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1. 发明申请

US20190204400A1 Techniques For Operating Magnetic Resonance Imagers to Crush Returns from Unwanted Coherence Pathways 审中-公开
公开(公告)号：US20190204400A1
公开(公告)日：2019-07-04
申请号：US16223626
申请日：2018-12-18
申请人： The Trustees of Columbia University in the City of New York
发明人： Karl Landheer , Christoph Juchem
IPC分类号： G01R33/46 , G01R33/44 , G01R33/54
CPC分类号： G01R33/4616 , G01R33/446 , G01R33/4608 , G01R33/4833 , G01R33/543
摘要： Techniques for crushing unwanted coherence pathways during magnetic resonance spectral (MRS) measurements include receiving first data that indicates a sequence of RF pulses with one or more target coherence pathways of spin states for a subject that has at least N≥1 coupled spin states of interest. A negative, non-integer amplitude is determined for at least one intervening crusher pulse emitted from at least one spatial gradient magnetic coil. The at least one intervening crusher pulse has a duration less than a time between successive pulses of the sequence of RF pulses; and, the intervening crusher pulse de-phases unwanted coherence pathways. A MRS device is operated using the intervening crusher pulse and the sequence of RF pulses.

2. 发明申请

US20180177428A1 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 审中-公开
公开(公告)号：US20180177428A1
公开(公告)日：2018-06-28
申请号：US15679734
申请日：2017-08-17
申请人： Nocimed, Inc. , The Regents of the University of California
发明人： James Clayton Peacock, III , John Patrick Claude , Paul Henry Kane , Jeffrey C. Lotz
IPC分类号： A61B5/055 , G01R33/565 , G01R33/485 , G01R33/46 , G01R33/34 , A61B5/00 , G01R33/3415
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527 , G06F19/00
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.

3. 发明申请

US20180143276A1 MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS AND METHODS USING ADIABATIC TIP-DOWN AND MATCHED ADIABATIC FLIP-BACK PULSES 审中-公开
公开(公告)号：US20180143276A1
公开(公告)日：2018-05-24
申请号：US15571633
申请日：2016-05-04
申请人： Duke University
发明人： David Wendell , Wolfgang Rehwald , Enn-Ling Chen , Raymond Kim
IPC分类号： G01R33/46 , G01R33/36 , G01R33/56 , G01R33/44 , G01R33/483
CPC分类号： G01R33/4616 , A61B5/055 , G01R33/3614 , G01R33/446 , G01R33/4838 , G01R33/5605 , G01R33/5607
摘要： Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization transfer preparation. The pulse sequence includes an adiabatic tip-down pulse and a matched adiabatic flip-back pulse for separating spins in a mobile spin pool from spins in a bound spin pool of an anatomical region of interest for imaging. The system includes radio frequency (RF) coils configured to transmit RF pulses in response to the pulse sequence and to acquire RF data in response to transmission of the RF pulses. Further, the system includes a processing system configured to process the RF data to provide a display image indicating different tissue types with discrimination.

4. 发明申请

US20170299664A1 USE OF NUCLEAR SPIN IMPURITIES TO SUPPRESS ELECTRONIC SPIN FLUCTUATIONS AND DECOHERENCE IN COMPOSITE SOLID-STATE SPIN SYSTEMS 有权
公开(公告)号：US20170299664A1
公开(公告)日：2017-10-19
申请号：US15635701
申请日：2017-06-28
申请人： RONALD L. WALSWORTH , NIR BAR-GILL , CHINMAY BELTHANGADY , LINH MY PHAM
发明人： RONALD L. WALSWORTH , NIR BAR-GILL , CHINMAY BELTHANGADY , LINH MY PHAM
IPC分类号： G01R33/032 , G01R33/60
CPC分类号： G01R33/58 , G01R33/1284 , G01R33/24 , G01R33/4616 , G01R33/60
摘要： A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath composed of electronic spin impurities and the nuclear spin bath composed of nuclear spin impurities. The concentration of nuclear spin impurities in the nuclear spin bath is controlled to a value chosen so as to allow the nuclear spin impurities to effect a suppression of spin fluctuations and spin decoherence caused by the electronic spin bath. Sensing devices such as magnetic field detectors can exploit such a spin bath suppression effect, by applying optical radiation to the electronic spins for initialization and readout, and apply-ing RF pulses to dynamically decouple the electronic spins from the electronic spin bath and the nuclear spin bath.

