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1. 发明授权

US06201103B1 Peptide nucleic acid incorporating a chiral backbone 失效
标题翻译：掺入手性骨架的肽核酸
公开(公告)号：US06201103B1
公开(公告)日：2001-03-13
申请号：US09209149
申请日：1998-12-10
申请人： Peter Nielsen , Ole Buchardt , Pierre Lagriffoul
发明人： Peter Nielsen , Ole Buchardt , Pierre Lagriffoul
IPC分类号： C07K500
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of peptide nucleic acid monomers are synthesized having chirality in the backbone. Peptide nucleic acid oligomers are synthesized to incorporate these chiral monomers.
摘要翻译：在骨架中合成具有手性的新一类肽核酸单体。合成肽核酸低聚物以引入这些手性单体。

2. 发明申请

US20060046255A1 Use of nucleic acid analogues in diagnostics and analytical procedures 审中-公开
公开(公告)号：US20060046255A1
公开(公告)日：2006-03-02
申请号：US11029005
申请日：2005-01-05
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： C12Q1/68 , C07H21/02 , C07K14/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.

3. 发明授权

US06451968B1 Peptide nucleic acids 失效
标题翻译：肽核酸
公开(公告)号：US06451968B1
公开(公告)日：2002-09-17
申请号：US08275951
申请日：1994-07-15
申请人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
发明人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
IPC分类号： C07H2100
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2525/107 , C12Q2537/119 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

4. 发明申请

US20050009041A1 Peptide nucleic acids and synthetic procedures therefor 审中-公开
标题翻译：肽核酸及其合成方法
公开(公告)号：US20050009041A1
公开(公告)日：2005-01-13
申请号：US10755118
申请日：2004-01-09
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： A61K38/00 , C07H21/00 , C07K5/06 , C07K5/078 , C07K7/06 , C07K7/08 , C07K14/00 , C12Q1/68
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2535/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：称为肽核酸的新一类化合物比相应的DNA更强地结合互补的ssDNA和RNA链。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

5. 发明申请

US20060160731A1 Peptide nucleic acids 审中-公开
公开(公告)号：US20060160731A1
公开(公告)日：2006-07-20
申请号：US10691012
申请日：2003-10-22
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： A61K48/00 , C07K14/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

6. 发明申请

US20050048552A1 Higher order structure and binding of peptide nucleic acids 审中-公开
标题翻译：高级结构和肽核酸的结合
公开(公告)号：US20050048552A1
公开(公告)日：2005-03-03
申请号：US10909914
申请日：2004-08-02
申请人： David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
发明人： David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
IPC分类号： A61K38/00 , C07H21/00 , C07K14/00 , C12N15/113 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N2310/15 , C12N2310/3181 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

7. 发明授权

US06441130B1 Linked peptide nucleic acids 失效
标题翻译：连接肽核酸
公开(公告)号：US06441130B1
公开(公告)日：2002-08-27
申请号：US08765798
申请日：1998-06-28
申请人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
发明人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
IPC分类号： A61K3800
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2537/119 , C12Q2525/107 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

8. 发明授权

US07223833B1 Peptide nucleic acid conjugates 失效
标题翻译：肽核酸缀合物
公开(公告)号：US07223833B1
公开(公告)日：2007-05-29
申请号：US08319411
申请日：1994-10-06
申请人： Peter Nielsen , Ole Buchardt , Soren Holst Sonnechsen , Jesper Lohse , Michael Egholm , Muthiah Manoharan , John Kiely , Michael Griffith , Kelly Sprankle
发明人： Peter Nielsen , Ole Buchardt , Soren Holst Sonnechsen , Jesper Lohse , Michael Egholm , Muthiah Manoharan , John Kiely , Michael Griffith , Kelly Sprankle
IPC分类号： C12Q1/68 , C07K5/00
CPC分类号： C07K14/003 , C12Q1/6832 , C12Q2525/107
摘要： A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：描述了一类新的肽核酸，其包括与其连接的缀合物。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

9. 发明授权

US07378485B2 Peptide nucleic acids with polyamide-containing backbones 失效
标题翻译：肽核酸与含聚酰胺的骨架
公开(公告)号：US07378485B2
公开(公告)日：2008-05-27
申请号：US10154890
申请日：2002-05-23
申请人： Ole Buchardt , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg
发明人： Ole Buchardt , Michael Egholm , Peter Eigil Nielsen , Rolf Henrik Berg
IPC分类号： C07K5/00 , C12Q1/68 , A61K38/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：称为肽核酸的新一类化合物比相应的DNA更强地结合互补的ssDNA和RNA链。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

10. 发明授权

US06357163B1 Use of nucleic acid analogues in diagnostics and analytical procedures 失效
标题翻译：在诊断和分析程序中使用核酸类似物
公开(公告)号：US06357163B1
公开(公告)日：2002-03-19
申请号：US08150156
申请日：1994-05-04
申请人： Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg
发明人： Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg
IPC分类号： C12Q168
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： Methods of capture, recognition, detection, identification or quantitation of nucleic acids and diagnostics uses generally are described in which are used: (a) a peptide nucleic acid (PNA) comprising a polyamide backbone bearing a plurality of ligands at respective spaced locations along said backbone, said ligands being each independently naturally occurring nucleobases, non-naturally occurring nucleobases or nucleobase-binding groups, each said ligand being bound directly or indirectly to a nitrogen atom in said backbone, and said ligand bearing nitrogen atoms mainly being separated from one another in said backbone by from 4 to 8 intervening atoms; or (b) a nucleic acid analogue capable of hybridizing to a nucleic acid of complementary sequence to form a hybrid which is more stable against denaturation by heat than a hybrid between the conventional deoxyribonucleotide corresponding to said analogue and said nucleic acid; or (c) a nucleic acid analogue capable of hybridizing to a double stranded nucleic acid in which one strand has a sequence complementary to said analogue, so as to displace the other strand from said one strand.
摘要翻译：通常描述了核酸和诊断用途的捕获，识别，检测，鉴定或定量的方法，其中使用：（a）肽核酸（PNA），其包含聚酰胺主链，所述聚酰胺主链在所述所述配体各自独立地是天然存在的核碱基，非天然存在的核碱基或核碱基结合基团，每个所述配体直接或间接地结合到所述主链中的氮原子，并且所述配位体氮原子主要彼此分离在所述骨架中通过4至8个插入的原子; 或（b）能够与互补序列核酸杂交的核酸类似物，以形成与对应于所述类似物的所述类似物和所述核酸的常规脱氧核糖核苷酸之间的杂交体相比，通过加热变性更稳定的杂交体; 或（c）能够与双链核酸杂交的核酸类似物，其中一条链具有与所述类似物互补的序列，以便从所述一条链取代另一条链。

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