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1. 发明申请

US20050048552A1 Higher order structure and binding of peptide nucleic acids 审中-公开
标题翻译：高级结构和肽核酸的结合
公开(公告)号：US20050048552A1
公开(公告)日：2005-03-03
申请号：US10909914
申请日：2004-08-02
申请人： David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
发明人： David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
IPC分类号： A61K38/00 , C07H21/00 , C07K14/00 , C12N15/113 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N2310/15 , C12N2310/3181 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

2. 发明申请

US20060046255A1 Use of nucleic acid analogues in diagnostics and analytical procedures 审中-公开
公开(公告)号：US20060046255A1
公开(公告)日：2006-03-02
申请号：US11029005
申请日：2005-01-05
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： C12Q1/68 , C07H21/02 , C07K14/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.

3. 发明申请

US20050009041A1 Peptide nucleic acids and synthetic procedures therefor 审中-公开
标题翻译：肽核酸及其合成方法
公开(公告)号：US20050009041A1
公开(公告)日：2005-01-13
申请号：US10755118
申请日：2004-01-09
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： A61K38/00 , C07H21/00 , C07K5/06 , C07K5/078 , C07K7/06 , C07K7/08 , C07K14/00 , C12Q1/68
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2535/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：称为肽核酸的新一类化合物比相应的DNA更强地结合互补的ssDNA和RNA链。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

4. 发明申请

US20060160731A1 Peptide nucleic acids 审中-公开
公开(公告)号：US20060160731A1
公开(公告)日：2006-07-20
申请号：US10691012
申请日：2003-10-22
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： A61K48/00 , C07K14/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

5. 发明授权

US06451968B1 Peptide nucleic acids 失效
标题翻译：肽核酸
公开(公告)号：US06451968B1
公开(公告)日：2002-09-17
申请号：US08275951
申请日：1994-07-15
申请人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
发明人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
IPC分类号： C07H2100
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2525/107 , C12Q2537/119 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

6. 发明授权

US07223833B1 Peptide nucleic acid conjugates 失效
标题翻译：肽核酸缀合物
公开(公告)号：US07223833B1
公开(公告)日：2007-05-29
申请号：US08319411
申请日：1994-10-06
申请人： Peter Nielsen , Ole Buchardt , Soren Holst Sonnechsen , Jesper Lohse , Michael Egholm , Muthiah Manoharan , John Kiely , Michael Griffith , Kelly Sprankle
发明人： Peter Nielsen , Ole Buchardt , Soren Holst Sonnechsen , Jesper Lohse , Michael Egholm , Muthiah Manoharan , John Kiely , Michael Griffith , Kelly Sprankle
IPC分类号： C12Q1/68 , C07K5/00
CPC分类号： C07K14/003 , C12Q1/6832 , C12Q2525/107
摘要： A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：描述了一类新的肽核酸，其包括与其连接的缀合物。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

7. 发明授权

US06441130B1 Linked peptide nucleic acids 失效
标题翻译：连接肽核酸
公开(公告)号：US06441130B1
公开(公告)日：2002-08-27
申请号：US08765798
申请日：1998-06-28
申请人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
发明人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
IPC分类号： A61K3800
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2537/119 , C12Q2525/107 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

8. 发明授权

US06201103B1 Peptide nucleic acid incorporating a chiral backbone 失效
标题翻译：掺入手性骨架的肽核酸
公开(公告)号：US06201103B1
公开(公告)日：2001-03-13
申请号：US09209149
申请日：1998-12-10
申请人： Peter Nielsen , Ole Buchardt , Pierre Lagriffoul
发明人： Peter Nielsen , Ole Buchardt , Pierre Lagriffoul
IPC分类号： C07K500
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of peptide nucleic acid monomers are synthesized having chirality in the backbone. Peptide nucleic acid oligomers are synthesized to incorporate these chiral monomers.
摘要翻译：在骨架中合成具有手性的新一类肽核酸单体。合成肽核酸低聚物以引入这些手性单体。

9. 发明授权

US5977296A Chiral peptide nucleic acid monomers and oligomers 失效
标题翻译：手性肽核酸单体和低聚物
公开(公告)号：US5977296A
公开(公告)日：1999-11-02
申请号：US366231
申请日：1994-12-28
申请人： Peter Nielsen , Ole Buchardt, deceased , by Mrs. D. Buchardt , Pierre Lagriffoul
发明人： Peter Nielsen , Ole Buchardt, deceased , by Mrs. D. Buchardt , Pierre Lagriffoul
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , A61P31/12 , A61P43/00 , C07H21/00 , C07H21/04 , C07K1/22 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/00 , C07K16/00 , C08G69/00 , C12N15/09 , C12Q1/68 , C07K5/02 , C07K7/02
CPC分类号： C07H21/00 , C07K14/003 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , A61K38/00
摘要： A novel class of peptide nucleic acid monomers are synthesized having chirality in the backbone. Peptide nucleic acid oligomers are synthesized to incorporate these chiral monomers.
摘要翻译：在骨架中合成具有手性的新一类肽核酸单体。合成肽核酸低聚物以引入这些手性单体。

10. 发明授权

US09328718B2 Method of calculating an electrical output of a wind power plant 有权
标题翻译：计算风力发电厂电力输出的方法
公开(公告)号：US09328718B2
公开(公告)日：2016-05-03
申请号：US13379473
申请日：2010-06-29
申请人： Peter Nielsen
发明人： Peter Nielsen
IPC分类号： G06F17/18 , F03D7/04
CPC分类号： F03D7/048 , F05B2260/80 , F05B2260/821 , F05B2260/84 , F05B2270/1033 , F05B2270/32 , F05B2270/321 , F05B2270/335 , Y02E10/723 , Y02P70/523
摘要： The invention relates to a method of calculating an electrical output of a wind power plant comprising a plurality of wind turbines. Instead of calculating the electrical output of the wind power plant as a simple aggregation of the outputs of each wind turbine, the method takes into account parameters which may vary stochastically throughout the wind power plant, e.g. pitch angle, stiffness in drive train, different possible production with regard to reactive and active effect, mechanical component properties as well as variability in relation to communication times between a power plant controller and the individual wind turbines. The method proposes to make adjustment to a simple aggregation calculation method based on analysis of such stochastic varying parameters.
摘要翻译：本发明涉及一种计算包括多个风力涡轮机的风力发电厂的电力输出的方法。代替将风力发电厂的电力输出计算为每个风力涡轮机的输出的简单汇总，该方法考虑了整个风力发电厂可能随机变化的参数，例如，传动系中的俯仰角，刚度，关于反作用和主动作用的不同可能的生产，机械部件性质以及与发电厂控制器和各个风力涡轮机之间的通信时间相关的变化性。该方法提出了基于这种随机变化参数分析的简单聚合计算方法的调整。

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