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1. 发明授权

US09170312B2 Phase-sensitive imaging of magnetization exchange and isotope flux 有权
标题翻译：磁化交换和同位素通量的相敏成像
公开(公告)号：US09170312B2
公开(公告)日：2015-10-27
申请号：US13360510
申请日：2012-01-27
申请人： Peder Larson , Adam B. Kerr , John M. Pauly , Daniel B. Vigneron
发明人： Peder Larson , Adam B. Kerr , John M. Pauly , Daniel B. Vigneron
IPC分类号： G01V3/00 , G01R33/46 , G01R33/563 , G01R33/485 , G01R33/56
CPC分类号： G01R33/4608 , G01R33/4616 , G01R33/485 , G01R33/5601 , G01R33/5605 , G01R33/56333
摘要： A method for imaging a substrate and product over time is provided. The substrate and product are magnetically tagged with at least one magnetic gradient where magnetically tagging provides a tag-dependent signal phase for the substrate and a different tag-dependent signal phase for the product. At least one readout of magnetically tagged substrate and product is provided over time. The tag-dependent signal phase is used to determine product that has been transformed from magnetically tagged substrate and substrate that has been transformed from magnetically tagged product over time.
摘要翻译：提供了一种用于对衬底和产品随时间成像的方法。衬底和产品用至少一个磁梯度进行磁性标记，其中磁性标签为衬底提供与标签相关的信号相位，并为产品提供不同的标签依赖信号相位。随着时间的推移，提供至少一个磁性标记的基板和产品读数。标签依赖信号相位用于确定已经从磁标记的产品随时间变换的磁性标记的基底和底物转变的产物。

2. 发明授权

US07795868B2 Hyperpolarized dynamic chemical shift imaging with tailored multiband excitation pulses 有权
标题翻译：超极化动态化学位移成像与定制的多频激励脉冲
公开(公告)号：US07795868B2
公开(公告)日：2010-09-14
申请号：US12247940
申请日：2008-10-08
申请人： Peder E. Larson , John M. Pauly , Daniel B. Vigneron , Albert Chen , Adam B. Kerr
发明人： Peder E. Larson , John M. Pauly , Daniel B. Vigneron , Albert Chen , Adam B. Kerr
IPC分类号： G01V3/00
CPC分类号： G01R33/485
摘要： A method for performing magnetic resonance spectroscopy is described. The method generally includes applying a tailored multiband spectral-spatial radio frequency excitation pulse to a sample including a first species and at least a second species having a different resonant frequency than the first species. The multiband excitation pulse excites the first species according to a first amplitude and excites the second species according to a second amplitude that is substantially greater than the first amplitude. Data is acquired from the sample. The acquired data is then utilized to generate a spectroscopic output. By way of example, the spectroscopic output is a spectroscopic image. In particular embodiments, the data for the first and second species is acquired dynamically over an observation window of time.
摘要翻译：描述用于执行磁共振光谱的方法。该方法通常包括将定制的多频谱 - 空间射频激励脉冲应用于包括具有与第一种类不同的共振频率的第一物种和至少第二种类的样品。所述多频带激励脉冲根据第一幅度激发所述第一种类，并且根据明显大于所述第一幅度的第二幅度激发所述第二种类。从样品中获取数据。然后利用获取的数据产生光谱输出。作为示例，分光输出是分光图像。在特定实施例中，在观察窗口上动态地获取第一和第二物种的数据。

