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1. 发明授权

US09017341B2 Multi-piece dual-chamber leadless intra-cardiac medical device and method of implanting same 有权
标题翻译：多片双室无引线心脏内心脏医疗器械及其植入方法
公开(公告)号：US09017341B2
公开(公告)日：2015-04-28
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61B19/00 , A61N1/05 , A61N1/375 , A61N1/372 , A61N1/365
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为锚定在心脏的第一腔室的第一壁部分内的电极组件。电极组件包括具有第一固定螺旋线的电极主体，从主体延伸的电极线段和位于电极线段上的第一段终止触点。该装置还包括壳体组件，其构造成锚固在心脏的第二腔室的第二壁部分内。壳体组件包括具有第二固定螺旋的主体，从主体延伸的壳体线段和位于壳体线段上的第二段终止触点。该装置还包括连接器块，其通过保持第一和第二段终止触点将电极线段电连接到壳体线段。

2. 发明授权

US09008777B2 Leadless intra-cardiac medical device with reduced number of feed-thrus 有权
标题翻译：无铅心脏内心脏医疗器械，饲料数量减少
公开(公告)号：US09008777B2
公开(公告)日：2015-04-14
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/00 , A61N1/375 , A61N1/368
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.
摘要翻译：无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。第一电极从端盖的近端突出。心脏内（IC）装置延伸部从电池盒的远端伸出。该延伸部包括电连接到电池壳体的第二电极。第二电极远离LIMD远端。电子模块位于端盖的内部空腔内并与第一和第二电极连通。

3. 发明授权

US08731665B1 Posture detection using pressure and other physiologic sensors 有权
标题翻译：使用压力和其他生理传感器的姿势检测
公开(公告)号：US08731665B1
公开(公告)日：2014-05-20
申请号：US11923286
申请日：2007-10-24
申请人： Xiaoyi Min , Laleh Jalali , Steve Koh , Gene A. Bornzin , Euljoon Park
发明人： Xiaoyi Min , Laleh Jalali , Steve Koh , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61N1/36535
摘要： Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.
摘要翻译：提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

4. 发明授权

US08700181B2 Single-chamber leadless intra-cardiac medical device with dual-chamber functionality and shaped stabilization intra-cardiac extension 有权
标题翻译：单室无引线心脏内心脏医疗器械，具有双室功能和形状稳定心脏扩张
公开(公告)号：US08700181B2
公开(公告)日：2014-04-15
申请号：US13352101
申请日：2012-01-17
申请人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/3684 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) configured to be implanted entirely within a heart of a patient includes a housing configured to be securely attached to an interior wall portion of a chamber of the heart, and a stabilizing intra-cardiac (IC) device extension connected to the housing. The stabilizing IC device extension may include a stabilizer arm, and/or an appendage arm, or an elongated body or a loop member configured to be passively secured within the heart.
摘要翻译：被配置为完全植入患者心脏的无引线心脏内心脏医疗装置（LIMD）包括被构造成可靠地附接到心脏室的内壁部分的壳体，以及稳定心脏内（IC）设备扩展连接到外壳。稳定IC装置延伸部可以包括稳定器臂和/或附肢臂，或者被配置为被动地固定在心脏内的细长主体或环形构件。

5. 发明授权

US08634912B2 Dual-chamber leadless intra-cardiac medical device with intra-cardiac extension 有权
标题翻译：具有心脏扩张的双室无引导心脏内心脏医疗器械
公开(公告)号：US08634912B2
公开(公告)日：2014-01-21
申请号：US13352136
申请日：2012-01-17
申请人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/3756
摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。心脏内延伸部的稳定臂与相邻的腔室相接合。心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

6. 发明申请

US20130296661A1 SYSTEM AND METHOD FOR IMPLANTING A PHYSIOLOGIC SENSOR ASSEMBLY 有权
标题翻译：用于植入生理传感器组件的系统和方法
公开(公告)号：US20130296661A1
公开(公告)日：2013-11-07
申请号：US13464590
申请日：2012-05-04
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
IPC分类号： A61B5/0205 , A61B5/103 , A61B5/145 , A61B5/0215 , A61B5/0402
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14532
摘要： An implantable physiologic sensor assembly is configured to be implanted within a patient. The assembly includes a module that houses an internal operative chamber, and a flexible pressure-detecting member connected to the module. The module and the pressure-detecting member are separated before implantation into the patient. At least a first end of the pressure-detecting member is configured to be inserted into an artery of the patient and a second end of the pressure-detecting member is connected to the module. The module is configured to be subcutaneously positioned within the patient.
摘要翻译：可植入生理传感器组件被配置为植入患者体内。组件包括容纳内部操作室的模块和连接到模块的柔性压力检测构件。模块和压力检测构件在植入之前被分离到患者体内。压力检测构件的至少第一端构造成插入到患者的动脉中，并且压力检测构件的第二端连接到模块。该模块被配置为皮下置于患者体内。

