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    • 5. 发明申请
    • Methods of determining film thicknesses for an aerosol delivery article
    • 确定气溶胶输送制品的膜厚度的方法
    • US20050037506A1
    • 2005-02-17
    • US10912462
    • 2004-08-04
    • Ron HaleAmy LuDaniel MyersJoshua Rabinowitz
    • Ron HaleAmy LuDaniel MyersJoshua Rabinowitz
    • A61K9/00A61K31/00A61M15/00G01N1/18
    • A61K9/007A61K9/0073A61K31/00A61M11/001A61M15/0028A61M2205/3653A61M2209/02
    • Methods for determining the film thickness of a compound composition needed to provide a selected purity and yield of a condensation aerosol via vaporization of the compound composition have applications in aerosol delivery technology, in pulmonary drug delivery, and in other therapeutic treatment regimes. The methods for determining such film thickness, for use in a device having a film of drug composition to be aerosolized, include generating purities and yields of a drug composition by vaporizing films of the drug composition from substrates at two or more temperatures in the range of 150° C. to 500° C. and two or more film thickness in the range of 0.05 to 50 microns, determining from these yields and purities if a thickness and temperature exist where the aerosol has at least 90% purity and at least 50% yield, and repeated such measurements until the selected purity and yield requirement are met.
    • 用于确定通过化合物组合物蒸发提供选择的纯度和产生缩合气溶胶所需的化合物组合物的膜厚度的方法可用于气雾剂递送技术,肺部药物递送和其它治疗方案中。 用于确定具有待雾化的药物组合物的膜的装置中的这种膜厚度的方法包括通过在两个或多个温度范围内从基材中蒸发药物组合物的膜而产生药物组合物的纯度和产率 150℃至500℃,以及0.05至50微米范围内的两个或多个膜厚度,如果存在厚度和温度,则气溶胶具有至少90%的纯度和至少50%的纯度, 产量和重复这样的测量,直到满足所选择的纯度和产量要求。