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1. 发明授权

US06293938B1 Photo-refractive keratectomy 失效
$Photo-refractive keratectomy$
标题翻译：光折射角膜切除术
公开(公告)号：US06293938B1
公开(公告)日：2001-09-25
申请号：US08695115
申请日：1996-08-08
申请人： David F. Muller , Mike D'Agati , Marc Friedman , Troy Harmon , Peter Klopotek , Alex Sacharoff , Evan Sherr
发明人： David F. Muller , Mike D'Agati , Marc Friedman , Troy Harmon , Peter Klopotek , Alex Sacharoff , Evan Sherr
IPC分类号： A61F908
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00872
摘要： The invention features improvements in PRK procedures that relate to preventing non-uniform removal of material from the corneal surface. It has been realized that photoablation by-products resulting during the PRK procedure can affect the accuracy and the predictability of the procedure. Under certain conditions, the plume of photoablation by-products that have left the corneal surface can non-uniformly redeposit onto the ablation area and thus affect the uniformity of subsequent material removal. The plume of photoablation by-products, in the space above the corneal surface, can also non-uniformly affect the escape of further photoablation products from the surface. In addition to the plume effects, it has been realized that the hydration level of the corneal tissue during the PRK procedure can vary over the ablation area and likewise non-uniformly affect the PRK procedure.
摘要翻译：本发明的特征在于PRK程序的改进涉及防止材料从角膜表面的不均匀去除。已经意识到，在PRK过程中产生的光消除副产物可能影响程序的准确性和可预测性。在某些条件下，离开角膜表面的光消融副产物的羽毛可能不均匀地再沉积到消融区域上，从而影响随后的材料去除的均匀性。在角膜表面以上的空间中，光消融副产物的羽毛也可以不均匀地影响进一步的光消化产物从表面的逸出。除了羽流效应之外，已经认识到在PRK程序期间角膜组织的水合水平可以在消融区域上变化，并且同样不均匀地影响PRK程序。

2. 发明授权

US5885275A Medical spacing guide 失效
标题翻译：医疗间距指南
公开(公告)号：US5885275A
公开(公告)日：1999-03-23
申请号：US007845
申请日：1998-01-15
申请人： David F. Muller
发明人： David F. Muller
IPC分类号： A61B17/00 , A61B18/00 , A61B18/20 , A61B18/22 , A61B19/00 , A61B17/36
CPC分类号： A61B18/203 , A61B18/22 , A61B2017/00747 , A61B2018/00452 , A61B2018/00476 , A61B2018/0097 , A61B2090/036 , A61B90/05
摘要： A system is provided to position an energy delivery handpiece a desired distance from a treatment site while at the same time protecting the handpiece, and energy transmitting optical fibers, from soiling due to tissue debris. The system includes one or more energy transmissive members that are formed from a material that allows the passage of electromagnetic (e.g., laser) energy therethrough. The energy transmissive members can be removably and replaceably attachable to one end of a spacer member. An opposite end of the spacer member is mountable to the energy delivery handpiece. The energy transmissive member is effective protect the handpiece from tissue eruptions. In one embodiment the energy transmissive member also is effective to focus electromagnetic energy upon the treatment site.
摘要翻译：提供了一种系统，用于将能量递送手持件从处理部位定位到期望的距离，同时保护手持件和能量传输光纤免受由于组织碎屑的污染。该系统包括由允许电磁（例如激光）能量通过其中的材料形成的一个或多个能量传输构件。能量传递构件可以可拆卸地且可更换地附接到间隔件的一端。隔离构件的相对端可安装到能量输送手持件上。能量传递构件有效地保护手持件免受组织喷发。在一个实施例中，能量传输构件还有效地将电磁能量聚焦在治疗部位上。