5. 发明授权

US09392959B2 MR spectroscopy system and method for diagnosing painful and non-painful intervertebral discs 有权
标题翻译： MR光谱系统和诊断疼痛性和非痛性椎间盘的方法
公开(公告)号：US09392959B2
公开(公告)日：2016-07-19
申请号：US14310721
申请日：2014-06-20
申请人： NOCIMED, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： James Clayton Peacock, III , John Patrick Claude , Paul Henry Kane , Jeffrey C. Lotz
IPC分类号： A61B5/05 , A61B5/055 , A61B5/00 , G01R33/485 , G01R33/3415 , G01R33/565 , G01R33/46
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527 , G06F19/00
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR）适用于给定的采集系列。诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

6. 发明授权

US09170312B2 Phase-sensitive imaging of magnetization exchange and isotope flux 有权
标题翻译：磁化交换和同位素通量的相敏成像
公开(公告)号：US09170312B2
公开(公告)日：2015-10-27
申请号：US13360510
申请日：2012-01-27
申请人： Peder Larson , Adam B. Kerr , John M. Pauly , Daniel B. Vigneron
发明人： Peder Larson , Adam B. Kerr , John M. Pauly , Daniel B. Vigneron
IPC分类号： G01V3/00 , G01R33/46 , G01R33/563 , G01R33/485 , G01R33/56
CPC分类号： G01R33/4608 , G01R33/4616 , G01R33/485 , G01R33/5601 , G01R33/5605 , G01R33/56333
摘要： A method for imaging a substrate and product over time is provided. The substrate and product are magnetically tagged with at least one magnetic gradient where magnetically tagging provides a tag-dependent signal phase for the substrate and a different tag-dependent signal phase for the product. At least one readout of magnetically tagged substrate and product is provided over time. The tag-dependent signal phase is used to determine product that has been transformed from magnetically tagged substrate and substrate that has been transformed from magnetically tagged product over time.
摘要翻译：提供了一种用于对衬底和产品随时间成像的方法。衬底和产品用至少一个磁梯度进行磁性标记，其中磁性标签为衬底提供与标签相关的信号相位，并为产品提供不同的标签依赖信号相位。随着时间的推移，提供至少一个磁性标记的基板和产品读数。标签依赖信号相位用于确定已经从磁标记的产品随时间变换的磁性标记的基底和底物转变的产物。

7. 发明申请

US20150253402A1 METABOLITE DETECTION SYSTEM AND OPERATION THEREOF 审中-公开
标题翻译：代谢物检测系统及其操作
公开(公告)号：US20150253402A1
公开(公告)日：2015-09-10
申请号：US14429126
申请日：2013-09-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Baolian Yang
IPC分类号： G01R33/465 , A61B5/00 , A61B5/055
CPC分类号： G01R33/465 , A61B5/055 , A61B5/0555 , A61B5/4058 , G01R33/4616 , G01R33/4833 , G01R33/485
摘要： A magnetic resonance (MR) system for detecting concentrations of one or more metabolites in a volume of interest (VOI), the system including at least one controller which: may apply to the VOI a multiple quantum filter (MQF) Point Resolved Spetroscopy (PRESS) sequence comprising first and second 90° RF pulses, a third 90° RF pulse, first and second 180° adiabatic pulses, and a composite dual-band delay alternating with nutation for tailored excitation (DANTE) pulse train having a plurality of N block pulses (N being an integer), the DANTE pulse train situated in time between the first and second 90° RF pulses, the first and second 180° adiabatic pulses situated in time after third 90° RF pulse; detect MR Free Induced Decay (FID) signal emitted from the VOI; and/or reconstruct the detected MR FID signal to obtain metabolite spectrum information.
摘要翻译：一种用于检测感兴趣体积（VOI）中的一种或多种代谢物的浓度的磁共振（MR）系统，所述系统包括至少一个控制器，所述至少一个控制器可以应用于VOI多重量子滤波器（MQF）点解决的Spetroscopy（PRESS ）序列，其包括第一和第二90°RF脉冲，第三90°RF脉冲，第一和第二180°绝热脉冲以及与用于具有多个N块的定制激励（DANTE）脉冲串交替的章动的复合双频带延迟脉冲（N为整数），DANTE脉冲串位于第一和第二90°RF脉冲之间的时间上，第一和第二180°绝热脉冲位于第三90°RF脉冲之后的时间; 检测从VOI发出的MR自由诱导衰减（FID）信号; 和/或重建检测到的MR FID信号以获得代谢频谱信息。

