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1. 发明授权

US11649265B2 Compositions and methods for the encapsulation and scalable delivery of agrochemicals 有权
公开(公告)号：US11649265B2
公开(公告)日：2023-05-16
申请号：US16606601
申请日：2018-04-30
申请人： AgroSpheres, Inc.
发明人： Ameer Hamza Shakeel , Sepehr Zomorodi , Joseph Thomas Frank , Zachery George Davis , Payam Pourtaheri
IPC分类号： A01N25/26 , A01N25/28 , C07K14/195 , A01N63/22 , C07K14/32 , C07K14/335 , C07K14/34 , C12N1/08 , C12N9/54 , A01N63/50 , C12N15/62 , C12N9/52 , A61K39/108 , B01F101/04
CPC分类号： C07K14/195 , A01N25/28 , A01N63/22 , A01N63/50 , C07K14/32 , C07K14/335 , C07K14/34 , C12N1/08 , C12N9/52 , C12N9/54 , C12N15/62 , A61K39/0258 , B01F2101/04 , C07K2319/705 , A01N63/50 , A01N63/27 , A01N47/06 , A01N47/24 , A01N47/36 , A01N51/00
摘要： The present disclosure is generally directed to an anucleated cell-based platforms for encapsulation and delivery of agricultural compounds. Disclosed herein are compositions for the stable and targeted delivery of agricultural compounds within achromosomal and/or anucleated cells. The present disclosure also provides methods of improving encapsulation and retention of agricultural compounds in achromosomal and/or anucleated cells.

2. 发明授权

US09574198B2 Bacteria and the uses thereof 有权
标题翻译：细菌及其用途
公开(公告)号：US09574198B2
公开(公告)日：2017-02-21
申请号：US14366333
申请日：2012-12-21
申请人： DEINOVE
发明人： Jean-Paul Leonetti , Juha-Pekka Pitkanen , Paula Jouhten
IPC分类号： C12N15/74 , C12N1/08 , C12P7/06 , C12P23/00 , C12P7/10 , C12N1/20 , C12N13/00 , C12R1/01 , C12N9/04 , C12N9/02
CPC分类号： C12N15/74 , C12N1/08 , C12N1/20 , C12N9/0006 , C12N9/0042 , C12N13/00 , C12P7/065 , C12P7/10 , C12P23/00 , C12R1/01 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to novel bacteria and the uses thereof. The invention particularly relates to bacteria having a metabolic pathway ratio between pentose phosphate and glycolysis greater than 0.5, and their uses in the chemical, pharmaceutical and agro-chemical industries, e.g., for producing compounds of industrial interest.
摘要翻译：本发明涉及新型细菌及其用途。本发明特别涉及具有大于0.5的戊糖磷酸盐和糖酵解之间的代谢途径比例的细菌，以及它们在化学，制药和农业化学工业中的用途，例如用于生产工业上有用的化合物。

3. 发明申请

US20160177291A1 Method and Device for Preparing a Sample of Biological Material Containing Target Cells and Accompanying Cells for Extracting Nucleic Acids of the Target Cells 审中-公开
标题翻译：用于制备含有靶细胞和伴随细胞的生物材料样品用于提取靶细胞的核酸的方法和装置
公开(公告)号：US20160177291A1
公开(公告)日：2016-06-23
申请号：US14910530
申请日：2014-07-30
申请人： ROBERT BOSCH GMBH
发明人： Bernd Faltin , Franz Laermer , Jochen Rupp , Peter Rothacher , Christian Dorrer , Sebastian Berning
IPC分类号： C12N15/10 , C07H1/06 , C12M1/00
CPC分类号： C12N15/1003 , C07H1/06 , C12M47/04 , C12M47/06 , C12N1/06 , C12N1/066 , C12N1/08 , C12N15/1017 , G01N29/00
摘要： A method for preparing a sample of biological materials containing target cells and accompanying cells for extracting nucleic acids of the target cells includes accumulating the target cells of the sample by separating the target cells or the accompanying cells from the sample. The method also includes digesting the target cells via chemical and/or physical lysis in order to produce a target cell lysate containing the nucleic acids of the target cells. The method furthermore includes purifying the nucleic acids from the target cell lysate in order to extract the nucleic acids of the target cells.
摘要翻译：制备含有目标细胞的生物材料样品的方法和用于提取靶细胞核酸的伴随细胞包括通过从样品中分离靶细胞或伴随的细胞来累积样品的靶细胞。该方法还包括通过化学和/或物理裂解消化靶细胞，以产生含有靶细胞核酸的靶细胞裂解物。该方法还包括从靶细胞裂解物纯化核酸以提取靶细胞的核酸。

