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1. 发明授权

US06387325B1 Assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample 失效
标题翻译：用于将复合生物流体样品中的成分成分与液体成分分离的装置
公开(公告)号：US06387325B1
公开(公告)日：2002-05-14
申请号：US09414803
申请日：1999-10-08
申请人： Preston Keusch , Stephen C. Wardlaw
发明人： Preston Keusch , Stephen C. Wardlaw
IPC分类号： G01N3300
CPC分类号： G01N1/4077 , G01N1/38 , G01N15/1456 , G01N2001/302 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G02B21/34
摘要： Formed constituents in an aqueous based fluid biologic material sample are separated from the aqueous constituent of the sample, and are concentrated in an examining instrument's focal plane where they can be examined under magnification. Examples of fluids that can be analyzed in this fashion include urine; cerebrospinal fluid; pleural fluid; ascites; fluids aspirated from cysts such as thyroid and breast cysts; cytologic specimens which have been placed in an aqueous fluid; platelet-rich plasma; and the like. The sample is placed in a chamber having a layer of a hydrophilic hydrogel covering a surface of the chamber. An opposite surface of the chamber is transparent, and may be formed by a microscope slide cover slip, or the like. The volume of hydrogel in the chamber is sufficient so that, when the hydrogel absorbs essentially all of the aqueous fraction of the sample, the hydrogel will expand and fill the chamber. The capture surface of the expanded hydrogel is preferably planar, and any formed constituents in the sample will be captured on the capture surface of the hydrogel layer, and will not be absorbed into the hydrogel. Formed constituents, such as: cells; bacteria; crystals; protozoa; ova; parasites; and the like, can be differentially highlighted by use of labeled antibodies, selective stains, or the like, so as to enable optical examination and differentiation of various formed constituents which may be in the sample. Formed constituents may be harvested from the capture surface of the expanded hydrogel layer for more detailed examination and analysis. The capture surface of the hydrogel may be provided with a plurality of beads for use in locating the capture surface with an optical scanning instrument, and for re-establishing previously scanned fields of view.
摘要翻译：将含水基流体生物材料样品中的成分与样品的水性成分分离，并浓缩在检查仪的焦平面上，在此可以在放大倍数下进行检查。可以以这种方式分析的流体的实例包括尿液; 脑脊液胸膜液腹水; 从囊肿如甲状腺和乳腺囊肿吸出的液体; 已经置于水性液体中的细胞学标本; 血小板富集血浆等等。将样品放置在具有覆盖室的表面的亲水性水凝胶层的室中。室的相对表面是透明的，并且可以由显微镜滑盖盖等形成。腔室中的水凝胶的体积是足够的，使得当水凝胶基本上吸收样品的所有含水部分时，水凝胶将膨胀并填充室。膨胀的水凝胶的捕获表面优选是平面的，并且样品中的任何形成的成分将被捕获在水凝胶层的捕获表面上，并且不会被吸收到水凝胶中。形成成分，如：细胞; 菌; 晶体原生动物奥娃寄生虫可以通过使用标记的抗体，选择性污渍等差异地突出显示，以便能够对可能在样品中的各种形成的成分进行光学检查和分化。可以从膨胀的水凝胶层的捕获表面收获成形成分，以进行更详细的检查和分析。水凝胶的捕获表面可以设置有多个珠子，用于使用光学扫描仪器来定位捕获表面，并且用于重建先前扫描的视场。

2. 发明授权

US4703761A Blood sampling device for obtaining small quantity of venous blood 失效
标题翻译：用于获取少量静脉血的采血装置
公开(公告)号：US4703761A
公开(公告)日：1987-11-03
申请号：US892265
申请日：1986-08-04
申请人： R. Rodion Rathbone , Stephen C. Wardlaw , R. Rodion Rathbone , Stephen C. Wardlaw
发明人： R. Rodion Rathbone , Stephen C. Wardlaw , R. Rodion Rathbone , Stephen C. Wardlaw
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/153 , A61B5/15003 , A61B5/150213 , A61B5/150251 , A61B5/150305 , A61B5/150755 , A61B5/150885 , B01L3/505 , A61B5/150221 , A61B5/150389 , A61B5/150503 , A61B5/150717 , A61B5/150786 , B01L2300/0838 , B01L2300/087 , B01L2300/0887
摘要： This device is adapted for taking venous blood samples without the aid of any auxiliary negative pressure. Venous blood pressure is the sole force which fills the device with the blood sample. The device includes a flexible plastic tube formed from polyethylene or the like and further includes a blood drawing needle mounted on one end of the tube. The tube is divided into a collection reservoir into which the sample is drawn, and a sampling reservoir into which the sample may be expressed from the collection area. A valve separates the two areas. Also included in an elastomeric needle closure which adapts the device for in situ centrifugation of the blood sample in a test tube.
摘要翻译：该装置适用于无需辅助负压的静脉血样。静脉血压是用血液样本填充装置的唯一力量。该装置包括由聚乙烯等形成的柔性塑料管，并且还包括安装在管的一端上的抽血针。将管分成收集容器，样品被抽取到其中，采样容器可以从收集区域中将样品表达出来。阀门分开两个区域。也包括在弹性体针头闭合件中，其适应装置用于试管中血样的原位离心。

