在系统总线上启动控制读取事务的机制，该系统总线耦合具有主机存储器的主机系统和连接到外围单元的接口，因为数据在主机系统和外围设备之间移动。将与主机存储器中的数据存储器部分相关联的控制信息写入存储输出数据和数据存储器部分的数据存储器部分的接口以接收输入数据。该接口包括控制器，用于通过首先获得相关联的数据部分的控制信息来在主机存储器和接口之间移动数据。该接口通过系统总线写入与接口和主机存储器之间的数据移动相关联的状态报告。因此，该机制使得能够在没有异常条件的情况下通过系统进行数据传输而不启动控制读取。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式