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1. 发明授权

US08647675B2 Silver nanoparticle antimicrobial coating for long-term and short-term infection resistance 有权
标题翻译：银纳米颗粒抗菌涂层长期和短期感染抗性
公开(公告)号：US08647675B2
公开(公告)日：2014-02-11
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61K9/14 , A01N55/02
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

2. 发明申请

US20130238085A1 SILVER NANOPARTICLE ANTIMICROBIAL COATING FOR LONG-TERM AND SHORT-TERM INFECTION RESISTANCE 有权
标题翻译：用于长期和短期感染电阻的银纳米抗微生物涂层
公开(公告)号：US20130238085A1
公开(公告)日：2013-09-12
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61F2/02 , A61N1/05 , A61F2/82 , B05D1/00 , A61N1/375
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

3. 发明申请

US20140005605A1 USE OF QUORUM SENSING INHIBITORS AND BIOFILM DISPERSING AGENTS FOR CONTROLLING BIOFILM-ASSOCIATED IMPLANTABLE MEDICAL DEVICE RELATED INFECTIONS 审中-公开
标题翻译：使用感官抑制剂和生物膜分散剂控制生物相关的可植入医疗器械相关感染
公开(公告)号：US20140005605A1
公开(公告)日：2014-01-02
申请号：US13536848
申请日：2012-06-28
申请人： Richard Samade , Prashant Dinesh , Yelena Nabutovsky , Gene A. Bornzin , John W. Poore , Annapurna Karicherla , Nirav Dalal
发明人： Richard Samade , Prashant Dinesh , Yelena Nabutovsky , Gene A. Bornzin , John W. Poore , Annapurna Karicherla , Nirav Dalal
IPC分类号： C09D133/10 , C09D129/04 , C09D167/02 , C09D139/06 , C09D175/04 , A61M5/00 , C09D167/00
CPC分类号： C09D133/10 , A61M5/00 , A61M5/14276 , A61M2205/0205 , A61M2205/0238 , C09D129/04 , C09D133/066 , C09D139/06 , C09D167/00 , C09D167/02 , C09D175/04 , C08K5/3432 , C08K5/1539 , C08L89/00
摘要： A coating on at least a portion of an implantable medical device includes a polymer and an agent that inhibits the formation of biofilms. The agent inhibiting the formation of a biofilm includes a quorum sensing inhibitor (QSI), a biofilm dispersing agent (BDA) or both. The agent may also be delivered via an actuator associated with the implantable medical device.
摘要翻译：可植入医疗装置的至少一部分上的涂层包括抑制生物膜形成的聚合物和试剂。抑制生物膜形成的试剂包括群体感应抑制剂（QSI），生物膜分散剂（BDA）或二者。药剂也可以经由与可植入医疗装置相关联的致动器递送。

4. 发明授权

US08798740B2 Single chamber leadless intra-cardiac medical device with dual-chamber functionality 有权
标题翻译：具有双室功能的单室无引线心脏内心脏医疗设备
公开(公告)号：US08798740B2
公开(公告)日：2014-08-05
申请号：US13352048
申请日：2012-01-17
申请人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
发明人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
IPC分类号： A61N1/00
CPC分类号： A61N1/3684 , A61N1/0573 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes a housing configured to be implanted entirely within a single local chamber of the heart.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为完全植入心脏的单个局部室内的壳体。

5. 发明申请

US20130116738A1 SINGLE CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH DUAL-CHAMBER FUNCTIONALITY 有权
标题翻译：具有双室功能的单室无内科医疗器械
公开(公告)号：US20130116738A1
公开(公告)日：2013-05-09
申请号：US13352048
申请日：2012-01-17
申请人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
发明人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
IPC分类号： A61N1/362 , A61N1/37 , A61M37/00
CPC分类号： A61N1/3684 , A61N1/0573 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes a housing configured to be implanted entirely within a single local chamber of the heart.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为完全植入心脏的单个局部室内的壳体。

6. 发明授权

US07418868B1 Pressure sensor and method of fabricating such a module 有权
标题翻译：压力传感器及其制造方法
公开(公告)号：US07418868B1
公开(公告)日：2008-09-02
申请号：US11359952
申请日：2006-02-21
申请人： Annapurna Karicherla , Sheldon Williams , Gene A. Bornzin , John W. Poore , Dion F. Davis
发明人： Annapurna Karicherla , Sheldon Williams , Gene A. Bornzin , John W. Poore , Dion F. Davis
IPC分类号： G01L7/00
CPC分类号： G01L19/142 , G01L19/0046 , G01L19/0061 , G01L19/0645
摘要： A body fluid pressure sensor module according to the invention comprises a housing having a first end and a second end and enclosing a pressure sensor. The pressure sensor is electrically coupled to a plurality of electrical conductors extending into the housing through a feedthrough disposed within, and hermetically sealing, the first end of the housing. The housing defines a chamber disposed between the feedthrough and the second end of the housing. The chamber contains a material in communication with the pressure sensor, the material being capable of transmitting pressure variations to the pressure sensor. The plurality of electrical conductors have ends within the housing, and the pressure sensor is mounted on the end of at least one of the conductors. Also disclosed are medical leads incorporating the pressure sensor module, and methods for fabricating the modules. The pressure sensor module is compact, and particularly so where cable conductors are utilized and the sensor is directly mounted on at least one of the cable conductors. The compactness of a pressure sensor module pursuant to the invention facilitates its incorporation into a small diameter, flexible medical lead enhancing its placement within a patient's body, for example, within the left atrium of the heart.
摘要翻译：根据本发明的体液压力传感器模块包括具有第一端和第二端并且包围压力传感器的壳体。压力传感器电耦合到通过设置在壳体的第一端内并且密封地密封壳体中的馈通部延伸到壳体中的多个电导体。壳体限定设置在馈通和壳体的第二端之间的室。该室包含与压力传感器连通的材料，该材料能够将压力变化传递到压力传感器。多个电导体具有在壳体内的端部，并且压力传感器安装在至少一个导体的端部上。还公开了结合压力传感器模块的医疗引线以及用于制造模块的方法。压力传感器模块是紧凑的，特别是在使用电缆导体并且传感器直接安装在至少一个电缆导体上的情况下。根据本发明的压力传感器模块的紧凑性便于其结合到小直径的柔性医疗引线中，从而增强其在患者身体内的放置，例如在心脏的左心房内。

