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    • 1. 发明申请
    • Ocular imaging
    • 眼部成像
    • US20080088795A1
    • 2008-04-17
    • US11786514
    • 2007-04-11
    • Lee GoldsteinNorman FordLeo ChylackPaul HartungMarc FriedmanEvan SherrStephen Fantone
    • Lee GoldsteinNorman FordLeo ChylackPaul HartungMarc FriedmanEvan SherrStephen Fantone
    • A61B3/14
    • A61B3/14A61B3/117
    • A system for performing quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and scattered by the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.
    • 用于在受试者的眼睛上执行准弹性光散射和荧光配体扫描的系统包括:被配置为朝向被检者的眼睛透射光的光源;被配置为聚焦从源发射并被受检者眼睛散射的光的透镜;测量反射器 被配置为接收聚焦光的至少一部分并且被配置为反射接收到的光的第一部分;配置和设置成接收所接收的光的第一部分并被配置为提供对应于第一部分的图像的标记的照相机 以及耦合到相机并被配置为分析图像中的光的强度以确定与眼睛的一部分的界面相对应的参考点的位置的处理器。
    • 2. 发明申请
    • Underwater adaptive camera housing
    • 水下自适应摄像机外壳
    • US20070071423A1
    • 2007-03-29
    • US11526980
    • 2006-09-26
    • Stephen FantoneStephen FantoneShaju Puthussery
    • Stephen FantoneStephen FantoneShaju Puthussery
    • G03B17/08
    • G03B17/08
    • An adaptive underwater camera housing and control interface for use with a broad range of camera brands and models. The camera housing is preferably formed of front and rear housing sections that are molded of clear transparent plastic and arranged to be moved between an open position for mounting a camera within the housing and a closed position in which the housing provides a watertight enclosure for protecting and communicating with a camera. Residing in the housing are a controller and communications interface by which a camera can be operated from outside the housing. Magnetic signals are preferably passed to the controller by external signal buttons operated by the user. The external signal buttons do not penetrate the interior surfaces of the housing thereby enhancing its water tightness. The housing is provided with a truncated hemispherical lens through which a camera views scenes to be photographed to reduce distortion and not foreshorten viewing angle and a flat window and diffuser for providing controlled artificial illumination to a scene.
    • 适用于水下摄像机的外壳和控制界面,适用于各种相机品牌和型号。 摄像机外壳优选地由前透明塑料和后壳体部分形成,所述前壳体和后壳体部分由透明透明塑料模制而成,并被设置成在用于将照相机安装在壳体内的打开位置和关闭位置之间移动,在该位置中,壳体提供防水外壳, 与相机通信 居住在房屋中的是控制器和通信接口,通过该接口可以从外壳外部操作相机。 磁信号优选地通过由用户操作的外部信号按钮传递到控制器。 外部信号按钮不会穿透外壳的内表面,从而提高其防水性。 外壳设置有截头半球形透镜,照相机通过该半透镜透镜观看要拍摄的场景以减少失真并且不缩小视角,以及平面窗口和扩散器,用于向场景提供受控的人造照明。
    • 4. 发明申请
    • In vivo optical measurements of hematocrit
    • 血细胞比容的体内光学测量
    • US20070004976A1
    • 2007-01-04
    • US11293652
    • 2005-12-02
    • Alex ZelenchukHoward KaufmanStephen Fantone
    • Alex ZelenchukHoward KaufmanStephen Fantone
    • A61B5/00
    • A61B5/14535A61B5/1455
    • An apparatus for measuring hematocrit of a subject's blood includes an optical source that generates an optical beam that illuminates subcutaneous vessels under a subject's skin. An optical element is positioned to receive a near field portion of the optical beam that is reflected from the subcutaneous vessels under the subject's skin. A scanning mechanism positions the optical element relative to the subcutaneous vessels under the subject's skin over a plurality of relative distances. An optical detector generates a plurality of electrical signals in response to detecting the near field portion of the optical beam that is reflected from the subcutaneous vessels under the subject's skin at the plurality of relative distances between the optical element and the subcutaneous vessels. A processor determines a value of hematocrit in the subcutaneous vessels illuminated by the optical beam from the plurality of electrical signals generated by the optical detector.
    • 用于测量受试者血液的血细胞比容的装置包括产生在对象皮肤下照射皮下血管的光束的光源。 光学元件被定位成接收从受试者皮肤下方的皮下血管反射的光束的近场部分。 扫描机构将光学元件相对于受试者皮肤下方的皮下血管定位在多个相对距离上。 光检测器响应于在光学元件和皮下血管之间的多个相对距离处检测在受试者皮肤下从皮下血管反射的光束的近场部分而产生多个电信号。 处理器确定由光学检测器产生的多个电信号由光束照射的皮下血管中的血细胞比容的值。
    • 6. 发明申请
    • Excitation and imaging of fluorescent arrays
    • 荧光阵列的激发和成像
    • US20050017191A1
    • 2005-01-27
    • US10618838
    • 2003-07-14
    • Jean MontaguStephen Fantone
    • Jean MontaguStephen Fantone
    • G01N21/64G02B21/16G01J1/42
    • G01N21/6452G01N21/6456G01N21/648G02B21/16
    • A support for an array of fluorescently labeled samples comprises a transparent body defining: (a) an array-support surface and (b) under the support surface, in spaced apart relationship thereto, a field of embedded optical features exposed to be illuminated by a broad light beam of excitation radiation addressed to the support from a predetermined general direction selected to produce a surface wave effect at the support surface, the field of embedded optical features and the support being so constructed that light of the beam incident on the features is launched through the support at an angle to the support surface that produces the surface wave effect of radiation in the manner that it can produce fluorescence from the labeled samples to be imaged beyond the support from a direction different from the direction of the illumination. Fine transmissive and reflective features having surfaces generally normal to radiation substantially at the critical angle, and a grating illuminated at a non-normal surface are shown. A data acquision system employing an elastic rotary motion reducer driven by a stepper motor, under computer control, directs a broad illumination beam through a series of small angular increments, an image is taken at each increment by a CCD camera, and based upon energy references on the array-support surface, a quilt image is formed, based on responses of the energy references associated with localized regions of each image.
    • 对荧光标记样品阵列的支持包括透明体,其限定:(a)阵列支撑表面和(b)在支撑表面下方与其间隔开的关系,暴露于由 从被选择以在支撑表面产生表面波效应的预定的大致方向到达支撑的宽光束的激发辐射,嵌入式光学特征的领域和支撑件被构造成使得入射到特征上的光束发射 通过支撑件以与支撑表面成一定角度的方式产生辐射的表面波效应,使得其可以从不同于照明方向的方向从待标记的样品产生荧光以从成像超过支撑。 示出了具有大致垂直于临界角的辐射的表面的细透射和反射特征,以及在非正常表面处照射的光栅。 采用由步进电机驱动的弹性旋转运动减速器的数据采集系统在计算机控制下通过一系列小的角度增量引导宽的照明光束,通过CCD照相机在每个增量处拍摄图像,并且基于能量参考 在阵列支撑表面上,基于与每个图像的局部区域相关联的能量参考的响应,形成被遮蔽图像。