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1. 发明申请

US20110076770A1 CULTURING METHOD OF MESENCHYMAL STEM CELL 有权
标题翻译：细胞干细胞的培养方法
公开(公告)号：US20110076770A1
公开(公告)日：2011-03-31
申请号：US12892223
申请日：2010-09-28
申请人： Yuhiro SAKAI , Katsuyuki Yamanaka , Mika Takeda , Tomohisa Okura , Koichiro Tsuji
发明人： Yuhiro SAKAI , Katsuyuki Yamanaka , Mika Takeda , Tomohisa Okura , Koichiro Tsuji
IPC分类号： C12N5/077
CPC分类号： C12N5/0663 , C12N2500/50
摘要： To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane in a liquid culture medium which is filled in a vessel, includes water as its main components and having a specific gravity between 1.06 and 1.10 g/ml at 37° C., and making a culture at a temperature 37±2° C. on a ceiling side surface of the vessel, preferably the specific gravity being regulated by use of at least one selected from silica fine powder coated by polyvinyl pyrrolidone, a water soluble copolymer of sucrose and epichlorohydrin, and a water soluble compound including a triiodo aromatic ring.
摘要翻译：为了有效地选择和增殖间充质干细胞而不需要专门的分离装置和复杂的分离操作，通过种植骨髓溶液，脐带血，外周血，滑膜中的至少一种来培养间充质干细胞在装在容器中的液体培养基中的羊膜包含水作为主要成分，在37℃下比重为1.06〜1.10g / ml，培养温度为37±2℃ ℃，优选通过使用选自由聚乙烯吡咯烷酮涂覆的二氧化硅细粉末，蔗糖和表氯醇的水溶性共聚物和水溶性化合物中选择的至少一种来调节比重，所述水溶性化合物包括三碘芳环。

2. 发明授权

US5505606A Nozzle hole sealing device for injection nozzle 失效
标题翻译：注嘴喷嘴孔密封装置
公开(公告)号：US5505606A
公开(公告)日：1996-04-09
申请号：US190120
申请日：1994-02-03
申请人： Susumu Ito , Katsuyuki Yamanaka , Akira Kouketsu , Kazunari Ijima
发明人： Susumu Ito , Katsuyuki Yamanaka , Akira Kouketsu , Kazunari Ijima
IPC分类号： B29C45/17 , B29C45/23 , B29C45/26 , B29C45/00
CPC分类号： B29C45/1755 , B29C45/232
摘要： A nozzle hole sealing device for an injection nozzle capable of blocking a hole at the tip of a nozzle by using a robot in purging an injection molding machine. The nozzle hole sealing device includes a tool changer for connecting the nozzle hole sealing device to a wrist of the robot and a nozzle sealing body for sealing a nozzle hole by contacting the nozzle tip of the injection molding machine, thereby composing a nozzle sealing robot tool as a whole. A chuck mechanism for keeping a nozzle tip in contact with the nozzle sealing body, a heat reserving heater for a nozzle tip contact portion, and a resin passage ranging from the nozzle tip contact portion to a purged resin discharge surface including a constant pressure open value disposed in the middle of the passage may be further included.
摘要翻译： PCT No.PCT / JP93 / 00757 Sec。 371日期：1994年2月3日 102（e）日期1994年2月3日PCT提交1993年6月4日PCT公布。公开号WO93 / 25369 日本特愿1993年12月23日。一种用于注射喷嘴的喷嘴孔密封装置，其能够通过使用机器人在吹扫注射成型机中阻塞喷嘴尖端的孔。喷嘴孔密封装置包括用于将喷嘴孔密封装置连接到机器人手腕的工具更换器和用于通过与注塑机的喷嘴头接触来密封喷嘴孔的喷嘴密封体，从而组成喷嘴密封机器人工具作为一个整体。用于保持喷嘴头与喷嘴密封体接触的卡盘机构，用于喷嘴头接触部分的储热加热器和从喷嘴头接触部分到包括恒压开启值的清洗树脂排出表面的树脂通道可以进一步包括设置在通道的中间。

3. 发明申请

US20060083771A1 Block-shaped scaffold for tissue engineering and production method thereof 审中-公开
公开(公告)号：US20060083771A1
公开(公告)日：2006-04-20
申请号：US11241997
申请日：2005-10-04
申请人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
发明人： Katsushi Yamamoto , Katsuyuki Yamanaka , Youko Suda , Tadashi Kaneko
IPC分类号： A61F2/00
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , C08L67/04
摘要： A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 μm diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.

