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1. 发明申请

US20050222631A1 Hierarchical data storage and analysis system for implantable medical devices 审中-公开
标题翻译：可植入医疗器械的分层数据存储和分析系统
公开(公告)号：US20050222631A1
公开(公告)日：2005-10-06
申请号：US10819400
申请日：2004-04-06
申请人： Nirav Dalal , Balakrishnan Shankar
发明人： Nirav Dalal , Balakrishnan Shankar
IPC分类号： A61B5/00 , A61N1/372 , A61N1/37
CPC分类号： A61N1/37282 , A61N1/37252 , G06F19/3418
摘要： A hierarchical data storage and analysis system for implantable medical devices is described. In an implementation, a method includes analyzing data collected by an implantable medical device (IMD) by utilizing a set of analytical capabilities. A determination is made, from the analyzing, whether to communicate the data to a computing device having additional analytical capabilities and storage space that are not available at the IMD.
摘要翻译：描述了用于可植入医疗装置的分级数据存储和分析系统。在实现中，一种方法包括通过利用一组分析能力来分析由可植入医疗装置（IMD）收集的数据。从分析中确定是否将数据传送到具有额外分析能力的计算设备和在IMD上不可用的存储空间。

2. 发明授权

US08798740B2 Single chamber leadless intra-cardiac medical device with dual-chamber functionality 有权
标题翻译：具有双室功能的单室无引线心脏内心脏医疗设备
公开(公告)号：US08798740B2
公开(公告)日：2014-08-05
申请号：US13352048
申请日：2012-01-17
申请人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
发明人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
IPC分类号： A61N1/00
CPC分类号： A61N1/3684 , A61N1/0573 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes a housing configured to be implanted entirely within a single local chamber of the heart.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为完全植入心脏的单个局部室内的壳体。

3. 发明授权

US08647675B2 Silver nanoparticle antimicrobial coating for long-term and short-term infection resistance 有权
标题翻译：银纳米颗粒抗菌涂层长期和短期感染抗性
公开(公告)号：US08647675B2
公开(公告)日：2014-02-11
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61K9/14 , A01N55/02
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

4. 发明申请

US20140005605A1 USE OF QUORUM SENSING INHIBITORS AND BIOFILM DISPERSING AGENTS FOR CONTROLLING BIOFILM-ASSOCIATED IMPLANTABLE MEDICAL DEVICE RELATED INFECTIONS 审中-公开
标题翻译：使用感官抑制剂和生物膜分散剂控制生物相关的可植入医疗器械相关感染
公开(公告)号：US20140005605A1
公开(公告)日：2014-01-02
申请号：US13536848
申请日：2012-06-28
申请人： Richard Samade , Prashant Dinesh , Yelena Nabutovsky , Gene A. Bornzin , John W. Poore , Annapurna Karicherla , Nirav Dalal
发明人： Richard Samade , Prashant Dinesh , Yelena Nabutovsky , Gene A. Bornzin , John W. Poore , Annapurna Karicherla , Nirav Dalal
IPC分类号： C09D133/10 , C09D129/04 , C09D167/02 , C09D139/06 , C09D175/04 , A61M5/00 , C09D167/00
CPC分类号： C09D133/10 , A61M5/00 , A61M5/14276 , A61M2205/0205 , A61M2205/0238 , C09D129/04 , C09D133/066 , C09D139/06 , C09D167/00 , C09D167/02 , C09D175/04 , C08K5/3432 , C08K5/1539 , C08L89/00
摘要： A coating on at least a portion of an implantable medical device includes a polymer and an agent that inhibits the formation of biofilms. The agent inhibiting the formation of a biofilm includes a quorum sensing inhibitor (QSI), a biofilm dispersing agent (BDA) or both. The agent may also be delivered via an actuator associated with the implantable medical device.
摘要翻译：可植入医疗装置的至少一部分上的涂层包括抑制生物膜形成的聚合物和试剂。抑制生物膜形成的试剂包括群体感应抑制剂（QSI），生物膜分散剂（BDA）或二者。药剂也可以经由与可植入医疗装置相关联的致动器递送。

