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1. 发明申请

US20070149952A1 Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser 审中-公开
标题翻译：用于表征患者神经系统事件倾向并与药剂分配器通信的系统和方法
公开(公告)号：US20070149952A1
公开(公告)日：2007-06-28
申请号：US11322150
申请日：2005-12-28
申请人： Mike Bland , Kent Leyde , David Snyder , Daniel Dilorenzo
发明人： Mike Bland , Kent Leyde , David Snyder , Daniel Dilorenzo
IPC分类号： A61K9/22
CPC分类号： G16H50/20 , G06F19/3418 , G06F19/3462 , G06F19/3468
摘要： The present invention provides systems and methods for managing intake of a pharmacological agent. In one method of the present invention, the systems and methods are for controlling intake of an anti-epileptic drug. In such embodiments, one or more signals from a patient are processed to predict an onset of a seizure. Upon the prediction of the seizure, the patient is allowed to access the pharmacological agent in a pharmacological agent dispenser.
摘要翻译：本发明提供了用于管理药理学摄入的系统和方法。在本发明的一种方法中，系统和方法用于控制抗癫痫药物的摄入。在这样的实施例中，来自患者的一个或多个信号被处理以预测癫痫发作。在预测癫痫发作后，允许患者在药剂分配器中进入药理剂。

2. 发明申请

US20070150024A1 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 有权
标题翻译：用于向患者推荐用于管理癫痫和其他神经障碍的适当动作的方法和系统
公开(公告)号：US20070150024A1
公开(公告)日：2007-06-28
申请号：US11321897
申请日：2005-12-28
申请人： Kent Leyde , Daniel Dilorenzo
发明人： Kent Leyde , Daniel Dilorenzo
IPC分类号： A61N1/00
CPC分类号： A61B5/4094 , A61B5/0476 , A61B5/048 , A61B5/7264 , A61B5/7275 , A61N1/36082 , A61N1/37247 , A61N1/37258 , G06F19/00
摘要： The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.
摘要翻译：本发明提供了用于治疗诸如癫痫的神经障碍的方法和系统。在一个实施例中，该方法包括测量来自患者的一个或多个信号并处理一个或多个信号以表征患者将来发作的倾向。其特征是缉获倾向之后用于确定管理或治疗预期癫痫发作的适当行动; 并且向患者传达指示适当动作的建议。

3. 发明申请

US20070150025A1 Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders 有权
标题翻译：用于推荐对患者进行适当药理学治疗以治疗癫痫和其他神经障碍的方法和系统
公开(公告)号：US20070150025A1
公开(公告)日：2007-06-28
申请号：US11321898
申请日：2005-12-28
申请人： Daniel Dilorenzo , Kent Leyde
发明人： Daniel Dilorenzo , Kent Leyde
IPC分类号： A61N1/00
CPC分类号： A61B5/4094 , A61B5/024 , A61B5/0476 , A61B5/4833 , A61B5/7264 , A61B5/7275 , A61M5/1723 , A61N1/36064 , A61N1/36082 , A61N1/37258 , G06F19/00
摘要： The present invention provides systems and methods for managing epilepsy. In one embodiment, a method of the present invention characterize a patient's propensity for a future epileptic seizure and communicates to the patient and/or a health care provider a therapy recommendation. The therapy recommendation is typically a function of the patient's propensity for the future epileptic seizure.
摘要翻译：本发明提供了用于治疗癫痫的系统和方法。在一个实施方案中，本发明的方法表征患者对未来癫痫发作的倾向，并且向患者和/或医疗保健提供者传达治疗推荐。治疗推荐通常是患者对未来癫痫发作倾向的功能。

4. 发明授权

US08606361B2 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
公开(公告)号：US08606361B2
公开(公告)日：2013-12-10
申请号：US13179133
申请日：2011-07-08
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

5. 发明授权

US07483747B2 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：US07483747B2
公开(公告)日：2009-01-27
申请号：US11182713
申请日：2005-07-15
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/00
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

6. 发明申请

US20080021341A1 Methods and Systems for Facilitating Clinical Trials 审中-公开
标题翻译：促进临床试验的方法和系统
公开(公告)号：US20080021341A1
公开(公告)日：2008-01-24
申请号：US11766756
申请日：2007-06-21
申请人： John Harris , Kent Leyde
发明人： John Harris , Kent Leyde
IPC分类号： A61B5/0476
CPC分类号： A61N1/37229 , A61B5/0031 , A61B5/0476 , A61B5/4094 , A61B2560/0214 , A61N1/36064
摘要： The present invention provides methods and systems for improving clinical trials of experimental therapies. The present invention uses minimally invasive, leadless implantable devices that facilitate long term monitoring of a physiological signal (e.g., neural signals) from a patient population which may provide an indication of the effect of the experimental therapy on the patient population. In preferred embodiments, neural signals are sampled from the patients in the patient population with an externally powered, leadless implanted device and are transmitted to an external device for further processing.
摘要翻译：本发明提供用于改善实验疗法的临床试验的方法和系统。本发明使用促进长期监测来自患者群体的生理信号（例如，神经信号）的微创无引导植入式装置，其可以提供实验治疗对患者群体的影响的指示。在优选实施例中，使用外部供电的无引线植入装置从患者群体中的患者采集神经信号，并将其传输到外部装置以进行进一步处理。