4. 发明申请

US20060073228A1 Injection device for injection molding machine 审中-公开
标题翻译：注塑机注塑装置
公开(公告)号：US20060073228A1
公开(公告)日：2006-04-06
申请号：US11242081
申请日：2005-10-04
申请人： Katsuyuki Yamanaka , Koichi Nishimura , Koji Shima , Satoshi Yano
发明人： Katsuyuki Yamanaka , Koichi Nishimura , Koji Shima , Satoshi Yano
IPC分类号： B29C47/96
CPC分类号： B29C45/5008 , B29C2045/5032
摘要： A driven pulley is attached via a bearing to a first housing that can move in the axial direction of injection. This driven pulley is connected to a rotation transmitting member by a spline coupling. An injection screw is fastened to this rotation transmitting member. Furthermore, this rotation transmitting member is attached to a second housing via a bearing so as to move in the axial direction. The first housing and second housing are respectively fastened to the outer ring part and inner 0ring part of a load detection device. Since the first and second housings are capable of relative movement in the axial direction of an injection shaft, no pre-load is generated in the load detection device. Movement of the driven pulley caused by the tension of the mounted belt is checked by a bearing. No frictional force is generated in the spline coupling part. Accordingly, the resin pressure that is applied to the injection screw can be accurately measured by the load detection device.
摘要翻译：从动皮带轮通过轴承安装到能够沿着注射轴向移动的第一壳体。该从动皮带轮通过花键联轴器与旋转传递部件连接。注射螺钉紧固在该旋转传递部件上。此外，该旋转传递构件经由轴承被附接到第二壳体，以沿轴向方向移动。第一壳体和第二壳体分别固定在负载检测装置的外圈部分和内部零部件上。由于第一壳体和第二壳体能够在注射轴的轴向方向上相对运动，因此在负载检测装置中不产生预加载。由安装带的张力引起的从动皮带轮的移动由轴承检查。在花键联接部中不产生摩擦力。因此，能够通过负载检测装置精确地测量施加到注射螺杆的树脂压力。

5. 发明申请

US20050276878A1 Extracting device of molded article 审中-公开
标题翻译：成型品的提取装置
公开(公告)号：US20050276878A1
公开(公告)日：2005-12-15
申请号：US11146101
申请日：2005-06-07
申请人： Ryo Nihei , Katsuyuki Yamanaka , Satoshi Kinoshita , Mitsuhiro Yasumura
发明人： Ryo Nihei , Katsuyuki Yamanaka , Satoshi Kinoshita , Mitsuhiro Yasumura
IPC分类号： B29C45/40 , B25J9/04 , B25J9/06 , B29C37/00 , B29C45/17 , B29C45/42
CPC分类号： B25J9/042 , B25J9/06 , B29C37/0007 , B29C45/42 , B29C2045/4283
摘要： An extracting device for easily exchanging a mold. The extracting device is attached to an upper side of a molding machine using an adapter plate. The extracting device includes a plurality of arms configured to rotate about vertical axes and a vertical motion arm, having a gripper, mounted to the end of the arms. The mold attached or to be attached to a mold fixing member is lifted, lowered or translated to the side of the molding machine. The arms of the extracting device are rotated to be away from a conveying path of the mold such that the arms do not obstruct the conveying path. In this way, a useful conveying path of the mold may be maintained, thereby the mold or a part of a crane or the like for the mold does not contact the extracting device and the mold may be easily exchanged.
摘要翻译：一种用于容易地更换模具的提取装置。提取装置使用适配器板附接到成型机的上侧。提取装置包括被构造为围绕垂直轴线旋转的多个臂和具有安装到臂的端部的夹持器的垂直运动臂。附接或附接到模具固定构件的模具被提升，降低或平移到模制机的侧面。提取装置的臂被旋转以远离模具的传送路径，使得臂不妨碍输送路径。以这种方式，可以保持模具的有用输送路径，从而模具或用于模具的起重机等的一部分不接触提取装置，并且模具可以容易地更换。

