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1. 发明授权

US12072402B2 Multiphoton magnetic resonance imaging 有权
公开(公告)号：US12072402B2
公开(公告)日：2024-08-27
申请号：US17664799
申请日：2022-05-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Chunlei Liu , Victor Han
IPC分类号： G01R33/389 , A61B5/055 , G01R33/3815 , G01R33/385
CPC分类号： G01R33/389 , A61B5/055 , G01R33/3815 , G01R33/3852
摘要： Systems and methods are provided for multiphotonic magnetic resonance imaging. The system uses one or more (B1,z) RF coils or oscillating gradients oriented along the z-axis to provide multiphoton resonances. The B1,z coils can be implemented as planar coils or solenoids. With the additional coils, standard slice-selective pulse sequences have all standard excitations replaced with multiphoton excitations that excite extra resonances. In vivo imaging using multiphoton excitation has signal to noise ratios comparable to single-photon excitations when similar pulse sequences are used. Since excitation is not bound to the Larmor frequency, new RF pulse sequences can be designed with imaging methods patterned after single-photon excitation concepts.

2. 发明申请

US20190011513A1 LOW-FIELD MAGNETIC RESONANCE IMAGING METHODS AND APPARATUS 审中-公开
公开(公告)号：US20190011513A1
公开(公告)日：2019-01-10
申请号：US16130712
申请日：2018-09-13
申请人： Hyperfine Research, Inc.
发明人： Michael Stephen Poole , Cedric Hugon , Hadrien A. Dyvorne , Laura Sacolick , William J. Mileski , Jeremy Christopher Jordan , Alan B. Katze, JR. , Jonathan M. Rothberg , Todd Rearick , Christopher Thomas McNulty
IPC分类号： G01R33/385 , G01R33/383 , G01R33/389 , A61B50/13 , A61B90/00
CPC分类号： G01R33/3852 , A61B5/0555 , A61B6/4405 , A61B50/13 , A61B90/00 , A61B2560/0431 , A61G13/104 , G01R33/34092 , G01R33/3642 , G01R33/3657 , G01R33/38 , G01R33/3802 , G01R33/3806 , G01R33/383 , G01R33/385 , G01R33/3854 , G01R33/3873 , G01R33/389 , G01R33/4215 , G01R33/422 , G01R33/445 , G01R33/48 , G01R33/5608
摘要： According to some aspects, a low-field magnetic resonance imaging system is provided. The low-field magnetic resonance imaging system comprises a magnetics system having a plurality of magnetics components configured to produce magnetic fields for performing magnetic resonance imaging, the magnetics system comprising, a B0 magnet configured to produce a B0 field for the magnetic resonance imaging system at a low-field strength of less than 0.2 Tesla (T), a plurality of gradient coils configured to, when operated, generate magnetic fields to provide spatial encoding of magnetic resonance signals, and at least one radio frequency coil configured to, when operated, transmit radio frequency signals to a field of view of the magnetic resonance imaging system and to respond to magnetic resonance signals emitted from the field of view, a power system comprising one or more power components configured to provide power to the magnetics system to operate the magnetic resonance imaging system to perform image acquisition, and a power connection configured to connect to a single-phase outlet to receive mains electricity and deliver the mains electricity to the power system to provide power needed to operate the magnetic resonance imaging system. According to some aspects, the power system operates the low-field magnetic resonance imaging system using an average of less than 1.6 kilowatts during image acquisition.

