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1. 发明授权

US06743356B1 High throughput high performance chromatography system 有权
标题翻译：高通量高性能色谱系统
公开(公告)号：US06743356B1
公开(公告)日：2004-06-01
申请号：US09699212
申请日：2000-10-27
申请人： Adam M. Fermier , Elias H. Hochman , Norberto A. Guzman , Stephen Scypinski
发明人： Adam M. Fermier , Elias H. Hochman , Norberto A. Guzman , Stephen Scypinski
IPC分类号： B01D1508
CPC分类号： G01N30/466 , G01N30/32 , G01N30/34 , G01N30/36 , G01N30/74 , G01N2030/324 , G01N2030/326 , G01N2030/347
摘要： A high throughput high performance chromatography system operating at a high mixing pressure including a plurality of pressurized solvent reservoirs, e.g. pumps, each maintaining an associated solvent at a substantially constant pressure. A plurality of flow control valves are connected downstream or upstream of the reservoirs for controlling the flow rate of the solvent into the respective columns. The number of reservoirs equals the number of solvents. Accordingly, the system reduces the number of pumps required thereby saving money and space. Furthermore, the system increases sample throughput, accelerates method development and minimizes organic waste.
摘要翻译：在高混合压力下操作的高通量高性能色谱系统，包括多个加压溶剂容器，例如，泵，每个保持在基本上恒定的压力下的相关溶剂。多个流量控制阀连接在储存器的下游或上游，用于控制溶剂进入相应柱的流速。水库的数量等于溶剂的数量。因此，该系统减少了所需的泵的数量，从而节省了钱和空间。此外，该系统提高了样品通量，加速了方法开发，并最大限度地减少了有机废物。

2. 发明授权

US6095202A Method and device for packing capillary columns 失效
标题翻译：包装毛细管柱的方法和装置
公开(公告)号：US6095202A
公开(公告)日：2000-08-01
申请号：US60486
申请日：1998-04-15
申请人： Luis A. Colon , Adam M. Fermier , Gary R. Sagerman
发明人： Luis A. Colon , Adam M. Fermier , Gary R. Sagerman
IPC分类号： B01D15/08 , G01N30/56
CPC分类号： B01D15/206 , G01N30/56 , G01N2030/562
摘要： The present invention features a method and apparatus with a rotatable central reservoir and radially extending support arms for packing chromatographic columns at a consistent gradient of particle impact by using centripetal forces to independently accelerate particles comprising a bed material through a filling opening at one end of the column and continuously as they move axially along the length of the column to their packed destination. The method and apparatus are particularly suitable for use in packing capillary columns having an interior diameter of about 500 microns or less.
摘要翻译：本发明的特征在于一种方法和设备，其具有可旋转的中心储存器和径向延伸的支撑臂，用于通过使用向心力独立地加速包含床材料的颗粒通过填充开口的颗粒撞击的一致梯度来填充色谱柱柱，并且它们沿柱的长度轴向移动到它们的包装目的地。所述方法和装置特别适用于包装内径为约500微米或更小的毛细管柱。

3. 发明授权

US07045288B2 Apparatus for the automation of chemical reaction kinetics studies 有权
公开(公告)号：US07045288B2
公开(公告)日：2006-05-16
申请号：US09816787
申请日：2001-03-23
申请人： Adam M. Fermier , Alan R. Oyler , Barbara L. Armstrong , James V. Weber , James Nalasco
发明人： Adam M. Fermier , Alan R. Oyler , Barbara L. Armstrong , James V. Weber , James Nalasco
IPC分类号： C12Q1/68 , C07H19/34
CPC分类号： G01N35/0099 , B01L7/00 , G01N13/00 , G01N2013/006
摘要： The present invention relates to an apparatus designed to perform chemical reaction kinetics studies and more particularly to an apparatus which is capable of conducting accelerated automated kinetics studies with user-defined temperature profiles and sampling periods. The apparatus includes at least one hot reaction block for heating one or more reaction vessels and at least one cold reaction block for cooling the one or more reaction vessels after heating thereof. The apparatus includes a robotic device for transferring one reaction vessel from one hot reaction block to one cold reaction block and a controller having a user interface for inputting a predetermined temperature profile and a predetermined sampling interval. The controller is in communication with the plurality of reaction blocks and the robotic device so as to instruct the robotic device to transfer one reaction vessel from one hot reaction block to one cold reaction block at a predefined transfer time within the predetermined sampling interval. The predetermined temperature profile represents the temperature of at least one of the hot reaction blocks over a time period of the study.

4. 发明授权

US06674022B2 Apparatus and method for transferring and weighing powder materials using pipette transfer devices 有权
标题翻译：使用移液器转移装置转移和称量粉末材料的装置和方法
公开(公告)号：US06674022B2
公开(公告)日：2004-01-06
申请号：US09816788
申请日：2001-03-23
申请人： Adam M. Fermier , John Troisi , James V. Weber
发明人： Adam M. Fermier , John Troisi , James V. Weber
IPC分类号： B01L302
CPC分类号： G01G23/3728 , G01G19/384 , G01N2035/1053
摘要： The present invention provides an apparatus for automatically transferring and weighing a powder material. The apparatus comprises a weigh station including a device for weighing the powder material in a container. A transfer device for collecting and dispensing the powder material is provided in which the device has a hollow body having a first end and a second end. The first end being operatively connected to a vacuum source so that a vacuum is selectively formed in the body. A collecting/dispensing tip is detachably coupled to the second end of the body. The tip is a hollow member with a tip orifice at one end so that a vacuum is formed in the tip upon actuation of the vacuum source. A controller for causing the selective actuation of the vacuum source and movement of at least one of the transfer device and the container is provided. The powder material is collected by placing the tip orifice in close proximity to a supply of the powder material resulting in a transfer quantity of powder material being collected in the tip orifice when the vacuum source is actuated. The powder material is transferred to the container by removing the vacuum resulting in the transfer quantity of powder material being dispensed into the container.
摘要翻译：本发明提供了一种用于自动转移和称重粉末材料的设备。该装置包括称重站，该称重站包括用于将粉末材料称重在容器中的装置。提供了用于收集和分配粉末材料的转移装置，其中装置具有具有第一端和第二端的中空体。第一端可操作地连接到真空源，使得在体内选择性地形成真空。收集/分配尖端可拆卸地联接到主体的第二端。尖端是在一端具有尖端孔的中空构件，使得在真空源致动时在尖端中形成真空。提供了用于使真空源的选择性致动和至少一个传送装置和容器的移动的控制器。通过将尖端孔放置成靠近粉末材料的供应物来收集粉末材料，导致当真空源被致动时在粉末孔中收集的粉末材料的转移量。通过去除导致分配到容器中的粉末材料的转移量的真空将粉末材料转移到容器。

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