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1. 发明申请

US20110009471A1 Oligonucleotide analogues and methods utilizing the same 有权
标题翻译：寡核苷酸类似物和利用其的方法
公开(公告)号：US20110009471A1
公开(公告)日：2011-01-13
申请号：US12804500
申请日：2010-07-22
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A61K31/7088 , A61K31/7084 , A61P29/00 , A61P17/06 , A61P31/18 , A61P31/22 , A61P31/16 , A61P35/00 , C07H21/04 , C12P19/34 , G01N33/50
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译：一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

2. 发明授权

US07816333B2 Oligonucleotide analogues and methods utilizing the same 有权
标题翻译：寡核苷酸类似物和利用其的方法
公开(公告)号：US07816333B2
公开(公告)日：2010-10-19
申请号：US11881775
申请日：2007-07-27
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译：一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

3. 发明申请

US20090149404A1 Oligonucleotide analogues and methods utilizing the same 有权
标题翻译：寡核苷酸类似物和利用其的方法
公开(公告)号：US20090149404A1
公开(公告)日：2009-06-11
申请号：US11881775
申请日：2007-07-27
申请人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
发明人： Masakatsu Kaneko , Koji Morita , Takeshi Imanishi
IPC分类号： A61K31/7084 , C12Q1/68 , C07H21/00
CPC分类号： C07H19/10 , C07H19/06 , C07H19/16 , C07H19/20 , Y02P20/55 , Y10T436/143333
摘要： A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which method comprises administering to said mammal in need of such prevention or treatment a pharmaceutically effective amount of an oligonucleotide analogue comprising two or more nucleoside units, wherein at least one of said nucleoside units is a structure of the formula (2): wherein A is methylene; and B is an unsubstituted purin-9-yl, an unsubstituted 2-oxo-pyrimidin-1-yl or a substituted purin-9-yl; or a pharmacologically acceptable salt thereof.
摘要翻译：一种用于预防或治疗哺乳动物的疾病，其可通过所述哺乳动物体内的寡核苷酸类似物或其药理学上可接受的盐的药理学上有用的反义或反应活性可预防或治疗的疾病，所述方法包括向需要的所述哺乳动物施用这样的预防或治疗药物有效量的包含两个或多个核苷单位的寡核苷酸类似物，其中所述核苷单元中的至少一个是式（2）的结构：其中A是亚甲基; 和B是未取代的嘌呤-9-基，未取代的2-氧代 - 嘧啶-1-基或取代的嘌呤-9-基; 或其药理学上可接受的盐。

4. 发明申请

US20090066930A1 MEASUREMENT SYSTEM 失效
标题翻译：测量系统
公开(公告)号：US20090066930A1
公开(公告)日：2009-03-12
申请号：US12207105
申请日：2008-09-09
申请人： Masakatsu Kaneko , Sze Yun Set , Chee Seong Goh , Morisato Namikawa , Yuichi Nagashima , Tomoharu Kotake , Hiroshi Yaguchi
发明人： Masakatsu Kaneko , Sze Yun Set , Chee Seong Goh , Morisato Namikawa , Yuichi Nagashima , Tomoharu Kotake , Hiroshi Yaguchi
IPC分类号： G01C3/08
CPC分类号： G01S7/4812 , G01B11/026 , G01S17/08
摘要： A measurement system 1 for measuring a distance to an object to be measured, includes: a half mirror 10; a measurement light emitting unit 11; a projection unit 12; a light-receiving unit 13; a distance calculation unit 14; and a diffusion lens 16.
摘要翻译：用于测量与待测物体的距离的测量系统1包括：半透半反镜10; 测量发光单元11; 投影单元12; 光接收单元13; 距离计算单元14; 和漫射透镜16。

5. 发明授权

US06631308B1 Off-line teaching apparatus 失效
标题翻译：离线教学仪器
公开(公告)号：US06631308B1
公开(公告)日：2003-10-07
申请号：US09659588
申请日：2000-09-11
申请人： Masakatsu Kaneko , Shinji Aoki
发明人： Masakatsu Kaneko , Shinji Aoki
IPC分类号： G05B1904
CPC分类号： G05B19/425 , G05B2219/35499 , G05B2219/36017 , G05B2219/36183 , G05B2219/39396 , G05B2219/40394
摘要： An off-line teaching apparatus comprises an operation command-receiving means for receiving an operation command inputted via an input/output port from a key input device or a coordinate input device and successively storing the operation command in a buffer; an operation command-reading means for successively reading the operation command stored in the buffer; an operation command-counting means for counting a number of operation commands stored in the buffer; and a confirmation sound-generating means for generating confirmation sound upon receipt of the operation, command by the operation command-receiving means when a counted value obtained by the operation command-counting means is not less than a predetermined number. Accordingly, the operator can be informed, in real time, of the fact that the system responds to the input of the operation command from the operator. Thus, it is possible to improve the operability of the off-line teaching.
摘要翻译：离线示教装置包括操作命令接收装置，用于从键输入装置或坐标输入装置接收经由输入/输出端口输入的操作命令，并将操作命令连续地存储在缓冲器中; 操作命令读取装置，用于连续读取存储在缓冲器中的操作命令; 操作命令计数装置，用于对存储在缓冲器中的操作命令的数量进行计数; 以及确认声音产生装置，用于当由操作命令计数装置获得的计数值不小于预定数量时，在接收到操作时产生确认声音，并由操作命令接收装置发出命令。因此，可以实时地通知操作者系统响应于来自操作者的操作命令的输入。因此，可以提高离线教学的可操作性。