3. 发明授权

US09873118B2 Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion 有权
公开(公告)号：US09873118B2
公开(公告)日：2018-01-23
申请号：US13341618
申请日：2011-12-30
申请人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： A61J1/06 , B01L3/00
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

4. 发明授权

US09696252B2 Apparatus for performing counts within a biologic fluid sample 有权
公开(公告)号：US09696252B2
公开(公告)日：2017-07-04
申请号：US12768062
申请日：2010-04-27
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： G02B21/34 , B01L3/00 , G01N15/14 , G01N15/00
CPC分类号： G01N15/1463 , B01L3/5027 , B01L3/508 , B01L2200/0684 , B01L2300/0822 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G02B21/34 , Y10T436/101666
摘要： An apparatus for enumerating one or more specific elements within a biologic fluid sample is provided. The apparatus includes a first planar member that is transparent, and a second planar member. The members are separated from one another by a substantially uniform height, and the height is sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber.

5. 发明申请

US20160320369A1 METHOD AND APPARATUS FOR PERFORMING HEMATOLOGIC ANALYSIS USING AN ARRAY-IMAGING SYSTEM FOR IMAGING AND ANALYSIS OF A CENTRIFUGED ANALYSIS TUBE 审中-公开
标题翻译：使用阵列成像系统进行血液分析的方法和装置，用于成像分析和分析分析管
公开(公告)号：US20160320369A1
公开(公告)日：2016-11-03
申请号：US15207074
申请日：2016-07-11
申请人： Joshua D. Levine , Robert A. Levine , Stephen C. Wardlaw , Craig Stout , David A. Clipper
发明人： Joshua D. Levine , Robert A. Levine , Stephen C. Wardlaw , Craig Stout , David A. Clipper
IPC分类号： G01N33/49 , G06T7/00 , B01L3/00 , B01L9/06 , G01N15/04 , G01N15/05
CPC分类号： G01N33/491 , B01L3/50215 , B01L9/065 , B01L2300/027 , B01L2300/0609 , B01L2300/0654 , B01L2300/0838 , G01N15/042 , G01N15/05 , G01N2015/045 , G01N2800/22 , G06T7/0012 , G06T2207/30024
摘要： A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region.
摘要翻译：提供了用于分析在毛细管内离心的血液样品的方法和装置。该装置包括管座，样品成像装置，处理器和样品数据显示器。样品成像装置可操作以在管的区域内产生样品的数字图像。该区域由离心后浮子所在的区域中位于管内腔中的样品的基本上所有的径向宽度和轴向长度限定。样品成像装置可操作以产生表示图像的信号。处理器适于基于来自样本成像装置的信号产生与图像内的感兴趣的频带相关的信息。样本数据显示器适于在该区域内显示样本的结果和/或数字图像。

6. 发明授权

US08774487B2 Method and apparatus for remotely performing hematologic analysis utilizing a transmitted image of a centrifuged analysis tube 有权
标题翻译：利用离心分析管的透射图像远程执行血液分析的方法和装置
公开(公告)号：US08774487B2
公开(公告)日：2014-07-08
申请号：US13016392
申请日：2011-01-28
申请人： Joshua D. Levine , Robert A. Levine , Stephen C. Wardlaw , Craig Stout , David A. Clipper
发明人： Joshua D. Levine , Robert A. Levine , Stephen C. Wardlaw , Craig Stout , David A. Clipper
IPC分类号： G06K9/00
CPC分类号： G01N33/491 , B01L3/50215 , B01L9/065 , B01L2300/027 , B01L2300/0609 , B01L2300/0654 , B01L2300/0838 , G01N15/042 , G01N15/05 , G01N2015/045 , G01N2800/22 , G06T7/0012 , G06T2207/30024
摘要： An apparatus for and method of analyzing hematologic samples deposited within a capillary tube is provided. The method includes the steps of: a) imaging a region of sample centrifuged within a capillary tube using a first analysis device, which region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube where the float resides after centrifugation, and producing signals representative of the image; b) communicating the signals representative of the image to a second analysis device independent of, and remotely located from, the first analysis device; c) processing the signals representative of the image using the second analysis device and producing analysis data based on the signals; and d) displaying the image of the region of the sample using the second analysis device.
摘要翻译：提供了一种用于分析沉积在毛细管内的血液样品的方法和方法。该方法包括以下步骤：a）使用第一分析装置对在毛细管内离心的样品的区域进行成像，该区域由位于管内腔内的样品的基本上所有的径向宽度和轴向长度限定离心后浮子位于其中，并产生代表图像的信号; b）将表示所述图像的信号传送到与所述第一分析装置无关并且远离所述第一分析装置的第二分析装置; c）使用第二分析装置处理表示图像的信号，并基于该信号产生分析数据; 以及d）使用所述第二分析装置显示所述样品的区域的图像。

