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1. 发明授权

US5310463A On-column junction for capillary columns 失效
标题翻译：用于毛细管柱的柱上结
公开(公告)号：US5310463A
公开(公告)日：1994-05-10
申请号：US975850
申请日：1992-11-13
申请人： Rajeev Dadoo , Luis A. Colon , Harvey A. Fishman , Jason B. Shear , Richard N. Zare
发明人： Rajeev Dadoo , Luis A. Colon , Harvey A. Fishman , Jason B. Shear , Richard N. Zare
IPC分类号： G01N30/02 , G01N30/16 , G01N30/28 , G01N30/60 , G01N30/84 , G01N27/26 , G01N27/447
CPC分类号： G01N30/606 , G01N30/16 , G01N30/6039 , G01N2030/162 , G01N2030/285 , G01N2030/8435 , G01N30/02 , G01N30/6034
摘要： An electrophoretic or chromatographic separation capillary containing a fluid defines a bore therein through which a sample travels and separates into components. The tube has a side wall defining a through hole therein which is surrounded by a medium including a substance. The substance is introduced into the capillary through the hole by means of gravity, pressure or electroosmosis. The substance introduced may be used to label sample components to enhance detection, or to enhance separation of sample components.
摘要翻译：含有流体的电泳或色谱分离毛细管限定了一个孔，样品通过该孔穿过并分离成组分。管具有限定其中的通孔的侧壁，该通孔被包括物质的介质包围。物质通过重力，压力或电沉积通过孔引入毛细管中。引入的物质可用于标记样品组分以增强检测，或增强样品组分的分离。

2. 发明授权

US5318680A On-column derivatization in capillary electrophoresis 失效
标题翻译：毛细管电泳中的柱上衍生
公开(公告)号：US5318680A
公开(公告)日：1994-06-07
申请号：US847176
申请日：1992-03-06
申请人： Harvey A. Fishman , Jason B. Shear , Luis A. Colon , Richard N. Zare , Jonathan V. Sweedler
发明人： Harvey A. Fishman , Jason B. Shear , Luis A. Colon , Richard N. Zare , Jonathan V. Sweedler
IPC分类号： G01N27/447 , G01N30/02 , G01N30/16 , G01N30/28 , G01N30/60 , G01N30/84 , G01N27/26
CPC分类号： G01N30/6039 , G01N27/44717 , G01N27/44773 , G01N30/16 , G01N2030/027 , G01N2030/162 , G01N2030/285 , G01N2030/8435 , G01N30/02 , G01N30/6034
摘要： An on-column derivatization scheme where a liquid or solid labeling reagent is provided in a capillary to react chemically with a sample in order to label the sample. Electrophoretic separation may be carried out immediately thereafter to simplify the derivatization, separation and detection process. By localizing the labeling process to a small area within the capillary, fast kinetics and high reaction yield are achieved.
摘要翻译：柱内衍生方案，其中在毛细管中提供液体或固体标记试剂以与样品进行化学反应以标记样品。此后可以进行电泳分离，以简化衍生化，分离和检测过程。通过将标记过程定位在毛细管内的一个小区域，实现了快速动力学和高反应产率。

3. 发明授权

US5342492A System for electrokinetic separation and detection where detection is performed at other than separation electric field 失效
标题翻译：用于除了分离电场以外进行检测的电动分离和检测系统
公开(公告)号：US5342492A
公开(公告)日：1994-08-30
申请号：US115466
申请日：1993-09-01
申请人： Rajeev Dadoo , Richard N. Zare , Luis A. Colon
发明人： Rajeev Dadoo , Richard N. Zare , Luis A. Colon
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/4473 , G01N27/44773
摘要： A voltage alternating between a high value and a low value is applied across a separation capillary in an electrophoretic system and electrochemical detection is performed only during time periods when a low voltage or no voltage is applied to the tube to improve the sensitivity of detection.
摘要翻译：在电泳系统中跨越分离毛细管施加在高值和低值之间交替的电压，并且仅在对管施加低电压或无电压以提高检测灵敏度的时间段期间进行电化学检测。

