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    • 4. 发明授权
    • High alkaline protease and use thereof
    • 高碱性蛋白酶及其用途
    • US08153413B2
    • 2012-04-10
    • US11719713
    • 2005-11-16
    • Jie LuZhi jun LiSi Hung VoYuji HatadaKen TakaiSusumu ItoKoki Horikoshi
    • Jie LuZhi jun LiSi Hung VoYuji HatadaKen TakaiSusumu ItoKoki Horikoshi
    • C12N9/00C12N9/92C12N1/20C12N15/00C07H21/04
    • C12N9/52
    • The invention aims to provide a novel alkaline protease having peculiar properties such as high alkali activity, resistance to surfactants and calcium-dependent thermostability and exhibiting excellent performance in highly alkaline detergents, and a gene coding for the amino acid sequence thereof. There is provided an alkaline protease with such properties that an active pH range is from 5 to 13, an optimum pH is approximately 12.6, an optimum temperature is 70° C., no activity drop by heating is observed up to 65° C. at pH 10 and the optimum temperature and the thermostability are not affected by Ca2+ ions. Specifically, there is provided, for example, an alkaline protease having an amino acid sequence constituting a mature enzyme as represented by SEQ ID NO: 3 or an amino acid sequence resulting from deletion, substitution, situs inversus arrangement, addition or insertion of a part of amino acids thereof, or derived from Alkaliphillus transvaalensis. The protease cleaves 26 peptide bonds among 29 peptide bonds of acidic insulin B-chain.
    • 本发明的目的在于提供一种具有高碱性,耐表面活性和钙依赖性热稳定性等特性,在高碱性洗涤剂中表现出优异性能的新型碱性蛋白酶及其氨基酸序列的编码基因。 提供了具有这样的性质的碱性蛋白酶,其活性pH范围为5至13,最佳pH为约12.6,最适温度为70℃,在65℃下不观察到加热下的活性降低 pH 10,最佳温度和热稳定性不受Ca2 +离子的影响。 具体地,例如提供了具有SEQ ID NO:3所示的构成成熟酶的氨基酸序列的氨基酸序列的碱性蛋白酶或由缺失,取代,位置反转排列,添加或插入部分 的氨基酸,或衍生自变形白菜(Alkaliphillus transvaalensis)。 蛋白酶在酸性胰岛素B链的29个肽键中切割26个肽键。
    • 6. 发明授权
    • Insert molding method and apparatus therefor
    • 嵌入成型方法及其设备
    • US6054075A
    • 2000-04-25
    • US913963
    • 1997-09-25
    • Yoshiharu InabaSusumu ItoMitsushi Yoshioka
    • Yoshiharu InabaSusumu ItoMitsushi Yoshioka
    • B29C33/12B29C31/00B29C37/00B29C45/14B29C45/42B29K105/20
    • B29C45/14008B29C31/008B29C37/0003B29C37/0007B29C45/42
    • An insert molding method and apparatus not requiring a multiple movable molds and permitting stable insert molding to be performed by means of light, small-sized equipment. A robot for removing a molded product and a robot for placing an insert member are arranged around a mold clamping mechanism, and making them perform removal of a molded product and placement of the insert member, respectively, during a mold opening process of a molding cycle. The molding apparatus does not requirs a plurality of lower molds (stationary molds) and accordingly permits to eliminate a turntable or a sliding table, whereby the molding apparatus can be reduced in size and weight. Further, since only one lower mold suffices to obtain one type of molded products, the manufacturing cost of molds can be reduced and the mold temperature control can be made easier, so that not only the molding conditions are stabilized but also the life of the mold can be prolonged by eliminating the poor positioning.
    • PCT No.PCT / JP97 / 00203 Sec。 371日期:1997年9月25日 102(e)1997年9月25日PCT PCT 1997年1月29日PCT公布。 公开号WO97 / 27985 PCT 日期1997年8月7日一种不需要多个可动模具的插入成型方法和装置,并且允许通过轻型小型设备进行稳定的嵌入成型。 用于移除模制产品的机器人和用于放置插入构件的机器人布置在模具夹持机构周围,并且使它们在模制周期的模具打开过程期间分别执行模制产品的移除和插入构件的放置 。 成型装置不要求多个下模(固定模),因此能够消除转盘或滑台,由此能够减小成型装置的尺寸和重量。 此外,由于只有一个下模具可以获得一种类型的模制产品,因此可以降低模具的制造成本,并且可以使模具温度控制更容易,从而不仅模制条件稳定而且模具的使用寿命 可以通过消除定位不良而延长。
    • 7. 发明授权
    • Nozzle hole sealing device for injection nozzle
    • 注嘴喷嘴孔密封装置
    • US5505606A
    • 1996-04-09
    • US190120
    • 1994-02-03
    • Susumu ItoKatsuyuki YamanakaAkira KouketsuKazunari Ijima
    • Susumu ItoKatsuyuki YamanakaAkira KouketsuKazunari Ijima
    • B29C45/17B29C45/23B29C45/26B29C45/00
    • B29C45/1755B29C45/232
    • A nozzle hole sealing device for an injection nozzle capable of blocking a hole at the tip of a nozzle by using a robot in purging an injection molding machine. The nozzle hole sealing device includes a tool changer for connecting the nozzle hole sealing device to a wrist of the robot and a nozzle sealing body for sealing a nozzle hole by contacting the nozzle tip of the injection molding machine, thereby composing a nozzle sealing robot tool as a whole. A chuck mechanism for keeping a nozzle tip in contact with the nozzle sealing body, a heat reserving heater for a nozzle tip contact portion, and a resin passage ranging from the nozzle tip contact portion to a purged resin discharge surface including a constant pressure open value disposed in the middle of the passage may be further included.
