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1. 发明公开

US20240268701A1 IMAGING SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20240268701A1
公开(公告)日：2024-08-15
申请号：US18642740
申请日：2024-04-22
申请人： SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
发明人： Jingyuan LYU , Qi LIU , Zhongqi ZHANG , Jian XU
IPC分类号： A61B5/055 , A61B6/00 , A61B6/03 , G01R33/24 , G01R33/46 , G01R33/48 , G01R33/483 , G01R33/561 , G01R33/563 , G01R33/565 , G06T3/16 , G06T7/00 , G06T7/215 , G06T7/262 , G06T7/269 , G06T9/00 , G06T11/00
CPC分类号： A61B5/055 , G01R33/4616 , G01R33/4818 , G01R33/561 , G01R33/56316 , G01R33/56563 , G01R33/5659 , G06T7/0016 , G06T9/008 , G06T11/003 , G06T11/005 , G06T11/008 , A61B6/032 , A61B6/5205 , G01R33/243 , G01R33/4833 , G01R33/5611 , G01R33/5617 , G01R33/5618 , G01R33/5619 , G01R33/56341 , G06T3/16 , G06T7/0012 , G06T7/215 , G06T7/262 , G06T7/269 , G06T2207/10072 , G06T2207/10084 , G06T2207/10088 , G06T2207/10092 , G06T2207/10096 , G06T2207/10104 , G06T2207/10108 , G06T2207/10132 , G06T2207/10136 , G06T2207/20182 , G06T2207/30004 , G06T2207/30048 , G06T2210/41 , G06T2210/52 , G06T2211/40 , G06T2211/416
摘要： An imaging method may include obtaining imaging data associated with a region of interest (ROI) of an object. The imaging data may correspond to a plurality of time-series images of the ROI. The imaging method may also include determining, based on the imaging data, a data set including a spatial basis and one or more temporal bases. The spatial basis may include spatial information of the imaging data. The one or more temporal bases may include temporal information of the imaging data. The imaging method may also include storing, in a storage medium, the spatial basis and the one or more temporal bases.

2. 发明申请

US20180329007A1 PHASE CYCLED MAGNETIC RESONANCE SPECTROSCOPE IMAGING 审中-公开
公开(公告)号：US20180329007A1
公开(公告)日：2018-11-15
申请号：US15774839
申请日：2016-11-09
申请人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL
发明人： Junyu Guo , Wilburn E. Reddick
IPC分类号： G01R33/485 , G01R33/46
CPC分类号： G01R33/485 , G01R33/4616 , G01R33/4838
摘要： Systems, methods, and other embodiments associated with phase cycled magnetic resonance spectroscopic imaging (PCSI). According to one embodiment, a method includes applying an excitation radio frequency (RF) pulse having a low flip angle to a sample. The method further includes adjusting the phase of the RF to sweep through a frequency range based, at least in part, on PCSI. Sampling is then performed in the frequency range. The method also includes receiving a set of data based, at least in part, on the sampling in the frequency range.

3. 发明申请

US20180267120A1 Multi-Banded RF-Pulse Enhanced Magnetization Imaging 审中-公开
公开(公告)号：US20180267120A1
公开(公告)日：2018-09-20
申请号：US15623496
申请日：2017-06-15
申请人： Siemens Healthcare GmbH , Regents of the University of Minnesota
发明人： Xiufeng Li , Gregory J. Metzger , Kamil Ugurbil , Dingxin Wang
IPC分类号： G01R33/46 , G01R33/56
CPC分类号： G01R33/4616 , G01R33/4835 , G01R33/56 , G01R33/5605
摘要： Embodiments can provide a method for multi-banded RF-pulse enhanced magnetization imaging, the method comprising determining, by a processor, a frequency offset against a central frequency by specifying an offset frequency for one or more RF coils close to a frequency peak of mobile water; and simultaneously applying, by one or more RF coils, one or more bands of Gaussian RF pulses around the central frequency to a patient from a medical imaging device; wherein the one or more bands of Gaussian RF pulses are symmetrically applied having a distance from the central frequency equal to the frequency offset.

4. 发明申请

US20180164234A1 NMR Measurement Method and Apparatus 审中-公开
公开(公告)号：US20180164234A1
公开(公告)日：2018-06-14
申请号：US15837215
申请日：2017-12-11
申请人： RIKEN , JEOL Ltd.
发明人： Yusuke Nishiyama
IPC分类号： G01N24/08 , G01R33/46 , G01R33/56 , G01R33/50
CPC分类号： G01N24/082 , G01N24/08 , G01N24/088 , G01R33/44 , G01R33/4608 , G01R33/4616 , G01R33/4641 , G01R33/50 , G01R33/5602 , G01R33/5605
摘要： A whole measurement process includes a plurality of step combinations. Each of the step combinations is composed of a solution-state measurement step and a solid-state measurement step. In the solution-state measurement step, solution-state NMR measurement is performed such that magnetization that is to be used in the solid-state measurement step remains. In the solid-state measurement step, solid-state NMR measurement is performed by using the magnetization that remains. No waiting time for recovering magnetization is provided between the solution-state measurement step and the solid-state measurement step. The solid-state measurement step may be performed earlier, and the solution-state measurement step may be performed later. Alternatively, the two steps may be performed simultaneously.

