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1. 发明申请

US20060175244A1 Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的装置及方法
公开(公告)号：US20060175244A1
公开(公告)日：2006-08-10
申请号：US11342749
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D35/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B04B5/0442 , B04B2005/0478
摘要： A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports. A stationary bead rake can be secured to the stationary tube and extend outward therefrom, the rake having distal ends that are spaced at a distance from the upright screen supports. The rake can comprise a longitudinal body, the center of which is secured to the rigid outlet tube. The separator-concentrator includes a valve assembly connecting the separation chamber and the concentration chamber. PRP concentrate is produced by contacting PRP with desiccated beads while the beads are stirred with a stationary rake, and rotating the concentration chamber at centrifugal speeds to separate PRP concentrate from the beads.
摘要翻译： PRP分离器集中器，其包括壳体，分离组件和浓缩组件。浓缩组件具有浓缩池。轴向同心的刚性固定出口管固定到壳体并且延伸穿过分离组件到达贮槽。分离组件附接到并定位在浓度组件上方，以形成围绕出口管可旋转的组合的分离器 - 集中器组合件。分离组件包括分隔室，内部具有深度过滤器，该深度过滤器具有孔和通道，其尺寸适于在离心过程中接收和捕获红细胞。浓缩室具有用于支撑干燥珠粒的底板和具有至少一个开口的屏幕的壁。集中器可以具有直立屏幕支撑件的分布，直立屏幕支撑件具有内表面和外表面，圆柱形屏幕支撑在直立屏幕支撑件的外表面上。固定的胎圈耙子可以固定到固定管并从其向外延伸，耙子具有与立式筛网支撑件间隔一定距离的远端。耙子可以包括纵向主体，其中心固定到刚性出口管。分离器集中器包括连接分离室和浓缩室的阀组件。 PRP浓缩物通过使PRP与干燥的珠粒接触而产生，同时将珠粒与固定的耙子一起搅拌，并且以离心速度旋转浓缩室以将PRP浓缩物与珠粒分离。

2. 发明申请

US20080011684A1 APPARATUS AND METHOD FOR PREPARING PLATELET RICH PLASMA AND CONCENTRATES THEREOF 有权
标题翻译：制备稀土等离子体及其浓度的装置和方法
公开(公告)号：US20080011684A1
公开(公告)日：2008-01-17
申请号：US11831605
申请日：2007-07-31
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D35/00 , B01D24/32 , B01D33/067
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.
摘要翻译：公开了一种富血小板血浆分离器组件。组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。底板，其具有向下倾斜到中心开口的上表面。内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。

3. 发明申请

US20060175242A1 Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的方法和装置
公开(公告)号：US20060175242A1
公开(公告)日：2006-08-10
申请号：US11342761
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D63/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译：本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。离心鼓分离器具有红细胞捕集器。除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏。

4. 发明申请

US20060175268A1 Plasma concentrator device 有权
公开(公告)号：US20060175268A1
公开(公告)日：2006-08-10
申请号：US11342982
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach , Richard Storrs
发明人： Randel Dorian , Michael Leach , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

5. 发明申请

US20100324450A1 Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components 有权
公开(公告)号：US20100324450A1
公开(公告)日：2010-12-23
申请号：US12854643
申请日：2010-08-11
申请人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
发明人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
IPC分类号： A61B5/153
CPC分类号： B01L3/502 , B01D17/0217 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478 , G01N33/491 , Y10T436/25375
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

6. 发明授权

US07374678B2 Apparatus and method for separating and concentrating fluids containing multiple components 有权
标题翻译：用于分离和浓缩含有多种组分的流体的装置和方法
公开(公告)号：US07374678B2
公开(公告)日：2008-05-20
申请号：US10932882
申请日：2004-09-02
申请人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
发明人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
IPC分类号： B01D17/038 , B01D21/26 , B04B1/02
CPC分类号： B01L3/502 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：允许分离和收集一部分样品的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

7. 发明申请

US20060243676A1 Method and apparatus for producing autologous clotting components 有权
公开(公告)号：US20060243676A1
公开(公告)日：2006-11-02
申请号：US11116153
申请日：2005-04-27
申请人： Matthew Swift , Barry Hecker , Michael Leach
发明人： Matthew Swift , Barry Hecker , Michael Leach
IPC分类号： C02F1/38
CPC分类号： A61M1/3679 , A61M2202/0427 , B01D15/00 , B01D17/0202 , B01D17/0217 , B01D17/10 , B01J20/046 , B01J20/10 , B01J20/26 , B01J20/261 , B01J20/262 , B01J2220/46
摘要： A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient.

