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1. 发明授权

US06441130B1 Linked peptide nucleic acids 失效
标题翻译：连接肽核酸
公开(公告)号：US06441130B1
公开(公告)日：2002-08-27
申请号：US08765798
申请日：1998-06-28
申请人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
发明人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
IPC分类号： A61K3800
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2537/119 , C12Q2525/107 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

2. 发明授权

US06451968B1 Peptide nucleic acids 失效
标题翻译：肽核酸
公开(公告)号：US06451968B1
公开(公告)日：2002-09-17
申请号：US08275951
申请日：1994-07-15
申请人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
发明人： Michael Egholm , Peter Nielsen , Ole Buchardt , Kim L. Dueholm , Leif Christensen , James M. Coull , John Kiely , Michael Griffith
IPC分类号： C07H2100
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2525/107 , C12Q2537/119 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

3. 发明授权

US07223833B1 Peptide nucleic acid conjugates 失效
标题翻译：肽核酸缀合物
公开(公告)号：US07223833B1
公开(公告)日：2007-05-29
申请号：US08319411
申请日：1994-10-06
申请人： Peter Nielsen , Ole Buchardt , Soren Holst Sonnechsen , Jesper Lohse , Michael Egholm , Muthiah Manoharan , John Kiely , Michael Griffith , Kelly Sprankle
发明人： Peter Nielsen , Ole Buchardt , Soren Holst Sonnechsen , Jesper Lohse , Michael Egholm , Muthiah Manoharan , John Kiely , Michael Griffith , Kelly Sprankle
IPC分类号： C12Q1/68 , C07K5/00
CPC分类号： C07K14/003 , C12Q1/6832 , C12Q2525/107
摘要： A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：描述了一类新的肽核酸，其包括与其连接的缀合物。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

4. 发明申请

US20080030824A1 Deformable Mirrors 有权
标题翻译：变形镜
公开(公告)号：US20080030824A1
公开(公告)日：2008-02-07
申请号：US11630252
申请日：2005-06-22
申请人： Michael Griffith , Sharon Radcliffe , Charles Laycock , Andrew McCarthy
发明人： Michael Griffith , Sharon Radcliffe , Charles Laycock , Andrew McCarthy
IPC分类号： G02B26/08 , G02B5/08 , G02B7/192
CPC分类号： G02B26/06 , G02B26/0825
摘要： The invention resides in the innovative use of deposition techniques in deformable mirrors. The use of deposition techniques allows contact pads for electrodes to be located wherever convenient. When applied to bimorph mirrors the invention enables both electro-restrictive layers to become active, increasing the stroke of the deformable mirror whilst retaining temperature insensitivity. A controllably-deformable mirror according to the invention comprises a deposition layer; a first electro-restrictive plate; a mirror surface; and a plurality of electrodes comprising a set of electrodes defined as regions on a first surface of the first electro-restrictive plate, the set of electrodes comprising a first electrode and a second electrode; and a common electrode on a second surface of the first electro-restrictive plate.
摘要翻译：本发明在于可变形反射镜中沉积技术的创新应用。使用沉积技术允许电极的接触垫位于任何方便的位置。当应用于双压电晶片镜时，本发明使电子限制层能够变得活跃，增加可变形反射镜的行程，同时保持温度不敏感性。根据本发明的可控制的可变形反射镜包括沉积层; 第一电极板; 镜面; 以及多个电极，其包括一组电极，所述电极被定义为在所述第一电极板的第一表面上的区域，所述电极组包括第一电极和第二电极; 以及在第一电极板的第二表面上的公共电极。

