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1. 发明申请

US20060161142A1 Multiple wavelength laser workstation 有权
公开(公告)号：US20060161142A1
公开(公告)日：2006-07-20
申请号：US11035680
申请日：2005-01-14
申请人： Rafael Sierra , Eric Koschmann , Joseph Day , Evan Sherr , James Boll
发明人： Rafael Sierra , Eric Koschmann , Joseph Day , Evan Sherr , James Boll
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/207 , A61N5/0616 , H01S3/061 , H01S3/08086 , H01S3/082 , H01S3/092 , H01S3/1611 , H01S3/1643 , H01S3/2383
摘要： Lasers capable of lasing at at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. An output coupler is positioned along a longitudinal axis at a first end of the lasing medium and a first mirror, movable beam block shutter and second mirror are positioned sequentially along the longitudinal axis of the lasing medium at a second end of the lasing medium. The first mirror is highly reflective at a first wavelength, and the second mirror is highly reflective at a second wavelength while being transparent at the first wavelength. The beam block shutter is movable between a first position along the longitudinal axis of the lasing medium and between the first and second mirrors and a second position away from the longitudinal axis of the lasing medium. Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. In certain embodiments, a switch connects the single energy storage network to a secondary winding of a high voltage trigger transformer, which is itself connected to the laser pump chambers. These high voltage trigger transformer serve to selectively ionize the excitation source in one of the laser pump chambers such that when the switch is closed, energy from the energy storage network will flow through the pump chamber whose excitation source(s) has been previously ionized. In other embodiments, the single energy storage network is connected to the excitation sources via active semiconductor switches that permit the release of portions of energy stored in the single energy storage network to one of the lasers, leaving additional energy to be immediately or rapidly released to the excitation source of the first or another laser. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy.

2. 发明授权

US07112195B2 Esophageal lesion treatment method 失效
标题翻译：食管病变治疗方法
公开(公告)号：US07112195B2
公开(公告)日：2006-09-26
申请号：US10728258
申请日：2003-12-04
申请人： James Boll , Evan Sherr , Jamie Koufman , George Cho
发明人： James Boll , Evan Sherr , Jamie Koufman , George Cho
IPC分类号： A61B18/22 , A61B18/00
CPC分类号： A61B18/24 , A61B2017/22051 , A61B2018/00982 , A61B2018/2272
摘要： Apparatus for the treatment of Barrett's esophagus, including: an inflatable balloon for insertion into the esophagus, an endoscope for passing inside the balloon on a distal end thereof, a laser fiber apparatus for insertion within the balloon in the esophagus, and a balloon inflation/deflation means in fluid communication with the balloon for inflating and emptying the balloon into and out of contact with the walls of the esophagus to be treated. The balloon may occlude the stomach from the esophagus during treatment.
摘要翻译：用于治疗巴雷特食道的装置，包括：用于插入食道的可充气气囊，用于在其远端通过气囊的内窥镜，用于插入食道中的气囊内的激光纤维装置，以及球囊充气/ 通气装置与球囊流体连通，用于使气囊膨胀和排空与被治疗的食管壁接触和脱离接触。治疗过程中，气囊可能会从食管闭塞胃。

3. 发明申请

US20080088795A1 Ocular imaging 有权
标题翻译：眼部成像
公开(公告)号：US20080088795A1
公开(公告)日：2008-04-17
申请号：US11786514
申请日：2007-04-11
申请人： Lee Goldstein , Norman Ford , Leo Chylack , Paul Hartung , Marc Friedman , Evan Sherr , Stephen Fantone
发明人： Lee Goldstein , Norman Ford , Leo Chylack , Paul Hartung , Marc Friedman , Evan Sherr , Stephen Fantone
IPC分类号： A61B3/14
CPC分类号： A61B3/14 , A61B3/117
摘要： A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.
摘要翻译：用于在受试者的眼睛上执行准弹性光散射和荧光配体扫描的系统包括：被配置为朝向被检者的眼睛透射光的光源;被配置为聚焦从源发射并被受检者眼睛散射的光的透镜;测量反射器被配置为接收聚焦光的至少一部分并且被配置为反射接收到的光的第一部分;配置和设置成接收所接收的光的第一部分并被配置为提供对应于第一部分的图像的标记的照相机以及耦合到相机并被配置为分析图像中的光的强度以确定与眼睛的一部分的界面相对应的参考点的位置的处理器。

4. 发明授权

US09020580B2 Systems and methods for monitoring time based photo active agent delivery or photo active marker presence 有权
标题翻译：用于监测基于时间的光活性剂递送或光活性标记存在的系统和方法
公开(公告)号：US09020580B2
公开(公告)日：2015-04-28
申请号：US13488097
申请日：2012-06-04
申请人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
发明人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
IPC分类号： A61B3/10 , A61N5/06 , A61B3/107 , A61B3/135 , A61F9/007 , A61K49/00 , A61F9/008 , A61N5/067 , A61M37/00
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

5. 发明授权

US06293938B1 Photo-refractive keratectomy 失效
$Photo-refractive keratectomy$
标题翻译：光折射角膜切除术
公开(公告)号：US06293938B1
公开(公告)日：2001-09-25
申请号：US08695115
申请日：1996-08-08
申请人： David F. Muller , Mike D'Agati , Marc Friedman , Troy Harmon , Peter Klopotek , Alex Sacharoff , Evan Sherr
发明人： David F. Muller , Mike D'Agati , Marc Friedman , Troy Harmon , Peter Klopotek , Alex Sacharoff , Evan Sherr
IPC分类号： A61F908
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00872
摘要： The invention features improvements in PRK procedures that relate to preventing non-uniform removal of material from the corneal surface. It has been realized that photoablation by-products resulting during the PRK procedure can affect the accuracy and the predictability of the procedure. Under certain conditions, the plume of photoablation by-products that have left the corneal surface can non-uniformly redeposit onto the ablation area and thus affect the uniformity of subsequent material removal. The plume of photoablation by-products, in the space above the corneal surface, can also non-uniformly affect the escape of further photoablation products from the surface. In addition to the plume effects, it has been realized that the hydration level of the corneal tissue during the PRK procedure can vary over the ablation area and likewise non-uniformly affect the PRK procedure.
摘要翻译：本发明的特征在于PRK程序的改进涉及防止材料从角膜表面的不均匀去除。已经意识到，在PRK过程中产生的光消除副产物可能影响程序的准确性和可预测性。在某些条件下，离开角膜表面的光消融副产物的羽毛可能不均匀地再沉积到消融区域上，从而影响随后的材料去除的均匀性。在角膜表面以上的空间中，光消融副产物的羽毛也可以不均匀地影响进一步的光消化产物从表面的逸出。除了羽流效应之外，已经认识到在PRK程序期间角膜组织的水合水平可以在消融区域上变化，并且同样不均匀地影响PRK程序。

6. 发明申请

US20120310083A1 SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE 有权
标题翻译：用于监控基于时间的照片活动代理商交付或照片活动标记的系统和方法
公开(公告)号：US20120310083A1
公开(公告)日：2012-12-06
申请号：US13488097
申请日：2012-06-04
申请人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
发明人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
IPC分类号： A61B6/08 , A61F9/01
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

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