3. 发明申请

US20180136298A1 A METHOD OF DETERMINING A GRADIENT IMPULSE RESPONSE FUNCTION DURING EXECUTION OF A MAGNETIC RESONANCE IMAGING OR SPECTROSCOPY SEQUENCE 审中-公开
公开(公告)号：US20180136298A1
公开(公告)日：2018-05-17
申请号：US15573284
申请日：2016-05-12
申请人： EIDGENOSSISCHE TECHNISCHE HOCHSCHULE , UNIVERSITAT ZURICH
发明人： Bertram Wilm , Christoph Barmet , Klaas P. Prussmann
IPC分类号： G01R33/565 , G01R33/389 , G01R33/58 , G01R33/46
CPC分类号： G01R33/56518 , G01R33/389 , G01R33/4625 , G01R33/58
摘要： A method of determining an actual gradient impulse response function during execution of a magnetic resonance (MR) imaging or spectroscopy sequence, wherein a main magnetic field is generated in a sample region of an MR apparatus by means of a main magnet and wherein superimposed time dependent gradient fields and radiofrequency fields in a first RF band are generated in the sample region according to a first MR sequence for forming images or spectra, the gradient fields being generated by gradient forming means of the MR apparatus operated according to a gradient forming sequence part of said first MR sequence, the MR apparatus further comprising at least one magnetic field probe. The method comprises the steps of: —operating said at least one magnetic field probe according to a second sequence, whereby a time dependent probe signal is repeatedly acquired from each magnetic field probe during a probe acquisition time window, thus providing at least one time dependent probe signal; —obtaining said actual gradient impulse response function by calculating an impulse response function from said at least one time dependent probe signal and from said gradient forming sequence part.

4. 发明申请

US20180031651A1 METHOD AND DEVICE FOR COMPENSATING FOR MAGNETIC NOISE FIELDS IN SPATIAL VOLUMES, AND NUCLEAR MAGNETIC RESONANCE IMAGING APPARATUS 审中-公开
公开(公告)号：US20180031651A1
公开(公告)日：2018-02-01
申请号：US15631415
申请日：2017-06-23
申请人： ESAOTE SpA
发明人： Paolo IAIA
IPC分类号： G01R33/3875 , G01R33/54 , G01R33/00
CPC分类号： G01R33/3875 , G01R33/0017 , G01R33/025 , G01R33/389 , G01R33/422 , G01R33/543 , G01R33/56563 , G01R33/5659
摘要： A method for compensating magnetic noise in a spatial volume in which two concurrently operating compensation loops are provided comprising:a closed compensation loop for magnetic noise fields outside the spatial volume and inside the electromagnetically environment;an open compensation loop for magnetic noise fields in the spatial volume;said two compensation loops generating each one a magnetic noise compensation field;said two compensation fields concurrently provide for compensation of the magnetic noise field in the spatial volume.

5. 发明申请

US20170016968A1 SYSTEMS AND METHODS FOR LOW POWER MAGNETIC FIELD GENERATION FOR ATOMIC SENSORS USING ELECTRO-PERMANENT MAGNETS 审中-公开
标题翻译：用于使用电子永磁体的原子传感器的低功率磁场产生的系统和方法
公开(公告)号：US20170016968A1
公开(公告)日：2017-01-19
申请号：US14802818
申请日：2015-07-17
申请人： Honeywell International Inc.
发明人： Kenneth Salit
IPC分类号： G01R33/24 , H01F7/02
CPC分类号： G01R33/24 , G01C19/58 , G01C19/62 , G01R33/26 , G01R33/383 , G01R33/389 , G04F5/14 , G21K1/006 , H01F7/0273 , H01F7/0284 , H01F13/00
摘要： Systems and methods for low power magnetic field generation for atomic sensors using electro-permanent magnets are provided. In one embodiment, a method for magnetic field generation for an atomic sensor comprises: laser cooling a sample of atoms in a chamber; and trapping the sample of atoms in a magneto-optical trap within the chamber by applying an atom trapping field across the sample of atoms using at least one pair of electro-permanent magnet units.
摘要翻译：提供了使用电永磁体的原子传感器的低功率磁场产生的系统和方法。在一个实施例中，用于原子传感器的磁场产生方法包括：激光冷却腔室中的原子样品; 以及通过使用至少一对电永磁体单元施加原子捕获场横跨原子样本，将原子样品捕获在室内的磁光阱中。

