专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US6117317A Chromatographic column and valve with movable valve sleeve 失效
标题翻译：色谱柱和带可动阀套的阀
公开(公告)号：US6117317A
公开(公告)日：2000-09-12
申请号：US862536
申请日：1997-05-23
申请人： Nicola Jane Dickson , Neil Frazer
发明人： Nicola Jane Dickson , Neil Frazer
IPC分类号： B01D15/08 , B01D15/14 , B01D15/20 , B01D15/22 , G01N30/02 , G01N30/20 , G01N30/56 , G01N30/60
CPC分类号： B01D15/14 , B01D15/206 , B01D15/22 , B01D15/08 , G01N2030/565 , G01N30/02 , G01N30/20 , G01N30/6004
摘要： A chromatography column having at least one central slurry valve positioned at either the top cell assembly and/or the bottom cell assembly. The central slurry valves have a pneumatically actuated valve sleeve which can be shifted to create three different flow configurations. One flow configuration allows for the simultaneous cleaning in place of the flow path used to charge the column with chromatography media and the separate processing of fluid through the chromatography media. The other flow configurations permit the reslurrying and removal of chromatography media from the column, and the subsequent repacking of the column with fresh chromatography media without disassembling the column.
摘要翻译：色谱柱，其具有位于顶部单元组件和/或底部单元组件中的至少一个中央浆料阀。中央浆液阀具有气动致动阀套筒，其可以移动以产生三种不同的流动构造。一个流动配置允许同时清洗来代替用色谱介质对色谱柱充电的流动路径，以及通过色谱介质分离处理流体。其他流动配置允许色谱介质从色谱柱中再浆化和除去，随后用新鲜的色谱介质重新包装色谱柱，而不需要拆卸色谱柱。

2. 发明申请

US20080004346A1 Methods and Compositions for Treatment of Intraepithelial Neoplasia 有权
标题翻译：用于治疗上皮内瘤变的方法和组合
公开(公告)号：US20080004346A1
公开(公告)日：2008-01-03
申请号：US11572349
申请日：2005-07-19
申请人： Neil Frazer , Jonathan Heller , Rocio Lopez , Melissa Rhodes , Ru Chih Huang , Richard Dalby , Niharika Khanna
发明人： Neil Frazer , Jonathan Heller , Rocio Lopez , Melissa Rhodes , Ru Chih Huang , Richard Dalby , Niharika Khanna
IPC分类号： A61K31/015 , A61K31/195 , A61P43/00
CPC分类号： A61K31/015 , A61K31/195
摘要： The present invention provides for compositions, kits and methods for treatment of intraepithelial neoplasia, where the compositions include catecholic butanes, which include NDGA derivatives.
摘要翻译：本发明提供了用于治疗上皮内瘤变的组合物，试剂盒和方法，其中组合物包括儿茶酚丁烷，其包括NDGA衍生物。

3. 发明申请

US20060027502A1 Chromatographic column seal 有权
公开(公告)号：US20060027502A1
公开(公告)日：2006-02-09
申请号：US11247025
申请日：2005-10-11
申请人： Melvyn Gill , Neil Frazer , John Dunkley , Geoff Purdom
发明人： Melvyn Gill , Neil Frazer , John Dunkley , Geoff Purdom
IPC分类号： B01D15/08
CPC分类号： G01N30/6026 , B01D15/22 , G01N30/6004 , G01N30/6017 , G01N2030/522
摘要： A seal on a movable top or bottom plate for use in a chromatography column. The plate is formed of a flow distributor connected to one or more movement rods that control the movement of the top plate within a chromatography column. The plate is formed of two pieces, a flow distributor and a seal plate. The seal plate is mounted on top of the flow distributor and has a seal that is essentially co-terminal with the outer edge of the flow distributor. The seal plate is attached to the flow distributor by one or more pins or threaded bolts and forms a space between them. The one or more pins contain one or more compression means for biasing the seal plate against the flow distributor. An opening is formed in the seal plate for the selective introduction of a pressurized energy source such as compressed air, gas or hydraulic fluid into the space to overcome the compression means. One or more seals are arranged between the seal plate and distributor to maintain the pressurized energy source between the two of them. Optionally the space may contain a closed bladder or reservoir connected to the opening to contain the pressurized energy source.

