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1. 发明授权

US5116839A Use of isoxazolin-3-one derivatives as antidepressants 失效
标题翻译：使用ISOXAZOLIN-3-ONE衍生物作为抗病毒剂
公开(公告)号：US5116839A
公开(公告)日：1992-05-26
申请号：US537517
申请日：1990-06-13
申请人： Nobuyoshi Iwata , Kenji Yoshimi , Mitsuo Nagano
发明人： Nobuyoshi Iwata , Kenji Yoshimi , Mitsuo Nagano
IPC分类号： A61K9/48 , A61K31/41 , A61K31/42 , A61K31/535 , A61K38/01
CPC分类号： A61K31/535 , A61K31/42
摘要： A method of treating depression comprising administering to a patient an effective antidepressive amount of a compound of the formula (I) ##STR1## wherein the endocyclic dotted line ##STR2## is a single bond; the exocyclic dotted line ##STR3## is a double bond; A is oxygen; B is a group of the formula (II) ##STR4## wherein m is 0 and n is 0 or 1; R.sup.3, R.sup.4 and the nitrogen to which they are attached together represent an alicyclic amino having a total of 5 or 6 ring atoms, of which one ring atom is the nitrogen and one ring atom is optionally an additional heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, the alicyclic amino being unsubstituted or, where there is an additional nitrogen heteroatom, the alicyclic amino having as a substituent a C.sub.1 -C.sub.3 alkyl on the additional nitrogen heteroatom; R.sup.1 is hydrogen or halogen; and R.sup.2 is an unsubstituted phenyl, a substituted phenyl having a substituent selected from the group consisting of C.sub.1-3 alkyl, C.sub.1-3 alkoxy, halogen and nitro, an unsubstituted 5- or 6-membered heterocyclic group having one or more of oxygen, sulfur or a nitrogen as heteroatoms, or a substituted 5- or 6-membered heterocyclic group having one or more of oxygen, sulfur or a nitrogen as heteroatoms and having at least one substituent selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1-3 alkoxy, halogen and nitro; or a pharmaceutically acceptable acid addition salt thereof.

2. 发明授权

US5262413A Use of isoxazolin-3-one derivatives as antidepressants 失效
标题翻译：异恶唑啉-3-酮衍生物作为抗抑郁药的使用
公开(公告)号：US5262413A
公开(公告)日：1993-11-16
申请号：US11208
申请日：1993-01-29
申请人： Nobuyoshi Iwata , Kenji Yoshimi , Mitsuo Nagano
发明人： Nobuyoshi Iwata , Kenji Yoshimi , Mitsuo Nagano
IPC分类号： A61K31/42 , A61K31/535 , A61K31/41 , A61K31/54
CPC分类号： A61K31/535 , A61K31/42
摘要： A method of treating depression comprising administering to a patient an effective amount of a compound of the formula (Ib): ##STR1## wherein R.sup.1b is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, an unsubstituted benzyl group, a substituted benzyl having at least one substitutent (b) selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, hydroxy, halogen, nitro, amino and C.sub.2 -C.sub.4 aliphatic carboxylic acylamino; unsubstituted phenyl or a substituted phenyl having at least one substitutent (b); R.sup.2b is hydrogen, C.sub.1 -C.sub.4 alkyl, unsubstituted phenyl, substituted phenyl having at least one substitutent (b), unsubstituted 5- or 6- membered heterocyclic having an oxygen, sulfur or nitrogen as a heteroatom, or substituted 5- or 6- membered heterocyclic having an oxygen, sulfur or nitrogen as a heteroatom and having at least one substitutent (b); and R.sup.3b and R.sup.4b are the same or different and each is hydrogen, C.sub.1 -C.sub.4 alkyl, unsubstituted benzyl, substituted benzyl having at least one substituent (b), unsubstituted phenyl, or substituted phenyl having at least one substitutent (b); or R.sup.3b, R.sup.4b and the nitrogen atom to which they are attached together represent an alicyclic amino group having a total of 5 or 6 ring atoms, or which one ring atom is the nitrogen atom and one ring atom is optionally an additional heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, the alicyclic amino group being unsubstituted or, where there is an additional nitrogen heteroatom, the alicyclic amino group having a C.sub.1 -C.sub.3 alkyl substitutent on the additional nitrogen heteroatom; or a pharmacologically acceptable acid addition salt thereof.
摘要翻译：治疗抑郁症的方法包括向患者施用有效量的式（Ib）化合物：其中R 1b是氢，卤素，C 1 -C 4烷基，C 2 -C 4烯基，C 2 -C 4炔基，未取代的苄基，具有至少一个选自C 1 -C 3烷基，C 1 -C 3烷氧基，羟基，卤素，硝基，氨基和C 2 -C 4脂族羧酸酰基氨基的取代基（b）的取代苄基; 未取代的苯基或具有至少一个取代基（b）的取代苯基; R2b是氢，C1-C4烷基，未取代的苯基，具有至少一个取代基（b）的取代苯基，具有氧，硫或氮作为杂原子的未取代的5-或6-元杂环，或取代的5-或6-元具有氧，硫或氮作为杂原子且具有至少一个取代基（b）的杂环基; 并且R 3b和R 4b相同或不同，各自为氢，C 1 -C 4烷基，未取代的苄基，具有至少一个取代基的取代苄基（b），未取代的苯基或具有至少一个取代基（b）的取代的苯基。或R 3b，R 4b和它们所连接的氮原子一起表示具有总共5或6个环原子的脂环族氨基，或者一个环原子是氮原子，一个环原子任选地是选自以下的杂原子：由氮，氧和硫组成的组，脂环族氨基是未取代的，或者在另外的氮杂原子上，在另外的氮杂原子上具有C1-C3烷基取代基的脂环族氨基; 或其药理学上可接受的酸加成盐。