7. 发明申请

US20050021118A1 Apparatuses and systems for applying electrical stimulation to a patient 审中-公开
标题翻译：用于向患者施加电刺激的装置和系统
公开(公告)号：US20050021118A1
公开(公告)日：2005-01-27
申请号：US10877830
申请日：2004-06-25
申请人： Chris Genau , Kent Leyde , Jay Miazga , Corinne Stern
发明人： Chris Genau , Kent Leyde , Jay Miazga , Corinne Stern
IPC分类号： A61N20060101 , A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/0531 , A61N1/0539 , A61N1/0551 , A61N1/3605 , A61N1/36082
摘要： Apparatuses and systems for applying electrical stimulation to a site on a patient. In one embodiment, an implantable electrode assembly includes an electrode array carried by a flexible support member. The electrode array can include a first plurality of electrodes spaced apart from a second plurality of electrodes. The first plurality of electrodes can be connected to a first lead line, and the second plurality of electrodes can be similarly connected to a second lead line. The first and second lead lines can be housed in a cable extending away from the support member. A distal end of the cable can include a connector for coupling the lead lines to an implantable pulse generator or other stimulus unit. In operation, the stimulus unit can bias the first plurality of electrodes at a first potential and the second plurality of electrodes at a second potential to generate an electric field proximate to a stimulation site.
摘要翻译：将电刺激施加到患者部位的装置和系统。在一个实施例中，可植入电极组件包括由柔性支撑构件承载的电极阵列。电极阵列可以包括与第二多个电极间隔开的第一多个电极。第一多个电极可以连接到第一引线，并且第二多个电极可以类似地连接到第二引线。第一引线和第二引线可以容纳在远离支撑构件的电缆中。电缆的远端可以包括用于将引线耦合到可植入脉冲发生器或其它刺激单元的连接器。在操作中，刺激单元可以以第一电位偏置第一多个电极，并且第二多个电极以第二电位偏置以产生靠近刺激部位的电场。

8. 发明申请

US20120041498A1 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 有权
标题翻译：用于增强或影响神经刺激效能和/或效率的系统和方法
公开(公告)号：US20120041498A1
公开(公告)日：2012-02-16
申请号：US13179133
申请日：2011-07-08
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

9. 发明申请

US20080208291A1 FREQUENCY SHIFT KEYING (FSK) MAGNETIC TELEMETRY FOR IMPLANTABLE MEDICAL DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于可移植医疗设备和相关系统和方法的频移键控（FSK）磁电报
公开(公告)号：US20080208291A1
公开(公告)日：2008-08-28
申请号：US11923553
申请日：2007-10-24
申请人： Kent Leyde , Michael Bland
发明人： Kent Leyde , Michael Bland
IPC分类号： A61N1/08
CPC分类号： G01D21/00 , A61B5/0031
摘要： A telemetry receive unit for use in an implantable medical device or system can include a coil unit, a single-bit analog to digital converter (ADC), a finite impulse response filter (FIR) coupled to the single-bit ADC, and an accumulator coupled to one or more filter taps of the FIR filter. The accumulator, in operation, can produce one or more data recognition signals corresponding to sampled bits at least temporarily stored at the FIR filter. In several examples, the data recognition signals discriminate between frequency modulated signals that are received at the coil unit, including frequency shift keying (FSK) modulated signals.
摘要翻译：用于可植入医疗设备或系统的遥测接收单元可以包括线圈单元，单比特模数转换器（ADC），耦合到单比特ADC的有限脉冲响应滤波器（FIR）和累加器耦合到FIR滤波器的一个或多个滤波器抽头。在操作中，累加器可以产生一个或多个对应于至少临时存储在FIR滤波器的采样位的数据识别信号。在几个示例中，数据识别信号区分在线圈单元接收的频率调制信号，包括频移键控（FSK）调制信号。

10. 发明申请

US20080071323A1 Methods and Systems Employing Intracranial Electrodes for Neurostimulation and/or Electroencephalography 审中-公开
标题翻译：使用颅内电极进行神经刺激和/或脑电图的方法和系统
公开(公告)号：US20080071323A1
公开(公告)日：2008-03-20
申请号：US11944259
申请日：2007-11-21
申请人： David Lowry , Bradford Gliner , Kent Leyde , Ben Clopton , Jay Miazga , Chris Genau
发明人： David Lowry , Bradford Gliner , Kent Leyde , Ben Clopton , Jay Miazga , Chris Genau
IPC分类号： A61N1/04
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Aspects of the invention relate to intracranial electrodes and methods for implanting and using intracranial electrodes. In one particular example, an intracranial electrode includes a shaft having a distal contact surface adapted to electrically contact a surface of a patient's brain, a head associated with the shaft, and threads adapted to fix the electrode with respect to the patient's skull. This electrode may have an adjustable length adapted to change a contact force of the distal contact surface against the surface of the brain by adjusting the length of the electrode.
摘要翻译：本发明的方面涉及用于植入和使用颅内电极的颅内电极和方法。在一个具体实例中，颅内电极包括具有远端接触表面的轴，该远端接触表面适于电接触患者大脑的表面，与该轴相关联的头部以及适于将电极相对于患者头骨固定的螺纹。该电极可以具有可调节的长度，其适于通过调节电极的长度来改变远端接触表面相对于脑的表面的接触力。

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