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1. 发明申请

US20130238085A1 SILVER NANOPARTICLE ANTIMICROBIAL COATING FOR LONG-TERM AND SHORT-TERM INFECTION RESISTANCE 有权
标题翻译：用于长期和短期感染电阻的银纳米抗微生物涂层
公开(公告)号：US20130238085A1
公开(公告)日：2013-09-12
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61F2/02 , A61N1/05 , A61F2/82 , B05D1/00 , A61N1/375
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

2. 发明授权

US08647675B2 Silver nanoparticle antimicrobial coating for long-term and short-term infection resistance 有权
标题翻译：银纳米颗粒抗菌涂层长期和短期感染抗性
公开(公告)号：US08647675B2
公开(公告)日：2014-02-11
申请号：US13415747
申请日：2012-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Annapurna Karicherla , Nirav Dalal , Prashant Dinesh , Richard Samade , John W. Poore
IPC分类号： A61K9/14 , A01N55/02
CPC分类号： A61K33/38 , A61F2/0077 , A61F2/02 , A61F2/30767 , A61F2/82 , A61F2002/30011 , A61F2002/3084 , A61F2310/0052 , A61K9/1611 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2400/12 , A61L2420/08 , A61N1/05 , A61N1/375 , A61N1/3758 , B05D1/00 , B22F1/0018 , B22F2303/01 , B82Y5/00 , B82Y30/00 , C01P2004/54
摘要： Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.
摘要翻译：本文公开了包括抗微生物层的可植入医疗装置。抗微生物层可以包括第一不同大小的银纳米颗粒，第二不同大小的银纳米颗粒和第三不同大小的银纳米颗粒。抗微生物层在可植入医疗装置的表面上延伸，并且在一些情况下，可植入医疗装置的表面可以用作沉积抗微生物层的基底。

3. 发明申请

US20140005605A1 USE OF QUORUM SENSING INHIBITORS AND BIOFILM DISPERSING AGENTS FOR CONTROLLING BIOFILM-ASSOCIATED IMPLANTABLE MEDICAL DEVICE RELATED INFECTIONS 审中-公开
标题翻译：使用感官抑制剂和生物膜分散剂控制生物相关的可植入医疗器械相关感染
公开(公告)号：US20140005605A1
公开(公告)日：2014-01-02
申请号：US13536848
申请日：2012-06-28
申请人： Richard Samade , Prashant Dinesh , Yelena Nabutovsky , Gene A. Bornzin , John W. Poore , Annapurna Karicherla , Nirav Dalal
发明人： Richard Samade , Prashant Dinesh , Yelena Nabutovsky , Gene A. Bornzin , John W. Poore , Annapurna Karicherla , Nirav Dalal
IPC分类号： C09D133/10 , C09D129/04 , C09D167/02 , C09D139/06 , C09D175/04 , A61M5/00 , C09D167/00
CPC分类号： C09D133/10 , A61M5/00 , A61M5/14276 , A61M2205/0205 , A61M2205/0238 , C09D129/04 , C09D133/066 , C09D139/06 , C09D167/00 , C09D167/02 , C09D175/04 , C08K5/3432 , C08K5/1539 , C08L89/00
摘要： A coating on at least a portion of an implantable medical device includes a polymer and an agent that inhibits the formation of biofilms. The agent inhibiting the formation of a biofilm includes a quorum sensing inhibitor (QSI), a biofilm dispersing agent (BDA) or both. The agent may also be delivered via an actuator associated with the implantable medical device.
摘要翻译：可植入医疗装置的至少一部分上的涂层包括抑制生物膜形成的聚合物和试剂。抑制生物膜形成的试剂包括群体感应抑制剂（QSI），生物膜分散剂（BDA）或二者。药剂也可以经由与可植入医疗装置相关联的致动器递送。

4. 发明授权

US08385999B1 Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
标题翻译：在植入式传感器中处理静脉血氧饱和度和血细胞比容信息
公开(公告)号：US08385999B1
公开(公告)日：2013-02-26
申请号：US12028261
申请日：2008-02-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/00
CPC分类号： A61N1/39 , A61B5/0031 , A61B5/14535 , A61B5/14551 , A61B5/4836 , A61N1/362
摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.
摘要翻译：提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。对光检测器的输出进行采样以测量透射光的强度。对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

5. 发明授权

US07630078B1 Calibrating implantable optical sensors 失效
标题翻译：校准植入光学传感器
公开(公告)号：US07630078B1
公开(公告)日：2009-12-08
申请号：US11683521
申请日：2007-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： G01B9/08
CPC分类号： A61B5/14542 , A61B5/02028 , A61B5/14535 , A61B5/1459 , A61B2560/0223 , A61N1/36557
摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度光源。基于由校准光检测器产生的校准信号来补偿透射光强度的变化。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

