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1. 发明申请

US20120077183A9 Reaction apparatus 有权
标题翻译：反应装置
公开(公告)号：US20120077183A9
公开(公告)日：2012-03-29
申请号：US12381953
申请日：2009-03-18
申请人： David Ward , David Edge , Nelson Nazareth
发明人： David Ward , David Edge , Nelson Nazareth
IPC分类号： C12Q3/00 , C12P19/34 , C12M1/00
CPC分类号： B01L7/52 , B01L3/50851 , B01L2300/0654 , B01L2300/0829 , B01L2300/12 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G01N21/0332 , G01N21/253 , G01N25/486 , G01N2021/0325 , G01N2021/6441
摘要： An apparatus 20 for biological or chemical reactions, in particular PCR, includes a heat removal module 22 adapted to receive snugly a reaction vessel 24 in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module 22 is formed of a thermally conductive material having therein a channel 64 adapted for the flow of a coolant liquid. The heat removal module 22 is constructed with an array of receiving stations 62 for the reception of a corresponding array of reaction vessels 24.
摘要翻译：用于生物或化学反应，特别是PCR的装置20包括适于接收反应容器24的散热模块22，以便在模块和容器之间产生良好的热导率接触。散热模块22由导热材料形成，其中具有适于流动冷却剂液体的通道64。散热模块22由接收站62的阵列构成，用于接收相应阵列的反应容器24。

2. 发明授权

US08597937B2 Reaction apparatus 有权
公开(公告)号：US08597937B2
公开(公告)日：2013-12-03
申请号：US12381953
申请日：2009-03-18
申请人： David Ward , David Edge , Nelson Nazareth
发明人： David Ward , David Edge , Nelson Nazareth
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , B01L3/50851 , B01L2300/0654 , B01L2300/0829 , B01L2300/12 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G01N21/0332 , G01N21/253 , G01N25/486 , G01N2021/0325 , G01N2021/6441
摘要： An apparatus 20 for biological or chemical reactions, in particular PCR, includes a heat removal module 22 adapted to receive snugly a reaction vessel 24 in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module 22 is formed of a thermally conductive material having therein a channel 64 adapted for the flow of a coolant liquid. The heat removal module 22 is constructed with an array of receiving stations 62 for the reception of a corresponding array of reaction vessels 24.

3. 发明申请

US20090263782A1 Reaction apparatus 有权
标题翻译：反应装置
公开(公告)号：US20090263782A1
公开(公告)日：2009-10-22
申请号：US12381953
申请日：2009-03-18
申请人： David Ward , David Edge , Nelson Nazareth
发明人： David Ward , David Edge , Nelson Nazareth
IPC分类号： C12Q3/00 , C12M1/00 , C12P19/34
CPC分类号： B01L7/52 , B01L3/50851 , B01L2300/0654 , B01L2300/0829 , B01L2300/12 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , G01N21/0332 , G01N21/253 , G01N25/486 , G01N2021/0325 , G01N2021/6441
摘要： An apparatus 20 for biological or chemical reactions, in particular PCR, includes a heat removal module 22 adapted to receive snugly a reaction vessel 24 in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module 22 is formed of a thermally conductive material having therein a channel 64 adapted for the flow of a coolant liquid. The heat removal module 22 is constructed with an array of receiving stations 62 for the reception of a corresponding array of reaction vessels 24.
摘要翻译：用于生物或化学反应，特别是PCR的装置20包括适于接收反应容器24的散热模块22，以便在模块和容器之间产生良好的热导率接触。散热模块22由导热材料形成，其中具有适于流动冷却剂液体的通道64。散热模块22由接收站62的阵列构成，用于接收相应阵列的反应容器24。

4. 发明申请

US20120183965A1 NUCLEIC ACID DETECTION 审中-公开
标题翻译：核酸检测
公开(公告)号：US20120183965A1
公开(公告)日：2012-07-19
申请号：US13261083
申请日：2010-06-14
申请人： David Ward , David Edge , Nelson Nazareth
发明人： David Ward , David Edge , Nelson Nazareth
IPC分类号： G01N21/64 , C12M1/40 , G01N21/17
CPC分类号： G01N21/6428 , B01L7/52 , B01L2300/0838 , B01L2400/0421 , C12Q1/686 , G01N21/645 , G01N27/447 , G01N27/44726 , G01N2021/0346 , G01N2021/6439 , G01N2021/6482 , C12Q2565/125 , C12Q2565/102 , C12Q2537/143
摘要： Apparatus for detecting a plurality of analytes in a sample and comprising: a reaction vessel; means for subjecting a sample in the reaction vessel to a multiplication process; a separation stage operable to separate amplimer constituents according to size; optical detection means for quantifying the sizes present and determining the colour of each size; and means for comparing the resulting quantification and colours with known data to determine the nature of the or each or a proportion of the or each target amplimers present. Processes employing the apparatus are also described.
摘要翻译：用于检测样品中多种分析物的装置，包括：反应容器; 用于使反应容器中的样品经受乘法的装置; 分离阶段，可操作以根据尺寸分离放大成分; 光学检测装置，用于量化存在的尺寸并确定每种尺寸的颜色; 以及用于将得到的定量和颜色与已知数据进行比较以确定存在的或每个或每个目标扩增子的比例的性质的装置。还描述了使用该装置的过程。

