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    • 2. 发明授权
    • Method of manufacturing cellular electrophysiology sensor chip
    • 细胞生物传感器芯片制造方法
    • US09184048B2
    • 2015-11-10
    • US13713065
    • 2012-12-13
    • Panasonic Corporation
    • Makoto TakahashiMasaya NakataniHiroshi UshioTakeki Yamamoto
    • H01L21/02G01N33/487
    • H01L21/02356G01N33/48728
    • A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties.
    • 细胞电生理学传感器适于测量测试电池的电气变化。 用于传感器的芯片包括隔膜以及在隔膜上主要含有二氧化硅的热氧化膜。 隔膜在硅层的上表面上包括硅层和二氧化硅层。 形成穿过硅层和二氧化硅层的通孔。 通孔具有在二氧化硅层处开口并且适于捕获测试电池的开口。 热氧化膜设置在通孔的内壁表面上,并且在通孔的开口处与二氧化硅层一体化。 这种细胞电生理学传感器芯片可以稳定地捕获测试细胞,并且即使测试细胞具有不同的性质也能稳定地提供gigaseal。
    • 8. 发明授权
    • Fluorescence detection device
    • 荧光检测装置
    • US09046490B2
    • 2015-06-02
    • US14498596
    • 2014-09-26
    • PANASONIC CORPORATIONSANYO Electric Co., Ltd.
    • Kenji NagatomiMasaya Nakatani
    • G01N21/64
    • G01N21/6486G01N21/645G01N21/6452G01N2021/6463
    • To provide a fluorescence detection device that can effectively remove autofluorescence using a simple configuration. A fluorescence detection device comprises: semiconductor laser for emitting excitation light; an objective lens for converging excitation light onto a sample on a biosensor substrate; an anamorphic lens which introduces astigmatism to fluorescence that is from the biosensor substrate and incident on the objective lens and that passed through the objective lens; a spectral element for separating the fluorescence into a plurality of light rays; and a fluorescence detector for receiving the light rays separated by the spectral element. On the light receiving surface of the fluorescence detector, the spectral element splits the fluorescence so that the fluorescence generated at the sample is separated from the fluorescence generated at a specific depth position other than the sample position.
    • 提供可以使用简单配置有效去除自体荧光的荧光检测装置。 荧光检测装置包括:用于发射激发光的半导体激光器; 用于将激发光会聚到生物传感器基板上的样品上的物镜; 一种变形透镜,其对来自生物传感器基板的荧光引入散光,并入射到物镜上并穿过物镜; 用于将荧光分离成多个光线的光谱元件; 以及用于接收由光谱元件分离的光线的荧光检测器。 在荧光检测器的光接收表面上,光谱元件分离荧光,使得在样品处产生的荧光与在样品位置以外的特定深度位置处产生的荧光分离。
    • 9. 发明申请
    • FLUORESCENCE DETECTION DEVICE
    • 荧光检测装置
    • US20150014552A1
    • 2015-01-15
    • US14498596
    • 2014-09-26
    • PANASONIC CORPORATIONSANYO Electric Co., Ltd.
    • Kenji NagatomiMasaya Nakatani
    • G01N21/64
    • G01N21/6486G01N21/645G01N21/6452G01N2021/6463
    • To provide a fluorescence detection device that can effectively remove autofluorescence using a simple configuration. A fluorescence detection device comprises: semiconductor laser for emitting excitation light; an objective lens for converging excitation light onto a sample on a biosensor substrate; an anamorphic lens which introduces astigmatism to fluorescence that is from the biosensor substrate and incident on the objective lens and that passed through the objective lens; a spectral element for separating the fluorescence into a plurality of light rays; and a fluorescence detector for receiving the light rays separated by the spectral element. On the light receiving surface of the fluorescence detector, the spectral element splits the fluorescence so that the fluorescence generated at the sample is separated from the fluorescence generated at a specific depth position other than the sample position.
    • 提供可以使用简单配置有效去除自体荧光的荧光检测装置。 荧光检测装置包括:用于发射激发光的半导体激光器; 用于将激发光会聚到生物传感器基板上的样品上的物镜; 变形透镜,其对来自生物传感器基板的荧光引入散光,并入射到物镜上并穿过物镜; 用于将荧光分离成多个光线的光谱元件; 以及用于接收由光谱元件分离的光线的荧光检测器。 在荧光检测器的光接收表面上,光谱元件分离荧光,使得在样品处产生的荧光与在样品位置以外的特定深度位置处产生的荧光分离。