3. 发明申请

US20100085046A1 HYPERPOLARIZED DYNAMIC CHEMICAL SHIFT IMAGING WITH TAILORED MULTIBAND EXCITATION PULSES 有权
标题翻译：具有多功能激光脉冲激光的高效动态化学转换成像
公开(公告)号：US20100085046A1
公开(公告)日：2010-04-08
申请号：US12247940
申请日：2008-10-08
申请人： Peder E. Larson , John M. Pauly , Daniel B. Vigneron , Albert Chen , Adam B. Kerr
发明人： Peder E. Larson , John M. Pauly , Daniel B. Vigneron , Albert Chen , Adam B. Kerr
IPC分类号： G01R33/46
CPC分类号： G01R33/485
摘要： A method for performing magnetic resonance spectroscopy is described. The method generally includes applying a tailored multiband spectral-spatial radio frequency excitation pulse to a sample including a first species and at least a second species having a different resonant frequency than the first species. The multiband excitation pulse excites the first species according to a first amplitude and excites the second species according to a second amplitude that is substantially greater than the first amplitude. Data is acquired from the sample. The acquired data is then utilized to generate a spectroscopic output. By way of example, the spectroscopic output is a spectroscopic image. In particular embodiments, the data for the first and second species is acquired dynamically over an observation window of time.
摘要翻译：描述用于执行磁共振光谱的方法。该方法通常包括将定制的多频谱 - 空间射频激励脉冲应用于包括具有与第一种类不同的共振频率的第一物种和至少第二种类的样品。所述多频带激励脉冲根据第一幅度激发所述第一种类，并且根据明显大于所述第一幅度的第二幅度激发所述第二种类。从样品中获取数据。然后利用获取的数据产生光谱输出。作为示例，分光输出是分光图像。在特定实施例中，在观察窗口上动态地获取第一和第二物种的数据。

4. 发明授权

US08035381B2 Optimized spectral-spatial pulse 有权
标题翻译：优化的光谱空间脉冲
公开(公告)号：US08035381B2
公开(公告)日：2011-10-11
申请号：US12259990
申请日：2008-10-28
申请人： Michael Lustig , Charles H. Cunningham , Albert P. Chen , Daniel B. Vigneron , John M. Pauly
发明人： Michael Lustig , Charles H. Cunningham , Albert P. Chen , Daniel B. Vigneron , John M. Pauly
IPC分类号： G01V3/00
CPC分类号： G01R33/4828 , G01R33/5607
摘要： A computer implemented method for designing a spectral-spatial pulse for exciting at least one passband and minimally exciting at least one stopband is provided. A uniform shaped spectral envelope is generated. For a plurality of kz≠0, kz dependent weights for a spectral envelope that approximate a kz=0 envelope and provides the at least one passband and the at least one stopband for each of the plurality of kz≠0 is generated.
摘要翻译：提供了一种用于设计用于激励至少一个通带和最少激励至少一个阻带的频谱空间脉冲的计算机实现的方法。产生均匀形状的光谱包络。对于多个kz≠0，生成近似kz = 0包络并且为多个kz≠0中的每一个提供至少一个通带和至少一个阻带的频谱包络的kz相关权重。

5. 发明申请

US20100102812A1 OPTIMIZED SPECTRAL-SPATIAL PULSE 有权
标题翻译：优化的光谱空间脉冲
公开(公告)号：US20100102812A1
公开(公告)日：2010-04-29
申请号：US12259990
申请日：2008-10-28
申请人： Michael Lustig , Charles H. Cunningham , Albert P. Chen , Daniel B. Vigneron , John M. Pauly
发明人： Michael Lustig , Charles H. Cunningham , Albert P. Chen , Daniel B. Vigneron , John M. Pauly
IPC分类号： G01R33/483 , G01R33/54
CPC分类号： G01R33/4828 , G01R33/5607
摘要： A computer implemented method for designing a spectral-spatial pulse for exciting at least one passband and minimally exciting at least one stopband is provided. A uniform shaped spectral envelope is generated. For a plurality of kz≠0, kz dependent weights for a spectral envelope that approximate a kz=0 envelope and provides the at least one passband and the at least one stopband for each of the plurality of kz≠0 is generated.
摘要翻译：提供了一种用于设计用于激励至少一个通带和最少激励至少一个阻带的频谱空间脉冲的计算机实现的方法。产生均匀形状的光谱包络。对于多个kz≠0，生成近似kz = 0包络并且为多个kz≠0中的每一个提供至少一个通带和至少一个阻带的频谱包络的kz相关权重。