3. 发明授权

US5505723A Photo-refractive keratectomy 失效
$Photo-refractive keratectomy$
标题翻译：光折射角膜切除术
公开(公告)号：US5505723A
公开(公告)日：1996-04-09
申请号：US195359
申请日：1994-02-10
申请人： David F. Muller
发明人： David F. Muller
IPC分类号： A61F9/008 , A61F9/009 , A61F9/01 , A61N5/06
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00844 , A61F2009/00872 , A61F9/009
摘要： Methods and apparatus as disclosed for shaping the cornea of a patient's eye such that the epithelial tissue of the patient's cornea is shaped into a preliminary shape, corresponding to a desired final stromal shape, using photoablative radiation, and then the preliminary shape of the epithelial tissue is transferred into the stromal tissue of the cornea using photoablative radiation, thereby shaping the cornea into the desired final stromal shape. The epithelium may be shaped using an erodible mask with a predefined profile of resistance to erosion, or by a graded intensity filter, or by selectively varying the dimension of an aperture that controls the area of the epithelial surface irradiated by the photoablative laser radiation or by other mechanisms that selectively expose regions of the epithelium, or by a scanning laser beam. The epithelium may also be shaped, without using an aperture or a mask, by using a beam of photoablative radiation with substantially uniform intensity distribution.
摘要翻译：公开的用于使患者眼睛的角膜成形的方法和装置，使得患者角膜的上皮组织被成形为初步形状，对应于期望的最终基质形状，使用光烧伤辐射，然后形成上皮组织的初步形状使用光照射辐射转移到角膜的基质组织中，从而将角膜成形为期望的最终基质形状。可以使用具有预定的抗侵蚀轮廓的侵蚀性掩模或者通过渐变强度过滤器，或者通过选择性地改变控制由光烧伤激光辐射照射的上皮表面的面积的孔的尺寸，或者通过选择性地暴露上皮的区域或通过扫描激光束的其它机制。通过使用具有基本均匀的强度分布的光照射辐射束，上皮也可以成形，而不使用孔或掩模。

4. 发明授权

US5296514A Corneal treatment agents 失效
标题翻译：角膜治疗剂
公开(公告)号：US5296514A
公开(公告)日：1994-03-22
申请号：US65640
申请日：1993-05-21
申请人： David F. Muller
发明人： David F. Muller
IPC分类号： A61K31/045 , A62K31/045
CPC分类号： A61K31/045 , Y10S514/912
摘要： Aliphatic alcohols are disclosed for promoting corneal healing following injury to the eye. Such compositions ameliorate corneal discomfort, alleviate visual artifacts, and/or reduce irritation caused by the eye injury. The compositions also promote the regrowth of epithelial tissue over the corneal surface.
摘要翻译：公开了用于促进眼睛损伤后的角膜愈合的脂肪族醇。这样的组合物改善角膜不适，减轻视觉伪像，和/或减少由眼睛损伤引起的刺激。组合物还促进角膜表面上皮组织的再生长。

5. 发明授权

US07248720B2 Method and system for generating a combined retina/iris pattern biometric 有权
标题翻译：用于生成组合视网膜/虹膜图案生物识别的方法和系统
公开(公告)号：US07248720B2
公开(公告)日：2007-07-24
申请号：US11087205
申请日：2005-03-23
申请人： David F. Muller , Gregory L. Heacock , David B. Usher
发明人： David F. Muller , Gregory L. Heacock , David B. Usher
IPC分类号： G06K9/00
CPC分类号： G06K9/00597
摘要： A method and system generates correlated biometric information by capturing an image of a retinal vessel pattern and simultaneously capturing an image of an iris minutia pattern. Retinal biometric data and iris biometric data are generated from the images. The retinal biometric data and the iris biometric data are then combined or linked to maintain the correlation between the two biometrics.
摘要翻译：方法和系统通过捕获视网膜血管图案的图像并同时捕获虹膜细节图案的图像来生成相关生物信息。从图像生成视网膜生物特征数据和虹膜生物特征数据。然后组合或连接视网膜生物特征数据和虹膜生物特征数据以维持两个生物特征之间的相关性。