3. 发明授权

US5217970A Use of isoxazolin-3-one derivatives as antidepressants 失效
标题翻译：异恶唑啉-3-酮衍生物作为抗抑郁药的使用
公开(公告)号：US5217970A
公开(公告)日：1993-06-08
申请号：US856494
申请日：1992-03-24
申请人： Nobuyoshi Iwata , Kenji Yoshimi , Mitsuo Nagano
发明人： Nobuyoshi Iwata , Kenji Yoshimi , Mitsuo Nagano
IPC分类号： A61K31/42 , A61K31/535
CPC分类号： A61K31/535 , A61K31/42
摘要： A method of treating depression comprising administering to a patient an effective antidepressive amount of a compound of the formula ##STR1## wherein either (i) the endocyclic dotted line ( ) is a double bond; the exoxyclic dotted line ( ) is a single bond;A is ##STR2## m is 1; n is 0; R.sup.3 and R.sup.4 are hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl or phenyl or R.sup.3, R.sup.4 and the nitrogen to which they are attached represent an alicyclic amino having 5 or 6 ring atoms, of which one ring atom is nitrogen and one ring atom is optionally an additional nitrogen, oxygen or sulfur heteroatom; R.sup.1 is hydrogen, halogen C.sub.1 -C.sub.4 alkyl C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, benzyl or phenyl; and R.sup.2 is hydrogen, C.sub.1 -C.sub.4 alkyl phenyl or a 5- or 6- membered heterocyclic; or(ii) the endocyclic dotted line ( ) is a single bond; the exocyclic dotted line ( ) is a double bond;A is oxygen;B is ##STR3## m is 0; n is 1; R.sup.3, R.sup.4 and the nitrogen to which they are attached together represent an alicyclic amino group having 5 or 6 ring atoms, of which one ring atom is nitrogen and one ring atom is optionally an additional nitrogen, oxygen or sulfur heteroatom; and R.sup.1 and R.sup.2, together with the carbon to which they are attached, represent phenyl fused to the isoxazole ring.
摘要翻译：一种治疗抑郁症的方法，包括向患者施用有效的抗抑郁量的下式化合物，其中（i）内环虚线（）是双键; 外消旋虚线（）是单键; A是 m是1; n为0; R3和R4是氢，C1-C4烷基，苄基或苯基或R3，R4，它们所连接的氮代表具有5或6个环原子的脂环族氨基，其中一个环原子是氮，一个环原子是任选的另外的氮，氧或硫杂原子; R1是氢，卤素C1-C4烷基C2-C4烯基，C2-C4炔基，苄基或苯基; 和R 2是氢，C 1 -C 4烷基苯基或5-或6-元杂环; 或（ii）内环虚线（）是单键; 环外虚线（）是双键; A是氧气; B是 m是0; n为1; R3，R4和它们所连接的氮一起表示具有5或6个环原子的脂环族氨基，其中一个环原子是氮，一个环原子任选地是另外的氮，氧或硫杂原子; 并且R 1和R 2与它们所连接的碳一起表示与异恶唑环稠合的苯基。