5. 发明申请

US20060103956A1 Deformable mirror 有权
标题翻译：变形镜
公开(公告)号：US20060103956A1
公开(公告)日：2006-05-18
申请号：US10537898
申请日：2003-12-18
申请人： Michael Griffith , Nicholas Archer , Leslie Laycock
发明人： Michael Griffith , Nicholas Archer , Leslie Laycock
IPC分类号： G02B5/08 , G02B7/195
CPC分类号： G02B26/0825 , G02B26/06
摘要： This invention relates to a hybrid deformable mirror. A deformable mirror is provided comprising a reflective surface provided on a substrate and a layer of deformable material attached to the substrate that is operable to deform the mirror and wherein the substrate is supported by an actuator that is operable to deform the mirror.
摘要翻译：本发明涉及一种混合可变形反射镜。提供了可变形反射镜，其包括设置在基板上的反射表面和附着到基板的可变形材料层，其可操作以使反射镜变形，并且其中基板由可操作以使反射镜变形的致动器支撑。

6. 发明申请

US20060103955A1 Deformable-mirror cooling 失效
标题翻译：变形镜冷却
公开(公告)号：US20060103955A1
公开(公告)日：2006-05-18
申请号：US10537894
申请日：2003-12-18
申请人： Michael Griffith , Nicholas Archer , Leslie Laycock
发明人： Michael Griffith , Nicholas Archer , Leslie Laycock
IPC分类号： G02B5/08
CPC分类号： G02B26/06 , G02B7/1815 , G02B26/0858
摘要： This invention relates to a cooled deformable-mirror and its mount. A deformable mirror is provided comprising a reflective element provided on a substrate that is secured to a deformable element, wherein the substrate comprises at least one channel having a pair of ports both located around the peripheral edge of the substrate. In addition, a deformable-mirror mount and the deformable mirror described above are provided, wherein the mount has a body with a central aperture defined by a supporting surface sized and shaped to support the mirror when installed, and wherein the mount is provided with at least a pair of channels that terminate to face the ports in the mirror when the mirror is installed, the channels of the mirror and the mount being connected via flexible seals.
摘要翻译：本发明涉及一种冷却的可变形反射镜及其底座。提供了一种可变形反射镜，其包括设置在基板上的反射元件，该反射元件固定在可变形元件上，其中该基板包括至少一个通道，该通道具有位于该基板的周缘周围的一对端口。另外，提供了上述可变形反射镜安装件和可变形反射镜，其中安装件具有主体，该主体具有由支撑表面限定的尺寸和形状的中心孔，该支撑表面在安装时支撑反射镜，并且其中安装件设置在当安装镜子时，至少一对通道终止于镜子中的端口，反射镜的通道和安装座通过柔性密封件连接。

7. 发明申请

US20050254111A1 Deformable mirror holders 有权
标题翻译：变形镜架
公开(公告)号：US20050254111A1
公开(公告)日：2005-11-17
申请号：US10520425
申请日：2004-10-20
申请人： Michael Griffith , Leslie Laycock , Nicholas Archer , Andrew McCarthy
发明人： Michael Griffith , Leslie Laycock , Nicholas Archer , Andrew McCarthy
IPC分类号： G02B7/185 , G02B7/188 , G02B26/08
CPC分类号： G02B26/0858 , G02B26/0825
摘要： This invention concerns improvements relating to a deformable-mirror holder for holding a mirror in a desired position, to within accepted tolerances, even whilst the mirror is deforming or in a deformed state. More particularly but not exclusively, this invention relates to a holder for a bimorph mirror. A deformable mirror holder (31) is provided comprising a body with a receiving portion for receiving a deformable mirror (30), and wherein the receiving portion is defined by a passive flexible support structure (41) such that, in use, to the support structure provides a supporting surface to the mirror. This invention extends to a deformable mirror and a deformable mirror holder as described above.
摘要翻译：本发明涉及与用于将反射镜保持在期望位置的可变形反射镜保持器相关的改进，即使在反射镜变形或处于变形状态下也是公认的公差。更具体地但不排他地，本发明涉及一种用于双压电晶片镜的保持器。提供了一种可变形反射镜保持器（31），其包括具有用于接收可变形反射镜（30）的接收部分的主体，并且其中所述接收部分由被动柔性支撑结构（41）限定，使得在使用中，结构为镜子提供支撑表面。本发明延伸到如上所述的可变形反射镜和可变形反射镜保持器。