4. 发明申请

US20060141029A1 Methods and compositions for delivery of catecholic butanes for treatment of diseases 审中-公开
标题翻译：用于递送儿茶酚丁烷用于治疗疾病的方法和组合物
公开(公告)号：US20060141029A1
公开(公告)日：2006-06-29
申请号：US11284110
申请日：2005-11-21
申请人： Jonathan Heller , Neil Frazer , Amy Tsui Collins
发明人： Jonathan Heller , Neil Frazer , Amy Tsui Collins
IPC分类号： A61K9/20 , A61K31/24
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/127 , A61K9/5153 , A61K31/24 , Y02A50/467
摘要： The present invention provides kits, methods and compositions for the treatment of diseases, such as, for example, non-cancer proliferative diseases, neurodegenerative diseases, diabetes and hypertension. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA Compounds in a pharmaceutically acceptable carrier or excipient by various routes of administration.
摘要翻译：本发明提供用于治疗诸如非癌症增殖性疾病，神经变性疾病，糖尿病和高血压的疾病的试剂盒，方法和组合物。本文的组合物含有至少一种儿茶酚丁烷的基本上纯的制剂，包括例如通过各种给药途径在药学上可接受的载体或赋形剂中的NDGA化合物。

5. 发明申请

US20060141025A1 Methods and compositions for delivery of catecholic butanes for treatment of tumors 失效
标题翻译：用于递送儿茶酚丁烷用于治疗肿瘤的方法和组合物
公开(公告)号：US20060141025A1
公开(公告)日：2006-06-29
申请号：US11284111
申请日：2005-11-21
申请人： Ru Huang , Richard Park , Chih-Chuan Chang , Yu-Chuan Liang , David Mold , Elaine Lin , Jonathan Heller , Neil Frazer
发明人： Ru Huang , Richard Park , Chih-Chuan Chang , Yu-Chuan Liang , David Mold , Elaine Lin , Jonathan Heller , Neil Frazer
IPC分类号： A61K9/48 , A61K31/24 , A61K31/205
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0078 , A61K9/1075 , A61K9/1271 , A61K31/205 , A61K31/24
摘要： The present invention provides kits, methods and compositions for the treatment of tumor and other proliferative diseases such as tumors. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.
摘要翻译：本发明提供用于治疗肿瘤和其它增殖性疾病如肿瘤的试剂盒，方法和组合物。本文的组合物含有至少一种儿茶酚丁烷的基本上纯的制剂，包括例如药学上可接受的载体或赋形剂中的NDGA化合物。将诸如NDGA或其衍生物的儿茶酚丁烷通过除了直接注射到受影响组织内的途径或受影响组织上的局部施用而施用于需要治疗的一个或多个受试者。

6. 发明申请

US20090155349A1 METHODS OF TREATING INFLUENZA VIRAL INFECTIONS 审中-公开
标题翻译：治疗流感病毒感染的方法
公开(公告)号：US20090155349A1
公开(公告)日：2009-06-18
申请号：US12280463
申请日：2007-02-23
申请人： Jonathan Daniel Heller , Scott Matthew Laster , Rocio Alejandra Lopez , Neil Frazer
发明人： Jonathan Daniel Heller , Scott Matthew Laster , Rocio Alejandra Lopez , Neil Frazer
IPC分类号： A61K9/127 , A61K31/05 , A61K31/136 , A61K31/225 , A61K31/24 , A61K31/195 , A61K31/351 , A61K31/405 , C12N5/08 , C12N7/06 , A61K9/14 , A61P31/16
CPC分类号： A61K31/085
摘要： Methods are described for treating an influenza viral infection or associated diseases, disorders or mechanisms in a subject, comprising administering to the subject a therapeutically effective amount of a catecholic butane of the general formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represents a hydrogen, a lower alkyl, a lower acyl, an alkylene, or —OR1 and —OR2 each independently represents an unsubstituted or substituted amino acid residue or pharmaceutically acceptable salt thereof; R3, R4, R5, R6, R10, R11, R12 and R13 each independently represents a hydrogen, or a lower alkyl; and R7, R8 and R9 each independently represents a hydrogen, —OH, a lower alkoxy, a lower acyloxy, an unsubstituted or substituted amino acid residue or pharmaceutically acceptable salt thereof, or any two adjacent groups together may be an alkyene dioxy; with the proviso in certain circumstances that where one of R7, R8 and R9 represents a hydrogen, then —OR1, —OR2 and the other two of R7, R8 and R9 do not simultaneously represent —OH.
摘要翻译：描述了用于治疗受试者中的流感病毒感染或相关疾病，病症或机制的方法，包括向受试者施用治疗有效量的通式（I）的儿茶酚丁烷或其药学上可接受的盐：其中R1和 R2各自独立地表示氢，低级烷基，低级酰基，亚烷基或-OR1和-OR2各自独立地表示未取代或取代的氨基酸残基或其药学上可接受的盐; R3，R4，R5，R6，R10，R11，R12和R13各自独立地表示氢或低级烷基; 并且R 7，R 8和R 9各自独立地表示氢，-OH，低级烷氧基，低级酰氧基，未取代或取代的氨基酸残基或其药学上可接受的盐，或任何两个相邻的基团可以是二烷氧基; 条件是在某些情况下，当R 7，R 8和R 9中的一个表示氢时，则-OR 1，-OR 2和R 7，R 8和R 9中的另外两个不同时表示-OH。

