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1. 发明申请

US20050267148A1 Benzimidazole derivative 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：US20050267148A1
公开(公告)日：2005-12-01
申请号：US11129508
申请日：2005-05-16
申请人： Naoki Tsuchiya , Tsuyoshi Mizuno , Hiroshi Saitou , Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
发明人： Naoki Tsuchiya , Tsuyoshi Mizuno , Hiroshi Saitou , Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
IPC分类号： A61K31/4184 , A61K31/4745 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D471/02
CPC分类号： C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06
摘要： The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.
摘要翻译：本发明是由下式（1）表示的硫代苯并咪唑衍生物或其医学上可接受的盐，其中所述硫代苯并咪唑衍生物及其医学上可接受的盐具有抑制人胃促胰酶的有效活性。因此，它们是临床适用于涉及人胃促胰酶的各种疾病的潜在的预防和/或治疗剂。

2. 发明授权

US06649656B1 Anthranilic acid derivatives 失效
标题翻译：邻氨基苯甲酸衍生物
公开(公告)号：US06649656B1
公开(公告)日：2003-11-18
申请号：US09744388
申请日：2001-04-04
申请人： Naoki Tsuchiya , Susumu Takeuchi , Takumi Takeyasu , Naoki Hase , Takao Yamori , Takashi Tsuruo
发明人： Naoki Tsuchiya , Susumu Takeuchi , Takumi Takeyasu , Naoki Hase , Takao Yamori , Takashi Tsuruo
IPC分类号： A61K31195
CPC分类号： C07D207/08 , C07C235/38 , C07C235/56 , C07C271/16 , C07C271/26 , C07C307/08 , C07C311/07 , C07C311/20 , C07C311/29 , C07C323/25 , C07C323/30 , C07C323/41 , C07C323/42 , C07C323/43 , C07C323/60 , C07C323/62 , C07C327/44 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2602/28 , C07D211/02 , C07D211/46 , C07D213/30 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/82 , C07D213/89 , C07D295/088 , C07D295/185 , C07D307/42 , C07D307/58 , C07D309/10 , C07D405/12
摘要： The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.
摘要翻译：本发明涉及由下式（1）或下式（2）表示的邻氨基苯甲酸衍生物或其药理学上允许的盐或溶剂合物。

3. 发明授权

US06890932B2 Anthranilic acid derivative 失效
标题翻译：邻氨基苯甲酸衍生物
公开(公告)号：US06890932B2
公开(公告)日：2005-05-10
申请号：US10355125
申请日：2003-01-31
申请人： Naoki Tsuchiya , Susumu Takeuchi , Takumi Takeyasu , Naoki Hase , Takao Yamori , Takashi Tsuruo
发明人： Naoki Tsuchiya , Susumu Takeuchi , Takumi Takeyasu , Naoki Hase , Takao Yamori , Takashi Tsuruo
IPC分类号： C07C235/38 , C07C235/56 , C07C271/16 , C07C271/26 , C07C307/08 , C07C311/07 , C07C311/20 , C07C311/29 , C07C323/25 , C07C323/30 , C07C323/41 , C07C323/42 , C07C323/43 , C07C323/60 , C07C323/62 , C07C327/44 , C07D207/08 , C07D211/02 , C07D211/46 , C07D213/30 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/82 , C07D213/89 , C07D295/092 , C07D295/185 , C07D307/42 , C07D307/58 , C07D309/10 , C07D405/12 , A61K31/435 , A01N43/40 , C07D213/00 , C07D213/63
CPC分类号： C07D207/08 , C07C235/38 , C07C235/56 , C07C271/16 , C07C271/26 , C07C307/08 , C07C311/07 , C07C311/20 , C07C311/29 , C07C323/25 , C07C323/30 , C07C323/41 , C07C323/42 , C07C323/43 , C07C323/60 , C07C323/62 , C07C327/44 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2602/28 , C07D211/02 , C07D211/46 , C07D213/30 , C07D213/64 , C07D213/643 , C07D213/70 , C07D213/82 , C07D213/89 , C07D295/088 , C07D295/185 , C07D307/42 , C07D307/58 , C07D309/10 , C07D405/12
摘要： The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.
摘要翻译：本发明涉及由下式（1）或下式（2）表示的邻氨基苯甲酸衍生物或其药理学上允许的盐或溶剂合物。

4. 发明授权

US07268145B2 Thiobenzimidazole derivatives 失效
标题翻译：硫代苯并咪唑衍生物
公开(公告)号：US07268145B2
公开(公告)日：2007-09-11
申请号：US10963710
申请日：2004-10-14
申请人： Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
发明人： Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
IPC分类号： A01N43/42 , A01N43/52 , A61K31/44 , A61K31/415 , C07D513/02
CPC分类号： C07D401/12 , C07D235/28 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.
摘要翻译：本发明是由下式（1）表示的硫代苯并咪唑衍生物或其医学上可接受的盐，其中所述硫代苯并咪唑衍生物及其医学上可接受的盐具有抑制人胃促胰酶的有效活性。因此，它们是临床适用于涉及人胃促胰酶的各种疾病的潜在的预防和/或治疗剂。

