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1. 发明申请

US20120197141A1 IMPLANTABLE ECHO DOPPLER FLOW SENSOR FOR MONITORING OF HEMODYNAMICS 审中-公开
标题翻译：用于监测血液动力学的可植入式ECHO多普勒流量传感器
公开(公告)号：US20120197141A1
公开(公告)日：2012-08-02
申请号：US13016101
申请日：2011-01-28
申请人： Guy Vanney , Thao Ngo , Scott Sjoquist , Dorab N. Sethna , Annapurna Karicherla , George K. Lewis , Dan E. Gutfinger , Gene A. Bornzin
发明人： Guy Vanney , Thao Ngo , Scott Sjoquist , Dorab N. Sethna , Annapurna Karicherla , George K. Lewis , Dan E. Gutfinger , Gene A. Bornzin
IPC分类号： A61B5/026
CPC分类号： A61B5/026 , A61B5/02158 , A61B5/6846 , A61B5/6856 , A61B5/6858 , A61B5/686 , A61B5/6862 , A61B5/6869 , A61B5/6882 , A61B8/06 , A61B8/065 , A61B8/12 , A61B8/445
摘要： Systems, devices and methods of monitoring blood flow velocity are disclosed herein. For example, one method of monitoring blood flow velocity includes: locating a blood flow velocity sensor near the ostium in the coronary sinus; and sensing towards a portion of the aorta. A second example method includes: locating a blood flow velocity sensor in a vein; and sensing towards an adjacent artery. A third example method includes: locating a blood flow velocity sensor near the tricuspid valve; and sensing towards a tricuspid valve annulus. A fourth example method includes: locating a blood flow velocity sensor right ventricular outflow tract; and sensing towards a portion of the aorta. A fifth example method includes: locating a blood flow velocity sensor in the great cardiac vein; and sensing towards a left anterior descending artery. A sixth example method includes: locating a blood flow velocity sensor in the right atrial appendage; and sensing towards a portion of the aorta.
摘要翻译：本文公开了监测血流速度的系统，装置和方法。例如，监测血流速度的一种方法包括：将血流速度传感器定位在冠状窦口附近; 并且朝向主动脉的一部分进行感测。第二示例性方法包括：将血流速度传感器定位在静脉中; 并向相邻动脉进行感测。第三示例性方法包括：在三尖瓣附近定位血流速度传感器; 并向三尖瓣环进行感测。第四示例性方法包括：定位血流速度传感器右心室流出道; 并且朝向主动脉的一部分进行感测。第五示例方法包括：在大心脏静脉中定位血流速度传感器; 并向左前降支动脉进行感测。第六示例性方法包括：在右心耳中定位血流速度传感器; 并且朝向主动脉的一部分进行感测。

2. 发明授权

US07389134B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07389134B1
公开(公告)日：2008-06-17
申请号：US11053374
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

3. 发明申请

US20130238085A1 SILVER NANOPARTICLE ANTIMICROBIAL COATING FOR LONG-TERM AND SHORT-TERM INFECTION RESISTANCE 有权
标题翻译：用于长期和短期感染电阻的银纳米抗微生物涂层
公开(公告)号：US20130238085A1
公开(公告)日：2013-09-12
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61F2/02 , A61N1/05 , A61F2/82 , B05D1/00 , A61N1/375
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

4. 发明授权

US07917216B1 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US07917216B1
公开(公告)日：2011-03-29
申请号：US11458649
申请日：2006-07-19
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

5. 发明授权

US07272448B1 Medical lead for placement in the pericardial sac 失效
标题翻译：医疗用铅放置在心包囊内
公开(公告)号：US07272448B1
公开(公告)日：2007-09-18
申请号：US11136786
申请日：2005-05-24
申请人： Kevin L. Morgan , Annapurna Karicherla
发明人： Kevin L. Morgan , Annapurna Karicherla
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： The lead body of a medical lead comprises a distal end portion carrying at least one electrode for placement in the pericardial sac of a human heart. The distal end portion of the lead body includes a multi-turn section having opposed ends, opposing forces applied to the ends tending to flatten the multi-turn section, the multi-turn section being thereby adapted to be retained within the pericardial sac. The turns of the multi-turn section may become progressively smaller from one end of the section to the other end of the section. The multi-turn section may have, in a relaxed state thereof, a generally conical, helical configuration. The at least one electrode may be carried adjacent to the end of the multi-turn section having the larger turns. Alternatively, the at least one electrode may be carried adjacent to the end of the multi-turn section having the smaller turns.
摘要翻译：医用引线的引线体包括承载至少一个用于放置在人心脏心包囊中的电极的远端部分。引线本体的远端部分包括具有相对端部的多匝部分，施加到端部的相对的力倾向于使多匝部分变平，所述多匝部分因此适于保持在心包囊内。多匝部分的匝可以从该部分的一端到该部分的另一端逐渐变小。多匝部分在其松弛状态下可具有大致圆锥形的螺旋形构造。至少一个电极可以靠近具有较大匝数的多匝部分的端部承载。或者，至少一个电极可以承载在具有较小匝数的多匝部分的端部附近。