5. 发明申请

US20130238085A1 SILVER NANOPARTICLE ANTIMICROBIAL COATING FOR LONG-TERM AND SHORT-TERM INFECTION RESISTANCE 有权
标题翻译：用于长期和短期感染电阻的银纳米抗微生物涂层
公开(公告)号：US20130238085A1
公开(公告)日：2013-09-12
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61F2/02 , A61N1/05 , A61F2/82 , B05D1/00 , A61N1/375
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

6. 发明申请

US20130116738A1 SINGLE CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH DUAL-CHAMBER FUNCTIONALITY 有权
标题翻译：具有双室功能的单室无内科医疗器械
公开(公告)号：US20130116738A1
公开(公告)日：2013-05-09
申请号：US13352048
申请日：2012-01-17
申请人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
发明人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
IPC分类号： A61N1/362 , A61N1/37 , A61M37/00
CPC分类号： A61N1/3684 , A61N1/0573 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes a housing configured to be implanted entirely within a single local chamber of the heart.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为完全植入心脏的单个局部室内的壳体。

7. 发明授权

US07596411B1 Apparatus and method for two-component bioelectrical impedance ratio measuring and monitoring 有权
标题翻译：用于双组分生物电阻抗比测量和监测的装置和方法
公开(公告)号：US07596411B1
公开(公告)日：2009-09-29
申请号：US11760487
申请日：2007-06-08
申请人： Vadim Sokurski , Nirav Dalal
发明人： Vadim Sokurski , Nirav Dalal
IPC分类号： A61N1/00 , A61B5/05
CPC分类号： A61B5/0537 , A61B5/4878 , A61B5/7275 , A61N1/36521
摘要： An implantable cardiac stimulation and rhythm management device includes an impedance measuring circuit which determines a patient's intra-thoracic impedance and the resistance and reactance components of the impedance. The device includes a microcontroller which calculates a ratio (Z/R) which equals the reactance (Z) divided by the resistance (R). The microcontroller is configured to use the calculated ratios to establish a baseline intra-thoracic fluid level, an upper bound relative to the baseline, and a lower bound relative to the baseline, and to monitor the Z/R ratio relative to the baseline and upper and lower bounds. When the Z/R ratios are outside of the established bounds, operating parameters of the stimulation and rhythm management may be altered by the microcontroller.
摘要翻译：可植入心脏刺激和节律管理装置包括阻抗测量电路，其确定患者的胸内阻抗和阻抗的电阻和电抗分量。该装置包括一个微控制器，它计算一个等于电抗（Z）除以电阻（R）的比率（Z / R）。微控制器被配置为使用计算的比率来建立基线胸腔内液位，相对于基线的上限和相对于基线的下限，并且相对于基线和上限监测Z / R比和下限。当Z / R比超出建立的界限时，刺激和节奏管理的操作参数可能由微控制器改变。

