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1. 发明申请

US20050034723A1 Substrates for drug delivery device and methods of preparing and use 审中-公开
标题翻译：用于药物输送装置的基材及其制备和使用方法
公开(公告)号：US20050034723A1
公开(公告)日：2005-02-17
申请号：US10912417
申请日：2004-08-04
申请人： Bryson Bennett , Ron Hale , Amy Lu , Daniel Myers , Krishnamohan Sharma , Joshua Rabinowitz
发明人： Bryson Bennett , Ron Hale , Amy Lu , Daniel Myers , Krishnamohan Sharma , Joshua Rabinowitz
IPC分类号： A61K9/00 , A61M11/04 , A61M11/00 , A61M15/00
CPC分类号： A61K31/553 , A61K9/00 , A61K9/007 , A61K9/0073 , A61M11/001 , A61M11/041 , A61M11/042 , A61M11/047
摘要： An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant exterior surface and a drug composition film on the exterior surface and is for use in an aerosol device. The thickness of the film and the surface of the substrate is such that the aerosol formed by vaporizing and condensing the drug composition the aerosol contain 10% by weight or less drug-degradation products and at least 50% of the total amount of the drug composition in the film. The methods for treating the exterior surface include heat and chemical treatment and formation of a protective overcoat.
摘要翻译：公开了一种用于生产冷凝气雾剂的组件和方法。组件包括具有耐氧化外表面的导热金属基底和外表面上的药物组合物膜，并用于气溶胶装置。膜的厚度和基材的表面使得通过气溶剂和冷凝药物组合物形成的气溶胶含有10重量％以下的药物降解产物和药物组合物总量的至少50％在电影里。用于处理外表面的方法包括加热和化学处理以及形成保护性外涂层。

2. 发明申请

US20070031340A1 Thin-film drug delivery article and method of use 有权
标题翻译：薄膜给药制品及使用方法
公开(公告)号：US20070031340A1
公开(公告)日：2007-02-08
申请号：US10633877
申请日：2003-08-04
申请人： Ron Hale , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley
发明人： Ron Hale , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley
IPC分类号： A61L9/04 , A61K9/14
CPC分类号： A61K9/7007 , A61K9/007 , Y10S514/958
摘要： An article for use in an aerosol device, for producing an aerosol of a drug composition is disclosed. The article includes a heat-conductive substrate having a surface with a selected surface area, and a drug composition film on the substrate surface having a selected film thickness of between 0.05 and 20 μm. The film thickness is such that an aerosol formed by vaporizing the drug composition by heating the substrate and condensing the vaporized compound contains 10% or less drug-degradation product and at least 50% of the total amount of drug composition contained in the film. The selected substrate surface area is such as to yield an effective human therapeutic dose of the drug aerosol. Also disclosed are methods of making and using the article.
摘要翻译：公开了一种用于产生药物组合物气溶胶的气溶胶装置的制品。所述制品包括具有选择的表面积的表面的导热基材和在所述基材表面上的具有0.05至20μm的选定膜厚度的药物组合物膜。膜厚度使得通过加热基底并冷凝汽化的化合物使药物组合物蒸发而形成的气溶胶含有10％以下的药物降解产物和膜中所含的药物组合物总量的至少50％。所选择的底物表面积是产生有效的人类治疗剂量的药物气溶胶。还公开了制造和使用制品的方法。

3. 发明申请

US20070028916A1 Rapid-heating drug delivery article and method of use 有权
标题翻译：快速加热药物输送物品及其使用方法
公开(公告)号：US20070028916A1
公开(公告)日：2007-02-08
申请号：US10633876
申请日：2003-08-04
申请人： Ron Hale , Peter Lloyd , Amy Lu , Daniel Myers , Reynaldo Quintana , Joshua Rabinowitz , Dennis Solas , Soonho Song , Curtis Tom , Martin Wensley
发明人： Ron Hale , Peter Lloyd , Amy Lu , Daniel Myers , Reynaldo Quintana , Joshua Rabinowitz , Dennis Solas , Soonho Song , Curtis Tom , Martin Wensley
IPC分类号： A61M11/00
CPC分类号： A61M11/041 , A61K9/007 , A61K9/0073 , A61M11/042 , A61M11/047 , A61M15/002 , A61M15/0028 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04 , Y10S514/958
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译：公开了一种用于生产冷凝气雾剂的装置，方法和系统。该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。