4. 发明授权

US5321037A Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants 失效
标题翻译：异恶唑衍生物用作脑脊液药物和中枢肌肉松弛剂
公开(公告)号：US5321037A
公开(公告)日：1994-06-14
申请号：US26271
申请日：1993-03-04
申请人： Mitsuo Nagano , Junichi Sakai , Nobuyoshi Iwata , Kazuo Kobayashi , Masao Kozuka , Kenji Yoshimi , Katsunori Kato , Yoshiko Kubo , Toshiyuki Tonohiro , Takao Hara
发明人： Mitsuo Nagano , Junichi Sakai , Nobuyoshi Iwata , Kazuo Kobayashi , Masao Kozuka , Kenji Yoshimi , Katsunori Kato , Yoshiko Kubo , Toshiyuki Tonohiro , Takao Hara
IPC分类号： A61K31/42 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/55 , C07D261/12 , C07D261/20
CPC分类号： A61K31/445 , A61K31/42 , A61K31/495 , A61K31/535 , A61K31/55 , C07D261/12 , C07D261/20
摘要： Compounds of formula (I): ##STR1## [in which: either (a) the dotted line ( ) is a single bond; A=is oxygen; and B is a group of formula (II): ##STR2## (in which m is 0 and n is 0 or 1) or (b) the dotted line ( ) is a double bond; A=is said group of formula (II) in which m is 1 and n is 0 or 1; and B is absent; and R.sup.1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R.sup.2 is hydrogen, halogen, alkyl, optionally substituted phenyl or heterocyclic; or R.sup.1 and R.sup.2, together with the carbon atoms to which they are attached, are a hydrocarbon ring fused to the isoxazole ring; R.sup.3 and R.sup.4 are each hydrogen, alkyl, optionally substituted benzyl or optionally substituted phenyl; or R.sup.3, R.sup.4 and the nitrogen atom to which they are attached together represent an alicyclic amino group]; and salts thereof may be used for the treatment of cerebral circulatory problems and for use as centrally acting muscle relaxants.
摘要翻译：（I）化合物：其中：（a）虚线（）是单键; A =是氧; （II）（其中m为0且n为0或1）或（b）虚线（）为双键的式（II）的基团： A =是式（II）的基团，其中m是1，n是0或1; B不存在 R 1为氢，卤素，烷基，烯基，炔基，任选取代的苄基或任选取代的苯基; R2是氢，卤素，烷基，任选取代的苯基或杂环; 或R 1和R 2与它们所连接的碳原子一起是与异恶唑环稠合的烃环; R 3和R 4各自为氢，烷基，任选取代的苄基或任选取代的苯基; 或R 3，R 4和它们所连接的氮原子一起表示脂环族氨基]。其盐可用于治疗脑循环问题并用作中枢肌肉松弛剂。