8. 发明授权

US07369898B1 System and method for responding to pulsed gradient magnetic fields using an implantable medical device 有权
标题翻译：使用可植入医疗装置对脉冲梯度磁场进行响应的系统和方法
公开(公告)号：US07369898B1
公开(公告)日：2008-05-06
申请号：US11020438
申请日：2004-12-22
申请人： Mark W. Kroll , Gene A. Bornzin , Sergio Shkurovich , Nirav Dalal
发明人： Mark W. Kroll , Gene A. Bornzin , Sergio Shkurovich , Nirav Dalal
IPC分类号： A61N1/08 , A61B5/05
CPC分类号： A61B5/055 , A61N1/36514 , A61N1/3688 , A61N1/37 , A61N1/3718
摘要： Implantable medical devices, such as pacemakers or implantable cardioverter defibrillators (ICDs), are vulnerable to the powerful magnetic fields associated with magnetic resonance imaging (MRI). In particular, pulsed gradient components, if strong enough, can induce parasitic currents that may damage the device or cause parasitic pacing that may trigger an arrhythmia in the patient. The static magnetic field components of the MRI typically do not induce parasitic currents, even though they may be as strong as the pulsed gradient components. Accordingly, techniques are described herein for specifically addressing the pulsed gradient components of the MRI fields so as to reduce the risk of parasitic currents. In one example, a pacemaker switches to tri-state pacing outputs in the presence of strong pulsed gradient magnetic fields. The device continues with normal bi-state pacing outputs so long as the pulsed gradient fields are not strong, even in the presence of a strong static magnetic field. As an added safety feature, the pacemaker switches to fixed-rate ventricular pacing whenever strong static MRI fields are detected.
摘要翻译：可植入的医疗设备，如起搏器或植入式心律转复除颤器（ICD）易受到与磁共振成像（MRI）相关的强大磁场的影响。特别地，如果足够强的脉冲梯度分量可以引起寄生电流，这些寄生电流可能会损坏器件或引起可引发患者心律失常的寄生起搏。 MRI的静态磁场分量通常不会引起寄生电流，即使它们可能与脉冲梯度分量一样强。因此，本文描述了用于专门寻址MRI场的脉冲梯度分量的技术，以便降低寄生电流的风险。在一个示例中，起搏器在存在强脉冲梯度磁场的情况下切换到三态起搏输出。只要脉冲梯度场不强，即使在存在强静态磁场的情况下，器件将继续进行正常的双态起搏输出。作为增加的安全功能，每当检测到强静态MRI场时，起搏器就切换到固定速率心室起搏。

9. 发明授权

US07174216B1 Notification system for implantable cardiac therapy devices 有权
标题翻译：植入式心脏治疗装置通知系统
公开(公告)号：US07174216B1
公开(公告)日：2007-02-06
申请号：US10652982
申请日：2003-08-28
申请人： Nirav Dalal
发明人： Nirav Dalal
IPC分类号： A61N1/00
CPC分类号： A61N1/37282 , G06F19/00 , G16H15/00 , G16H80/00
摘要： An implementation of a technology, described herein, for implantable medical therapy devices and techniques related to notifications related to the use of such devices. One implementation, described herein, provides a notification system for notifying implantable cardiac therapy device (ICTD) patients (and possibly others) in a manner that is comprehensive, integrated, efficient, effective, and quick. This abstract itself is not intended to limit the scope of this patent. The scope of the present invention is pointed out in the appending claims.
摘要翻译：本文描述的用于可植入医疗治疗装置和与使用这种装置有关的通知相关的技术的技术的实现。本文描述的一个实施方式提供了一种通知系统，用于以综合，集成，有效，有效和快速的方式通知可植入心脏治疗装置（ICTD）患者（以及可能的其他患者）。本摘要本身并不旨在限制本专利的范围。在所附权利要求中指出了本发明的范围。

10. 发明授权

US06842645B2 Presentation architecture for network supporting implantable cardiac therapy device 有权
标题翻译：支持植入式心脏治疗装置的网络呈现架构
公开(公告)号：US06842645B2
公开(公告)日：2005-01-11
申请号：US10008592
申请日：2001-11-09
申请人： Nirav Dalal
发明人： Nirav Dalal
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/37282 , G06F19/00 , G16H15/00 , G16H80/00
摘要： A cardiac therapy network architecture collects data output by an implantable cardiac therapy device, processes that data, and distributes it to various knowledge workers. The cardiac therapy network implements a presentation architecture that formats and encodes the data using different formats and protocols to facilitate distribution to and presentation on various computing devices that might be utilized by the knowledge workers.
摘要翻译：心脏治疗网络架构收集由可植入心脏治疗装置输出的数据，处理数据并将其分发给各种知识工作者。心脏治疗网络实现了一种演示架构，其使用不同的格式和协议对数据进行格式化和编码，以便于在知识工作者可能利用的各种计算设备上分发和呈现。

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