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1. 发明申请

US20100120172A1 SUBSTANCE WITH ANTITHROMBOTIC ACTIVITY AND METHOD FOR DETECTING GLYCOKALLIDIN 审中-公开
标题翻译：具有抗血小板活性的物质和用于检测谷丙素的方法
公开(公告)号：US20100120172A1
公开(公告)日：2010-05-13
申请号：US12548898
申请日：2009-08-27
申请人： Naoyuki Fukuchi , Fumie Futaki , Morikazu Kito , Seiichi Sato , Takayuki Kajiura , Yukitsugu Ono , Koichi Ishii , Akiko Tanaka , Junko Shinozaki , Yasuko Jojima
发明人： Naoyuki Fukuchi , Fumie Futaki , Morikazu Kito , Seiichi Sato , Takayuki Kajiura , Yukitsugu Ono , Koichi Ishii , Akiko Tanaka , Junko Shinozaki , Yasuko Jojima
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , C07K14/755 , C07K2317/52 , C07K2319/00 , C07K2319/30 , G01N33/86 , G01N2333/755
摘要： A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by fusing the carboxyl terminal of a partial protein containing the von Willebrand factor-binding site of glycoprotein Ib with the amino terminal of the Fc region of an immunoglobulin molecule. Then the Fc region of the above immunoglobulin molecule is detected to thereby detect the binding between the von Willebrand factor and the glycoprotein Ib or inhibition of this binding.
摘要翻译：一种方便检测血管性血友病因子与糖蛋白Ⅰb之间的结合的方法及其中使用的方法。固定在反应容器中的存在于布可菌素的反应器中的血管性血友病因子结合于通过将含有糖蛋白1b的血管性血友病变因子结合位点的部分蛋白的羧基末端与羧基末端相连的氨基末端免疫球蛋白分子的Fc区。然后检测上述免疫球蛋白分子的Fc区，从而检测血管性血友病因子与糖蛋白Ib之间的结合或抑制该结合。

2. 发明授权

US07608695B2 Substance with antithrombotic activity and method for detecting glycokallidin 失效
标题翻译：具有抗血栓活性的物质和检测糖蛋白的方法
公开(公告)号：US07608695B2
公开(公告)日：2009-10-27
申请号：US10825127
申请日：2004-04-16
申请人： Naoyuki Fukuchi , Fumie Futaki , Morikazu Kito , Seiichi Sato , Takayuki Kajiura , Yukitsugu Ono , Koichi Ishii , Akiko Tanaka , Junko Shinozaki , Yasuko Jojima
发明人： Naoyuki Fukuchi , Fumie Futaki , Morikazu Kito , Seiichi Sato , Takayuki Kajiura , Yukitsugu Ono , Koichi Ishii , Akiko Tanaka , Junko Shinozaki , Yasuko Jojima
IPC分类号： C12P21/08
CPC分类号： C07K14/705 , C07K14/755 , C07K2317/52 , C07K2319/00 , C07K2319/30 , G01N33/86 , G01N2333/755
摘要： A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric protein constructed by fusing the carboxyl terminal of a partial protein containing the von Willebrand factor-binding site of glycoprotein Ib with the amino terminal of the Fc region of an immunoglobulin molecule. Then the Fc region of the above immunoglobulin molecule is detected to thereby detect the binding between the von Willebrand factor and the glycoprotein Ib or inhibition of this binding.
摘要翻译：一种方便检测血管性血友病因子与糖蛋白Ⅰb之间的结合的方法及其中使用的方法。固定在反应容器中的存在于布可菌素的反应器中的血管性血友病因子结合于通过将含有糖蛋白1b的血管性血友病变因子结合位点的部分蛋白的羧基末端与羧基末端相连的氨基末端免疫球蛋白分子的Fc区。然后检测上述免疫球蛋白分子的Fc区，从而检测血管性血友病因子与糖蛋白Ib之间的结合或抑制该结合。

3. 发明申请

US20120034364A1 USE OF PEPTIDES FOR IMPARTING KOKUMI 有权
标题翻译：使用胶囊切割KOKUMI
公开(公告)号：US20120034364A1
公开(公告)日：2012-02-09
申请号：US13249523
申请日：2011-09-30
申请人： FUMIE FUTAKI , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
发明人： FUMIE FUTAKI , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
IPC分类号： A23L1/227 , C07K5/072
CPC分类号： A23L27/22 , A23L27/21
摘要： The inventors of this invention have conducted the search for a variety of compounds which may possess a desired CaSR agonist activity to thus find out a substance capable of imparting a kokumi, which shows a more excellent kokumi-imparting effect, in particular, a kokumi-imparting effect of the initial taste-imparting type one, which is excellent in the stability and which can easily be produced at a low cost and the present invention thus provide a kokumi-imparting agent consisting of such a substance as well as a complex kokumi-imparting agent comprising the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting agent consisting of γ-Glu-Abu (L-γ-glutamyl-L-2-amino-butyric acid) and a complex kokumi-imparting agent comprising the foregoing substance and another substance having a CaSR agonist activity, in combination.
摘要翻译：本发明的发明人已经进行了可能具有所需CaSR激动剂活性的各种化合物的寻找，从而找出能够赋予kokumi的物质，这表现出更优异的赋粉效果，特别是kokumi- 赋予了稳定性优异且易于以低成本制造的初始味觉赋予型赋予效果，因此本发明提供了由这种物质组成的赋粉剂以及复合的kokumi- 包含该物质和具有CaSR激动剂活性的其它物质组合的赋形剂。更具体地说，本发明提供由γ-Glu-Abu（L-γ-谷氨酰基-L-2-氨基 - 丁酸）和包含上述物质的复合kokumi赋予剂和另一种物质具有CaSR激动剂活性。