4. 发明授权

US5480525A Machine-accessible electrochemical detector for capillary electrophoresis 失效
标题翻译：用于毛细管电泳的机器可访问的电化学检测器
公开(公告)号：US5480525A
公开(公告)日：1996-01-02
申请号：US235299
申请日：1994-04-29
申请人： Luis A. Colon , Rajeev Dadoo , William H. Whitted , Richard N. Zare , Andrew G. Ewing , Sandra S. Ferris , Jennifer U. Woelker
发明人： Luis A. Colon , Rajeev Dadoo , William H. Whitted , Richard N. Zare , Andrew G. Ewing , Sandra S. Ferris , Jennifer U. Woelker
IPC分类号： G01N27/07 , G01N27/447 , B01D61/42 , B01D61/46
CPC分类号： G01N27/4473 , G01N27/44704 , G01N27/44721
摘要： End-column detectors are provided in which either a sensing microelectrode or optical fiber is placed at the end of the separation capillary. Additionally, an alignment apparatus is provided to facilitate the manual or automated positioning of either type of sensing device relative to the end of the separation capillary. The invention provides detectors that are sensitive, reliable, and easy to construct and to operate.
摘要翻译：提供端柱检测器，其中感测微电极或光纤放置在分离毛细管的末端。此外，提供了一种对准装置以便于相对于分离毛细管的端部手动或自动定位任一类型的感测装置。本发明提供了敏感，可靠，易于构造和操作的检测器。

5. 发明授权

US6095202A Method and device for packing capillary columns 失效
标题翻译：包装毛细管柱的方法和装置
公开(公告)号：US6095202A
公开(公告)日：2000-08-01
申请号：US60486
申请日：1998-04-15
申请人： Luis A. Colon , Adam M. Fermier , Gary R. Sagerman
发明人： Luis A. Colon , Adam M. Fermier , Gary R. Sagerman
IPC分类号： B01D15/08 , G01N30/56
CPC分类号： B01D15/206 , G01N30/56 , G01N2030/562
摘要： The present invention features a method and apparatus with a rotatable central reservoir and radially extending support arms for packing chromatographic columns at a consistent gradient of particle impact by using centripetal forces to independently accelerate particles comprising a bed material through a filling opening at one end of the column and continuously as they move axially along the length of the column to their packed destination. The method and apparatus are particularly suitable for use in packing capillary columns having an interior diameter of about 500 microns or less.
摘要翻译：本发明的特征在于一种方法和设备，其具有可旋转的中心储存器和径向延伸的支撑臂，用于通过使用向心力独立地加速包含床材料的颗粒通过填充开口的颗粒撞击的一致梯度来填充色谱柱柱，并且它们沿柱的长度轴向移动到它们的包装目的地。所述方法和装置特别适用于包装内径为约500微米或更小的毛细管柱。

6. 发明授权

US5869152A Silica materials 失效
标题翻译：二氧化硅材料
公开(公告)号：US5869152A
公开(公告)日：1999-02-09
申请号：US609425
申请日：1996-03-01
申请人： Luis A. Colon
发明人： Luis A. Colon
IPC分类号： C03C3/06 , C03C14/00 , B32B9/00
CPC分类号： B01J20/287 , C03C14/008 , C03C3/06 , B01J2220/54 , C03C2201/60 , C03C2214/17 , G01N2030/484 , Y10T428/131 , Y10T428/1393 , Y10T428/2982 , Y10T428/2996
摘要： The present invention relates to silica materials and particles having surfaces which define an interior. The interior includes interior silicon atoms at least a portion of which is bonded to a substituted or unsubstituted alkyl moiety. In a preferred aspect of the present invention, the silica material also has surface silicon atoms to which are bonded substituted or unsubstituted alkyl moieties. A capillary tube coated on its inner surface with the silica material of the present invention is also disclosed. The silica materials of the present invention are resistant to degradation at high or low pH and are particularly useful as chromatographic stationary phases, especially for use in open tubular liquid chromatography and open tubular electrochromatography.
摘要翻译：本发明涉及二氧化硅材料和具有限定内部的表面的颗粒。内部包括内部硅原子，其至少一部分键合到取代或未取代的烷基部分。在本发明的优选方面，二氧化硅材料还具有与取代或未取代的烷基部分键合的表面硅原子。还公开了在其内表面上涂覆有本发明的二氧化硅材料的毛细管。本发明的二氧化硅材料在高或低pH下耐降解，特别适用于色谱固定相，特别适用于开放式管式液相色谱和开放式管式电色谱。