7. 发明申请

US20130238056A1 RF-POWERED COMMUNICATION FOR IMPLANTABLE DEVICE 审中-公开
标题翻译：用于可植入设备的RF供电通信
公开(公告)号：US20130238056A1
公开(公告)日：2013-09-12
申请号：US13413560
申请日：2012-03-06
申请人： John W. Poore , Gene A. Bornzin
发明人： John W. Poore , Gene A. Bornzin
IPC分类号： A61N1/08
CPC分类号： A61N1/37276 , A61B5/0031 , A61B5/076 , A61B2560/0209
摘要： A communication circuit of an implantable device is coupled to a power source (e.g., including a battery) upon receipt of a radiofrequency (RF) signal at the implantable device. A circuit that controls whether the communication circuit is to be coupled to the power source obtains its power from the received RF signal. Thus, the implantable device is able to perform RF signal monitoring (e.g., RF “sniffing”) without using battery power. Battery power is then used for subsequent communication operations after it has been determined that the implantable device is receiving RF signals (e.g., from a verified external device).
摘要翻译：在可植入装置接收到射频（RF）信号时，可植入装置的通信电路耦合到电源（例如，包括电池）。控制通信电路是否耦合到电源的电路从接收的RF信号获得其功率。因此，可植入装置能够在不使用电池电力的情况下执行RF信号监视（例如，RF“嗅探”）。在确定可植入装置正在接收RF信号（例如，从已验证的外部装置）之后，将电池功率用于随后的通信操作。

8. 发明申请

US20130204312A1 SYSTEMS AND METHODS FOR CONTROLLING PACING INDUCED DYSSYNCHRONY TO REDUCE ISCHEMIC INJURY USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：使用可植入医疗装置来控制皮肤诱导性神经元以减少异常损伤的系统和方法
公开(公告)号：US20130204312A1
公开(公告)日：2013-08-08
申请号：US13365061
申请日：2012-02-02
申请人： Jong Gill , Kwangdeok Lee , Kyungmoo Ryu , Gene A. Bornzin
发明人： Jong Gill , Kwangdeok Lee , Kyungmoo Ryu , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36557 , A61N1/3682 , A61N1/3684 , A61N1/3686
摘要： Techniques are provided for use by an implantable medical device for optimizing the amount of ventricular dyssynchrony induced within a patient during protective pacing. In one example, the device analyzes intracardiac electrogram signals to detect an ischemic event within the heart. The device then delivers pacing stimulus in accordance with adjustable pacing parameters to induce ventricular dyssynchrony within the heart and adjusts the pacing parameters within a range of permissible values to achieve a preferred degree of ventricular dyssynchrony within the patient, so long as there is no significant reduction in left ventricular pumping functionality. Preferably, the pacing parameters are adjusted to maximize or otherwise optimize the degree of dyssynchrony induced within the patient. If a significant reduction in LV pumping functionality is detected, the dyssynchrony-inducing pacing is preferably suspended to avoid any deterioration in the condition of the heart. Techniques for detecting early onset of ischemia are also disclosed.
摘要翻译：技术被提供用于由可植入医疗装置用于在保护性起搏期间优化患者内引起的心室不同步的量。在一个实例中，该装置分析心内电描记信号以检测心脏内的缺血事件。然后，该装置根据可调整的起搏参数提供起搏刺激，以诱导心脏内的心室不同步，并在允许值的范围内调整起搏参数，以在患者体内达到优选的心室不同步程度，只要没有显着的减少在左心室泵功能。优选地，起搏参数被调整以最大化或以其他方式优化患者内诱发的不同步程度。如果检测到LV泵送功能的显着降低，则优选暂停不同步的起搏，以避免心脏状况的任何恶化。还公开了用于检测早期发作缺血的技术。

9. 发明申请

US20130138006A1 SINGLE CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE HAVING DUAL CHAMBER SENSING WITH SIGNAL DISCRIMINATION 审中-公开
标题翻译：具有信号识别的双室感觉的单室无内科医疗设备
公开(公告)号：US20130138006A1
公开(公告)日：2013-05-30
申请号：US13485534
申请日：2012-05-31
申请人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi
发明人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi
IPC分类号： A61B5/042
CPC分类号： A61B5/042 , A61B5/6869 , A61N1/368 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes multiple electrodes that allow for stimulation and sensing of the right ventricle (RV) and sensing of the right atrium (RA), even though it is entirely located in the RV. The LIMD includes a housing having a proximal end configured to engage local tissue in the local chamber and electrodes located at multiple locations along the housing. Sensing circuitry is configured to define a far field (FF) channel between a first combination of the electrodes to sense FF signals occurring in the adjacent chamber. The sensing circuitry is configured to define a near field (NF) channel between a second combination of the electrodes to sense NF signals occurring in the local chamber. A controller is configured to analyze the NF and FF signals to determine whether the NF and FF signals collectively indicate that a validated event of interest occurred in the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗器械（LIMD）包括多个电极，即使完全位于RV中，也能够对右心室（RV）进行刺激和感测，并检测右心房（RA）。 LIMD包括壳体，其具有被配置为接合局部室中的局部组织的近端和位于沿壳体的多个位置处的电极。感测电路被配置为在电极的第一组合之间定义远场（FF）通道，以感测在相邻室中发生的FF信号。感测电路被配置为在电极的第二组合之间限定近场（NF）通道，以感测在局部室中发生的NF信号。控制器被配置为分析NF和FF信号以确定NF和FF信号是否共同表示在邻近室中发生了有效的感兴趣事件。

10. 发明授权

US08449472B2 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for prevention of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏预防房性快速性心律失常
公开(公告)号：US08449472B2
公开(公告)日：2013-05-28
申请号：US12891429
申请日：2010-09-27
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61B5/02 , A61N1/00
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems and method for use therewith are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments are for use with an implantable device that includes one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering Atrial Anti-Tachycardia Pacing (AATP) and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用的方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。具体实施方案用于可植入装置，其包括一个或多个心房电极，用于感测心房颤动（AF）和/或递送心房抗心动过速起搏（AATP）和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

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