5. 发明授权

US5643923A Quinuclidinyloxy-isoxazole compounds and their therapeutic uses 失效
标题翻译：喹喔啉氧基 - 异恶唑化合物及其治疗用途
公开(公告)号：US5643923A
公开(公告)日：1997-07-01
申请号：US937445
申请日：1992-08-27
申请人： Mitsuo Nagano , Takeo Kobayashi , Junichi Sakai , Masao Kozuka , Nobuyoshi Iwata , Yoshiko Kubo
发明人： Mitsuo Nagano , Takeo Kobayashi , Junichi Sakai , Masao Kozuka , Nobuyoshi Iwata , Yoshiko Kubo
IPC分类号： A61K31/445 , A61K31/42 , A61P25/28 , C07D261/12 , C07D261/20 , C07D413/04 , C07D413/12 , C07D413/14 , C07D453/02 , A61K31/44 , C07D261/04
CPC分类号： C07D453/02 , C07D413/10 , C07D413/14
摘要： Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, halogen or alkyl; R.sup.2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R.sup.1 and R.sup.2 together form a group of formula --CR.sup.4 .dbd.CR.sup.5 --CR.sup.6 .dbd.CR.sup.7 --, where R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R.sup.3 is piperidyl, substituted piperidyl or quinuclidinyl. The compounds are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.
摘要翻译：式（I）的化合物：其中R 1是氢，卤素或烷基; R2是氢，烷基，任意取代的苯基或杂环; 或R 1和R 2一起形成式-CR 4 = CR 5 -CR 6 = CR 7 - ，其中R 4，R 5，R 6和R 7是氢，卤素，烷基，烷氧基，卤代甲基，烷基氨基，二烷基氨基，羟基，硝基，脂族羧酸酰氨基或氨基; 并且R 3是哌啶基，取代的哌啶基或奎宁环基。该化合物可用于治疗和预防认知障碍，特别是老年性痴呆，包括阿尔茨海默氏病。还提供了制备化合物的方法。

6. 发明授权

US4403718A Method and apparatus for automatically controlling travel of two plastics film strips as a bag material or the like 失效
标题翻译：用于自动控制作为袋材料等的两个塑料膜条的行进的方法和装置
公开(公告)号：US4403718A
公开(公告)日：1983-09-13
申请号：US312132
申请日：1981-10-16
申请人： Mitsuo Nagano
发明人： Mitsuo Nagano
IPC分类号： B65H20/06 , B31B1/10 , B31B19/10 , B65B41/18 , B65H20/08 , B65H23/18 , B65H23/188 , B65H26/00 , B65H23/00 , B65H23/04 , B65H23/10
CPC分类号： B65H23/1886 , B65B41/18 , B31B2219/022
摘要： This invention provides an improved method and apparatus for automatically controlling travel of two transversely spaced parallel plastics film strips in a bag-making machine or the like that can correct rapidly the relative positional gaps produced between the register marks on the strips by means of a new retarding device for the strips as incorporated in the apparatus.
摘要翻译：本发明提供了一种改进的方法和装置，用于自动控制制袋机等中两个横向间隔开的平行塑料薄膜条的行进，该制袋机等可以通过新的方式快速校正条带上的对准标记之间产生的相对位置间隙用于装在装置中的条带的延迟装置。

7. 发明授权

US4904680A Amino acid derivatives having anti-tumor activity and compositions containing them 失效
标题翻译：具有抗肿瘤活性的氨基酸衍生物和含有它们的组合物
公开(公告)号：US4904680A
公开(公告)日：1990-02-27
申请号：US146955
申请日：1988-01-22
申请人： Takashi Matsui , Mitsuo Nagano , Koichi Kitamura , Fusaaki Shimizu
发明人： Takashi Matsui , Mitsuo Nagano , Koichi Kitamura , Fusaaki Shimizu
IPC分类号： C07D233/90 , A61K31/16 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/455 , A61P35/00 , A61P37/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C237/06 , C07C237/22 , C07C301/00 , C07C303/38 , C07C303/40 , C07C311/00 , C07D207/16 , C07D213/82 , C07D233/64 , C07D277/06 , C07D333/24 , C07D333/38 , C07D521/00
CPC分类号： C07D213/82 , C07D207/16 , C07D277/06 , C07D333/38
摘要： Amino acid amides of formula (I): ##STR1## wherein R.sup.1 -R.sup.5 and Y represent a variety of organic groups and atoms (including where R.sup.2, Y and the adjacent nitrogen atom together represent a thiazolidine or pyrrolidine group) and X represents carbonyl or sulfonyl are mostly new compounds and have valuable anti-tumor and immuno-regulatory activities. They may be formulated in compositions for pharmaceutical use.
摘要翻译：式（I）的氨基酸酰胺：其中R1-R5和Y代表各种有机基团和原子（包括其中R2，Y和相邻氮原子一起代表噻唑烷或吡咯烷基团）和X 代表羰基或磺酰基大多是新化合物，具有有价值的抗肿瘤和免疫调节活性。它们可以配制成药物用组合物。

