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1. 发明申请

US20060046255A1 Use of nucleic acid analogues in diagnostics and analytical procedures 审中-公开
公开(公告)号：US20060046255A1
公开(公告)日：2006-03-02
申请号：US11029005
申请日：2005-01-05
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： C12Q1/68 , C07H21/02 , C07K14/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.

2. 发明申请

US20050009041A1 Peptide nucleic acids and synthetic procedures therefor 审中-公开
标题翻译：肽核酸及其合成方法
公开(公告)号：US20050009041A1
公开(公告)日：2005-01-13
申请号：US10755118
申请日：2004-01-09
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： A61K38/00 , C07H21/00 , C07K5/06 , C07K5/078 , C07K7/06 , C07K7/08 , C07K14/00 , C12Q1/68
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2535/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：称为肽核酸的新一类化合物比相应的DNA更强地结合互补的ssDNA和RNA链。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

3. 发明申请

US20060160731A1 Peptide nucleic acids 审中-公开
公开(公告)号：US20060160731A1
公开(公告)日：2006-07-20
申请号：US10691012
申请日：2003-10-22
申请人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
发明人： Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg
IPC分类号： A61K48/00 , C07K14/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

4. 发明申请

US20050048552A1 Higher order structure and binding of peptide nucleic acids 审中-公开
标题翻译：高级结构和肽核酸的结合
公开(公告)号：US20050048552A1
公开(公告)日：2005-03-03
申请号：US10909914
申请日：2004-08-02
申请人： David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
发明人： David Ecker , Ole Buchardt , Michael Egholm , Peter Nielsen , Rolf Berg , Niels Mollegaard
IPC分类号： A61K38/00 , C07H21/00 , C07K14/00 , C12N15/113 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N2310/15 , C12N2310/3181 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

5. 发明授权

US06610650B1 Modulation of cellular transcription factor activity 失效
标题翻译：调节细胞转录因子活性
公开(公告)号：US06610650B1
公开(公告)日：2003-08-26
申请号：US09610264
申请日：2000-07-06
申请人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
发明人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
IPC分类号： A01N3718
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：一类新的化合物，称为肽核酸，形成双链结构，并与ssDNA形成双链结构。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

6. 发明授权

US06228982B1 Double-stranded peptide nucleic acids 失效
标题翻译：双链肽核酸
公开(公告)号：US06228982B1
公开(公告)日：2001-05-08
申请号：US08088661
申请日：1993-07-02
申请人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
发明人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
IPC分类号： C07K500
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：一类新的化合物，称为肽核酸，形成双链结构，并与ssDNA形成双链结构。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

7. 发明授权

US4196037A Apparatus for manufacturing cylindrical tubes 失效
标题翻译：圆柱管制造装置
公开(公告)号：US4196037A
公开(公告)日：1980-04-01
申请号：US839466
申请日：1977-10-04
申请人： Rolf Berg
发明人： Rolf Berg
IPC分类号： B31C3/04 , B65H81/00
CPC分类号： B31C3/04
摘要： Apparatus for manufacturing cylindrical tubes from paper or similar fibrous materials. A layer of plastics material which becomes tacky when heated provided on a paper web is heated through the paper web then pressed against a plastics foil web with one edge of the plastics foil web extending beyond the corresponding edge of the paper web. The joined webs are wound helically onto a mandril with the extended edge of the plastics foil web overlapping a corresponding opposite second edge of the plastics foil web. A string of molten adhesive is applied along the extended edge on the mandril. The mandril is cooled to maintain the foil layer nearest the mandril below its melting temperature.
摘要翻译：用于从纸或类似纤维材料制造圆柱形管的装置。一层塑料材料，当被加热设置在纸幅上时变粘，加热通过纸幅然后压在塑料箔片上，塑料箔片的一个边缘延伸超过纸幅的相应边缘。连接的纤维网螺旋地缠绕在心轴上，塑料箔片的延伸边缘与塑料箔片的相应的相对的第二边缘重叠。一串熔融粘合剂沿着延长的边缘施加在心轴上。将曼荼尔冷却以使箔层最靠近其熔融温度以下。

8. 发明授权

US4087299A Method and apparatus for manufacturing cylindrical tubes 失效
标题翻译：圆柱管制造方法及装置
公开(公告)号：US4087299A
公开(公告)日：1978-05-02
申请号：US742154
申请日：1976-11-15
申请人： Rolf Berg
发明人： Rolf Berg
IPC分类号： B31C3/00 , B65H81/08 , B65H81/00
CPC分类号： B65H81/08 , B31C3/00
摘要： The present invention relates to a method of manufacturing from paper and other similar fibrous materials cylindrical tubes comprising an inner, dense, liquid-tight plastics foil layer, in which method at least one paper web and a plastics foil web are wound helically together on a rotating mandril with the plastics foil web located against the forming surface of the mandril, and in which the plastics foil web is bonded to the paper web by means of an adhesive. The invention also relates to an apparatus for carrying out the method.
摘要翻译：本发明涉及一种从纸和其它类似的纤维材料制成的方法，所述圆形管包括内部致密的液密塑料箔层，其中至少一个纸幅和塑料箔片沿螺旋形地缠绕在一起旋转的心轴与塑料箔片位于心形管的成形表面上，并且其中塑料箔片通过粘合剂结合到纸幅上。本发明还涉及一种用于执行该方法的装置。