6. 发明授权

US5613965A Corneal reprofiling using an annular beam of ablative radiation 失效
标题翻译：使用消融辐射的环形光束进行角膜再生
公开(公告)号：US5613965A
公开(公告)日：1997-03-25
申请号：US351826
申请日：1994-12-08
申请人： David F. Muller
发明人： David F. Muller
IPC分类号： A61B18/20 , A61F9/007 , A61F9/01 , B23K26/073 , G02B3/04 , A61N5/02
CPC分类号： G02B3/04 , A61F9/00804 , A61F9/0081 , A61F9/00819 , B23K26/0734 , A61F2009/00844 , A61F2009/00872
摘要： Methods and systems are disclosed for corneal reprofiling employing an annular beam of ablative radiation to correct refractive errors in vision, and/or create "blend zones" in order to reduce any surface discontinuities on the cornea following hyperopia-correcting or astigmatism-correcting procedures. Preferably, the methods and systems of the present invention also operate to change the intensity distribution of the light beam, such that the annulus of radiation has a varying intensity as a function of radius and, thereby, achieves a blending or other desired effect with the least number of pulses. Methods of photorefractive keratectomy (PRK) are disclosed, including the steps of (a) selectively reprofiling a cornea of an eye by removing a volume of corneal tissue with ablative radiation to form a reprofiled region in the optical zone which steepens, at least in part, the central curvature of the cornea; and (b) applying to a peripheral region of the cornea an annular beam of ablative radiation having an intensity which varies radially from a inner to a outer segment of the annular beam to create a blend zone, thereby providing a smooth transition between the repro filed region and an unablated region of the cornea. Optical lens elements also are disclosed having a generally conic front face and a rear face which is generally perpendicular to the path of the incident beam. Light passing through this optical element will be refracted into an annular beam. Variations in the intensity profile of the annular beam can be introduced by employing an initial beam which has a non-uniform profile, or by modifying the shape of either the front face or the rear face of the optical element.
摘要翻译：公开了使用消融辐射的环形光束矫正视力中的屈光不正的角膜再生方法和系统，和/或创建“混合区域”，以便在远视矫正或散光矫正程序之后减少角膜上的任何表面不连续性。优选地，本发明的方法和系统还用于改变光束的强度分布，使得辐射环带具有作为半径的函数的变化的强度，从而实现与脉冲数量最少。公开了光折射角膜切除术（PRK）的方法，包括以下步骤：（a）通过用消融辐射去除一定体积的角膜组织来选择性地重新生成眼睛的角膜，以在光学区域中形成复原区域，至少部分地陡峭，角膜的中心曲率; 和（b）向角膜的周围区域施加环形光束，其具有从环形束的内部段到外部段的径向变化的强度，从而产生混合区域，由此提供了复原区域之间的平滑过渡区域和角膜未明确的区域。公开了光学透镜元件，其具有大致圆锥前表面和大体上垂直于入射光束的路径的后表面。穿过该光学元件的光将折射成环形光束。可以通过采用具有不均匀轮廓的初始光束或通过改变光学元件的正面或背面的形状来引入环形光束的强度分布的变化。

