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1. 发明授权

US06660830B1 Peptides with antiproliferative properties 失效
标题翻译：具有抗增殖性质的肽
公开(公告)号：US06660830B1
公开(公告)日：2003-12-09
申请号：US09155165
申请日：1999-06-07
申请人： Razvan T Radulescu
发明人： Razvan T Radulescu
IPC分类号： C07K500
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/001 , C07K14/4702
摘要： The present invention relates to antiproliferative peptides which are derived from a tumor suppressor protein and bind to growth factor segments or growth factor receptor segments. The invention also relates to nucleic acids (DNAs/RNAs) which code for these peptides and structurally homologous peptide nucleic acids and pharmaceutical compositions containing such peptides. The invention can be used in biotechnology, molecular biology, bioinformatics and in the diagnosis and therapy of hyperproliferative disorders, in particular cancer and atherosclerosis.
摘要翻译：本发明涉及衍生自肿瘤抑制蛋白并结合生长因子区段或生长因子受体区段的抗增殖肽。本发明还涉及编码这些肽和结构同源肽核酸的核酸（DNA / RNA）和含有这些肽的药物组合物。本发明可用于生物技术，分子生物学，生物信息学和过度增殖性疾病，特别是癌症和动脉粥样硬化的诊断和治疗。

2. 发明授权

US06335018B1 High molecular weight major outer membrane protein of moraxella 失效
标题翻译： moraxella的高分子量主要外膜蛋白
公开(公告)号：US06335018B1
公开(公告)日：2002-01-01
申请号：US08431718
申请日：1995-05-01
申请人： Ken Sasaki , Robin E. Harkness , Michel H. Klein
发明人： Ken Sasaki , Robin E. Harkness , Michel H. Klein
IPC分类号： C07K500
CPC分类号： C07K14/212 , A61K39/00 , C07K2319/02 , Y02A50/466 , Y10S530/806 , Y10S530/825
摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.
摘要翻译：分离和纯化的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白具有约200kDa的分子量。大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

3. 发明授权

US06323313B1 Annexin derivative with endogenous chelation sites 失效
标题翻译：具有内源性螯合位点的膜联蛋白衍生物
公开(公告)号：US06323313B1
公开(公告)日：2001-11-27
申请号：US09324096
申请日：1999-06-01
申请人： Jonathan F. Tait , David S. Brown
发明人： Jonathan F. Tait , David S. Brown
IPC分类号： C07K500
CPC分类号： C07K5/081 , A61K51/087 , A61K51/088 , C07K14/4721
摘要： Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X1-Gly-X2, where X1 and X2 are selected from Gly and Cys, where at least one of X1 or X2 is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.
摘要翻译：公开了具有包含氨基酸延伸的N-末端螯合位点的修饰的膜联蛋白。氨基酸延伸包括氨基酸序列X1-Gly-X2，其中X1和X2选自Gly和Cys，其中X1或X2中的至少一个是Cys。放射性核素容易被修饰的膜联蛋白螯合，以提供可用于体内血管血栓形成和细胞凋亡成像的放射性标记的膜联蛋白。

4. 发明授权

US06320024B1 Method for design of substances that enhance memory and improve the quality of life 有权
标题翻译：设计增强记忆和提高生活质量的物质的方法
公开(公告)号：US06320024B1
公开(公告)日：2001-11-20
申请号：US09264709
申请日：1999-03-09
申请人： Eugene Roberts
发明人： Eugene Roberts
IPC分类号： C07K500
CPC分类号： C07D245/04 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/0808 , C07K5/0812 , C07K5/1019
摘要： A topographic model useful to design and synthesize memory-enhancing substances is disclosed. Administration of substances designed by this method to enhance memory in mammals, including humans, is disclosed. Such substances include peptides having the amino acid sequence Val Phe Phe.
摘要翻译：公开了一种用于设计和合成记忆增强物质的地形模型。公开了通过该方法设计的用于增强包括人在内的哺乳动物记忆的物质的施用。这些物质包括具有氨基酸序列Val Phe Phe的肽。

5. 发明授权

US06281330B1 Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor 失效
标题翻译：具有超吸收受体的受体的类固醇/甲状腺超家族成员的多聚体形式
公开(公告)号：US06281330B1
公开(公告)日：2001-08-28
申请号：US08486403
申请日：1995-06-05
申请人： Ronald M. Evans , Michael B. Mc Keown , Anthony E. Oro , William A. Segraves , Tso-Pang Yao
发明人： Ronald M. Evans , Michael B. Mc Keown , Anthony E. Oro , William A. Segraves , Tso-Pang Yao
IPC分类号： C07K500
CPC分类号： C07K14/44 , A61K38/00 , A61K48/00 , C07K14/70567 , C07K14/721 , C12N15/85 , C12N2830/00 , C12N2830/002 , C12N2830/75 , C12Q1/6897
摘要： In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
摘要翻译：根据本发明，已经发现，受体的类固醇/甲状腺超家族的各种成员可以与昆虫来源的超吸虫受体相互作用，形成多聚体物质。因此，至少一种受体的类固醇/甲状腺超家族与至少二尖晶状体受体的二聚化结构域之间的相互作用调节所述类固醇/甲状腺超家族成员能够激活维持在激素表达下的基因转录的能力在所述超家族成员的同源配体存在下控制。