9. 发明授权

US4225376A Method for producing a laminated surface 失效
标题翻译：层压表面的制造方法
公开(公告)号：US4225376A
公开(公告)日：1980-09-30
申请号：US909428
申请日：1978-05-25
申请人： Rolf Berg
发明人： Rolf Berg
IPC分类号： B29C53/00 , B29C65/00 , B29C65/02 , B29C65/20 , B29C70/08 , B29C70/50 , C09J5/06 , B29C27/02
CPC分类号： B29C66/45 , B29C65/3644 , B29C65/3656 , B29C65/368 , B29C66/71 , B29C66/72321 , B29C66/83413 , B29C66/83415 , B29C66/91411 , B29C66/91431 , B29C66/91641 , B29C66/91645 , B29C66/919 , B29C66/91935 , B29C70/088 , B29C70/504 , B32B38/0036 , C09J5/06 , B29C66/91413 , B29K2023/00 , B29K2023/06 , B29L2009/00 , B32B2317/12
摘要： In the bonding of two webs, each having a polyolefin resin surface thereon, to form a laminate the polyolefin surface of a first of said webs is heated to a temperature at which the resin will melt or become tacky, while the polyolefin surface of the second of said webs is heated to a given temperature. The heated surfaces are then brought together in a manner to form a substantially permanent bond therebetween. One advantage of the method is that extremely thick high-density plastic foils can be bonded successfully to fibrous carriers.
摘要翻译：在两个纤维网的接合中，每个在其上具有聚烯烃树脂表面，以形成层压体，将第一个所述纤维网的聚烯烃表面加热到树脂将熔化或变粘的温度，而第二个的聚烯烃表面的所述纤维网被加热到给定的温度。然后将加热的表面以一种在其间形成基本上永久的接合的方式被接合在一起。该方法的一个优点是，非常厚的高密度塑料箔可以成功地粘合到纤维载体上。

10. 发明授权

US4662231A Sample taking device 失效
标题翻译：采样装置
公开(公告)号：US4662231A
公开(公告)日：1987-05-05
申请号：US672180
申请日：1984-11-15
申请人： Ulrich Schaarschmidt , Rolf Berg
发明人： Ulrich Schaarschmidt , Rolf Berg
IPC分类号： G01T7/02 , G01N1/00 , G01N1/10 , G01N33/00 , G21F7/04 , G01N1/28 , G01N1/14 , G01N1/34
CPC分类号： G01N1/10 , G01N2001/1037 , G01N2033/0093 , G01N2035/0481
摘要： An apparatus for taking a sample of a toxic and/or radioactive substance byntroducing such substance into a sample vessel. The apparatus includes a rotatable cylinder containing a recess for receiving a sample vessel. A drive shaft is connected to the cylinder for imparting rotary and axial movements to the cylinder for moving the recess of the cylinder between first and second positions. A needle head filling system is arranged above the cylinder at the first position for filling a sample vessel with toxic and/or radioactive substances. The cylinder is lifted by the shaft for engagement with the needle head filling system when being filled and lowered by the shaft after being filled. An inlet and outlet conduit is provided having one end for receiving from and discharging into the recess of the cylinder a sample vessel, the one end being located above the cylinder at the second position. A stripper is located between the cylinder and the needle head filling system for disengaging the sample vessel from the needle head filling system when the cylinder is lowered by the shaft after being filled.
摘要翻译：一种用于通过将这种物质引入样品容器中来获取有毒和/或放射性物质样品的装置。该装置包括可旋转的圆筒，其容纳用于接收样品容器的凹部。驱动轴连接到气缸，用于向气缸提供旋转和轴向运动，用于在第一和第二位置之间移动气缸的凹部。针头填充系统布置在气缸上方的第一位置，用于填充具有有毒和/或放射性物质的样品容器。在被填充之后，当轴被轴被填充和下降时，气缸被提升以与针头填充系统接合。入口和出口导管设置有一端，用于从气缸的凹槽中接收和排出样品容器，一端位于第二位置的气缸上方。汽缸和针头填充系统之间设有一个汽提器，用于当汽缸在充满后由轴下降时，将样品容器与针头填充系统脱开。

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