6. 发明授权

US08175668B1 Implantable multi-wavelength venous oxygen saturation and hematocrit sensor and method 有权
标题翻译：可植入多波长静脉血氧饱和度和血细胞比容传感器及方法
公开(公告)号：US08175668B1
公开(公告)日：2012-05-08
申请号：US11877056
申请日：2007-10-23
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552 , A61B5/1459 , A61N1/36557
摘要： An intravenous implantable optical sensor assesses the relative absorbance of multiple wavelengths of light in order to determine oxygen saturation. The calculation of oxygen saturation is enhanced by use of a function of hematocrit which is derived from the relative absorbance of light of an isobestic wavelength along two different length paths through the blood. The use of the hematocrit-dependent term and multiple wavelengths of light to calculate oxygen saturation provides results that are less susceptible to noise and variation in hematocrit and thus provides a more accurate measure of oxygen saturation over a wider range of conditions than previously possible. The optical sensor may form part of an implantable system which performs the calculation of oxygen saturation and uses the results for a diagnostic or therapeutic purpose.
摘要翻译：静脉注射光学传感器评估多个波长的光的相对吸光度以确定氧饱和度。通过使用血细胞比容的功能来提高氧饱和度的计算，血细胞比容的功能来源于通过血液的两条不同长度路径的异质波长的光的相对吸光度。使用血细胞比容相关术语和多个波长的光来计算氧饱和度提供的结果不太容易受噪声和血细胞比容的变化，因此在比以前可能的更宽的条件下提供更准确的氧饱和度测量。光学传感器可以形成可执行氧饱和度的计算的可植入系统的一部分，并将结果用于诊断或治疗目的。

7. 发明申请

US20110098546A1 ASSESSING MEDICAL CONDITIONS BASED ON VENOUS OXYGEN SATURATION AND HEMATOCRIT INFORMATION 审中-公开
标题翻译：基于静脉氧饱和度和血压信息评估医疗条件
公开(公告)号：US20110098546A1
公开(公告)日：2011-04-28
申请号：US12976493
申请日：2010-12-22
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/029 , A61B5/04001 , A61B5/0464 , A61B5/0816 , A61B5/14535 , A61B5/14539 , A61B5/7285 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： Methods for assessing, diagnosing and treating medical conditions using SvO2 and hematocrit measurements alone, or in combination with other measurements related to cardiac activity are provided. These includes methods for distinguishing true anemia from diluted anemia, methods for anemia detection, methods for measuring disease progression based on anemia trending, methods for managing therapy delivery, methods for managing heart failure drug therapies, methods for cardiac output optimization based on SvO2, methods for cardiac resynchronization therapy lead placement, method for detection of heart failure decompensation, and methods to monitor and treat systolic versus diastolic heart failure are provided.
摘要翻译：提供了使用SvO2和血细胞比容测量单独评估，诊断和治疗医疗条件或与心脏活动相关的其他测量结合的方法。这些包括区分真正贫血与稀释性贫血的方法，贫血检测方法，基于贫血趋势测量疾病进展的方法，管理治疗递送的方法，管理心力衰竭药物治疗的方法，基于SvO2的心输出优化方法用于心脏再同步治疗铅放置，心脏失代偿失代偿检测方法以及监测和治疗心脏收缩期与舒张性心力衰竭的方法。

8. 发明授权

US07181282B1 Implantable cardiac device with PVC density monitoring, and therapy control and method 有权
标题翻译：具有PVC密度监测的植入心脏装置，以及治疗控制和方法
公开(公告)号：US07181282B1
公开(公告)日：2007-02-20
申请号：US10868272
申请日：2004-06-14
申请人： Rose A. Province , Yelena Nabutovsky , Gene A. Bornzin
发明人： Rose A. Province , Yelena Nabutovsky , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/36514 , A61N1/3702
摘要： An implantable cardiac device provides a learned premature ventricular contraction density function responsive to detected premature ventricular contractions. A current premature ventricular contraction density is then compared to the learned premature ventricular contraction density function to derive an indication of a condition of a heart and/or to control therapy administered to the heart.
摘要翻译：可植入的心脏装置提供了一种学习的早产儿心室收缩密度函数，以响应于检测到的早产性心室收缩。然后将目前的早产性心室收缩密度与学习的早产性心室收缩密度函数进行比较，以得出心脏状态的指示和/或控制施用于心脏的治疗。

9. 发明授权

US08170664B1 Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
标题翻译：使用由其确定的可植入传感器和斜坡来监测心脏病
公开(公告)号：US08170664B1
公开(公告)日：2012-05-01
申请号：US11931165
申请日：2007-10-31
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.
摘要翻译：本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。确定斜率，其中斜率表示在一段时间内生理特性的变化。基于斜率的大小来监测心脏病。在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。根据斜率的变化监测患者心脏病变化。

10. 发明申请

US20090036788A1 SYSTEMS AND METHODS FOR DETECTION OF VT AND VF FROM REMOTE SENSING ELECTRODES 有权
标题翻译：用于从远程感测电极检测VT和VF的系统和方法
公开(公告)号：US20090036788A1
公开(公告)日：2009-02-05
申请号：US12244607
申请日：2008-10-02
申请人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
发明人： Yelena Nabutovsky , Taraneh Ghaffari Farazi , Anders Bjorling , Kjell Noren , Gene A. Bornzin
IPC分类号： A61B5/0456
CPC分类号： A61B5/046 , A61B5/04011 , A61B5/0464 , A61N1/3702 , A61N1/3956
摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.
摘要翻译：提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。然后使用所选择的监测模式进行室性心律失常监测。

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