5. 发明申请

US20060040976A1 Thiobenzimidazole derivatives 失效
标题翻译：硫代苯并咪唑衍生物
公开(公告)号：US20060040976A1
公开(公告)日：2006-02-23
申请号：US10963710
申请日：2004-10-14
申请人： Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
发明人： Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
IPC分类号： C07D471/02 , A61K31/4745 , A61K31/4184
CPC分类号： C07D401/12 , C07D235/28 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.
摘要翻译：本发明是由下式（1）表示的硫代苯并咪唑衍生物或其医学上可接受的盐，其中所述硫代苯并咪唑衍生物及其医学上可接受的盐具有抑制人胃促胰酶的有效活性。因此，它们是临床适用于涉及人胃促胰酶的各种疾病的潜在的预防和/或治疗剂。

6. 发明申请

US20070275995A1 Thiobenzimidazole derivatives 审中-公开
公开(公告)号：US20070275995A1
公开(公告)日：2007-11-29
申请号：US11797975
申请日：2007-05-09
申请人： Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
发明人： Yoshiyuki Matsumoto , Susumu Takeuchi , Naoki Hase
IPC分类号： A61K31/4164 , A61K31/44 , A61P19/00 , A61P19/02 , A61P37/08 , A61P9/00
CPC分类号： C07D401/12 , C07D235/28 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

7. 发明申请

US20080318961A1 Drugs comprising chymase inhibitors and ACE inhibitors as effective ingredients 审中-公开
标题翻译：包含胃促胰酶抑制剂和ACE抑制剂作为有效成分的药物
公开(公告)号：US20080318961A1
公开(公告)日：2008-12-25
申请号：US12153897
申请日：2008-05-27
申请人： Hidenori Urata , Naoki Hase , Naoki Tsuchiya
发明人： Hidenori Urata , Naoki Hase , Naoki Tsuchiya
IPC分类号： A61K31/5025 , A61K31/506 , A61P9/00 , A61K31/4166
CPC分类号： A61K45/06
摘要： It is an object of the present invention to provide drugs which are effective for treatment of hypertension, cardiac disease (cardiac hypertrophy, cardiac failure, myocardial infarction, etc.), cerebral apoplexy, nephritis and the like. The invention also provides circulatory disease treatment agents in forms that allow combined use of chymase inhibitors and ACE inhibitors, and circulatory disease treatment methods which produce simultaneous chymase inhibition and ACE inhibition.
摘要翻译：本发明的目的是提供对治疗高血压，心脏病（心脏肥大，心力衰竭，心肌梗塞等），脑中风，肾炎等有效的药物。本发明还以允许组合使用胃促胰酶抑制剂和ACE抑制剂的形式提供循环系统疾病治疗剂，以及产生同时胃促胰酶抑制和ACE抑制的循环系统疾病治疗方法。

8. 发明授权

US5808144A Benzene derivatives 失效
标题翻译：苯衍生物
公开(公告)号：US5808144A
公开(公告)日：1998-09-15
申请号：US875284
申请日：1997-07-23
申请人： Masaichi Hasegawa , Takumi Takeyasu , Naoki Tsuchiya , Naoki Hase , Katsushi Takahashi , Takashi Kamimura
发明人： Masaichi Hasegawa , Takumi Takeyasu , Naoki Tsuchiya , Naoki Hase , Katsushi Takahashi , Takashi Kamimura
IPC分类号： C07C235/38 , C07C229/00 , C07C321/00
CPC分类号： C07C235/38 , C07C2101/14
摘要： Novel benzene derivatives of the formula (I) shown below, pharmacological salts thereof, pharmacological solvates of the above-mentioned benzene derivatives and salts, pharmaceutical compositions including, as active ingredients, the above-mentioned compounds, and especially, prophylactic or therapeutic medicines for allergic diseases. ##STR1## wherein R.sup.1 =H, C.sub.1 -C.sub.12 cyclic or straight or branched chain alkyl group (which may be substituted by one or more C.sub.6 -C.sub.10 aryloxy groups), C.sub.7 -C.sub.12 aralkyl group (of which the aryl group may be substituted one or more of halogen, methyl and methoxy, or C.sub.3 -C.sub.10 alkenyl which may be substituted by one or more phenyl groups; A=O, S or CH.sub.2 group, B=CO or CZ.sub.2 CO group (Z=H or F), R.sup.2 =H or C.sub.1 -C.sub.4 alkyl group, X=halogen or methyl group, and Y=H, NO.sub.2 or CN group.
摘要翻译： PCT No.PCT / JP96 / 03456 Sec。 371日期1997年7月23日 102（e）日期1997年7月23日PCT提交1995年11月27日PCT公布。第WO97 / 19910号公报日期：1997年5月6日下述式（I）的新型苯衍生物，其药理学盐，上述苯衍生物和盐的药理学溶剂化物，作为活性成分的上述化合物，特别是预防性或用于过敏性疾病的治疗药物。（I）其中R1 = H，C1-C12环状或直链或支链烷基（其可被一个或多个C 6 -C 10芳氧基取代），C 7 -C 12芳烷基（其芳基可以取代一个或多个卤素，甲基和甲氧基，或可被一个或多个苯基取代的C 3 -C 10链烯基; A = O，S或CH 2基团，B = CO或CZ 2 CO基团（Z = H或F），R2 = H或C1-C4烷基，X =卤素或甲基，Y = H，NO2或CN基团。

