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1. 发明申请

US20070031340A1 Thin-film drug delivery article and method of use 有权
标题翻译：薄膜给药制品及使用方法
公开(公告)号：US20070031340A1
公开(公告)日：2007-02-08
申请号：US10633877
申请日：2003-08-04
申请人： Ron Hale , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley
发明人： Ron Hale , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley
IPC分类号： A61L9/04 , A61K9/14
CPC分类号： A61K9/7007 , A61K9/007 , Y10S514/958
摘要： An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0.05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.
摘要翻译：公开了一种用于产生药物组合物气溶胶的气溶胶装置的制品。所述制品包括具有选择的表面积的表面的导热基材和在所述基材表面上的具有0.05至20μm的选定膜厚度的药物组合物膜。膜厚度使得通过加热基底并冷凝汽化的化合物使药物组合物蒸发而形成的气溶胶含有10％以下的药物降解产物和膜中所含的药物组合物总量的至少50％。所选择的底物表面积是产生有效的人类治疗剂量的药物气溶胶。还公开了制造和使用制品的方法。

2. 发明申请

US20070028916A1 Rapid-heating drug delivery article and method of use 有权
标题翻译：快速加热药物输送物品及其使用方法
公开(公告)号：US20070028916A1
公开(公告)日：2007-02-08
申请号：US10633876
申请日：2003-08-04
申请人： Ron Hale , Peter Lloyd , Amy Lu , Daniel Myers , Reynaldo Quintana , Joshua Rabinowitz , Dennis Solas , Soonho Song , Curtis Tom , Martin Wensley
发明人： Ron Hale , Peter Lloyd , Amy Lu , Daniel Myers , Reynaldo Quintana , Joshua Rabinowitz , Dennis Solas , Soonho Song , Curtis Tom , Martin Wensley
IPC分类号： A61M11/00
CPC分类号： A61M11/041 , A61K9/007 , A61K9/0073 , A61M11/042 , A61M11/047 , A61M15/002 , A61M15/0028 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04 , Y10S514/958
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译：公开了一种用于生产冷凝气雾剂的装置，方法和系统。该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

3. 发明申请

US20070122353A1 Drug condensation aerosols and kits 审中-公开
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US20070122353A1
公开(公告)日：2007-05-31
申请号：US11504419
申请日：2006-08-15
申请人： Ron Hale , Craig Hodges , Peter Lloyd , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley , Jeffrey McKinney , Alejandro Zaffaroni
发明人： Ron Hale , Craig Hodges , Peter Lloyd , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley , Jeffrey McKinney , Alejandro Zaffaroni
IPC分类号： A61K9/14
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒。典型地，试剂盒中所含的装置具有用于加热药物的元件，其在基底上以薄膜形式包被，并含有治疗有效剂量的药物药物以气溶胶形式施用，并且允许蒸气冷却以形成气溶胶的元素。还公开了使用这些气溶胶和试剂盒的方法。

4. 发明申请

US20050126562A1 Treatment of breakthrough pain by drug aerosol inhalation 审中-公开
标题翻译：药物气雾剂吸入治疗突破性疼痛
公开(公告)号：US20050126562A1
公开(公告)日：2005-06-16
申请号：US10996162
申请日：2004-11-23
申请人： Joshua Rabinowitz , William Shen , Martin Wensley
发明人： Joshua Rabinowitz , William Shen , Martin Wensley
IPC分类号： A61J7/04 , A61M11/00 , A61M11/04 , A61M15/00 , A61M16/00
CPC分类号： A61M15/00 , A61J7/0445 , A61M11/041 , A61M11/042 , A61M15/0003 , A61M15/0045 , A61M15/0051 , A61M2016/0021 , A61M2202/064 , A61M2205/60
摘要： Devices comprising a housing defining an airway, at least one support configured to couple to the airway comprising at least one area selected from a first area and a second area, wherein a first compound is disposed on the first area, and a second compound is disposed on the second area, and wherein the second compound can counteract the pharmacological effects of the first compound; and a mechanism configured to release the first compound into the airway, wherein the device comprises at least one first area and at least one second area are disclosed. Methods of producing an aerosol of a first compound comprising providing at least one first area on which is disposed a first compound, and at least one second area on which is disposed a second compound, providing an airflow over at least a portion of the at least one first area, and releasing the first compound from at least a portion of at least one first area into the airflow, wherein the first compound forms an aerosol in the airflow, are also disclosed. Methods of using the devices and the methods of producing an aerosol are also disclosed.
摘要翻译：包括限定气道的壳体的装置，至少一个支撑件，其配置成耦合到气道，所述至少一个区域选自第一区域和第二区域，其中第一化合物设置在第一区域上，并且设置第二化合物并且其中所述第二化合物可抵消所述第一化合物的药理作用; 以及构造成将第一化合物释放到气道中的机构，其中所述装置包括至少一个第一区域和至少一个第二区域。生产第一化合物气溶胶的方法，包括提供至少一个第一区域，其上设置有第一化合物，以及至少一个第二区域，第二化合物在其上设置有第二化合物，其至少在至少一部分上提供气流一个第一区域，并且将第一化合物从至少一个第一区域的至少一部分释放到气流中，其中第一化合物在空气流中形成气溶胶。还公开了使用该装置的方法和产生气溶胶的方法。

5. 发明申请

US20050268911A1 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 有权
标题翻译：多剂量凝露气溶胶装置及其形成冷凝气溶胶的方法
公开(公告)号：US20050268911A1
公开(公告)日：2005-12-08
申请号：US10861554
申请日：2004-06-03
申请人： Steven Cross , Matthieu Herbette , Andrew Kelly , Daniel Myers , William Shen , Ryan Timmons , Curtis Tom , Justin Virgili , Martin Wensley
发明人： Steven Cross , Matthieu Herbette , Andrew Kelly , Daniel Myers , William Shen , Ryan Timmons , Curtis Tom , Justin Virgili , Martin Wensley
IPC分类号： A61M11/04 , A61M15/00 , A61M16/00 , F23D11/00
CPC分类号： H05B1/0244 , A61M11/002 , A61M11/041 , A61M11/042 , A61M15/0021 , A61M15/0045 , A61M15/0048 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M16/1075 , A61M16/14 , H05B2203/021
摘要： Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.
摘要翻译：公开了在气流中夹带物质的装置和方法。冷凝气溶胶输送装置和一贯生产多剂量物质（例如药物）的方法，其具有高纯度，高产率，其特征在于适于肺部输送的粒度分布，并且其可以以单剂量施用于使用者也被披露。

6. 外观设计

USD419082S Refractometric analyzer 失效
$Refractometric analyzer$
公开(公告)号：USD419082S
公开(公告)日：2000-01-18
申请号：US99428
申请日：1999-01-21
申请人： Martin Wensley , Jeffrey Dickert
设计人： Martin Wensley , Jeffrey Dickert

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