7. 发明申请

US20130029373A1 METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING 有权
标题翻译：使用荧光猝灭和/或漂白分析个体细胞或颗粒物的方法和装置
公开(公告)号：US20130029373A1
公开(公告)日：2013-01-31
申请号：US13645075
申请日：2012-10-04
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

8. 发明授权

US08241572B2 Disposable chamber for analyzing biologic fluids 有权
标题翻译：一次性分析生物液体室
公开(公告)号：US08241572B2
公开(公告)日：2012-08-14
申请号：US13206636
申请日：2011-08-10
申请人： Stephen C. Wardlaw
发明人： Stephen C. Wardlaw
IPC分类号： G01N33/00 , G01N21/75 , G01N31/22 , G01N33/52 , B01L3/00 , B01L99/00
CPC分类号： G01N33/48764 , B01L3/5027 , B01L3/502738 , B01L2200/025 , B01L2200/12 , B01L2300/0877 , B01L2300/0887 , B01L2400/0406 , G01N1/2813 , G01N1/312 , G01N21/03 , G01N33/492 , G01N35/00009 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2021/0346 , G01N2021/0364 , Y10T436/101666 , Y10T436/25375
摘要： An apparatus for analyzing biologic fluid is provided that includes first and second planar members, and at least three separators. At least one of the first planar member and second planar member is transparent. The separators are disposed between the planar members, and each individually has a height. The separators collectively having a mean height, and separate the planar members to form a chamber having a height extending between the planar members. At least one of the first planar member, second planar member, or separators is sufficiently deformable when the first planar member and second planar member are drawn toward each other by capillary force from a biologic fluid quiescently residing within the chamber to cause the mean chamber height to be substantially equal to the mean height of the separators.
摘要翻译：提供了用于分析生物流体的装置，其包括第一和第二平面构件以及至少三个分离器。第一平面构件和第二平面构件中的至少一个是透明的。分隔件设置在平面构件之间，并且每个分别具有高度。分离器共同具有平均高度，并且分离平面构件以形成具有在平面构件之间延伸的高度的室。当第一平面构件和第二平面构件通过毛细管力从静止在腔室内的生物液体拉向彼此时，第一平面构件，第二平面构件或隔板中的至少一个可充分变形，以使平均室高度基本上等于分离器的平均高度。

9. 发明授权

US08133738B2 Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
标题翻译：利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的血细胞比容的方法和装置
公开(公告)号：US08133738B2
公开(公告)日：2012-03-13
申请号：US13116837
申请日：2011-05-26
申请人： Robert A. Levine , Stephen C. Wardlaw , Darryn Unfricht , Niten V. Lalpuria
发明人： Robert A. Levine , Stephen C. Wardlaw , Darryn Unfricht , Niten V. Lalpuria
IPC分类号： G01N33/48 , G01N33/86
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

10. 发明申请

US20120034647A1 METHOD AND APPARATUS FOR AUTOMATED WHOLE BLOOD SAMPLE ANALYSES FROM MICROSCOPY IMAGES 审中-公开
标题翻译：用于自动化全血样本的方法和装置分析从微观图像
公开(公告)号：US20120034647A1
公开(公告)日：2012-02-09
申请号：US13204415
申请日：2011-08-05
申请人： David Herzog , Zhizhou Wang , Stephen C. Wardlaw , Min Xie
发明人： David Herzog , Zhizhou Wang , Stephen C. Wardlaw , Min Xie
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： G01N15/1475 , G01N21/5907 , G01N21/6458 , G01N33/49 , G01N33/5094 , G01N2015/008
摘要： A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel; c) creating at least one image of the sample quiescently residing within the chamber; d) identifying target constituents within the sample image; e) quantitatively analyzing at least some of the identified target constituents within the image relative to one or more predetermined quantitatively determinable features; and f) identifying at least one type of target constituent within the identified target constituents using the quantitatively determinable features.
摘要翻译：提供了用于识别生物样品内的一种或多种靶组分（例如白细胞）的方法和装置。该方法包括以下步骤：a）向样品中加入至少一种着色剂; b）将样品放置在由至少一个透明板限定的室中; c）产生静止在室内的样品的至少一个图像; d）识别样本图像中的目标成分; e）相对于一个或多个预定的可定量确定的特征定量地分析图像内的所识别的目标成分中的至少一些; 以及f）使用所述可定量确定的特征来识别所识别的目标成分内的至少一种类型的目标成分。

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