5. 发明授权

US11447767B2 Apparatus for and methods of the disruption of a biological cell 有权
公开(公告)号：US11447767B2
公开(公告)日：2022-09-20
申请号：US13261540
申请日：2011-06-15
申请人： Nelson Nazareth , David Ward , David Edge
发明人： Nelson Nazareth , David Ward , David Edge
IPC分类号： C12N15/10 , B01L7/00 , C12N1/06 , F25B21/04 , C12N1/08 , B01L3/00
摘要： Disrupting a biological cell includes freezing, boiling or perhaps alternately freezing and boiling material containing the biological cell using a thermoelectric cell with a working face, and a base face whereof is contiguous with a heat source/sink at a substantially constant temperature. Apparatus for the disruption process includes a peltier cell, a base face, which is flexibly attached to a heat source/sink held at a constant temperature, and a working face contiguous with a reaction vessel or holder thereof. Reversal of the voltage in the peltier cell enables the working face alternately to reach below freezing and above boiling temperatures, and/or with use of a resistive wire on the vessel or holder for heating, with the TEC used purely for cooling. The materials of the base face tend to inhibit disintegration of the peltier cell brought about by expansion and contraction by heat.

6. 发明申请

US20130115670A1 CELL DISRUPTION 审中-公开
标题翻译：细胞破坏
公开(公告)号：US20130115670A1
公开(公告)日：2013-05-09
申请号：US13261540
申请日：2011-06-15
申请人： Nelson Nazareth , David Ward , David Edge
发明人： Nelson Nazareth , David Ward , David Edge
IPC分类号： C12N15/10
CPC分类号： C12N15/1003 , B01L3/5029 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , C12N1/066 , C12N1/08 , F25B21/04
摘要： A process for the disruption of a biological cell comprising freezing, boiling or perhaps alternately freezing and boiling the material containing the biological cell using a thermoelectric cell a base face whereof is contiguous with a heat sink/source held at a substantially constant temperature and a working face . Apparatus for carrying out the disruption process comprises a peltier cell a base face of which is flexibly attached to a heat sink arranged to be kept at a constant temperature of around 50° C. and a working face of which is contiguous with a reaction vessel or a reaction vessel holder. Reversal of the voltage in the peltier cell enables the working face alternately to reach below freezing and above boiling temperatures, and/or with use of a resistive wire on the vessel holder for heating with the TEC used purely for cooling The peltier cell base face is constructed of materials which tend to inhibit disintegration of the peltier cell brought about by expansion and contraction under heat.
摘要翻译：一种用于破坏生物细胞的方法，包括使用热电池冷冻，沸腾或者可能交替地冷冻和沸腾含有生物细胞的材料，其基面与保持在基本上恒定的温度的热沉/源连接，并且工作脸。用于进行破碎过程的装置包括一个珀耳帖细胞，其基面被柔性地附接到散热器，该散热器被设置成保持在约50℃的恒定温度，其工作面与反应容器相连，反应容器支架。在皮肤细胞中的电压反转使得工作面交替地达到低于冰点和沸点以上的温度，和/或使用电阻丝在容器保持器上用于纯化用于冷却的TEC加热珀耳帖细胞基面是由倾向于抑制由加热引起的膨胀和收缩引起的珀耳帖细胞崩解的材料构成。

7. 发明申请

US20170232441A1 APPARATUS AND METHOD FOR THERMOCYCLIC BIOCHEMICAL OPERATIONS 审中-公开
公开(公告)号：US20170232441A1
公开(公告)日：2017-08-17
申请号：US15330040
申请日：2015-01-28
申请人： Nelson Nazareth , David Edge , Adam Tyler
发明人： Nelson Nazareth , David Edge , Adam Tyler
IPC分类号： B01L7/00 , B01L9/06 , G01N21/64 , G01N35/00 , G01N35/02 , B01L3/00 , B01L9/00
CPC分类号： B01L9/523 , B01L3/502753 , B01L3/50851 , B01L7/52 , B01L9/06 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/082 , B01L2200/147 , B01L2300/0654 , B01L2300/0672 , B01L2300/0681 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2400/0421 , C12Q1/6818 , C12Q1/686 , G01N21/01 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N35/0099 , G01N35/028 , G01N2021/6417 , G01N2021/6439 , G01N2021/6484 , G01N2035/00326 , G01N2035/00396 , G01N2201/068
摘要： An amplicon separation apparatus and process for enabling the identification of a plurality of target DNA molecules in a sample such as blood, the apparatus including a consumable and a docking instrument for receiving the consumable. The consumable incorporates a reaction vessel heating station, a reaction vessel content transfer station, an amplicon size separation station, and a reader station. The instrument controls and monitors the consumable and the operation thereof.