6. 发明申请

US20050276877A1 Extracting device of molded article 审中-公开
标题翻译：成型品的提取装置
公开(公告)号：US20050276877A1
公开(公告)日：2005-12-15
申请号：US11145956
申请日：2005-06-07
申请人： Ryo Nihei , Katsuyuki Yamanaka , Satoshi Kinoshita , Mitsuhiro Yasumura
发明人： Ryo Nihei , Katsuyuki Yamanaka , Satoshi Kinoshita , Mitsuhiro Yasumura
IPC分类号： B29C33/44 , B25J9/04 , B25J9/06 , B29C37/00 , B29C45/42 , B29C45/76
CPC分类号： B29C45/42 , B25J9/042 , B25J9/06 , B29C37/0007
摘要： An extracting device capable of extracting a molded article to both of a front side and a back side of a molding machine. The extracting device is loaded on an upper side of the molding machine. The extracting device includes a plurality of arms configured to rotate about vertical axes and a vertical motion arm mounted to the end of the arms. The vertical motion arm has a gripper at its front end for gripping the molded article. The molded article may be extracted to the back side of the machine by moving the end of the arms rotatable about the vertical axes to the back side. Also, the molded article may be extracted to the front side of the machine by moving the end of the arms to the front side. Even when the molded article is extracted to the front side of the molding machine, the extracting device cannot disturb the work of the operator and the safety of the operator may be ensured. In setting a molding condition, for example, the work of the operator may be simplified by extracting the molded article to the front side.
摘要翻译：一种提取装置，其能够将模塑制品提取到成型机的前侧和后侧。提取装置装载在成型机的上侧。提取装置包括被配置为围绕垂直轴线旋转的多个臂和安装到臂的端部的垂直运动臂。垂直运动臂在其前端具有夹持器，用于夹紧模制品。通过将可绕垂直轴线旋转的臂的端部移动到背面，模制品可以被提取到机器的后侧。此外，通过将臂的端部移动到前侧，模制品可以被抽出到机器的前侧。即使当模制品被提取到成型机的前侧时，提取装置也不会妨碍操作者的工作，并且可以确保操作者的安全。在设定成型条件时，例如，可以通过将模制品提取到前侧来简化操作者的工作。

7. 发明申请

US20050233029A1 Mold clamping mechanism for injection molding machine 失效
标题翻译：注塑机模具夹紧机构
公开(公告)号：US20050233029A1
公开(公告)日：2005-10-20
申请号：US11098473
申请日：2005-04-05
申请人： Katsuyuki Yamanaka , Koichi Nishimura , Shingo Okada , Naruhiro Nishimura
发明人： Katsuyuki Yamanaka , Koichi Nishimura , Shingo Okada , Naruhiro Nishimura
IPC分类号： B29C45/66 , B29C45/17
CPC分类号： B29C45/1761 , B29C45/661 , B29C2045/1788
摘要： Jack-up bolts are provided at two places along the rear platen movement direction on both sides of a lower part of a rear platen of an injection molding machine. The jack-up bolt engages threadedly with a bolt hole formed in the rear platen, and a lower end face of the jack-up bolt abuts on the upper surface of a slide plate to support the rear platen. A fixing bolt is inserted in a through hole formed in the jack-up bolt, and is threadedly engaged with a tap hole provided in the slide plate, by which the rear platen and the slide plate are integrated. The rear platen moves while being supported by the slide plate. When the tilt of the rear platen is corrected, the fixing, bolt is loosened and the jack-up bolt is turned, by which a distance between the rear platen and the slide plate is adjusted.
摘要翻译：在注射成型机的后台板的下部的两侧，沿着后板移动方向的两个位置设置有夹头螺栓。起升螺栓与形成在后压板中的螺栓孔螺纹接合，并且起升螺栓的下端面抵靠滑板的上表面以支撑后压板。将固定螺栓插入形成在自升式螺栓中的通孔中，并且与设置在滑板中的抽头孔螺纹接合，后压板和滑板通过该通孔被一体化。后台板在被滑板支撑的同时移动。当校正后压板的倾斜度时，松开固定螺栓，并且旋转自升式螺栓，由此调整后压板和滑板之间的距离。

8. 发明授权

US5997780A Zero point adjusting method for pressure detector of an injection molding machine and an apparatus therefor 失效
标题翻译：注射成型机的压力检测器的零点调整方法及其装置
公开(公告)号：US5997780A
公开(公告)日：1999-12-07
申请号：US860457
申请日：1997-06-25
申请人： Susumu Ito , Masao Kamiguchi , Noriaki Neko , Katsuyuki Yamanaka , Toshiaki Ichihara
发明人： Susumu Ito , Masao Kamiguchi , Noriaki Neko , Katsuyuki Yamanaka , Toshiaki Ichihara
IPC分类号： G01L1/00 , B29C45/50 , B29C45/76 , B29C45/77
CPC分类号： B29C45/766 , B29C45/77 , B29C2045/1792 , B29C2045/5032 , B29C2045/773
摘要： A zero point adjusting method and apparatus for a pressure detector of an injection molding machine, capable of carrying out a zero point adjustment of the pressure detector when external loads acting on the pressure detector are completely removed without disassembling an injection mechanism. An advance limit position Qf and a retreat limit position Qb of a screw are detected by driving the screw with a low output to determine an intermediate position Pm. By moving the screw to the intermediate position Pm, a resin reaction force acting directly on the screw is removed. Reciprocating motion in which an amplitude decreases gradually is imparted to the screw, thereby causing a backlash, having equal plays in the advance and retreat directions, between a ball nut and a ball screw. Then, the zero point adjustment of the pressure detector is made.
摘要翻译： PCT No.PCT / JP96 / 03124 Sec。 371日期：1997年6月23日 102（e）日期1997年6月23日PCT 1996年10月25日PCT公布。第WO97 / 15431号公报日期1997年5月1日一种用于注射成型机的压力检测器的零点调整方法和装置，其能够在不拆卸注射机构的情况下完全除去作用在压力检测器上的外部负载时对压力检测器进行零点调整。通过以低输出驱动螺杆来检测螺杆的前进极限位置Qf和后退极限位置Qb，以确定中间位置Pm。通过将螺杆移动到中间位置Pm，直接作用在螺钉上的树脂反作用力被去除。向螺杆施加逐渐减小的往复运动，从而在滚珠螺母和滚珠丝杠之间产生具有在前进和后退方向上相等的间隙的间隙。然后，进行压力检测器的零点调整。