5. 发明授权

US09939510B2 Use of nuclear spin impurities to suppress electronic spin fluctuations and decoherence in composite solid-state spin systems 有权
公开(公告)号：US09939510B2
公开(公告)日：2018-04-10
申请号：US15790007
申请日：2017-10-22
申请人： Ronald L. Walsworth , Nir Bar-Gill , Chinmay Belthangady , Linh My Pham
发明人： Ronald L. Walsworth , Nir Bar-Gill , Chinmay Belthangady , Linh My Pham
IPC分类号： G11C11/00 , G01R33/58 , G01R33/12 , G01R33/24
CPC分类号： G01R33/58 , G01R33/1284 , G01R33/24 , G01R33/4616 , G01R33/60
摘要： A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and applying RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

6. 发明申请

US20170082714A1 METHOD OF DESIGNING AND GENERATING PULSES FOR MAGNETIC RESONANCE IMAGING 审中-公开
公开(公告)号：US20170082714A1
公开(公告)日：2017-03-23
申请号：US15126222
申请日：2015-04-16
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Aurélien MASSIRE , Nicolas BOULANT
IPC分类号： G01R33/561 , G01R33/483
CPC分类号： G01R33/5617 , G01R33/4616 , G01R33/4836 , G01R33/5612
摘要： A method of designing a refocusing pulse or pulse train for Magnetic Resonance Imaging comprises the steps of: a) determining a phase-free performance criterion representative of a proximity between a rotation of nuclear spins induced by the pulse and a target operator, summed or averaged over one or more voxels of an imaging region of interest; and b) adjusting a plurality of control parameters of the pulse to maximize the phase-free performance criterion; wherein each target operator is chosen so the phase-free performance criterion takes a maximum value when the nuclear spins within all voxels undergo a rotation of a same angle θ around a rotation axis lying in a plane perpendicular to a magnetization field B0, called a transverse plane, with an arbitrary orientation; wherein the angle θ is different from Mπ radians, with integer M, preferably with θ

7. 发明授权

US09529064B2 Broad bandwidth magnetic resonance spectroscopy at high static (B0) magnetic field using polarization transfer 有权
标题翻译：使用极化转移的高静态（B0）磁场下的宽带磁共振光谱
公开(公告)号：US09529064B2
公开(公告)日：2016-12-27
申请号：US13984910
申请日：2012-01-10
申请人： Baolian Yang , David Leslie Foxall
发明人： Baolian Yang , David Leslie Foxall
IPC分类号： G01R33/32 , G01R33/46 , G01R33/483 , G01R33/485
CPC分类号： G01R33/32 , G01R33/4608 , G01R33/4616 , G01R33/483 , G01R33/485
摘要： A magnetic resonance (MR) generating a static (BO) magnetic field of 5 Tesla or higher controller is configured to control an MR scanner to perform an MR sequence (14) including: performing an excitation/localization sub-sequence (30) on a subject disposed in the static (BO) magnetic field generated by the MR scanner to excite 1H polarization in a selected spatial region of the subject; performing 5 a polarization transfer sub-sequence (32) to transfer localized 1H polarization generated by the excitation/localization sub-sequence to a selected species of non-proton nuclei; and performing a magnetic resonance spectroscopy (MRS) readout sub-sequence (40) to acquire MRS data for the selected species of non-proton nuclei in the selected spatial region of the subject. The polarization transfer sub-sequence includes a pair of phase 10 distortion canceling trapezoidal 180° refocusing pulses (36, 37) operating on the selected species of non-proton nuclei.
摘要翻译：产生5特斯拉或更高控制器的静态（BO）磁场的磁共振（MR）被配置为控制MR扫描器执行MR序列（14），包括：在一个（或多个）磁带上执行激励/定位子序列（30）被放置在由MR扫描仪产生的静态（BO）磁场中，以激发被摄体的选定空间区域中的1H偏振; 执行5个偏振转移子序列（32）以将由激发/定位子序列产生的局部1H偏振转移到选定种类的非质子核; 以及执行磁共振波谱（MRS）读出子序列（40）以获取所选择的所述对象空间区域中所选择的非质子核物种的MRS数据。极化转移子序列包括在所选择的非质子核的种类上操作的一对相位10失真消除梯形180°重聚焦脉冲（36,37）。

