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1. 发明申请

US20060214659A1 RF pulses for long T2 suppression in MRI 有权
标题翻译：射频脉冲在MRI中长T2抑制
公开(公告)号：US20060214659A1
公开(公告)日：2006-09-28
申请号：US11180339
申请日：2005-07-12
申请人： Peder Larson , John Pauly , Steven Conolly
发明人： Peder Larson , John Pauly , Steven Conolly
IPC分类号： G01V3/00
CPC分类号： G01R33/446
摘要： In imaging a first species having a short T2 magnetic resonance parameter in the presence of a second and third species having longer T2 parameters, a method of suppressing signals from the longer T2 species comprises the steps of: a) applying a RF saturation pulse with multiple suppression bands for the second and third species to excite nuclei spins of the longer T2 species with the magnitude of the RF pulse being sufficiently low so as not to excite nuclei spins of the short T2 species, the RF saturation pulse being sufficiently long to rotate the longer T2 species nuclei spins into a transverse plane, and b) dephasing the longer T2 species nuclei spins in the transverse plane. An imaging pulse sequence is then applied to image the short T2 species. Alternatively, the method can comprise the steps of a) applying a first inversion pulse for selective inverting species of the second longer T2 species, b) obtaining first image signals after step a, c) applying a second inversion pulse for selectively inverting species of the third longer T2 species, d) obtaining second image signals after step c), and e) combining the first image signals and the second image signal to image the first short T2 species with the longer second and third species cancelling in the combination. In each of these methods, either the second or third longer T2 species can be suppressed without suppressing the other by applying the RF saturation or inversion pulse only to the species to be suppressed.
摘要翻译：在具有较长T2参数的第二和第三物种存在下成像具有短T2磁共振参数的第一物种时，抑制来自较长T2物种的信号的方法包括以下步骤：a）施加具有多个的T2饱和脉冲第二和第三物种的抑制带激发较长T2物种的核心旋转，其中RF脉冲的幅度足够低，以便不激发短T2物质的核旋转，RF饱和脉冲足够长以旋转更长的T2物种核转入横向平面，并且b）在横向平面中去除更长的T2种类核自旋。然后应用成像脉冲序列对短T2物种进行成像。或者，该方法可以包括以下步骤：a）施加用于第二较长T2种类的选择性反转种类的第一反转脉冲，b）在步骤a之后获得第一图像信号，c）施加第二反转脉冲以选择性地反转第三较长的T2物种，d）在步骤c）之后获得第二图像信号，以及e）组合第一图像信号和第二图像信号以对组合中较长的第二和第三个物种进行消除的第一短T2物种进行成像。在这些方法的每一种中，通过仅对要抑制的物质施加RF饱和或反转脉冲，可以抑制第二或第三较长的T2物种，而不会抑制另一个。

2. 发明授权

US09170312B2 Phase-sensitive imaging of magnetization exchange and isotope flux 有权
标题翻译：磁化交换和同位素通量的相敏成像
公开(公告)号：US09170312B2
公开(公告)日：2015-10-27
申请号：US13360510
申请日：2012-01-27
申请人： Peder Larson , Adam B. Kerr , John M. Pauly , Daniel B. Vigneron
发明人： Peder Larson , Adam B. Kerr , John M. Pauly , Daniel B. Vigneron
IPC分类号： G01V3/00 , G01R33/46 , G01R33/563 , G01R33/485 , G01R33/56
CPC分类号： G01R33/4608 , G01R33/4616 , G01R33/485 , G01R33/5601 , G01R33/5605 , G01R33/56333
摘要： A method for imaging a substrate and product over time is provided. The substrate and product are magnetically tagged with at least one magnetic gradient where magnetically tagging provides a tag-dependent signal phase for the substrate and a different tag-dependent signal phase for the product. At least one readout of magnetically tagged substrate and product is provided over time. The tag-dependent signal phase is used to determine product that has been transformed from magnetically tagged substrate and substrate that has been transformed from magnetically tagged product over time.
摘要翻译：提供了一种用于对衬底和产品随时间成像的方法。衬底和产品用至少一个磁梯度进行磁性标记，其中磁性标签为衬底提供与标签相关的信号相位，并为产品提供不同的标签依赖信号相位。随着时间的推移，提供至少一个磁性标记的基板和产品读数。标签依赖信号相位用于确定已经从磁标记的产品随时间变换的磁性标记的基底和底物转变的产物。

3. 发明申请

US20130193966A1 PHASE-SENSITIVE IMAGING OF MAGNETIZATION EXCHANGE AND ISOTOPE FLUX 有权
标题翻译：磁化交换和同位素磁通的相敏感成像
公开(公告)号：US20130193966A1
公开(公告)日：2013-08-01
申请号：US13360510
申请日：2012-01-27
申请人： Peder LARSON , Adam B. KERR , John M. PAULY , Daniel B. VIGNERON
发明人： Peder LARSON , Adam B. KERR , John M. PAULY , Daniel B. VIGNERON
IPC分类号： G01R33/48
CPC分类号： G01R33/4608 , G01R33/4616 , G01R33/485 , G01R33/5601 , G01R33/5605 , G01R33/56333
摘要： A method for imaging a substrate and product over time is provided. The substrate and product are magnetically tagged with at least one magnetic gradient where magnetically tagging provides a tag-dependent signal phase for the substrate and a different tag-dependent signal phase for the product. At least one readout of magnetically tagged substrate and product is provided over time. The tag-dependent signal phase is used to determine product that has been transformed from magnetically tagged substrate and substrate that has been transformed from magnetically tagged product over time.
摘要翻译：提供了一种用于对衬底和产品随时间成像的方法。衬底和产品用至少一个磁梯度进行磁性标记，其中磁性标签为衬底提供与标签相关的信号相位，并为产品提供不同的标签依赖信号相位。随着时间的推移，提供至少一个磁性标记的基板和产品读数。标签依赖信号相位用于确定已经从磁标记的产品随时间变换的磁性标记的基底和底物转变的产物。

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