6. 发明授权

US06330495B1 Off-line teaching method and apparatus for the same 失效
标题翻译：离线教学方法和设备相同
公开(公告)号：US06330495B1
公开(公告)日：2001-12-11
申请号：US09161233
申请日：1998-09-28
申请人： Masakatsu Kaneko , Shinji Aoki
发明人： Masakatsu Kaneko , Shinji Aoki
IPC分类号： G05B1500
CPC分类号： B25J9/1671 , G05B19/425 , G05B2219/39083 , G05B2219/39135 , G05B2219/40317 , G05B2219/40479
摘要： The process effected by an application-deciding means as one of constitutive components of a display-processing means is used to start a teaching application corresponding to a robot model designated by using a coordinate input device, of a plurality of robot models displayed on a screen of a monitor to make it possible to perform teaching based on the designated robot model. Accordingly, it is possible to easily start the application corresponding to the designated robot model when the plurality of robot models displayed on the monitor are operated by using a keyboard or a pointing device (for example, a mouse).
摘要翻译：使用由应用决定装置作为显示处理装置的构成部件之一的处理，开始对应于在屏幕上显示的多个机器人模型使用坐标输入装置指定的机器人模型的教学应用的监视器，使得可以基于指定的机器人模型执行教学。因此，通过使用键盘或指示装置（例如鼠标）来操作监视器上显示的多个机器人模型时，可以容易地开始与指定的机器人模型对应的应用。

7. 发明授权

US06256552B1 Method for setting tool-based working condition in off-line teaching 失效
标题翻译：在离线教学中设置工具工作条件的方法
公开(公告)号：US06256552B1
公开(公告)日：2001-07-03
申请号：US09146071
申请日：1998-09-02
申请人： Shinji Aoki , Masakatsu Kaneko
发明人： Shinji Aoki , Masakatsu Kaneko
IPC分类号： G06F1900
CPC分类号： G05B19/40937 , B23K11/252 , Y02P90/265
摘要： A method for setting a tool-based working condition in off-line teaching makes it possible to automatically set an optimum tool-based working condition while referring to specifications of a tool and workpiece-based working conditions so that reduced operation time required for the off-line teaching is efficiently realize. The method comprises steps of designating a welding point on CAD data of a workpiece; a step of retrieving one or more part codes concerning the welding point; a step of obtaining a combination of attribute codes necessary for the welding concerning the retrieved one or more part codes; a step of deciding a workpiece-based working condition on the basis of the obtained combination of attribute codes; a step of judging whether or not the decided workpiece-based working condition is included in specified specifications of a tool; and a step of retrieving a tool-based working condition suitable for the workpiece-based working condition from the specifications of the tool if the workpiece-based working condition is included in the specifications of the tool, so that teaching data is reflected thereby.
摘要翻译：一种用于在离线教学中设定基于工具的工作条件的方法使得可以在参考工具的规格和基于工件的工作条件的同时自动设置最佳的基于工具的工作状态，从而减少关闭所需的操作时间线上教学有效实现。该方法包括以下步骤：指定工件的CAD数据上的焊接点; 检索关于焊接点的一个或多个部件代码的步骤; 获得关于所检索的一个或多个部件代码的焊接所需的属性代码的组合的步骤; 基于所获得的属性代码的组合来确定基于工件的工作条件的步骤; 判断所确定的基于工件的工作状态是否包括在工具的规定规格中的步骤; 以及如果基于工件的工作条件包括在工具的规格中，则从工具的规格检索适合于基于工件的工作条件的基于工具的工作条件的步骤，从而反映教学数据。