8. 发明授权

US4545942A Amino-acid derivatives, their preparation and their use as pharmaceuticals 失效
标题翻译：氨基酸衍生物，其制备及其作为药物的用途
公开(公告)号：US4545942A
公开(公告)日：1985-10-08
申请号：US597817
申请日：1984-04-09
申请人： Mitsuo Nagano , Koichi Hirai , Kouichi Kitamura , Kenkichi Shinkai , Hiroshi Yasuda
发明人： Mitsuo Nagano , Koichi Hirai , Kouichi Kitamura , Kenkichi Shinkai , Hiroshi Yasuda
IPC分类号： A61K31/275 , A61K20060101 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61P35/00 , A61P37/04 , C07C20060101 , C07C67/00 , C07C253/00 , C07C255/24 , C07C255/26 , C07C255/29 , C07C255/32 , C07C255/44 , C07C255/56 , C07C255/66 , C07D317/68 , C07C121/78
CPC分类号： C07C255/00
摘要： New compounds useful as immunoregulatory and antineoplastic agents are amino-acid derivatives of formula: ##STR1## wherein: n is an integer from 1 to 5;R.sup.1 is a hydrogen atom, an alkyl group, a haloalkyl group, a halogen atom, a mercapto group, an alkylmercapto group, a hydroxy group, an alkoxy group, an acyloxy group, a carboxyl group, an alkoxycarbonyl group, an amino group, an alkyl-substituted amino group, an aryl-substituted amino group, an acylamino group, a haloalkoxycarbonylamino group, an alkanesulphonyl group, a nitro group or a cyano group (and, when n is an integer from 2 to 5, the radicals R.sup.1 may be the same or different);R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or an alkyl group;R.sup.4 is a hydrogen atom, an alkyl group, a cyano group, a cyanoalkyl group, a hydroxyalkyl group, an alkoxycarbonyl group, a carboxyl group, an aryl group, an aralkyl group, a mercaptoalkyl group, an alkylthioalkyl group, or a thioalkyl group (the free bond of the sulphur in said thioalkyl group being joined to the sulphur of another moiety of the same formula); andA is a hydroxy group, an alkoxy group, an amino group, an alkyl-substituted amino group (optionally halogen- or carbamoyl- substituted in the alkyl moiety), a hydrazino group, an alkyl- or aryl- substituted hydrazino group, a hydroxylamino group, an alkoxyamino group or an aralkyloxyamino group;and the pharmaceutically acceptable salts thereof.
摘要翻译：可用作免疫调节和抗肿瘤剂的新化合物是下式的氨基酸衍生物：其中：n是1至5的整数; R1是氢原子，烷基，卤代烷基，卤素原子，巯基，烷基巯基，羟基，烷氧基，酰氧基，羧基，烷氧基羰基，氨基，烷基取代的氨基，芳基取代的氨基，酰氨基，卤代烷氧基羰基氨基，链烷磺酰基，硝基或氰基（当n为2至5的整数时，基团R 1可以相同或不同）; R2和R3可以相同或不同，各自为氢原子或烷基; R4是氢原子，烷基，氰基，氰基烷基，羟基烷基，烷氧基羰基，羧基，芳基，芳烷基，巯基烷基，烷硫基烷基或硫代烷基（所述硫代烷基中的硫的游离键与相同式的另一部分的硫连接）; 并且A是羟基，烷氧基，氨基，烷基取代的氨基（在烷基部分中任选被卤素取代或氨基甲酰基取代），肼基，烷基或芳基取代的肼基，羟基氨基，烷氧基氨基或芳烷氧基氨基; 及其药学上可接受的盐。