6. 发明申请

US20160041249A1 METHOD AND MAGNETIC RESONANCE APPARATUS FOR GENERATING AT LEAST ONE COMBINATION IMAGE DATASET 审中-公开
标题翻译：用于生成至少一个组合图像数据的方法和磁共振装置
公开(公告)号：US20160041249A1
公开(公告)日：2016-02-11
申请号：US14823372
申请日：2015-08-11
申请人： Siemens Aktiengesellschaft
发明人： Kuan Jin Lee , Dominik Paul , Mario Zeller
IPC分类号： G01R33/565
CPC分类号： G01R33/5611 , G01R33/246 , G01R33/28 , G01R33/387 , G01R33/389 , G01R33/4816 , G01R33/4818 , G01R33/4828 , G01R33/483 , G01R33/4833 , G01R33/4835 , G01R33/4838 , G01R33/5607
摘要： In a method and apparatus for generating a magnetic resonance (MR) image MR data are acquired from a subject as datasets in parallel with multiple RF coils, with first parallel dataset being acquired with a first parameter set and at least one further parallel dataset being acquired with a second parameter set. A first intermediate image dataset and at least one further intermediate image dataset are reconstructed with at least one of (a) the first intermediate image dataset being reconstructed from said first parallel dataset using a calibration data item derived from said at least one further parameter set, and (b) said at least one further intermediate image dataset is reconstructed from said at least one further parallel dataset using a calibration data item derived from said first parameter set. A combination image dataset is generated by combining said first intermediate image dataset and said at least one further intermediate dataset.
摘要翻译：在用于生成磁共振（MR）图像的方法和装置中，MR数据作为与多个RF线圈并联的数据集从主体获取，其中第一并行数据集被获取具有第一参数集并且至少一个进一步的并行数据集被获取具有第二个参数集。重建第一中间图像数据集和至少一个另外的中间图像数据集，其中（a）使用从所述至少一个另外的参数集导出的校准数据项从所述第一并行数据集重构第一中间图像数据集中的至少一个，和（b）使用从所述第一参数集导出的校准数据项，从所述至少一个另外的并行数据集重建所述至少一个另外的中间图像数据集。通过组合所述第一中间图像数据集和所述至少一个其它中间数据集来生成组合图像数据集。

7. 发明授权

US09213073B2 Method and apparatus for compensating for drift in magnetic field strength in superconducting magnets 有权
标题翻译：用于补偿超导磁体磁场强度漂移的方法和装置
公开(公告)号：US09213073B2
公开(公告)日：2015-12-15
申请号：US14185273
申请日：2014-02-20
申请人： Nicholas Paul Aley
发明人： Nicholas Paul Aley
IPC分类号： G01R33/387 , G01R33/389 , G01R33/3815 , H01F6/06
CPC分类号： G01R33/387 , G01R33/3815 , G01R33/389 , H01F6/06
摘要： An MRI system has a cylindrical superconducting magnet assembly contained in a bore tube of a cylindrical vacuum vessel (OVC), and a gradient coil assembly situated within the OVC bore tube. In an imaging region within a bore of the gradient coil assembly, the magnet assembly produces a magnetic field that is subject to drift during operation of the MRI system. Compensating material is located at a radial position between the imaging region and the magnet in a location that will be heated over a range of temperatures during operation of the MRI system. The compensating material is adjustable between two magnetic phases in response to an applied physical characteristic, which is selectively applied thereto so as to change the compensating material from a first magnetization to a second magnetization, and thereby compensate the drift.
摘要翻译： MRI系统具有包含在圆柱形真空容器（OVC）的孔管中的圆柱形超导磁体组件和位于OVC孔管内的梯度线圈组件。在梯度线圈组件的孔内的成像区域中，磁体组件产生在MRI系统操作期间经受漂移的磁场。在MRI系统的操作期间，补偿材料位于成像区域和磁体之间的径向位置，该位置将在温度范围内被加热。响应于施加的物理特性，补偿材料在两个磁相之间是可调节的，其被选择性地施加到其上，以便将补偿材料从第一磁化改变为第二磁化，从而补偿漂移。