8. 发明授权

US06226567B1 Off-line teaching apparatus 失效
标题翻译：离线教学仪器
公开(公告)号：US06226567B1
公开(公告)日：2001-05-01
申请号：US09144472
申请日：1998-08-31
申请人： Masakatsu Kaneko , Shinji Aoki
发明人： Masakatsu Kaneko , Shinji Aoki
IPC分类号： G05B1500
CPC分类号： G05B19/425 , G05B2219/35499 , G05B2219/36017 , G05B2219/36183 , G05B2219/39396 , G05B2219/40394
摘要： An off-line teaching apparatus comprises an operation command-receiving means for receiving an operation command inputted via an input/output port from a key input device or a coordinate input device and successively storing the operation command in a buffer; an operation command-reading means for successively reading the operation command stored in the buffer; an operation command-counting means for counting a number of operation commands stored in the buffer; and a confirmation sound-generating means for generating confirmation sound upon receipt of the operation command by the operation command-receiving means when a counted value obtained by the operation command-counting means is not less than a predetermined number. Accordingly, the operator can be informed, in real time, of the fact that the system responds to the input of the operation command from the operator. Thus, it is possible to improve the operability of the off-line teaching.
摘要翻译：离线示教装置包括操作命令接收装置，用于从键输入装置或坐标输入装置接收经由输入/输出端口输入的操作命令，并将操作命令连续地存储在缓冲器中; 操作命令读取装置，用于连续读取存储在缓冲器中的操作命令; 操作命令计数装置，用于对存储在缓冲器中的操作命令的数量进行计数; 以及确认声音发生装置，用于当由操作命令计数装置获得的计数值不小于预定数量时，通过操作命令接收装置接收到操作命令时产生确认声音。因此，可以实时地通知操作者系统响应于来自操作者的操作命令的输入。因此，可以提高离线教学的可操作性。

9. 发明授权

US5674856A Modified oligodeoxyribonucleoditides 失效
标题翻译：改良的寡脱氧核糖核苷酸
公开(公告)号：US5674856A
公开(公告)日：1997-10-07
申请号：US393510
申请日：1995-02-23
申请人： Hidehiko Furukawa , Kenji Momota , Hitoshi Hotoda , Makoto Koizumi , Masakatsu Kaneko
发明人： Hidehiko Furukawa , Kenji Momota , Hitoshi Hotoda , Makoto Koizumi , Masakatsu Kaneko
IPC分类号： C07H21/02 , A61K31/695 , A61K31/70 , A61K31/711 , A61P31/12 , C07C317/00 , C07C317/50 , C07C323/00 , C07C323/52 , C07H21/00 , C07H21/04 , C08B37/00 , C08F12/00 , C08F20/00 , C08G65/00 , A61K48/00
CPC分类号： C07H21/00 , C07H21/04
摘要： Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.
摘要翻译：提供了用于治疗或预防可能是人的哺乳动物的病毒感染的化合物。这些化合物是寡脱氧核糖核酸衍生物，并且与这些化合物的新途径也与更一般效用的中间体一起提供。活性化合物具有通式（1）：其中R 1，R 2和R 3是氢原子，烷基，如所定义的芳基和如所定义的蒽醌基; Z是碳或硅; 或R 2，R 3和Z一起表示芴基或呫吨; R4是氢原子，如所定义的烷基，如所定义的芳基; Y1，Y3和Y4是氧，硫或> NH; Y2是氧，硫，> NH，亚烷基或亚苯基; X是如所定义的亚烷基; m和n为0〜10; B为链长3〜9的寡脱氧核糖核苷酸; 或其盐。

10. 发明授权

US07110859B2 Setting method and setting apparatus for operation path for articulated robot 有权
标题翻译：铰接式机器人操作路径的设置方法和设定装置
公开(公告)号：US07110859B2
公开(公告)日：2006-09-19
申请号：US10468365
申请日：2001-11-22
申请人： Kaoru Shibata , Ryo Nakajima , Masakatsu Kaneko
发明人： Kaoru Shibata , Ryo Nakajima , Masakatsu Kaneko
IPC分类号： G06F19/00
CPC分类号： B25J9/1666 , B23K11/11 , G05B2219/39094 , G05B2219/45104
摘要： A temporary operation path is set by connecting a plurality of welding points in a virtual space generated by a computer to investigate whether an end effector can be operated along the temporary operation path. If the operation cannot be operated, a path to avoid interference with a workpiece is set automatically while extracting a portion in which the workpiece exists in the internal space surrounded by the end effector in order to set a narrow-area operation path for withdrawing the end effector from a welding point. Next, in order to set a wide-area operation path for making movement between withdrawing points, a template operation is applied, in which the end effector is moved by a prescribed distance in a prescribed direction.
摘要翻译：通过将由计算机生成的虚拟空间中的多个焊接点连接起来来调查末端执行器是否可以沿着临时操作路径操作来设置临时操作路径。如果无法操作操作，则自动设置避免工件干涉的路径，同时在由端部执行器包围的内部空间中提取工件的部分提取部分，以便设置用于取出端部的窄区域操作路径效应器从焊接点。接下来，为了设定用于在抽出点之间移动的广域操作路径，应用模板操作，其中端部执行器沿规定方向移动规定距离。

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