4. 发明申请

US20120264169A1 DNASE EXPRESSION IN RECOMBINANT HOST CELLS 有权
标题翻译：重组质粒细胞中的DNASE表达
公开(公告)号：US20120264169A1
公开(公告)日：2012-10-18
申请号：US13532268
申请日：2012-06-25
申请人： Michael Dolberg Rasmussen , Jon Martin Persson
发明人： Michael Dolberg Rasmussen , Jon Martin Persson
IPC分类号： C12N9/00 , C12N9/88 , C12P21/00 , C12N9/02 , C12N9/10 , C12N9/90 , C12N1/21 , C12N9/14
CPC分类号： C12N1/08 , C12N9/22 , C12N15/75
摘要： The present invention relates to cells producing at least one polypeptide of interest and expressing one or more recombinant nuclease encoding gene(s) thereby producing the nuclease(s), and methods for producing a polypeptide of interest essentially free from contaminating DNA, said method comprising the steps of: (a) cultivating a cell that produces at least one polypeptide of interest and expresses one or more recombinant nuclease encoding gene(s) thereby producing the nuclease(s); and (b) isolating the polypeptide of interest.
摘要翻译：本发明涉及产生感兴趣的至少一种目的多肽并表达一种或多种重组核酸酶编码基因从而产生核酸酶的细胞，以及用于生产基本上不含污染DNA的目标多肽的方法，所述方法包括步骤：（a）培养产生至少一种目的多肽的细胞，并表达一种或多种重组核酸酶编码基因从而产生核酸酶; 和（b）分离感兴趣的多肽。

5. 发明申请

US20100136547A1 Pure miRNA Sample Preparation Method 审中-公开
标题翻译：纯miRNA样品制备方法
公开(公告)号：US20100136547A1
公开(公告)日：2010-06-03
申请号：US12554606
申请日：2009-09-04
申请人： Kai Qin LAO
发明人： Kai Qin LAO
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1003 , C12N1/06 , C12N1/08 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2330/10 , C12N2330/30 , C12P19/34 , C12Q1/68 , C12N2310/3521
摘要： The present teachings provide novel methods, compositions, and kits for analyzing mature micro RNAs (miRNAs). By taking advantage of the observation that most mature miRNAs in cells are tightly associated with RISCs, the present teachings provide approaches for studying mature miRNAs without the complications of additional nucleic acids. For example, in some embodiments the present teachings provide a method of purifying mature miRNAs comprising heating a sample to form a lysate, and, degrading the additional nucleic acids. The resulting mixture lacks the additional nucleic acids, and contains mature miRNAs associated with RISCs. Liberating the mature miRNAs from RISCs, for example by a protease, a detergent, and/or heat, can result in a pure collection of mature miRNAs.
摘要翻译：本教导提供用于分析成熟微RNA（miRNA）的新型方法，组合物和试剂盒。通过利用细胞中大多数成熟miRNA与RISC紧密相关的观察，本教导提供了研究成熟miRNA而没有附加核酸并发症的方法。例如，在一些实施方案中，本发明提供纯化成熟miRNA的方法，包括加热样品以形成裂解物，并降解其它核酸。所得混合物缺乏额外的核酸，并且含有与RISC相关的成熟miRNA。从RISC解离成熟的miRNA，例如通过蛋白酶，洗涤剂和/或加热，可导致成熟miRNA的纯收集。

6. 发明申请

US20090226962A1 MICROBIAL STRAINS AND PROCESSES FOR THE MANUFACTURE OF BIOMATERIALS 有权
标题翻译：用于制造生物材料的微生物菌株和方法
公开(公告)号：US20090226962A1
公开(公告)日：2009-09-10
申请号：US11924350
申请日：2007-10-25
申请人： Gjalt W. Huisman , Laura Z. Luo , Oliver P. Peoples
发明人： Gjalt W. Huisman , Laura Z. Luo , Oliver P. Peoples
IPC分类号： C12P21/00 , C12N1/21 , C12P7/44 , C12P19/06
CPC分类号： C12N1/08 , C12N9/22 , C12P7/625
摘要： DNA constructs and genetically engineered microbial strains constructed using these DNA constructs, which produce a nuclease enzyme with specificity for DNA and/or RNA, are provided. These strains secrete nuclease into the periplasm or growth medium in an amount effective to enhance productivity and/or recovery of polymer, and are particularly suited for use in high cell density fermentation processes. These constructs are useful for modifying microbial strains to improve production and recovery processes for polymers such as intracellular proteins, such as enzymes, growth factors, and cytokines; for producing polyhydroxyalkanoates; and for producing extracellular polysaccharides, such as xanthan gum, alginates, gellan gum, zooglan, hyaluronic acid and microbial cellulose.
摘要翻译：提供使用这些DNA构建体构建的DNA构建体和遗传工程化的微生物菌株，其产生对DNA和/或RNA具有特异性的核酸酶。这些菌株以有效提高聚合物的生产力和/或回收率的量将核酸酶分泌到周质或生长培养基中，并且特别适用于高细胞密度发酵过程。这些构建体可用于修饰微生物菌株以改善聚合物如细胞内蛋白质如酶，生长因子和细胞因子的生产和回收过程; 用于生产聚羟基链烷酸酯; 并且用于生产细胞外多糖，例如黄原胶，藻酸盐，结冷胶，动物胶，透明质酸和微生物纤维素。