7. 发明授权

US5437658A Method and system for laser thermokeratoplasty of the cornea 失效
标题翻译：角膜激光热机器人成形术的方法与系统
公开(公告)号：US5437658A
公开(公告)日：1995-08-01
申请号：US957702
申请日：1992-10-07
申请人： David F. Muller , Alex C. Sacharoff
发明人： David F. Muller , Alex C. Sacharoff
IPC分类号： A61F9/007 , A61F9/01 , A61N5/06
CPC分类号： A61F9/00821 , A61F2009/00844 , A61F2009/00853 , A61F2009/00872
摘要： The invention is a system and method for modifying the corneal curvature by irradiating the cornea to deliver thermal energy to the stroma. The system includes multiple irradiation ports for introducing electromagnetic radiation of a wavelength suitable for absorption in the stroma; positioning means, such as a hemi-spherical dome with several tracks for positioning the irradiation ports, respectively, at locations of a preselected geometric pattern relative to the pretreated cornea, the geometric pattern being selected to correspond to a desired modified shape of the cornea; transmission means adapted to deliver controlled amounts of the radiation from a radiation source to each of the irradiation ports; and the irradiation ports, positioned at the locations of the geometric pattern, constructed to introduce the radiation to treatment volumes of the stroma in a cooperative manner to induce desired shrinkage of the collagenous stromal tissue and cause change in the corneal curvature. Each treatment volume, formed by a radiation pattern emanating from one irradiation port or by intersection of radiation patterns emanating from multiple irradiation ports, is created in a controllable manner to have a desired volume and energy profile. The transmission means that includes fiber optic waveguides are connected to distribution means for dispensing controlled amounts of the radiation to each of the fiber optic waveguides. The system also includes inspection means for observing and evaluating the shrinkage of collagenous tissue.
摘要翻译：本发明是通过照射角膜以将热能传递给基质来改变角膜曲率的系统和方法。该系统包括用于引入适于吸收在基质中的波长的电磁辐射的多个辐射端口; 定位装置，例如具有多个轨道的半球形穹顶，分别用于将照射端口定位在相对于预处理的角膜的预选几何图案的位置处，几何图案被选择为对应于期望的角膜修改形状; 传输装置，适于将辐射源的辐射的受控量传送到每个照射端口; 并且位于几何图案位置处的照射端口被构造成以协作的方式将辐射引入基质的治疗体积，以引起胶原性基质组织的期望收缩并引起角膜曲率的变化。通过从一个照射端口发出的辐射图形或通过从多个照射端口发出的辐射图的相交形成的每个处理体积以可控的方式产生以具有期望的体积和能量分布。包括光纤波导的传输装置连接到分配装置，用于将受控量的辐射分配给每个光纤波导。该系统还包括用于观察和评估胶原组织收缩的检查装置。

8. 发明授权

US5324281A Laser reprofiling system employing a photodecomposable mask 失效
标题翻译：使用光可分解掩模的激光再生系统
公开(公告)号：US5324281A
公开(公告)日：1994-06-28
申请号：US964925
申请日：1992-10-22
申请人： David F. Muller
发明人： David F. Muller
IPC分类号： A61B17/30 , A61F9/008 , A61F9/01 , A61B5/06
CPC分类号： A61F9/008 , A61F9/00817 , A61B2017/306 , A61F2009/00872 , A61F9/00804 , A61F9/00819
摘要： A laser system for reprofiling a surface, such as the corneal surface of an eye, comprising a laser and a photoreactive mask disposed between the laser means and the surface for providing a predefined profile of resistance to laser radiation, such that, upon irradiation of the mask, a portion of the laser radiation is selectively absorbed and another portion is transmitted to the surface, in accordance with the mask profile, to selectively erode the surface. The mask can be connected to the support structure and disposed in optical alignment with the laser means and the surface. The mask can be directly integrated with support structure attached to the surface or spatially separated from the surface and imaged onto the surface. In one preferred embodiment, the mask includes a transparent matrix and light-absorbing dispersoids selectively distributed within the matrix, such that the dispersed elements are progressively bleached by exposure to the laser radiation.
摘要翻译：一种用于重新编织诸如眼睛的角膜表面的表面的激光系统，包括设置在激光装置和表面之间的激光和光反应掩模，用于提供对激光辐射的预定的轮廓，使得在照射掩模，根据掩模轮廓，激光辐射的一部分被选择性地吸收，另一部分被透射到表面，以选择性地侵蚀表面。掩模可以连接到支撑结构并且与激光装置和表面光学对准地设置。掩模可以直接与附着在表面上的支撑结构或空间上与表面分离并成像到表面上。在一个优选实施例中，掩模包括透明基质和选择性分布在基质内的光吸收分散体，使得分散的元素通过暴露于激光辐射而逐渐漂白。