8. 发明申请

US20150241532A1 MAGNETIC RESONANCE SPECTROSCOPY WITH PHASE ROTATION 审中-公开
标题翻译：具有相位旋转的磁共振光谱
公开(公告)号：US20150241532A1
公开(公告)日：2015-08-27
申请号：US14630973
申请日：2015-02-25
申请人： Siemens Aktiengesellschaft
发明人： Radhouene Neji , Christian Schuster
IPC分类号： G01R33/46 , G01R33/48 , G01R33/483 , G01R33/385
CPC分类号： G01R33/4616 , G01R33/385 , G01R33/4828 , G01R33/4831 , G01R33/485 , G01R33/565
摘要： In a method and magnetic resonance (MR) apparatus for acquiring an MR signal from an examination subject according to a pulse sequence, a first radio-frequency pulse is applied with a first phase and a gradient field is simultaneously applied in a first direction. Second and third radio-frequency pulses, with second and third phases, respectively, are applied simultaneously with a gradient field in a second direction. A fourth and a fifth radio-frequency pulse, with a fourth and a fifth phase, respectively, are applied and simultaneously with a gradient field in a third direction. A signal with a receiver phase is acquired =. The pulse sequence is repeated a number of times under phase rotation, wherein the third and fourth radio-frequency pulses in each repetition have the same phase, and the signals acquired in the repetition are added.
摘要翻译：在用于根据脉冲序列从检查对象获取MR信号的方法和磁共振（MR）装置中，以第一相位施加第一射频脉冲，并且沿第一方向同时施加梯度场。分别具有第二和第三相的第二和第三射频脉冲与第二方向上的梯度场同时施加。分别施加第四和第五相的第四和第五射频脉冲，并与第三方向上的梯度场同时施加。获取具有接收器相位的信号=。脉冲序列在相位旋转下重复多次，其中每个重复中的第三和第四射频脉冲具有相同的相位，并且添加在重复中获取的信号。

9. 发明申请

US20150212169A1 METHODS AND APPARATUS FOR SAMPLE TEMPERATURE CONTROL IN NMR SPECTROMETERS 审中-公开
标题翻译： NMR光谱仪中样品温度控制的方法和装置
公开(公告)号：US20150212169A1
公开(公告)日：2015-07-30
申请号：US14562028
申请日：2014-12-05
申请人： President and Fellows of Harvard College
发明人： Sebastian Hiller , Gerhard Wagner
IPC分类号： G01R33/31 , G01R33/46 , G01R33/34
CPC分类号： G01R33/31 , G01R33/34092 , G01R33/4608 , G01R33/4616 , G01R33/4625
摘要： Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature-lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.
摘要翻译：描述了在某些情况下精确度和精度低于约0.1K的NMR调制仪中可以控制和稳定样品温度的方法和装置（称为“温度锁定”）。在常规设置中，样品加热引起通过高功率射频脉冲的实验不容易检测到并且通过繁琐的手动过程来校正。相比之下，本文公开的温度锁定在不同的NMR实验过程中将样品自动维持在相同的参考温度。温度锁定可以通过连续或非连续测量合适的温度锁定核的共振频率并同时适应温度控制信号来使样品稳定在参考温度值。可以使用具有可变长度的扫描周期将样品保持在实验全长的热平衡。

10. 发明授权

US09041396B2 Dynamic B0 field detection by magnetic resonance navigators, and correction for multichannel reception and/or transmission RF coil configurations 有权
标题翻译：通过磁共振导航器的动态B0场检测，以及多通道接收和/或发射RF线圈配置的校正
公开(公告)号：US09041396B2
公开(公告)日：2015-05-26
申请号：US13355937
申请日：2012-01-23
申请人： Josef Pfeuffer , Lawrence Wald
发明人： Josef Pfeuffer , Lawrence Wald
IPC分类号： G01V3/00 , G01R33/24 , G01R33/46 , G01R33/565 , G01R33/483 , G01R33/561
CPC分类号： G01R33/243 , G01R33/4616 , G01R33/4835 , G01R33/5616 , G01R33/56563
摘要： In a method for calculating a B0 field map (a map of the basic magnetic field) in a magnetic resonance apparatus, a navigator pulse is emitted and navigator response resulting from the navigator pulse are detected in at least some channels of a multichannel RF coil array. Each channel of the multichannel RF coil array includes an RF coil and spatial information regarding the respective positions of the individual RF coils is made available to a processor, together with the multiple navigator signals. Using the spatial information obtained from the position of the RF coils that respectively detected the navigator response signals, a B0 field map is generated, without the need for spatial encoding the respective navigator response signals.
摘要翻译：在用于计算磁共振装置中的B0场映射（基本磁场的映射）的方法中，发射导航脉冲，并且在多通道RF线圈阵列的至少一些通道中检测由导航脉冲导致的导航器响应。多通道RF线圈阵列的每个通道包括RF线圈，并且关于各个RF线圈的相应位置的空间信息与多个导航器信号一起可用于处理器。使用从分别检测到导航器响应信号的RF线圈的位置获得的空间信息，生成B0场映射，而不需要对各个导航器响应信号进行空间编码。

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