8. 发明申请

US20180214879A1 NUCLEIC ACID AMPLIFICATION 审中-公开
公开(公告)号：US20180214879A1
公开(公告)日：2018-08-02
申请号：US15932653
申请日：2016-09-30
申请人： Nelson Nazareth , David Edge , Adam Tyler
发明人： Nelson Nazareth , David Edge , Adam Tyler
IPC分类号： B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/508 , B01L2200/04 , B01L2200/12 , B01L2300/042 , B01L2300/0672 , B01L2300/0851 , B01L2300/0883 , B01L2300/12 , B01L2300/18 , C12Q1/68 , C12Q1/686 , G01N21/0303 , G01N2021/6439
摘要： A nucleic acid amplification (NAA) reaction vessel includes two opposing major walls a minor wall system, having two minor walls which are attached to the major walls, define a reaction chamber having a base, with the major and minor walls being formed of a thermally conductive material. An inlet port permits the introduction of fluid into the reaction vessel, and a cap is arranged for sealing the inlet port. A light transmissive window is located at the base of the vessel reaction chamber. The vessel has a capacity greater than 100 microlitres. Process and apparatus employing the reaction vessel are also described.

9. 发明申请

US20150144299A1 APPARATUS INCLUDING A VESSEL CUP ASSEMBLY FOR HEATING AND COOLING LOW VOLUME BIOLOGICAL REACTION VESSELS AND METHODS ASSOCIATED THEREWITH 审中-公开
标题翻译：装置包括用于加热和冷却低体积生物反应器的血管杯组件及其相关方法
公开(公告)号：US20150144299A1
公开(公告)日：2015-05-28
申请号：US13261654
申请日：2011-11-08
申请人： Nelson Nazareth , David Edge , Antony Drtscoll
发明人： Nelson Nazareth , David Edge , Antony Drtscoll
IPC分类号： F25B21/02 , B65D81/38
CPC分类号： F25B21/02 , B01L7/52 , B01L9/06 , B01L2300/0627 , B01L2300/0832 , B01L2300/1822 , B01L2300/1827 , B01L2300/1894 , B65D81/38
摘要： A vessel cup assembly 98 for receiving a chemical and/or biological reaction process vessel 200 containing reactants and processing the reaction therein includes a reaction vessel receiving portion 100, a heater portion 101, and a cooling portion 102, wherein the assembly is of integral construction.
摘要翻译：用于接纳包含反应物并在其中处理反应的化学和/或生物反应处理容器200的容器杯组件98包括反应容器容纳部分100，加热器部分101和冷却部分102，其中组件是一体构造的。

10. 发明申请

US20080035651A1 Wine bottle serving ware and manufacturing process 审中-公开
标题翻译：酒瓶服务和制造过程
公开(公告)号：US20080035651A1
公开(公告)日：2008-02-14
申请号：US11890999
申请日：2007-08-07
申请人： David Edge
发明人： David Edge
IPC分类号： A47G19/00
CPC分类号： B65D1/0207 , B44C5/00
摘要： A glass wine bottle serving ware and the method of manufacturing that uses a standard glass wine bottle. The outside surface of the bottle is first treated with a cleaning-wetting solution that cleans and removes oil from the surface, and keeps the outside surface fog free. Mini egg shell frits and optional gold mica is then applied to the wet inside surface. A U-shaped copper wire is bent and attached to the top of the wine bottle that will serve as a device for hanging. The bottle is then placed inside a glass kiln. A piece of ceramic is placed under the neck of the bottle to create a bent handle when heating. The wine bottle is then heated in a sequential manner to create a flat, serving ware with a bent handle.
摘要翻译：玻璃酒瓶服务器和使用标准玻璃酒瓶的制造方法。首先用清洁润湿溶液处理瓶的外表面，以清洁和去除表面上的油，并保持外表无雾。然后将迷你蛋壳玻璃料和可选的金云母施加到湿的内表面。 U形铜线弯曲并附着在酒瓶的顶部，将作为悬挂装置。然后将瓶子放置在玻璃窑内。将一块陶瓷放置在瓶颈的下方，以在加热时产生弯曲的手柄。然后将葡萄酒瓶按顺序加热，以形成具有弯曲手柄的平坦的服务器皿。

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