9. 发明授权

US4126745A 7-Methoxycephalosporin derivatives 失效
标题翻译： 7-甲氧基头孢菌素衍生物
公开(公告)号：US4126745A
公开(公告)日：1978-11-21
申请号：US676488
申请日：1976-04-13
申请人： Hideo Nakao , Hiroaki Yanagisawa , Bunji Shimizu , Masakatsu Kaneko , Mitsuo Nagano , Shinichi Sugawara
发明人： Hideo Nakao , Hiroaki Yanagisawa , Bunji Shimizu , Masakatsu Kaneko , Mitsuo Nagano , Shinichi Sugawara
IPC分类号： A61K31/545 , C07D20060101 , C07D205/08 , C07D257/04 , C07D279/04 , C07D501/00 , C07D501/36 , C07D501/40 , C07D501/50 , C07D501/57 , C07D501/60
CPC分类号： C07D501/57 , Y02P20/55
摘要： A compound having the formula ##STR1## wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula ##STR2## wherein X.sub.1 represents a halogen atom with a compound having the formulaY -- Hwherein Y has the same meaning as defined above, or (b) reacting a compound having the formula ##STR3## wherein R represents a protective group for the carboxyl group with a compound having the formulaY -- CH.sub.2 COX.sub.2wherein X.sub.2 represents a halogen atom and Y has the same meaning as defined above and removing the protective group for the carboxyl group from the resulting product, or (c) reacting a compound having the formula ##STR4## wherein A represents an acetoxy group or a carbamoyloxy group and Y has the same meaning as defined above with 5-mercapto-1-methyl-1H-tetrazole or its alkali metal salt.
摘要翻译：具有式“IMAGE”的化合物，其中Y表示2-羧乙硫基或三氟甲硫基，其无毒的药学上可接受的盐可用作抗菌剂。它们可以通过以下方法来制备：（a）使具有式“IMAGE”的化合物（其中X1表示卤素原子）与具有式Y-H的化合物反应，其中Y具有与上述相同的含义，或（b）使具有其中R表示具有式Y-CH 2 COX 2的化合物的羧基保护基，其中X 2表示卤素原子，Y表示与上述相同的含义，并且从该基团除去羧基的保护基团得到的产物，或（c）使具有式“IMAGE”的化合物，其中A表示乙酰氧基或氨基甲酰氧基，Y与上述定义同上，与5-巯基-1-甲基-1H-四唑或其碱金属盐。

10. 发明授权

US4662942A Cement additives 失效
标题翻译：水泥添加剂
公开(公告)号：US4662942A
公开(公告)日：1987-05-05
申请号：US778729
申请日：1985-09-20
申请人： Yasuharu Koga , Jiro Yasumura , Mitsuo Nagano
发明人： Yasuharu Koga , Jiro Yasumura , Mitsuo Nagano
IPC分类号： C04B24/18 , C04B24/22 , C04B24/26 , C04B24/30 , C04B24/32 , C04B24/38 , C04B28/02 , C08G12/40 , C04B7/35
CPC分类号： C08G12/40 , C04B24/22 , C04B28/02
摘要： A cement additive comprising at least two fluidizing agents wherein one of the fluidizing agents is a saponified product of a sulfonated styrene-maleic acid copolymer and the other is one or more of a formalin condensate of naphthalenesulfonic acid and a polyoxyethylene-based compound.The cement additive of this invention is added to a cement composition (cement paste, mortar or concrete) and especially prevents a reduction in the fluidity with a lapse of time.
摘要翻译：一种包含至少两种流化剂的水泥添加剂，其中一种流化剂是磺化苯乙烯 - 马来酸共聚物的皂化产物，另一种是萘磺酸和聚氧乙烯基化合物的福尔马林缩合物中的一种或多种。将本发明的水泥添加剂添加到水泥组合物（水泥糊，砂浆或混凝土）中，特别是防止流动性随时间的降低。

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