8. 发明申请

US20080111302A1 GLOBAL PROPERTY TRADING BOARD GAME 有权
标题翻译：全球物业贸易板游戏
公开(公告)号：US20080111302A1
公开(公告)日：2008-05-15
申请号：US11560134
申请日：2006-11-15
申请人： Michael Griffith
发明人： Michael Griffith
IPC分类号： A63F3/00
CPC分类号： A63F3/00072
摘要： A global property trading board game having a game board with a continuous travel path divided into stations being associated with respective countries and having markings, including economic values representative of the respective countries' gross domestic product. Movement of a game-piece along the travel path is determined by a chance-controlled device. Each player is allocated a line of credit represented by international business cards in various monetary denominations. The respective players are further assigned a global region constituting a trade-bloc of countries. A player may acquire the assets of any country corresponding to the station in which the game-piece is located, assuming the assets are not owned by another player, by payment of the designated economic value utilizing the player's international business cards. When a competing player's game-piece is located within a station wherein the assets are owned by another player the competing player must pay a tax to that player. Several of the stations are keyed to playing cards that impose either a monetary penalty, or a monetary reward; other stations affect advancement of the respective player's game-piece. The player who acquires all or most of the countries' assets within its assigned trade-bloc and has successfully defended its home sovereignty is the victor.
摘要翻译：一个全球性的物业交易板游戏，具有连续旅行路径的游戏板，分为与各自国家相关联的站点，并具有标记，包括代表各国国内生产总值的经济价值。沿着行进路径的游戏机的移动由机会控制的设备确定。每位玩家以各种货币面值分配国际名片代表的信用额度。各参与者进一步被划分为构成贸易集团国家的全球区域。假设资产不是由另一个玩家拥有的，通过使用玩家的国际名片支付指定的经济价值，玩家可以获取对应于游戏机所在车站的任何国家的资产。当竞争对手的游戏机位于站内时，其中资产由另一玩家拥有，竞争玩家必须向该玩家支付税款。其中几个站点是打卡片的钥匙，可以施加罚款或金钱奖励; 其他车站影响到各自的玩家游戏的进步。获得全部或大部分国家在其指定贸易集团内的资产，并成功维护其家庭主权的球员是胜利者。

9. 发明申请

US20060082909A1 Deformable-mirror holder 失效
标题翻译：可变形镜架
公开(公告)号：US20060082909A1
公开(公告)日：2006-04-20
申请号：US10538120
申请日：2003-12-18
申请人： Michael Griffith , Nicolas Archer , Leslie Laycock
发明人： Michael Griffith , Nicolas Archer , Leslie Laycock
IPC分类号： G02B7/182
CPC分类号： G02B26/06 , G02B7/1815 , G02B26/0825
摘要： This invention relates to a deformable-mirror holder for holding a mirror in a desired position, to within accepted tolerances, even whilst the mirror is deforming or in a deformed state. In particular, this invention relates to a holder for a bimorph mirror. A deformable-mirror holder is provided comprising a body with a central aperture for receiving a deformable mirror, the central aperture being defined by a plurality of flexible beams, with each flexible beam having an end shaped to provide a supporting surface and a flexible portion that connects the beam's end to the holder's body.
摘要翻译：本发明涉及一种用于将反射镜保持在期望位置的可变形反射镜保持器，即使在镜子变形或处于变形状态下，也可以在公认的公差范围内。特别地，本发明涉及一种用于双压电晶片镜的保持器。提供了一种可变形反射镜保持器，其包括具有用于接收可变形反射镜的中心孔的主体，中心孔由多个柔性梁限定，每个柔性梁具有成形为提供支撑表面的端部和柔性部分，将梁的端部连接到支架的主体。

10. 外观设计

USD439724S1 Dress tie 失效
标题翻译：连衣裙
公开(公告)号：USD439724S1
公开(公告)日：2001-04-03
申请号：US29107822
申请日：1999-07-12
申请人： Michael Griffith
设计人： Michael Griffith

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