6. 发明申请

US20130012824A1 CORONARY VENOUS SYSTEM PRESSURE SENSING 审中-公开
标题翻译：冠状静脉系统压力感测
公开(公告)号：US20130012824A1
公开(公告)日：2013-01-10
申请号：US13614620
申请日：2012-09-13
申请人： Guy Vanney , Scott Salys , Thao Ngo , Elizabeth Nee , Annapurna Karicherla , Ravisankar Gurusamy , Gene A. Bornzin
发明人： Guy Vanney , Scott Salys , Thao Ngo , Elizabeth Nee , Annapurna Karicherla , Ravisankar Gurusamy , Gene A. Bornzin
IPC分类号： A61B5/0215
CPC分类号： A61B5/02158 , A61N1/3627 , A61N1/36564 , A61N1/395 , A61N2001/0585
摘要： Disclose herein is a method of measuring pressures in a coronary sinus. In one embodiment, the method includes: introducing a distal portion of a lead or tool into the coronary sinus, wherein the distal portion includes first and second pressure sensors and at least one selectably expandable member; expanding the at least one expandable member such that the first and second sensors are isolated from each other within the coronary sinus; and taking pressure measurements with the first and second sensors when isolated from each other.
摘要翻译：这里公开的是测量冠状窦压力的方法。在一个实施例中，该方法包括：将引导件或工具的远端部分引入冠状窦，其中远端部分包括第一和第二压力传感器和至少一个可选择地可扩张的构件; 膨胀所述至少一个可膨胀构件，使得所述第一和第二传感器在所述冠状窦内彼此隔离; 并且当彼此隔离时，利用第一和第二传感器进行压力测量。

7. 发明授权

US08209031B1 Implantable lead for measuring physiologic information 有权
标题翻译：用于测量生理信息的可植入铅
公开(公告)号：US08209031B1
公开(公告)日：2012-06-26
申请号：US11696962
申请日：2007-04-05
申请人： Rodolfo Rodriguez , Annapurna Karicherla
发明人： Rodolfo Rodriguez , Annapurna Karicherla
IPC分类号： A61N1/05
CPC分类号： A61B5/0215 , A61B5/686 , A61B5/6869 , A61B2562/0247 , A61B2562/0252 , A61N1/056 , A61N1/36564 , H01L41/1132
摘要： An implantable lead includes a lead body, having a distal end and a proximal end, configured to be implanted in a patient, and a connector provided at the proximal end. A load detection assembly is provided on the lead body, wherein the load detection assembly includes a housing that holds a sensor and a load transfer element. The load transfer element engages the sensor and conveys a force induced on the load transfer element to the sensor. Optionally, the housing may isolate the sensor from lateral forces and the load transfer element may only convey, to the sensor, longitudinal forces that are directed in a predetermined single direction. For example, the load transfer element may only convey, to the sensor, longitudinal forces that are directed perpendicular to a surface of the sensor.
摘要翻译：可植入引线包括具有远端和近端的引线体，构造成植入患者体内，以及设置在近端的连接器。负载检测组件设置在引线主体上，其中负载检测组件包括保持传感器和负载传递元件的壳体。负载传递元件与传感器接合并将在负载传递元件上感应的力传递到传感器。可选地，壳体可以将传感器与侧向力隔离，并且负载传递元件可以仅向传感器传送以预定的单个方向指向的纵向力。例如，载荷传递元件可以仅向传感器输送垂直于传感器表面的纵向力。

8. 发明授权

US07908017B1 Lead deployable myocardial infarction patch 有权
标题翻译：引导可部署的心肌梗死贴片
公开(公告)号：US07908017B1
公开(公告)日：2011-03-15
申请号：US11467884
申请日：2006-08-28
申请人： Annapurna Karicherla , Kevin L. Morgan
发明人： Annapurna Karicherla , Kevin L. Morgan
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： A method of delivering a myocardial infarction patch to a surface of a heart is disclosed herein. In one embodiment, the method includes deploying the patch from an intra pericardial lead.
摘要翻译：本文公开了将心肌梗死贴片递送至心脏表面的方法。在一个实施例中，该方法包括从心包内引导部署补片。

9. 发明申请

US20090249617A1 METHOD FOR MAKING IMPLANTABLE MEDICAL DEVICES HAVING CARBON NANOTUBE-BASED ANTI-ELECTROSTATIC COATINGS 审中-公开
标题翻译：制备具有碳纳米管基抗静电涂层的可植入医疗器械的方法
公开(公告)号：US20090249617A1
公开(公告)日：2009-10-08
申请号：US12466975
申请日：2009-05-15
申请人： Annapurna Karicherla , Buehl E. Truex , Sheldon Williams
发明人： Annapurna Karicherla , Buehl E. Truex , Sheldon Williams
IPC分类号： H01R43/00 , B32B9/00 , B32B27/40 , B32B27/06 , B32B27/32
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/3752 , Y10T29/49117 , Y10T428/31551 , Y10T428/31938
摘要： A method of fabricating an implantable medical device having a receptacle adapted to receive a connector assembly attached to a proximal end of an implantable lead. A distal end portion of the implantable lead carries at least one electrode electrically connected with a terminal contact on the connector assembly. The receptacle contains at least one internal insulative sealing surface. An anti-static coating comprising carbon nanotubes is applied to the at least one internal insulative sealing surface.
摘要翻译：一种制造可植入医疗装置的方法，其具有适于容纳连接到可植入引线的近端的连接器组件的插座。可植入引线的远端部分承载与连接器组件上的端子触点电连接的至少一个电极。容器包含至少一个内部绝缘密封表面。将包含碳纳米管的防静电涂层施加到至少一个内部绝缘密封表面。

10. 发明授权

US07450999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07450999B1
公开(公告)日：2008-11-11
申请号：US11053566
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/378
CPC分类号： A61N1/057 , A61B5/02152 , A61B5/02158 , A61B5/6853 , A61B5/6857 , A61B5/6882
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

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