7. 发明申请

US20100140154A1 GROUP IV METAL OXIDE MONOLITHIC COLUMNS 审中-公开
标题翻译：第四组金属氧化物单晶柱
公开(公告)号：US20100140154A1
公开(公告)日：2010-06-10
申请号：US12280069
申请日：2005-03-09
申请人： Luis A. Colon , David C. Hoth
发明人： Luis A. Colon , David C. Hoth
IPC分类号： B01D15/22 , C08J9/00
CPC分类号： C01G1/02 , B01J20/06 , B01J20/26 , B01J20/28042 , B01J20/28083 , B01J20/282 , B01J2220/58 , B01J2220/82 , C01G25/02 , C01G27/02 , C01P2004/03 , C04B35/46 , C04B35/486 , C04B35/624 , C04B35/632 , C04B35/63452 , C04B35/63488 , C04B38/0045 , C04B2111/00793 , C04B2235/441 , C04B2235/95 , G01N2030/528 , C04B35/48 , C04B38/0054
摘要： The present invention discloses methods of preparing a continuous, porous metal oxide monolith in a container. The method involves providing a reaction mixture containing a metal salt or metal alkoxide compound, a solvent, and a porogenic reagent. Next, an epoxide is added to the reaction mixture under conditions effective to initiate condensation and polymerization of the reaction mixture. Then, a container is filled with the reaction mixture after epoxide addition to obtain a continuous, porous metal oxide monolith in the container. The present invention also discloses columns including a tubular container and a continuous, porous Group IV metal oxide monolith in contact with the inner walls of the tubular container, where the Group IV metal oxide monolith is free of any support or matrix material, and other articles including a continuous, porous Group IV metal oxide monolith, where the metal oxide monolith is free of any support or matrix material.
摘要翻译：本发明公开了在容器中制备连续多孔金属氧化物整料的方法。该方法包括提供含有金属盐或金属醇盐化合物，溶剂和致孔剂的反应混合物。接下来，在有效引发反应混合物的缩合和聚合的条件下，向反应混合物中加入环氧化物。然后，在加入环氧化物之后，用反应混合物填充容器，以在容器中获得连续的多孔金属氧化物整料。本发明还公开了包括管状容器和与管状容器的内壁相接触的连续多孔的第IV族金属氧化物整体的柱，其中第IV族金属氧化物整料没有任何载体或基体材料，以及其它制品包括连续的多孔IV族金属氧化物整料，其中金属氧化物整料不含任何载体或基质材料。