8. 发明授权

US06930814B2 Calibrating voltage controllable optical components in communication systems 失效
标题翻译：通讯系统校准电压可控光学元件
公开(公告)号：US06930814B2
公开(公告)日：2005-08-16
申请号：US10467548
申请日：2002-02-01
申请人： Peter James Livermore , Graham Butler , Michael Leach , Darren Vass
发明人： Peter James Livermore , Graham Butler , Michael Leach , Darren Vass
IPC分类号： G01R35/00 , G02F1/01 , G02F1/03 , G02F1/21 , G02B26/00 , G02B6/26 , G02F1/035 , G02F1/295
CPC分类号： G02F1/0123 , G02F2001/212 , G02F2203/21
摘要： A method of, and apparatus for, setting an operating (control) voltage of a voltage controllable optical component, such as a Mach-Zehnder optical modulator, having a periodic voltage/optical parameter (optical power) characteristic include an up/down counter and a digital to analog converter operable to set the voltage applied to the component to a predetermined initial value, a device for measuring the optical parameter, and another device for sequentially progressively increasing and decreasing the voltage (incrementing/decrementing the counter) with respect to the predetermined value, and for determining respective voltage values which produce maximum and minimum values of the optical parameter. The voltage is set to a value intermediate the maximum and minimum voltage values. Further, the apparatus determines the sense of the slope of that portion of the periodic characteristic lying between the maximum and minimum values for use by a control loop during subsequent operation of the optical component.
摘要翻译：具有周期性电压/光学参数（光功率）特性的诸如马赫 - 策德尔光调制器的电压可控光学部件的操作（控制）电压的方法和装置包括上/下计数器和数模转换器，其可操作以将施加到所述部件的电压设置为预定初始值;测量所述光学参数的装置;以及用于依次逐渐增加和减小所述电压（递增/递减所述计数器）相对于所述光学参数的装置并且用于确定产生光学参数的最大值和最小值的各个电压值。电压设置为最大和最小电压值之间的值。此外，该装置确定位于最大值和最小值之间的周期特性的该部分的斜率的感测值，以在光学部件的后续操作期间由控制回路使用。

9. 发明授权

US08748600B2 Cyclic triazo sodium channel blockers 有权
标题翻译：环状三唑钠通道阻滞剂
公开(公告)号：US08748600B2
公开(公告)日：2014-06-10
申请号：US13382741
申请日：2010-07-08
申请人： Michael Leach , Karl Franzmann , Dieter Riddall , Laurence Harbige
发明人： Michael Leach , Karl Franzmann , Dieter Riddall , Laurence Harbige
IPC分类号： C07D253/07 , A61K31/53 , A61P25/08 , A61P25/28 , A61P25/04
CPC分类号： C07D253/07 , C07D409/06
摘要： The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The triazine compounds are of formula (I) wherein: R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when R1 is hydrogen or ═NH when R1 is a substituent group; R3 and R4 are both carbocyclic, heterocyclic or alkyl groups and may be same or different; and R5 is hydrogen, alkyl or a cyclic aryl group, with the proviso that: when R3 and R4 are both alkyl they are linked to form a cycloalkyl group, and R5 is a cyclic aromatic group; and when R3 and R4 are both carbocyclic or heterocyclic groups, R5 is hydrogen or an alkyl group; or a salt thereof.
摘要翻译：本发明涉及具有钠通道阻断性质的三嗪化合物，以及该化合物用于制备用于治疗相关病症的药物的用途。三嗪化合物具有式（I），其中：R 1是氢或取代基; R2是氨基或取代基; 当R 1为氢时，N *为氨基，或当R 1为取代基时为= NH; R 3和R 4均为碳环，杂环或烷基，可以相同或不同; 并且R 5为氢，烷基或环状芳基，条件是：当R 3和R 4均为烷基时，它们连接形成环烷基，R 5为环状芳基; 当R 3和R 4均为碳环或杂环基时，R 5为氢或烷基; 或其盐。

10. 发明授权

US07179391B2 Apparatus and method for separating and concentrating fluids containing multiple components 有权
标题翻译：用于分离和浓缩含有多种组分的流体的装置和方法
公开(公告)号：US07179391B2
公开(公告)日：2007-02-20
申请号：US10445381
申请日：2003-05-23
申请人： Michael Leach , Jennifer E. Woodell-May , Joel Higgins
发明人： Michael Leach , Jennifer E. Woodell-May , Joel Higgins
IPC分类号： B01D17/038 , B01D21/26 , B04B1/02
CPC分类号： B01L3/502 , B01D17/0217 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478 , G01N33/491 , Y10T436/25375
摘要： An apparatus that allows for separating and collecting a concentrated fraction of a fluid, such as a whole blood sample, adipose tissue, or a bone marrow sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. The apparatus includes a container to be placed to a centrifuge after being filled with a whole blood sample. A buoy or fraction separator, which has a density less than that of red blood cells of a whole blood sample, is disposed in the container. During the centrifuge process the buoy separates the red blood cells from another fraction of the whole blood. After the centrifuge process is finished a plunger is used to produce at least two other fractions, including a plasma fraction and a buffy coat. Then, the buffy coat may be removed from the container without commingling the fractions of the sample.
摘要翻译：允许分离和收集流体（例如全血样品，脂肪组织或骨髓样品）的浓缩级分的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。该装置包括在填充全血样品之后放置到离心机上的容器。将具有小于全血样品的红细胞密度的浮标或级分分离器设置在容器中。在离心机过程中，浮标将红细胞与全血的另一部分分开。离心机过程完成后，使用柱塞产生至少两个其它部分，包括血浆部分和血沉棕黄层。然后，可以将血沉棕黄层从容器中取出，而不会混合样品的部分。

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