4. 发明申请

US20070122353A1 Drug condensation aerosols and kits 审中-公开
标题翻译：药物冷凝气溶胶和试剂盒
公开(公告)号：US20070122353A1
公开(公告)日：2007-05-31
申请号：US11504419
申请日：2006-08-15
申请人： Ron Hale , Craig Hodges , Peter Lloyd , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley , Jeffrey McKinney , Alejandro Zaffaroni
发明人： Ron Hale , Craig Hodges , Peter Lloyd , Amy Lu , Daniel Myers , Joshua Rabinowitz , Martin Wensley , Jeffrey McKinney , Alejandro Zaffaroni
IPC分类号： A61K9/14
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒。典型地，试剂盒中所含的装置具有用于加热药物的元件，其在基底上以薄膜形式包被，并含有治疗有效剂量的药物药物以气溶胶形式施用，并且允许蒸气冷却以形成气溶胶的元素。还公开了使用这些气溶胶和试剂盒的方法。

5. 发明申请

US20050037506A1 Methods of determining film thicknesses for an aerosol delivery article 审中-公开
标题翻译：确定气溶胶输送制品的膜厚度的方法
公开(公告)号：US20050037506A1
公开(公告)日：2005-02-17
申请号：US10912462
申请日：2004-08-04
申请人： Ron Hale , Amy Lu , Daniel Myers , Joshua Rabinowitz
发明人： Ron Hale , Amy Lu , Daniel Myers , Joshua Rabinowitz
IPC分类号： A61K9/00 , A61K31/00 , A61M15/00 , G01N1/18
CPC分类号： A61K9/007 , A61K9/0073 , A61K31/00 , A61M11/001 , A61M15/0028 , A61M2205/3653 , A61M2209/02
摘要： Methods for determining the film thickness of a compound composition needed to provide a selected purity and yield of a condensation aerosol via vaporization of the compound composition have applications in aerosol delivery technology, in pulmonary drug delivery, and in other therapeutic treatment regimes. The methods for determining such film thickness, for use in a device having a film of drug composition to be aerosolized, include generating purities and yields of a drug composition by vaporizing films of the drug composition from substrates at two or more temperatures in the range of 150° C. to 500° C. and two or more film thickness in the range of 0.05 to 50 microns, determining from these yields and purities if a thickness and temperature exist where the aerosol has at least 90% purity and at least 50% yield, and repeated such measurements until the selected purity and yield requirement are met.
摘要翻译：用于确定通过化合物组合物蒸发提供选择的纯度和产生缩合气溶胶所需的化合物组合物的膜厚度的方法可用于气雾剂递送技术，肺部药物递送和其它治疗方案中。用于确定具有待雾化的药物组合物的膜的装置中的这种膜厚度的方法包括通过在两个或多个温度范围内从基材中蒸发药物组合物的膜而产生药物组合物的纯度和产率 150℃至500℃，以及0.05至50微米范围内的两个或多个膜厚度，如果存在厚度和温度，则气溶胶具有至少90％的纯度和至少50％的纯度，产量和重复这样的测量，直到满足所选择的纯度和产量要求。

6. 发明申请

US20070286816A1 Drug and excipient aerosol compositions 审中-公开
标题翻译：药物和赋形剂气溶胶组合物
公开(公告)号：US20070286816A1
公开(公告)日：2007-12-13
申请号：US11744799
申请日：2007-05-04
申请人： Ron Hale , Joshua Rabinowitz , Daniel Myers , Amy Lu , Alejandro Zaffaroni
发明人： Ron Hale , Joshua Rabinowitz , Daniel Myers , Amy Lu , Alejandro Zaffaroni
IPC分类号： A61K9/12
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译：本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。这些气溶胶是通过在使薄膜上的气体通过膜的同时，快速加热涂覆有厚度为0.05至20μm的药物的薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件以形成气溶胶。还公开了使用这些气溶胶和试剂盒的方法。