8. 发明授权

US06913714B2 Method of producing thermoplastic polycarbonate films having low optical retardation values 失效
标题翻译：具有低光学延迟值的热塑性聚碳酸酯膜的制造方法
公开(公告)号：US06913714B2
公开(公告)日：2005-07-05
申请号：US10301175
申请日：2002-11-21
申请人： Shu Liu , Luis A. Colon
发明人： Shu Liu , Luis A. Colon
IPC分类号： B29C43/24 , B29C43/22 , B29C43/46 , B29C47/88 , B29C47/92 , B29D7/01 , B29K69/00 , B29L7/00 , B29D11/00
CPC分类号： B29C47/8845 , B29C43/22 , B29C43/46 , B29C47/0021 , B29C47/886 , B29C47/889 , B29C47/92 , B29C2947/92095 , B29C2947/92123 , B29C2947/92209 , B29C2947/92247 , B29C2947/92409 , B29C2947/92447 , B29C2947/9259 , B29C2947/92609 , B29C2947/92704 , B29C2947/92904 , B29C2947/92923 , B29D7/01 , B29K2069/00 , B29K2995/0032
摘要： A method of preparing a thermoplastic polycarbonate film having an optical retardation value of less than or equal to 20 nm, is described. The method includes: (a) forming a molten extrudate (20) of a thermoplastic polycarbonate polymer in an extruder (11) having a terminal die (17) through which the molten extrudate is passed, the molten extrudate having a temperature of 150° C. to 400° C. upon emerging from terminal die (17); and (b) passing molten extrudate (20), from die (17), between two counter-rotating rolls (23 and 26) each having an elastomeric polymer surface (35 and 38), the counter-rotating rolls having a roll speed ratio and a nip (41), the distance between the terminal die (17) and the nip (41) being a die-nip distance (47). The extrudate temperature, the roll speed ratio and the die-nip distance (47) are each selected such that a thermoplastic polycarbonate film (32) having an optical retardation value of less than or equal to 20 nm is formed.
摘要翻译：描述了制备具有小于或等于20nm的光学延迟值的热塑性聚碳酸酯膜的方法。该方法包括：（a）在挤出机（11）中形成热塑性聚碳酸酯聚合物的熔融挤出物（20），该挤出机具有熔融挤出物通过的末端模头（17），熔融挤出物的温度为150℃ 在从端子模具（17）出来时达到400℃; 和（b）使来自模具（17）的熔融挤出物（20）在具有弹性体聚合物表面（35和38）的两个反转辊（23和26）之间通过，所述反向旋转辊具有辊速比和辊隙（41）之间，所述端子模具（17）和压区（41）之间的距离为压模间隙距离（47）。挤出物温度，辊速比和模夹间距（47）各自被选择成使得具有小于或等于20nm的光学延迟值的热塑性聚碳酸酯膜（32）形成。

9. 发明授权

US6016689A Aerosol-generated sol-gel derived thin films and applications thereof 失效
标题翻译：气溶胶产生的溶胶 - 凝胶衍生的薄膜及其应用
公开(公告)号：US6016689A
公开(公告)日：2000-01-25
申请号：US752460
申请日：1996-11-18
申请人： Frank V. Bright , Luis A. Colon , Jeffrey D. Jordan , Richard A. Dunbar
发明人： Frank V. Bright , Luis A. Colon , Jeffrey D. Jordan , Richard A. Dunbar
IPC分类号： G01N33/552 , G01N7/00
CPC分类号： G01N33/552
摘要： A sensor having a substrate overlayed with a sol-gel layer, a chemical sensing species deposited upon the sol-gel layer, and a thin film of a second sol-gel layer overlaying and entrapping the species. The effect of this sensor is that the species exhibits a significant portion of its intrinsic function over a period of time. In yet another embodiment of the subject invention, a method is disclosed to form a thin sol-gel layer upon an ambient substrat. This method ensures the integrity, stability and functionality of the chemical sensing species within the sol-gel layers.
摘要翻译：一种传感器，其具有覆盖有溶胶 - 凝胶层的基底，沉积在溶胶 - 凝胶层上的化学感测物质和覆盖并捕获物种的第二溶胶 - 凝胶层的薄膜。该传感器的作用是物种在一段时间内表现出其内在功能的重要部分。在本发明的另一个实施方案中，公开了一种在环境基质上形成薄溶胶 - 凝胶层的方法。该方法确保溶胶 - 凝胶层内的化学感测物质的完整性，稳定性和功能性。

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