8. 发明申请

US20140232398A1 METHODS AND APPARATUS FOR COMPENSATING FOR DRIFT IN MAGNETIC FIELD STRENGTH IN SUPERCONDUCTING MAGNETS 审中-公开
标题翻译：用于补偿超级磁铁磁场强度的方法和装置
公开(公告)号：US20140232398A1
公开(公告)日：2014-08-21
申请号：US14185332
申请日：2014-02-20
申请人： Nicholas Paul Aley
发明人： Nicholas Paul Aley
IPC分类号： G01R33/3873 , G01R33/3815
CPC分类号： G01R33/3873 , G01R33/3815 , G01R33/389
摘要： An MRI system has compensating material located at a radial position between the imaging region and the basic field magnet in a location that will be heated over a range of temperatures during operation of the MRI system. The compensating material has a magnetic susceptibility that varies with temperature over the range of temperatures in a manner opposite to the variation in magnetic susceptibility of the material of the OVC bore tube of the basic field magnet over the range of temperatures.
摘要翻译： MRI系统具有位于成像区域和基本磁场磁体之间的径向位置处的补偿材料，该位置将在MRI系统的操作期间将在温度范围内被加热。补偿材料具有在温度范围内以与温度范围内的基本场磁体的OVC孔管的材料的磁化率的变化相反的方式随温度变化的磁化率。

9. 发明申请

US20130187653A1 ACTIVATION OF FIELD COILS OF A MAGNETIC RESONANCE SYSTEM HAVING EDDY CURRENT COMPENSATION 有权
标题翻译：具有EDDY电流补偿的磁共振系统的现场线圈的激活
公开(公告)号：US20130187653A1
公开(公告)日：2013-07-25
申请号：US13554870
申请日：2012-07-20
申请人： Eva Eberlein , Ralph Kimmlingen , Franz Schmitt , Johann Schuster
发明人： Eva Eberlein , Ralph Kimmlingen , Franz Schmitt , Johann Schuster
IPC分类号： G01R33/54
CPC分类号： G01R33/543 , G01R33/389
摘要： A controller of a magnetic resonance system determines an activation signal vector based on a target field predetermined for the controller in conjunction with field characteristics of field coils known to the controller. The activation signal vector includes a respective activation signal for each field coil. The controller determines the activation signal vector such that within a predetermined examination volume of the magnetic resonance system, any deviation of an ideal field that would result if ideal coils were subjected to the activation signals of the activation signal vector from the target field is minimized. The controller determines a compensation signal vector based on the activation signal vector in conjunction with eddy current characteristics of the field coils known to the controller. The compensation signal vector is used to minimize a deviation of an actual field from the target field within the predetermined examination volume of the magnetic resonance system.
摘要翻译：磁共振系统的控制器结合控制器已知的场线圈的场特性，基于为控制器预定的目标场确定激活信号矢量。激活信号向量包括用于每个励磁线圈的相应启动信号。控制器确定激活信号向量，使得在磁共振系统的预定检查体积内，如果理想线圈受到来自目标场的激活信号矢量的激活信号的任何理想场的偏差都将最小化。控制器基于激活信号向量结合控制器已知的励磁线圈的涡流特性来确定补偿信号向量。补偿信号矢量被用于最小化在磁共振系统的预定检查体积内的实际场与目标场的偏差。

10. 发明授权

US08258903B2 Superconducting, actively shielded magnet 有权
标题翻译：超导，主动屏蔽磁铁
公开(公告)号：US08258903B2
公开(公告)日：2012-09-04
申请号：US12687975
申请日：2010-01-15
申请人： Guenter Schnur
发明人： Guenter Schnur
IPC分类号： H01F1/00 , H01F7/00 , H01F6/00
CPC分类号： G01R33/389 , G01R33/3815 , G01R33/3875 , G01R33/421 , H01F6/06
摘要： A superconducting, actively shielded magnet has a first and second superconducting coil modules that generate a homogeneous magnetic field in a first direction in an operating volume of the magnet and that reduces the scatter magnetic field in an environment of the magnet. A third superconducting coil module is arranged in proximity to the first and second coil modules. The third coil module is fashioned to generate a compensation gradient field given occurrence of an interference gradient field in the environment so that the effect of the interference gradient field in the operating volume is reduced.
摘要翻译：超导主动屏蔽的磁体具有第一和第二超导线圈模块，其在磁体的操作体积中沿第一方向产生均匀的磁场，并且减小磁体环境中的散射磁场。第三超导线圈模块布置成靠近第一和第二线圈模块。给定第三线圈模块以产生在环境中产生干涉梯度场的补偿梯度场，从而降低了操作体积中的干涉梯度场的影响。

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