4. 发明申请

US20120282386A1 LANTHIONINE DERIVATIVES 有权
标题翻译： LANIONION衍生物
公开(公告)号：US20120282386A1
公开(公告)日：2012-11-08
申请号：US13533469
申请日：2012-06-26
申请人： Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
发明人： Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
IPC分类号： C07D281/06 , A23L1/226
CPC分类号： A23C9/156 , A23L27/204 , C07D281/06 , C07K5/0215
摘要： The present invention provides a variety of compounds having a CaSR agonist activity which possesses a superior kokumi-imparting function, and more particularly provides a kokumi-imparting composition, which contains the foregoing compound, and/or another substance having a CaSR agonist activity, in combination. The present invention also provides a kokumi-imparting composition which includes a lanthionine derivative and/or another substance having a CaSR agonist activity.
摘要翻译：本发明提供了各种具有CaSR激动剂活性的化合物，其具有优异的赋粉功能，更具体地，提供含有上述化合物和/或另一种具有CaSR激动剂活性的物质，赋予赋粉组合物，组合。本发明还提供了一种赋形剂组合物，其包含具有CaSR激动剂活性的叶酸衍生物和/或其它物质。

5. 发明授权

US09844226B2 Use of peptides for imparting kokumi 有权
公开(公告)号：US09844226B2
公开(公告)日：2017-12-19
申请号：US13249523
申请日：2011-09-30
申请人： Fumie Futaki , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
发明人： Fumie Futaki , Reiko Yasuda , Seiichi Sato , Takashi Miyaki , Naohiro Miyamura , Yuzuru Eto
IPC分类号： A23L1/22 , A23L27/22 , A23L27/21
CPC分类号： A23L27/22 , A23L27/21
摘要： A substance is described which is capable of imparting a kokumi, which shows a more excellent kokumi-imparting effect, in particular, the initial taste-imparting type of kokumi-imparting effect, which is excellent in the stability and which can easily be produced at a low cost. Additionally, a kokumi-imparting composition which includes a substance as well as a kokumi-imparting agent including the substance and other substances possessing the CaSR agonist activities in combination. More particularly, the present invention herein provides a kokumi-imparting composition consisting of γ-Glu-Abu (L-γ-glutamyl-L-2-amino-butyric acid) and a complex kokumi-imparting agent which includes the foregoing substance and another substance having a CaSR agonist activity, in combination.

6. 发明授权

US08568814B2 Lanthionine derivatives 有权
标题翻译：黄嘌呤衍生物
公开(公告)号：US08568814B2
公开(公告)日：2013-10-29
申请号：US13533469
申请日：2012-06-26
申请人： Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
发明人： Seiichi Sato , Fumie Futaki , Reiko Yasuda , Sachise Eto , Yumiko Suzuki , Takaho Tajima , Yuzuru Eto , Yuki Tahara
IPC分类号： A23L1/226
CPC分类号： A23C9/156 , A23L27/204 , C07D281/06 , C07K5/0215
摘要： The present invention provides a variety of compounds having a CaSR agonist activity which possesses a superior kokumi-imparting function, and more particularly provides a kokumi-imparting composition, which contains the foregoing compound, and/or another substance having a CaSR agonist activity, in combination. The present invention also provides a kokumi-imparting composition which includes a lanthionine derivative and/or another substance having a CaSR agonist activity.
摘要翻译：本发明提供了各种具有CaSR激动剂活性的化合物，其具有优异的赋粉功能，更具体地，提供含有上述化合物和/或另一种具有CaSR激动剂活性的物质，赋予赋粉组合物，组合。本发明还提供了一种赋形剂组合物，其包含具有CaSR激动剂活性的叶酸衍生物和/或其它物质。