7. 发明申请

US20090047705A1 MICROORGANISM-DERIVED PSYCHROPHILIC ENDONUCLEASE 失效
标题翻译：微生物衍生的磷酸内切酶
公开(公告)号：US20090047705A1
公开(公告)日：2009-02-19
申请号：US11908062
申请日：2006-03-08
申请人： Naoyuki Awazu , Toshihiro Shodai , Hikaru Takakura , Masanari Kitagawa , Hiroyuki Mukai , Ikunoshin Kato
发明人： Naoyuki Awazu , Toshihiro Shodai , Hikaru Takakura , Masanari Kitagawa , Hiroyuki Mukai , Ikunoshin Kato
IPC分类号： C12P21/06 , C12N9/14 , C07H21/04 , C12P19/34 , C12N1/21
CPC分类号： C12N9/22 , C12N1/08 , C12P19/34 , C12P21/00 , C12Q1/6848
摘要： A polypeptide having an endonuclease activity derived from a psychrophilic microorganism Shewanella sp. strain AC10, which exhibits high activity at low temperatures, can remove any nucleic acid present in a protein solution and can reduce the viscosity of a protein extract; and a nucleic acid encoding the polypeptide.
摘要翻译：具有衍生自嗜冷微生物Shewanella sp。的内切核酸酶活性的多肽。在低温下表现出高活性的菌株AC10可以去除蛋白质溶液中存在的任何核酸，并且可以降低蛋白质提取物的粘度; 和编码该多肽的核酸。

8. 发明申请

US20070280914A1 Method and use of a lactic acid bacteria with increased acid tolerance 有权
标题翻译：具有增加耐酸性的乳酸菌的方法和用途
公开(公告)号：US20070280914A1
公开(公告)日：2007-12-06
申请号：US11446648
申请日：2006-06-05
申请人： Eamonn Connolly
发明人： Eamonn Connolly
IPC分类号： A61K35/74 , C12N1/20
CPC分类号： A61K35/747 , A23L33/135 , A23Y2220/71 , C12N1/08 , C12R1/225
摘要： The invention provides certain plasmid cured strains of lactic acid bacteria modified for their capability of better acid-tolerance, a method of modifying such strains, and products containing such strains.
摘要翻译：本发明提供了一些对其耐酸性更好的改良的乳酸菌的某些质粒固化菌株，这种菌株的修饰方法以及含有该菌株的产品。

9. 发明申请

US20050032225A1 Competent bacteria 有权
标题翻译：感染细菌
公开(公告)号：US20050032225A1
公开(公告)日：2005-02-10
申请号：US10655914
申请日：2003-09-05
申请人： Frederick Blattner , Gyorgy Posfai , Christopher Herring , Guy Plunkett , Jeremy Glasner , Trevor Twose
发明人： Frederick Blattner , Gyorgy Posfai , Christopher Herring , Guy Plunkett , Jeremy Glasner , Trevor Twose
IPC分类号： C12N1/08 , C12N1/21 , C12N15/74
CPC分类号： C12N1/08
摘要： The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced genome sizes, are disclosed which are highly transformation competent. A medium and methodology is taught which enables transformation efficiencies to be increased further.
摘要翻译：本发明公开了一种具有遗传工程化至少比其天然母本基因组的基因组小10％的基因组的细菌具有更好的转化能力。公开了具有显着降低的基因组大小的特异性大肠杆菌菌株，其具有高度转化能力。介绍了一种可以进一步提高转换效率的介质和方法。

10. 发明授权

US5739030A Production of food 失效
标题翻译：生产食物
公开(公告)号：US5739030A
公开(公告)日：1998-04-14
申请号：US696821
申请日：1996-08-20
申请人： Philip Nigel Ward
发明人： Philip Nigel Ward
IPC分类号： A23J3/20 , A23J1/18 , C12N1/08 , C12N1/14 , C12R1/77
CPC分类号： C12N1/14 , A23J1/18 , C12N1/08
摘要： The RNA content of Fungi Imperfecti, for example Fusarium graminearum can be reduced with low protein loss by heating it in the presence of its growth medium to a temperature above 68.degree. C. and separating growth medium from it.
摘要翻译： PCT No.PCT / GB95 / 00368 Sec。 371日期：1996年8月20日 102（e）日期1996年8月20日PCT提交1995年2月22日PCT公布。第WO95 / 23843号公报日期1995年9月8日真菌缺陷的RNA含量，例如禾谷镰刀菌，可以通过在其生长培养基存在下将其加热至68℃以上并将生长培养基从其中分离而将蛋白质损失降低。

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