    • PCT No.PCT / JP93 / 00757 Sec。 371日期:1994年2月3日 102(e)日期1994年2月3日PCT提交1993年6月4日PCT公布。 公开号WO93 / 25369 日本特愿1993年12月23日。一种用于注射喷嘴的喷嘴孔密封装置,其能够通过使用机器人在吹扫注射成型机中阻塞喷嘴尖端的孔。 喷嘴孔密封装置包括用于将喷嘴孔密封装置连接到机器人手腕的工具更换器和用于通过与注塑机的喷嘴头接触来密封喷嘴孔的喷嘴密封体,从而组成喷嘴密封机器人工具 作为一个整体。 用于保持喷嘴头与喷嘴密封体接触的卡盘机构,用于喷嘴头接触部分的储热加热器和从喷嘴头接触部分到包括恒压开启值的清洗树脂排出表面的树脂通道 可以进一步包括设置在通道的中间。
    • 8. 发明授权
    • Fault location method for a parallel two-circuit transmission line with
n terminals
    • 具有n个端子的并行双回路传输线的故障定位方法
    • US5485394A
    • 1996-01-16
    • US443765
    • 1995-05-18
    • Kenji MurataKazuo SonoharaSusumu ItoKyoji IshizuTokuo Emura
    • Kenji MurataKazuo SonoharaSusumu ItoKyoji IshizuTokuo Emura
    • H02H7/26G01R31/00
    • H02H7/267
    • A method of locating a fault point in a parallel two-circuit transmission line in an n-terminal system. When a single fault occurs at one place in one circuit of the transmission line and when a multiple fault occurs at the same place in the two circuits, a distance to the fault may be calculated by the method of this invention. The method comprises the steps of transforming the transmission line into a T three-terminal parallel two-circuit transmission line circuit having three branches, calculating a value representing a length of one of the three branches on the basis of differential currents flowing into the branch points of the transmission line, determining if that value represents the distance from a terminal connected to the branch point to the fault point, employing the value as the distance to the fault point if the value represents such a distance, repeating the value calculation and determination for the other two branches if the value does not represent the distance to the fault, determining a next branch point for which to perform equivalent transformation with respect to, and repeating the previous steps until the fault is found.
    • 一种在n端系统中的并联双回路传输线中的故障点的定位方法。 当单个故障发生在传输线路的一个电路中的一个位置,并且当在两个电路中的相同位置发生多个故障时,可以通过本发明的方法来计算到故障的距离。 该方法包括以下步骤:将传输线变换成具有三个分支的T三端并行两电路传输线电路,根据流入分支点的差分电流计算表示三个分支之一的长度的值 确定该值是否表示从连接到分支点的终端到故障点的距离,如果该值表示该距离,则将该值用作到故障点的距离,重复该值计算和确定 其他两个分支如果该值不代表与该故障的距离,则确定相对于其执行等效变换的下一分支点,并且重复前述步骤直到发现故障。
    • 9. 发明授权
    • Screw linkage structure for use in an injection molding machine
    • 用于注塑机的螺杆联动结构
    • US5344303A
    • 1994-09-06
    • US75474
    • 1993-06-16
    • Satoshi TakatsugiSusumu Ito
    • Satoshi TakatsugiSusumu Ito
    • B29C45/60B29C45/17
    • B29C45/1775
    • A screw linkage structure in an injection molding machine comprises a screw (8) having at its base a spline portion (11), a spline bush (9) for receiving the spline portion (11), a screw sleeve (4) having a front surface to which the spline bush (9) is secured, and a retainer (10) serving to prevent the screw (8) from being disengaged from the spline bush (9). The spline portion (11) formed on the screw base is fitted into the spline bush (9) and includes an annular groove (15). The spline bush (9) has a through-hole acting as a retainer attachment hole (16) at the position corresponding to the annular groove (15) of the screw base to be fitted thereinto. The retainer (10) is then inserted into the retainer attachment hole (16) of the spline bush (9) until its leading edge reach the annular groove (15) of the screw base, thereby preventing the screw (8) from being disengaged from the screw sleeve (4).
    • PCT No.PCT / JP92 / 01361 Sec。 371日期:1993年6月16日 102(e)日期1993年6月16日PCT提交1992年10月20日PCT公开号 出版物WO93 / 08010 日期:1993年04月29日。注射成型机中的螺杆连接结构包括在其基部具有花键部分(11)的螺钉(8),用于容纳花键部分(11)的花键衬套(9),螺钉 具有固定花键衬套(9)的前表面的套筒(4)和用于防止螺钉(8)从花键衬套(9)脱离的保持器(10)。 形成在螺纹基座上的花键部分(11)装配到花键衬套(9)中并且包括环形槽(15)。 花键衬套(9)具有作为保持器安装孔(16)的通孔,该安装孔位于对应于安装在其中的螺钉底座的环形槽(15)的位置。 然后将保持器(10)插入到花键衬套(9)的保持器附接孔(16)中,直到其前缘到达螺钉底座的环形槽(15),从而防止螺钉(8)脱离 螺钉套筒(4)。