6. 发明授权

US07042214B2 Non-linear symmetric sweep spectral-spatial RF pulses for MR spectroscopy 有权
标题翻译：用于MR光谱的非线性对称扫描频谱 - 空间RF脉冲
公开(公告)号：US07042214B2
公开(公告)日：2006-05-09
申请号：US10823979
申请日：2004-04-13
申请人： Charles H. Cunningham , John M. Pauly , Daniel B. Vigneron
发明人： Charles H. Cunningham , John M. Pauly , Daniel B. Vigneron
IPC分类号： G01V3/00
CPC分类号： G01R33/446 , G01R33/4828
摘要： A method for designing non-linear phase 180° spectral-spatial radio frequency pulses that can be used for spectral editing in magnetic resonance spectroscopic imaging. A novel feature of the pulse is a symmetric sweep developed by the spectral profile from the outside edges of the spectral window towards the middle whereby coupled components are tipped simultaneously and over a short interval. Pulses have been designed for lactate editing at 1.5T and 3T. The spectral and spatial spin-echo profiles of the RF pulses can be measured experimentally and altered in an iterative manner. Spectral-spatial radio frequency (SSRF) pulses allow simultaneous selection in both frequency and spatial domains. These pulses are particularly important for clinical and research magnetic resonance spectroscopy (MRS) applications for suppression of large water and lipid resonances.
摘要翻译：用于设计可用于磁共振光谱成像中的光谱编辑的非线性相位180°频谱空间射频脉冲的方法。脉冲的新颖特征是通过从频谱窗口的外边缘向中间的光谱轮廓展开的对称扫描，由此耦合的部件同时并且在短的间隔内翻转。脉冲设计用于1.5T和3T的乳酸盐编辑。 RF脉冲的频谱和空间自旋回波曲线可以通过实验测量并以迭代方式进行改变。频谱空间射频（SSRF）脉冲允许在频域和空间域中同时进行选择。这些脉冲对于抑制大量水和脂质共振的临床和研究磁共振波谱（MRS）应用尤为重要。

7. 发明授权

US06304084B1 Method of improved magnetic resonance spectroscopic localization using spectral-spatial pulses 失效
标题翻译：使用光谱空间脉冲改进磁共振光谱定位的方法
公开(公告)号：US06304084B1
公开(公告)日：2001-10-16
申请号：US09019967
申请日：1998-02-06
申请人： John Star-Lack , John M. Pauly , Daniel B. Vigneron
发明人： John Star-Lack , John M. Pauly , Daniel B. Vigneron
IPC分类号： G01V300
CPC分类号： G01R33/446
摘要： The present invention uses spectral-spatial 180° refocusing pulses in the point resolved spectroscopy (PRESS) localization sequence. The PRESS sequence uses a series of three pulses having a tilt angle pattern of 90°-180°-180°. The first excitation pulses in the present invention is a spatially selective 90° tilt angle pulse. The following two pulses are spectral-spatial refocusing pulses which provide multi-dimensional selectivity. This feature allows for enhanced solvent suppression, reduced chemical shift induced spatial displacement and an ability to refocus weakly coupled spins. In a preferred embodiment, the spectral-spatial pulses are time-asymmetric and identical, providing for a linear phase profile by means of phase compensation between the two refocusing pulses. Alternatively, a linear phase profile can be provided by using time-symmetric refocusing pulses. The time-asymmetric feature is preferred because it results in lower applied RF power and shorter echo times.
摘要翻译：本发明在点解析光谱（PRESS）定位序列中使用光谱空间180重新聚焦脉冲。 PRESS序列使用一系列具有90-180 -180的倾斜角度图案的三个脉冲。本发明中的第一激发脉冲是空间选择性90°倾斜角脉冲。以下两个脉冲是提供多维选择性的光谱 - 空间重聚焦脉冲。该特征允许增强溶剂抑制，减少化学位移引起的空间位移和重新聚焦弱耦合旋转的能力。在优选实施例中，频谱空间脉冲是时间不对称的和相同的，通过两个重聚焦脉冲之间的相位补偿提供线性相位分布。或者，可以通过使用时间对称重新聚焦脉冲来提供线性相位分布。时间不对称特征是优选的，因为它导致较低的施加的RF功率和较短的回波时间