7. 发明申请

US20050079166A1 Self-contained heating unit and drug-supply unit employing same 审中-公开
标题翻译：独立加热单元和采用其的药物供应单元
公开(公告)号：US20050079166A1
公开(公告)日：2005-04-14
申请号：US10850895
申请日：2004-05-20
申请人： Ramesh Damani , Ron Hale , Daniel Myers , Reynaldo Quintana , Dennis Solas , Soonho Song , Pravin Soni , Curtis Tom
发明人： Ramesh Damani , Ron Hale , Daniel Myers , Reynaldo Quintana , Dennis Solas , Soonho Song , Pravin Soni , Curtis Tom
IPC分类号： A01N25/00 , A61K35/00 , A61K47/00 , A61M11/04 , B05D1/18 , B65D81/34 , C06B33/00 , C06B33/06 , C06C7/00 , C06C9/00 , C09K5/18 , C23C24/08 , F21K5/00 , F24V30/00 , H01J49/04 , H01L21/26 , H01L21/324 , H01L21/42 , H01L21/477
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
摘要翻译：公开了能够快速加热的加热单元，药物供应单元和药物输送物品。公开了一种加热单元，其包括基板和能够经受放置在基板内的放热金属氧化反应的固体燃料。还公开了药物供应单元和药物递送物品，其中固体燃料构造成将基底加热到足以快速热蒸发其上设置的药物的温度。

8. 发明申请

US20060094916A1 Direct return of oxygenate recycle stream in olefin production process 有权
公开(公告)号：US20060094916A1
公开(公告)日：2006-05-04
申请号：US11235975
申请日：2005-09-27
申请人： Lawrence Lacijan , Daniel Myers , Paolo Palmas
发明人： Lawrence Lacijan , Daniel Myers , Paolo Palmas
IPC分类号： C07C1/00
CPC分类号： B01J8/26 , B01J4/002 , B01J8/0055 , B01J8/1818 , B01J2208/00292 , B01J2219/00006 , C07C1/20 , Y02P30/42 , Y10S585/921 , C07C11/02
摘要： The invention is a process and the corresponding apparatus for producing light olefins from oxygenates in an OTO reactor comprising sending an oxygenate feed stream through a feed stream distributor into an OTO reactor, contacting the oxygenates with a catalyst to produce a mixture comprising light olefins, diolefins, unreacted oxygenate and other by-products; separating the unreacted oxygenate and diolefins from said light olefins and said by-products; and returning the unreacted oxygenate and diolefins to the OTO reactor. The unreacted oxygenate and diolefins are sent through at least one feed nozzle into said reactor at a point separate from the oxygenate feed stream.

9. 发明申请

US20060094915A1 Purge gas streams to stagnant zones within oxygenate-to-olefin reactor 有权
公开(公告)号：US20060094915A1
公开(公告)日：2006-05-04
申请号：US11235974
申请日：2005-09-27
申请人： Paolo Palmas , Daniel Myers
发明人： Paolo Palmas , Daniel Myers
IPC分类号： C07C1/00 , B01J19/00
CPC分类号： B01J8/1863 , B01J8/0055 , B01J8/1818 , B01J8/26 , B01J2208/00274 , B01J2208/00292 , B01J2208/00707 , B01J2219/00006 , B01J2219/00247 , C07C1/20 , Y02P30/42 , C07C11/02
摘要： The present invention comprises a process for conversion of oxygenates to olefins comprising contacting within a reactor the oxygenates with a catalyst to produce light olefins and wherein the reactor comprises at least two zones, a first zone wherein gas circulates at a faster rate than a second zone wherein a gas circulates at a slower rate; and inserting a quantity of inert gas into the second zone to increase circulation of any materials located in said second zone. The invention prevents accumulation of undesirable by-products within stagnant zones within the reactor and reduces the amount of coke deposited on catalyst or on surfaces within these zones.

10. 发明授权

US5693638A Method of treating a migraine headache 失效
标题翻译：治疗偏头痛的方法
公开(公告)号：US5693638A
公开(公告)日：1997-12-02
申请号：US802748
申请日：1997-02-20
申请人： Daniel Myers
发明人： Daniel Myers
IPC分类号： A61K31/5415 , A61K31/54
CPC分类号： A61K31/5415
摘要： The present invention is directed to the treatment of a migraine headache with a composition containing leuko methylene blue as the active ingredient.
摘要翻译：本发明涉及用含有白细胞亚甲蓝作为活性成分的组合物治疗偏头痛。

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