7. 发明授权

US08673168B2 Method for producing silicon fine particles and method for controlling particle diameter of silicon fine particles 失效
标题翻译：硅微粒的制造方法和硅微粒的粒径的控制方法
公开(公告)号：US08673168B2
公开(公告)日：2014-03-18
申请号：US13821603
申请日：2011-09-09
申请人： Seiichi Sato , Mari Miyano , Shigeki Endo , Osamu Shiino , Shingo Ono , Masato Yoshikawa
发明人： Seiichi Sato , Mari Miyano , Shigeki Endo , Osamu Shiino , Shingo Ono , Masato Yoshikawa
IPC分类号： B44C1/22 , C03C15/00 , C03C25/68 , C23F1/00
CPC分类号： B44C1/227 , C01B33/025 , C01B33/037
摘要： An object and project of the present invention is to provide a method for producing silicon fine particles and a method for controlling a particle diameter of silicon fine particles which enable efficient production of silicon fine particles having a uniform particle diameter. A the characteristics of the present invention is producing silicon fine particles having a smaller particle diameter than silicon particles and controlling a particle diameter of silicon fine particles by immersing the silicon particles into an etching solution and irradiating the silicon particles immersed in the etching solution with light having a larger energy than a band gap energy of the silicon particles.
摘要翻译：本发明的目的和项目是提供一种硅微粒的制造方法和控制硅微粒的粒径的方法，能够有效地制造具有均匀粒径的硅微粒。本发明的特征在于制造粒径小于硅粒子的硅微粒，通过将硅粒子浸渍在蚀刻溶液中并照射浸渍在蚀刻溶液中的硅粒子来控制硅微粒的粒径具有比硅颗粒的带隙能量更大的能量。

8. 发明授权

US08575153B2 Pyridine-3-carboxyamide derivative 有权
标题翻译：吡啶-3-甲酰胺衍生物
公开(公告)号：US08575153B2
公开(公告)日：2013-11-05
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/506 , C07D239/48
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂化物。

9. 发明申请

US20120028983A1 NOVEL COMPOUND HAVING 3-HETEROARYLPYRIMIDIN-4-(3H)-ONE STRUCTURE AND PHARMACEUTICAL PREPARATION CONTAINING SAME 失效
标题翻译：具有3-叔丁基嘧啶-4-（3H） - 酮结构的新型化合物和含有它们的药物制备
公开(公告)号：US20120028983A1
公开(公告)日：2012-02-02
申请号：US13263023
申请日：2010-04-16
申请人： Toru Miura , Kazuhiro Onogi , Seiichi Sato , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Kazuhiro Onogi , Seiichi Sato , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： A61K31/53 , C07D403/14 , C07D413/14 , C07D417/14 , A61P13/12 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , C07D401/14 , A61K31/513
CPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Disclosed is a compound which has both an angiotensin-II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, renal diseases, arteriosclerosis, inflammatory diseases, type-2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. [In the formula, A represents a 5- to 10-membered heteroaryl group; R1 and R2 independently represent a C1-6 alkyl group; and each of R3 to R5 is absent or represents H, a halogen atom, OH, NO2, a halo-C1-6 alkyl group, a (substituted) C1-6 alkoxy group, a (substituted) C3-6 cycloalkyloxy group, or a 5- to 10-membered heteroaryl group.]
摘要翻译：公开了具有血管紧张素-II受体拮抗作用和PPARγ活化活性的化合物，可用作高血压，心脏病，心绞痛，脑血管病，脑循环障碍，缺血性外周循环障碍的预防和/或治疗剂肾脏疾病，动脉硬化，炎性疾病，2型糖尿病，糖尿病并发症，胰岛素抵抗综合征，X综合征，代谢综合征和高胰岛素血症。 [式中，A表示5至10元杂芳基; R1和R2独立地表示C1-6烷基; 并且R 3至R 5不存在或表示H，卤素原子，OH，NO 2，卤代C 1-6烷基，（取代的）C 1-6烷氧基，（取代的）C 3-6环烷氧基或 5至10元杂芳基。]

10. 发明授权

US07919203B2 Battery box structure, inter-locking structure of electrical equipment box, and electrical equipment box structure 有权
标题翻译：电池盒结构，电气设备箱的互锁结构和电气箱结构
公开(公告)号：US07919203B2
公开(公告)日：2011-04-05
申请号：US11664699
申请日：2005-10-07
申请人： Kentaro Shibuya , Hiroshi Kosaka , Keishi Kousaka , Koichi Hasegawa , Seiichi Sato
发明人： Kentaro Shibuya , Hiroshi Kosaka , Keishi Kousaka , Koichi Hasegawa , Seiichi Sato
IPC分类号： H01M2/10
CPC分类号： H01M2/105
摘要： A battery box structure includes a battery module, a holding frame which holds the battery module, a case which is made from expanded insulating resin and which stores the holding frame, and an elastic member secured to the holding frame and arranged between the battery module and the case, wherein the elastic member includes an upper wall and flanges extending from both side edges of the upper wall, and wherein a distance between the flanges is substantially the same as a width of a protrusion of the holding frame for securing the elastic member to the holding frame.
摘要翻译：电池盒结构包括电池模块，保持电池模块的保持框架，由膨胀绝缘树脂制成并存储保持框架的壳体，以及固定到保持框架并布置在电池模块和所述弹性构件包括上壁和从所述上壁的两个侧边缘延伸的凸缘，并且所述凸缘之间的距离与用于将所述弹性构件固定的所述保持框架的突起的宽度基本相同保持框架。

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