7. 发明申请

US20060113232A1 Chromatography columns 审中-公开
公开(公告)号：US20060113232A1
公开(公告)日：2006-06-01
申请号：US11325205
申请日：2006-01-04
申请人： John Dunkley , Neil Frazer , Melvyn Gill
发明人： John Dunkley , Neil Frazer , Melvyn Gill
IPC分类号： B01D15/08
CPC分类号： G01N30/56 , B01D15/20 , B01D15/22 , G01N30/6021 , G01N30/6047 , G01N30/6082 , G01N2030/522 , G01N2030/562 , Y10T29/49721 , G01N30/6004
摘要： The present invention relates to a chromatography column that removes the longitudinal load from the column tube altogether and transfers it to a yoke and stanchion arrangement situated around but external to the column tube. By using the yoke/stanchion system, the central adjuster can be used to move the top end into and out of the housing. Thus, when internal pressure is applied to the column, the tube experiences no longitudinal load. Additionally, the yoke and stanchion design allows for complete removal of the end from the tube without cumbersome disassembly. Moreover, the yoke provides a place to retain the end while the tube is being filled, emptied, cleaned or repaired.

8. 发明授权

US08440648B2 Methods and compositions for treatment of intraepithelial neoplasia 有权
标题翻译：用于治疗上皮内瘤变的方法和组合物
公开(公告)号：US08440648B2
公开(公告)日：2013-05-14
申请号：US11572349
申请日：2005-07-19
申请人： Neil Frazer , Jonathan Heller , Rocio Lopez , Melissa Rhodes , Ru Chih C. Huang , Richard Dalby , Niharika Khanna
发明人： Neil Frazer , Jonathan Heller , Rocio Lopez , Melissa Rhodes , Ru Chih C. Huang , Richard Dalby , Niharika Khanna
IPC分类号： A01N37/12 , A01N37/44 , A01N27/00 , A01N43/00 , A61K31/195 , A61K31/015 , A61K31/33
CPC分类号： A61K31/015 , A61K31/195
摘要： The present invention provides for compositions, kits and methods for treatment of intraepithelial neoplasia, where the compositions include catecholic butanes, which include NDGA derivatives.
摘要翻译：本发明提供了用于治疗上皮内瘤变的组合物，试剂盒和方法，其中组合物包括儿茶酚丁烷，其包括NDGA衍生物。

9. 发明申请

US20110135711A1 Methods and Compositions for Delivery of Catecholic Butanes for Treatment of Tumors 审中-公开
标题翻译：用于递送用于治疗肿瘤的儿茶酚丁烷的方法和组合物
公开(公告)号：US20110135711A1
公开(公告)日：2011-06-09
申请号：US12790894
申请日：2010-05-31
申请人： Ru Chih C. Huang , Richard Park , Chih-Chuan Chang , Yu-Chuan Liang , David Mold , Elaine Lin , Jonathan Heller , Neil Frazer
发明人： Ru Chih C. Huang , Richard Park , Chih-Chuan Chang , Yu-Chuan Liang , David Mold , Elaine Lin , Jonathan Heller , Neil Frazer
IPC分类号： A61K31/225 , A61K31/05 , A61K9/127 , A61K31/09 , A61K31/222 , A61P35/00 , A61P29/00 , A61P31/18
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0078 , A61K9/1075 , A61K9/1271 , A61K31/205 , A61K31/24
摘要： The present invention provides kits, methods and compositions for the treatment of diseases such as cancers. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.
摘要翻译：本发明提供用于治疗诸如癌症的疾病的试剂盒，方法和组合物。本文的组合物含有至少一种儿茶酚丁烷的基本上纯的制剂，包括例如药学上可接受的载体或赋形剂中的NDGA化合物。将诸如NDGA或其衍生物的儿茶酚丁烷通过除了直接注射到受影响组织内的途径或受影响组织上的局部施用而施用于需要治疗的一个或多个受试者。

10. 发明授权

US07728036B2 Methods for delivery of catecholic butanes for treatment of tumors 失效
标题翻译：用于递送儿茶酚丁烷用于治疗肿瘤的方法
公开(公告)号：US07728036B2
公开(公告)日：2010-06-01
申请号：US11284111
申请日：2005-11-21
申请人： Ru Chih C. Huang , Richard Park , Chih-Chuan Chang , Yu-Chuan Liang , David Mold , Elaine Lin , Jonathan Heller , Neil Frazer
发明人： Ru Chih C. Huang , Richard Park , Chih-Chuan Chang , Yu-Chuan Liang , David Mold , Elaine Lin , Jonathan Heller , Neil Frazer
IPC分类号： A61K31/22
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0078 , A61K9/1075 , A61K9/1271 , A61K31/205 , A61K31/24
摘要： The present invention provides kits, methods and compositions for the treatment of tumor and other proliferative diseases such as tumors. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.
摘要翻译：本发明提供用于治疗肿瘤和其它增殖性疾病如肿瘤的试剂盒，方法和组合物。本文的组合物包含至少一种儿茶酚丁烷的基本上纯的制剂，包括例如药学上可接受的载体或赋形剂中的NDGA化合物。将诸如NDGA或其衍生物的儿茶酚丁烷通过除了直接注射到受影响组织内的途径或受影响组织上的局部施用而施用于需要治疗的一个或多个受试者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式