6. 发明授权

US06248863B1 Phoh homolog 失效
标题翻译： Pho同系物
公开(公告)号：US06248863B1
公开(公告)日：2001-06-19
申请号：US09343986
申请日：1999-06-29
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07K500
CPC分类号： C07K14/31 , A61K39/00 , C07K16/1275 , C12N9/78 , C12Y305/04025
摘要： The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for anitbacterial compounds.
摘要翻译：本发明提供phoH同系物多肽和编码phoH同源多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用phoH同系物多肽来筛选脱细菌化合物的方法。

7. 发明授权

US06667387B1 HCV core peptides 失效
标题翻译： HCV核心肽
公开(公告)号：US06667387B1
公开(公告)日：2003-12-23
申请号：US09576824
申请日：2000-05-23
申请人： Robert De Leys
发明人： Robert De Leys
IPC分类号： C07K500
CPC分类号： C07K14/005 , C07K1/13 , C07K2319/00 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12N2770/24222 , G01N33/531 , G01N33/56983 , G01N33/56988 , G01N33/6878 , G01N2333/18
摘要： This invention is directed toward a peptide corresponding to an immunologically important viral epitope. Specifically, the peptide corresponds to an immunodominant epitope identified in the gp41 region of the human immunodeficiency virus type 1 (HIV-1), strain Ant70. This peptide has the following amino acid sequence: NH2-Leu-Trp-Gly-Cys-Lys-Gly-Lys-Leu-Val-Cys-CO2H. The invention also relates to the use of this peptide, particularly when biotinylated in the form of complexes of streptavidin-biotinylated peptides or of avidin-biotinylated peptides, for the in vitro determination of HIV-1-specific antibodies.
摘要翻译：本发明涉及对应于免疫重要的病毒表位的肽。具体地，该肽对应于在人类免疫缺陷病毒1型（HIV-1），菌株Ant70的gp41区域中鉴定的免疫显性表位。该肽具有以下氨基酸序列：NH2-Leu-Trp-Gly-Cys-Lys-Gly-Lys-Leu-Val-Cys-CO2H。本发明还涉及该肽的用途，特别是当以链霉抗生物素蛋白 - 生物素化肽或抗生物素蛋白 - 生物素化肽的复合物的形式生物素化时，用于体外测定HIV-1特异性抗体。

8. 发明授权

US06624288B1 Gamma-conopeptides 有权
标题翻译：伽玛肽
公开(公告)号：US06624288B1
公开(公告)日：2003-09-23
申请号：US09210952
申请日：1998-12-15
申请人： Michael Fainzilber , Karel S. Kits , Alma L. Burlingame , Baldomero M. Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes J. Cruz , Julita Imperial , Clark Colledge
发明人： Michael Fainzilber , Karel S. Kits , Alma L. Burlingame , Baldomero M. Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes J. Cruz , Julita Imperial , Clark Colledge
IPC分类号： C07K500
CPC分类号： C07K14/43504 , A61K38/00
摘要： This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more &ggr;-carboxyglutamate residues. More specifically, the present invention is directed to &ggr;-conopeptides having the general formula I: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7 (SEQ ID NO:1), as described herein; or having the general formula II: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8 (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7 (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:4), as described herein; or having the general formula V: Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa8-Leu-Xaa9 (SEQ ID NO:5), as described herein. The invention further relates to specific &ggr;-conopeptides, specific pro-&ggr;-conopeptides and nucleic acids encoding the pro-&ggr;-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.
摘要翻译：本发明涉及长度约25-40个残基的相对较短的肽，其在锥形蜗牛的毒液中或天然存在的肽的类似物中天然可用量少，并且其包括三个环化二硫键和一个或多个γ- 羧基谷氨酸残基。更具体地，本发明涉及具有通式I的X射线衍生肽：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7（SEQ ID NO：1），如本文所述; 或具有如本文所定义的通式II：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8（SEQ ID NO：2）或具有通式III：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7（SEQ ID NO：3）在这里或具有通式IV：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7（SEQ ID NO：4）在这里或具有通式V：Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr -Cys-Xaa8-Leu-Xaa9（SEQ ID NO：5），如本文所述。本发明进一步涉及具体的γ-配体肽，特异性前-γ-肽和编码前γ-多肽的核酸。本发明还包括肽的药学上可接受的盐。这些肽可用作神经元起搏器钙通道的激动剂。

9. 发明授权

US06495662B1 Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) 有权
标题翻译：甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
公开(公告)号：US06495662B1
公开(公告)日：2002-12-17
申请号：US09421379
申请日：1999-10-20
申请人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
发明人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
IPC分类号： C07K500
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
摘要翻译：公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，以及含有所述肽的药物组合物以及用于产生所述肽的合成和重组方法。还公开了使用含有所述肽的治疗有效的药物组合物治疗哺乳动物状况的方法，其特征在于骨量减少。还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。还公开了所述化合物的诊断和治疗方法。

10. 发明授权

US06462021B1 Use of low molecular weight thrombin inhibitor 失效
标题翻译：使用低分子量凝血酶抑制剂
公开(公告)号：US06462021B1
公开(公告)日：2002-10-08
申请号：US09705912
申请日：2000-11-06
申请人： David Gustafsson
发明人： David Gustafsson
IPC分类号： C07K500
CPC分类号： A61K31/397
摘要： According to the invention there is provided the use of melagatran, or a pharmaceutically-acceptable derivative thereof, for the manufacture of a medicament for the treatment of ischemic disorders in patients having, or at risk of, non-valvular atrial fibrillation.
摘要翻译：根据本发明，提供了用于制备用于治疗患有非瓣膜性房颤的患者或具有非瓣膜性心房颤动风险的患者的缺血性疾病的药物的用途的美沙巴坦或其药学上可接受的衍生物的用途。

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