9. 发明授权

US5214071A Corneal treatment agents 失效
标题翻译：角膜治疗剂
公开(公告)号：US5214071A
公开(公告)日：1993-05-25
申请号：US855308
申请日：1992-03-23
申请人： David F. Muller
发明人： David F. Muller
IPC分类号： A61K31/045
CPC分类号： A61K31/045 , Y10S514/912
摘要： Aliphatic alcohols are disclosed for the treatment of discomfort and visual artifacts following laser surgical procedures on the cornea of the eye. Such compositions reduce the inflammation associated with photorefractive keratectomy and promote the regrowth of epithelial tissue over the reprofiled corneal surface.
摘要翻译：公开了用于治疗眼睛角膜激光外科手术后的不适和视觉伪影的脂肪族醇。这样的组合物减少与光折射角膜切除术相关的炎症并促进上皮组织在复制角膜表面上的再生长。

10. 发明授权

US5993441A Control of photorefractive keratectomy 失效
$Control of photorefractive keratectomy$
标题翻译：控制光折射角膜切除术
公开(公告)号：US5993441A
公开(公告)日：1999-11-30
申请号：US695673
申请日：1996-08-08
申请人： David F. Muller , Alex C. Sacharoff , Peter J. Klopotek
发明人： David F. Muller , Alex C. Sacharoff , Peter J. Klopotek
IPC分类号： A61B17/00 , A61B19/00 , A61F9/01 , A61N5/06
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00808 , A61B2017/00017 , A61B2017/00176 , A61B2017/00181 , A61B2017/00194 , A61B90/30 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/00895
摘要： A method and system are described for performing photorefractive keratectomy procedure employing pulses of photoablative radiation to selectively ablate corneal tissue of a patient's eye in an ablation zone on the anterior corneal surface to produce a desired refractive correction in the corneal tissue. The method and system employ control of the effect of ocular fluid at the corneal surface so as to reduce the disturbance of such fluid on the desired ablation process while maintaining hydration of the corneal tissue. Controlling the average repetition rate of the radiation pulses applied to the corneal surface so as to reduce intrapulse fluid accumulation at the corneal surface without dehydrating the corneal tissue, selecting an increased fluence level of the pulse applied to the corneal surface to reduce the effect of fluid accumulation at the corneal surface, and applying evaporative energy to the site of incidence of a pulse of an ablative beam prior to incidence of said pulse at said site are shown as ways to effect this control. Application of the new method and system to wide area ablation techniques and to scanning techniques are described Reduction of irregularities when ablating large areas, e.g., grater than 5.5 cm is made possible in either case.
摘要翻译：描述了一种用于进行光折射角膜切除术的方法和系统，其使用光消融辐射的脉冲来选择性地在前角膜表面上的消融区域中烧蚀患者眼睛的角膜组织，以在角膜组织中产生期望的屈光矫正。该方法和系统采用对角膜表面上的眼液的影响的控制，以便在保持角膜组织的水合作用的同时减少所需消融过程中的这种流体的干扰。控制施加到角膜表面的辐射脉冲的平均重复率，以减少角膜表面的脉冲内液体积聚，而不会使角膜组织脱水，选择施加到角膜表面的脉冲的增加的注量水平以减少流体的影响在所述位置处的所述脉冲入射之前，在角膜表面积聚并将蒸发能量施加到烧蚀光束的脉冲的入射部位被示出为实现该控制的方式。描述了将新方法和系统应用于广域消融技术和扫描技术的描述。在任何一种情况下，当切割大面积（例如，大于5.5cm）时，减少不规则性成为可能。

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