9. 发明授权

US5445511A Core push-out apparatus 失效
标题翻译：核心推出装置
公开(公告)号：US5445511A
公开(公告)日：1995-08-29
申请号：US196119
申请日：1994-02-16
申请人： Susumu Ito , Katsuyuki Yamanaka , Akira Kouketsu , Kazunari Ijima
发明人： Susumu Ito , Katsuyuki Yamanaka , Akira Kouketsu , Kazunari Ijima
IPC分类号： B29C33/30 , B29C33/76 , B29C45/17 , B29C45/26 , B29C45/36
CPC分类号： B29C45/1756 , B29C33/306 , B29C45/2675
摘要： This apparatus, preferably applicable to a molding machine using the core change type dies, is capable of pushing out the inserted core from the mother mold, thereby facilitating the core extracting operation by the robots. A mother mold of a complementary die in the core change type dies is constituted by a main body and an intermediate plate which is disposed behind the main body and to be movable in both the forward and backward directions. A core fixing and releasing mechanism is provided on the intermediate plate. Furthermore, there is provided a push-out device disposed in a clearance formed between the main body and the intermediate plate when the intermediate plate is shifted rearward. The push-out device has its one surface abutting on a front surface of a core and its another surface abutting on a rear surface of the main body. The push-out device is attached to a distal end of an arm of a robot, combined with a molding machine, so that the push-out device is slidable in both the forward and backward directions and is urged rearward, if necessary.
摘要翻译： PCT No.PCT / JP93 / 00775 Sec。 371日期：1994年2月16日 102（e）日期1994年2月16日PCT提交1993年6月10日PCT公布。公开号WO93 / 25363 日期为1993年12月23日。该装置优选适用于使用芯型型模的成形机，能够从母模推出插入的芯，从而便于机器人进行芯抽取操作。芯型模具中的互补模具的母模由主体和中间板构成，该主体和中间板设置在主体后面并且能够沿前后两个方向移动。在中间板上设置有芯固定和释放机构。此外，当中间板向后移动时，设置有形成在主体和中间板之间的间隙中的推出装置。推出装置的一个表面邻接在芯的前表面上，并且其另一表面邻接在主体的后表面上。推出装置连接到机器人的臂的远端，与成型机组合，使得推出装置可以在前后方向上滑动，并且如果需要则向后推动。

10. 发明申请

US20100158982A1 SHEET FOR GUIDING REGENERATION OF MESENCHYMAL TISSUE AND PRODUCTION METHOD THEREOF 有权
标题翻译：引导生殖组织再生及其生产方法的论文
公开(公告)号：US20100158982A1
公开(公告)日：2010-06-24
申请号：US12709748
申请日：2010-02-22
申请人： Toshitsugu KAWATA , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
发明人： Toshitsugu KAWATA , Kaoru Tenjo , Koichiro Tsuji , Katsuyuki Yamanaka
IPC分类号： A61K35/28 , A61K9/70 , A61P19/00 , A61P21/00
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it, seeding a mesenchymal cell grown after taking from biotissue, and differentiating the mesenchymal cell to a mesenchymal tissue precursor cell, where the mesenchymal tissue precursor cell and an extracellular substrate are adhered on the surface of the porous sheet containing a culture medium, and the extracellular substrate is secreted in a process of the mesenchymal cell being differentiated to the mesenchymal tissue precursor cell.
摘要翻译：为了提供一种用于引导具有改善的成形性，强度，吸收性和效率的间充质组织再生的片材，该片材通过以下步骤制备：在通过冷冻溶解有有机溶剂的生物可吸收聚合物材料制成的多孔片材的表面中含有培养基并将其干燥，接种从生物组织取出后生长的间充质细胞，并将间充质细胞分化为间充质组织前体细胞，其中间充质组织前体细胞和细胞外基质粘附在含有培养基的多孔片材的表面上，并且细胞外基质在分化成间充质组织前体细胞的间充质细胞的过程中分泌。

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