7. 发明授权

US08175668B1 Implantable multi-wavelength venous oxygen saturation and hematocrit sensor and method 有权
标题翻译：可植入多波长静脉血氧饱和度和血细胞比容传感器及方法
公开(公告)号：US08175668B1
公开(公告)日：2012-05-08
申请号：US11877056
申请日：2007-10-23
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/1459 , A61N1/36557
摘要： An intravenous implantable optical sensor assesses the relative absorbance of multiple wavelengths of light in order to determine oxygen saturation. The calculation of oxygen saturation is enhanced by use of a function of hematocrit which is derived from the relative absorbance of light of an isobestic wavelength along two different length paths through the blood. The use of the hematocrit-dependent term and multiple wavelengths of light to calculate oxygen saturation provides results that are less susceptible to noise and variation in hematocrit and thus provides a more accurate measure of oxygen saturation over a wider range of conditions than previously possible. The optical sensor may form part of an implantable system which performs the calculation of oxygen saturation and uses the results for a diagnostic or therapeutic purpose.
摘要翻译：静脉注射光学传感器评估多个波长的光的相对吸光度以确定氧饱和度。通过使用血细胞比容的功能来提高氧饱和度的计算，血细胞比容的功能来源于通过血液的两条不同长度路径的异质波长的光的相对吸光度。使用血细胞比容相关术语和多个波长的光来计算氧饱和度提供的结果不太容易受噪声和血细胞比容的变化，因此在比以前可能的更宽的条件下提供更准确的氧饱和度测量。光学传感器可以形成可执行氧饱和度的计算的可植入系统的一部分，并将结果用于诊断或治疗目的。

8. 发明申请

US20110098546A1 ASSESSING MEDICAL CONDITIONS BASED ON VENOUS OXYGEN SATURATION AND HEMATOCRIT INFORMATION 审中-公开
标题翻译：基于静脉氧饱和度和血压信息评估医疗条件
公开(公告)号：US20110098546A1
公开(公告)日：2011-04-28
申请号：US12976493
申请日：2010-12-22
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/029 , A61B5/04001 , A61B5/0464 , A61B5/0816 , A61B5/14535 , A61B5/14539 , A61B5/7285 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： Methods for assessing, diagnosing and treating medical conditions using SvO2 and hematocrit measurements alone, or in combination with other measurements related to cardiac activity are provided. These includes methods for distinguishing true anemia from diluted anemia, methods for anemia detection, methods for measuring disease progression based on anemia trending, methods for managing therapy delivery, methods for managing heart failure drug therapies, methods for cardiac output optimization based on SvO2, methods for cardiac resynchronization therapy lead placement, method for detection of heart failure decompensation, and methods to monitor and treat systolic versus diastolic heart failure are provided.
摘要翻译：提供了使用SvO2和血细胞比容测量单独评估，诊断和治疗医疗条件或与心脏活动相关的其他测量结合的方法。这些包括区分真正贫血与稀释性贫血的方法，贫血检测方法，基于贫血趋势测量疾病进展的方法，管理治疗递送的方法，管理心力衰竭药物治疗的方法，基于SvO2的心输出优化方法用于心脏再同步治疗铅放置，心脏失代偿失代偿检测方法以及监测和治疗心脏收缩期与舒张性心力衰竭的方法。

9. 发明授权

US08385999B1 Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
标题翻译：在植入式传感器中处理静脉血氧饱和度和血细胞比容信息
公开(公告)号：US08385999B1
公开(公告)日：2013-02-26
申请号：US12028261
申请日：2008-02-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/00
CPC分类号： A61N1/39 , A61B5/0031 , A61B5/14535 , A61B5/14551 , A61B5/4836 , A61N1/362
摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.
摘要翻译：提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。对光检测器的输出进行采样以测量透射光的强度。对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

10. 发明授权

US07630078B1 Calibrating implantable optical sensors 失效
标题翻译：校准植入光学传感器
公开(公告)号：US07630078B1
公开(公告)日：2009-12-08
申请号：US11683521
申请日：2007-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： G01B9/08
CPC分类号： A61B5/14542 , A61B5/02028 , A61B5/14535 , A61B5/1459 , A61B2560/0223 , A61N1/36557
摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度光源。基于由校准光检测器产生的校准信号来补偿透射光强度的变化。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

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