8. 发明申请

US20160299204A1 Method for Two Field Nuclear Magnetic Resonance Measurements 审中-公开
标题翻译：两场核磁共振测量方法
公开(公告)号：US20160299204A1
公开(公告)日：2016-10-13
申请号：US15096287
申请日：2016-04-12
申请人： Bruker S.A.S. , Ecole normale supérieur , Centre National de la Recherche Scientifique , Université Pierre et Marie Curie (Paris 6)
发明人： Samuel Cousin , Cyril Charlier , Fabien Ferrage , Jean-Max Tyburn , Thorsten Marquardsen
IPC分类号： G01R33/46 , G01R33/387 , G01R33/44
CPC分类号： G01R33/4616 , G01R33/307 , G01R33/3635 , G01R33/387 , G01R33/445 , G01R33/4633
摘要： A method for carrying out two-field nuclear magnetic resonance (=2FNMR) measurements involves preparing a sample (9a) in a first working volume (5) of a highly homogeneous magnetic field with a first field strength; transferring the sample (9a) to a second working volume (7) with a magnetic field having lower homogeneity and having a second field strength, wherein the first field strength is at least 2 Tesla larger than the second field strength; manipulating the sample (9a) at the second working volume (7) by applying a sequence of radio-frequency (=RF) and/or field gradient pulses; transferring the sample (9a) back to the first working volume (5); and detecting an NMR signal of the sample (9a) in the first working volume (5). The method allows for NMR experiments with which more and/or improved quality information about an investigated sample can be obtained.
摘要翻译：用于进行两场核磁共振（= 2FNMR）测量的方法包括在具有第一场强的高均匀磁场的第一工作体积（5）中准备样品（9a）将样品（9a）转移到具有较低均匀性并具有第二场强的磁场的第二工作体积（7），其中第一场强比第二场强大至少2特斯拉; 通过施加射频（= RF）和/或场梯度脉冲序列来操纵第二工作体积（7）处的样品（9a）将样品（9a）返回到第一工作容积（5）; 以及检测所述第一工作容积（5）中的样品（9a）的NMR信号。该方法允许NMR实验，可以获得关于被研究样品的更多和/或改进的质量信息。

9. 发明申请

US20160077026A1 METHOD AND AN APPARATUS TO MEASURE FLOW PROPERTIES, INCLUDING FLOW RATES, REGIME AND RELATIVE CONCENTRATIONS OF PHASES IN MULTIPHASIC FLUIDS USING NUCLEAR MAGNETIC RESONANCE RELAXATION IN THE ROTATING FRAME 审中-公开
标题翻译：方法和测量流动特性的装置，包括使用旋转框架中的核磁共振放松的多相流体中相流的流量，相对浓度和相对浓度
公开(公告)号：US20160077026A1
公开(公告)日：2016-03-17
申请号：US14855369
申请日：2015-09-15
申请人： DANTE ANDRES PUSIOL , JULIA INES GARCIA
发明人： DANTE ANDRES PUSIOL , JULIA INES GARCIA
IPC分类号： G01N24/08 , G01F1/56
CPC分类号： G01N24/08 , G01F1/716 , G01N24/082 , G01N24/10 , G01R33/383 , G01R33/445 , G01R33/448 , G01R33/4616 , G01R33/5602 , G01R33/56308 , G01R33/56341 , G01R33/60
摘要： Rotating frame magnetic resonance based method and apparatus to measure and analyze flow properties in flowing complex fluids. The method consists on: 1) polarizing NMR active spins in a magnetic field region, 2) relaxing the plurality of individual macroscopic magnetizations in a second magnetic field region, wherein a plurality of radiofrequency pulses are irradiating said phases of said multiphasic fluid, wherein phase individual rotating frame relaxation times weight magnetization of said individual phases at said downstream end, wherein a plurality of contrast degrees between respective magnetization of individual phases, 3) measuring the total macroscopic magnetization in a third magnetic field region on an NMR measurement segment, and 4) reading the multidimensional data matrix with a tangible computer readable medium. The apparatus consists on: 1) a first magnet with constant magnetic field intensity, 2) a second magnet with variable rotating-frame pulse sequences at a plurality of radiofrequency sequences, intensity and time, 3) a third magnet having radio frequency antennas and field gradient coils (NMR module), and 4) a computing digital processor.
摘要翻译：基于旋转框架磁共振的方法和装置，用于测量和分析流动复杂流体中的流动性质。该方法包括：1）在磁场区域中极化NMR活性自旋，2）在第二磁场区域中放宽多个单独的宏观磁化，其中多个射频脉冲照射所述多相流体的所述相，其中相单个旋转框架松弛时间在所述下游端处所述各个相位的重量磁化，其中各个相位的相应磁化之间的多个对比度，3）测量NMR测量段上的第三磁场区域中的总宏观磁化强度，以及4 ）用有形的计算机可读介质读取多维数据矩阵。该装置包括：1）具有恒定磁场强度的第一磁体，2）具有多个射频序列，强度和时间的可变旋转帧脉冲序列的第二磁体，3）具有射频天线和场的第三磁体梯度线圈（NMR模块），以及4）计算数字处理器。

10. 发明申请

US20150112183A1 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 有权
标题翻译： MR光谱系统及其诊断方法，用于诊断阴性和非阴性椎间盘
公开(公告)号：US20150112183A1
公开(公告)日：2015-04-23
申请号：US14310721
申请日：2014-06-20
申请人： James Peacock, III , John Patrick Claude , Paul Henry Kane , Jeffrey C. Lotz
发明人： James Peacock, III , John Patrick Claude , Paul Henry Kane , Jeffrey C. Lotz
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527 , G06F19/00
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR）适用于给定的采集系列。诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

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