9. 发明申请

US20070032466A1 Drug containing chymase inhibitor as the active ingredient 审中-公开
标题翻译：药物含有胃促胰酶抑制剂作为活性成分
公开(公告)号：US20070032466A1
公开(公告)日：2007-02-08
申请号：US10568711
申请日：2004-08-20
申请人： Hidenori Urata , Naoki Hase , Naoki Tsuchiya
发明人： Hidenori Urata , Naoki Hase , Naoki Tsuchiya
IPC分类号： A61K31/513 , A61K31/4745 , A61K31/4184 , A61K31/4412 , A61K31/397 , A61K31/381
CPC分类号： A61K31/00 , A61K31/4184 , C07D413/12
摘要： The present invention provides drugs containing chymase inhibitors as active ingredients for improving glucose intolerance or preventing and/or treating diseases caused by glucose intolerance. The diseases caused by glucose intolerance are diabetes and/or diabetes complications, wherein the diabetes complications include diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, hyperinsulinism, insulin resistance syndrome, arteriosclerosis, acute coronary syndrome, arteriosclerosis obliterans, angitis, stroke, hypertension, renal insufficiency, nephropathy, nephritis, renal artery aneurysm, renal infarction, obesity and the like.
摘要翻译：本发明提供含有胃促胰酶抑制剂作为改善葡萄糖耐受不良或预防和/或治疗由葡萄糖不耐受引起的疾病的活性成分的药物。由葡萄糖不耐受引起的疾病是糖尿病和/或糖尿病并发症，其中糖尿病并发症包括糖尿病性肾病，糖尿病性视网膜病变，糖尿病性周围神经病变，高胰岛素血症，胰岛素抵抗综合征，动脉硬化，急性冠状动脉综合征，闭塞性动脉硬化症，血管炎，中风，高血压，肾功能不全，肾病，肾炎，肾动脉瘤，肾梗死，肥胖等。

10. 发明授权

US08435641B2 Process for producing heat-resistant flexible laminate and heat-resistant flexible laminate produced thereby 有权
标题翻译：由此生产耐热柔性层压材料和耐热柔性层压材料的方法
公开(公告)号：US08435641B2
公开(公告)日：2013-05-07
申请号：US10532766
申请日：2003-10-09
申请人： Takashi Kikuchi , Naoki Hase , Hiroyuki Tsuji , Yasuo Fushiki
发明人： Takashi Kikuchi , Naoki Hase , Hiroyuki Tsuji , Yasuo Fushiki
IPC分类号： B32B27/06 , B32B27/36
CPC分类号： B32B15/08 , B32B7/12 , B32B15/20 , B32B37/0007 , B32B37/26 , B32B2307/306 , B32B2307/734 , B32B2309/105 , B32B2311/00 , B32B2311/12 , B32B2379/08 , B32B2457/08 , H05K1/0393 , H05K3/022 , H05K3/386 , H05K2201/0154 , H05K2201/0355 , H05K2201/068 , H05K2203/068 , Y10T156/10 , Y10T428/31678 , Y10T428/31721
摘要： A method for manufacturing a heat resistant flexible laminate effectively enabling avoidance of not only visual defects but occurrence of dimensional changes, and a heat resistant flexible laminate are provided. In a process for laminating a heat resistant adhesive material and a metallic foil by thermal lamination, a film-like protective material is disposed between a pressurized surface and the metallic foil at the time of thermal lamination. At this time, coefficients of linear expansion in a temperature range of 200 degree C. to 300 degree C. of the heat resistant adhesive material and the protective material are within a range of a coefficient of linear expansion of the metallic foil ±10 ppm/degrees C. Thereby, occurrence of visual defects is not only effectively avoidable, but excellent dimensional change after etching may be exhibited.
摘要翻译：提供了一种制造耐热柔性层压材料的方法，其有效地避免了不仅视觉缺陷，而且避免了尺寸变化的发生，而且提供了耐热柔性层压材料。在通过热层压层压耐热粘合剂材料和金属箔的方法中，在热层压时，膜状保护材料设置在加压表面和金属箔之间。此时，耐热粘合剂材料和保护材料的200℃〜300℃的温度范围内的线膨胀系数在金属箔的线膨胀系数±10ppm / 因此，视觉缺陷的发生不仅可以有效地避免，而且可以显示蚀刻后的优异的尺寸变化。

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