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    • 6. 发明申请
    • Treatment of breakthrough pain by drug aerosol inhalation
    • 药物气雾剂吸入治疗突破性疼痛
    • US20050126562A1
    • 2005-06-16
    • US10996162
    • 2004-11-23
    • Joshua RabinowitzWilliam ShenMartin Wensley
    • Joshua RabinowitzWilliam ShenMartin Wensley
    • A61J7/04A61M11/00A61M11/04A61M15/00A61M16/00
    • A61M15/00A61J7/0445A61M11/041A61M11/042A61M15/0003A61M15/0045A61M15/0051A61M2016/0021A61M2202/064A61M2205/60
    • Devices comprising a housing defining an airway, at least one support configured to couple to the airway comprising at least one area selected from a first area and a second area, wherein a first compound is disposed on the first area, and a second compound is disposed on the second area, and wherein the second compound can counteract the pharmacological effects of the first compound; and a mechanism configured to release the first compound into the airway, wherein the device comprises at least one first area and at least one second area are disclosed. Methods of producing an aerosol of a first compound comprising providing at least one first area on which is disposed a first compound, and at least one second area on which is disposed a second compound, providing an airflow over at least a portion of the at least one first area, and releasing the first compound from at least a portion of at least one first area into the airflow, wherein the first compound forms an aerosol in the airflow, are also disclosed. Methods of using the devices and the methods of producing an aerosol are also disclosed.
    • 包括限定气道的壳体的装置,至少一个支撑件,其配置成耦合到气道,所述至少一个区域选自第一区域和第二区域,其中第一化合物设置在第一区域上,并且设置第二化合物 并且其中所述第二化合物可抵消所述第一化合物的药理作用; 以及构造成将第一化合物释放到气道中的机构,其中所述装置包括至少一个第一区域和至少一个第二区域。 生产第一化合物气溶胶的方法,包括提供至少一个第一区域,其上设置有第一化合物,以及至少一个第二区域,第二化合物在其上设置有第二化合物,其至少在至少一部分上提供气流 一个第一区域,并且将第一化合物从至少一个第一区域的至少一部分释放到气流中,其中第一化合物在空气流中形成气溶胶。 还公开了使用该装置的方法和产生气溶胶的方法。