8. 发明授权

US07659718B1 Blip design for random sampling compressed sensing of flyback 3D-MRSI 有权
标题翻译：闪回3D-MRSI的随机采样压缩感测的Blip设计
公开(公告)号：US07659718B1
公开(公告)日：2010-02-09
申请号：US12183391
申请日：2008-07-31
申请人： Michael Lustig , Zhong-Min Hu , Daniel B. Vigneron , John M. Pauly
发明人： Michael Lustig , Zhong-Min Hu , Daniel B. Vigneron , John M. Pauly
IPC分类号： G01V3/00
CPC分类号： G01R33/485 , G01R33/5601 , G01R33/5608 , G01R33/5611 , G01R33/5616
摘要： A method of providing a magnetic resonance spectral image (MRSI) is provided. A magnetic resonance imaging excitation is applied. Data is acquired, comprising applying an oscillating gradient in a first dimension and applying blips in at least a second dimension in a pseudo-random order to acquire pseudo-random temporally undersampled spectral data in at least two planes. The pseudo-random order is used to reconstruct a magnetic resonance spectral image in at least two dimensions.
摘要翻译：提供了一种提供磁共振光谱图像（MRSI）的方法。应用磁共振成像激励。获取数据，包括在第一维度中应用振荡梯度并以伪随机顺序在至少第二维度中施加blips以在至少两个平面中获取伪随机时间上欠采样的光谱数据。伪随机顺序用于在至少两个维度上重建磁共振光谱图像。

9. 发明申请

US20100026294A1 BLIP DESIGN FOR RANDOM SAMPLING COMPRESSED SENSING OF FLYBACK 3D-MRSI 有权
标题翻译：用于随机采样的BLIP设计压缩感应3D-MRSI
公开(公告)号：US20100026294A1
公开(公告)日：2010-02-04
申请号：US12183391
申请日：2008-07-31
申请人： Michael Lustig , Zhong-Min Hu , Daniel B. Vigneron , John M. Pauly
发明人： Michael Lustig , Zhong-Min Hu , Daniel B. Vigneron , John M. Pauly
IPC分类号： G01R33/54
CPC分类号： G01R33/485 , G01R33/5601 , G01R33/5608 , G01R33/5611 , G01R33/5616
摘要： A method of providing a magnetic resonance spectral image (MRSI) is provided. A magnetic resonance imaging excitation is applied. Data is acquired, comprising applying an oscillating gradient in a first dimension and applying blips in at least a second dimension in a pseudo-random order to acquire pseudo-random temporally undersampled spectral data in at least two planes. The pseudo-random order is used to reconstruct a magnetic resonance spectral image in at least two dimensions.
摘要翻译：提供了一种提供磁共振光谱图像（MRSI）的方法。应用磁共振成像激励。获取数据，包括在第一维度中应用振荡梯度并以伪随机顺序在至少第二维度中施加blips以在至少两个平面中获取伪随机时间上欠采样的光谱数据。伪随机顺序用于在至少两个维度上重建磁共振光谱图像。

10. 发明授权

US5905377A Method and apparatus for correcting gradient system and static magnetic field in magnetic resonance imaging 失效
标题翻译：用于校正磁共振成像中梯度系统和静磁场的方法和装置
公开(公告)号：US5905377A
公开(公告)日：1999-05-18
申请号：US690528
申请日：1996-07-31
申请人： Adam B. Kerr , John M. Pauly
发明人： Adam B. Kerr , John M. Pauly
IPC分类号： G01R33/389 , G01R33/565 , G01V3/00
CPC分类号： G01R33/389 , G01R33/56518 , G01R33/56563
摘要： Time-varying error between a prescribed magnetic field and an actual magnetic field is identified from a self-encoding technique and the measurement of detected responses to various magnetic read-out gradients. The gradients can be a sinusoidal, step function, or other suitable form which enables the actual responses to be obtained from which transfer functions can be defined. In one embodiment, the data can effectively frequency sample the transfer function of the system. A gradient-recalled echo occurs each time the self-encode lobe is refocussed, and the phase of the echo peak is used to estimate the time variation of the main magnetic field, B.sub.0 (t).
摘要翻译：从自编码技术和对各种磁读出梯度的检测到的响应的测量来识别规定磁场和实际磁场之间的时变误差。梯度可以是正弦，阶梯函数或其他合适的形式，其使得能够从可以定义传递函数获得实际响应。在一个实施例中，数据可以有效地对系统的传递函数进行频率采样。每次自编码波瓣重新聚焦时都会发生梯度回波，回波峰值的相位用于估计主磁场B0（t）的时间变化。

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