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1. 发明申请

US20120041498A1 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 有权
标题翻译：用于增强或影响神经刺激效能和/或效率的系统和方法
公开(公告)号：US20120041498A1
公开(公告)日：2012-02-16
申请号：US13179133
申请日：2011-07-08
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

2. 发明授权

US07565200B2 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 有权
标题翻译：用于选择刺激部位并进行治疗的系统和方法，包括治疗帕金森病症状，其他运动障碍和/或药物副作用
公开(公告)号：US07565200B2
公开(公告)日：2009-07-21
申请号：US10986614
申请日：2004-11-12
申请人： Allen Wyler , Brad Fowler
发明人： Allen Wyler , Brad Fowler
IPC分类号： A61N1/18
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.
摘要翻译：公开了用于治疗运动障碍的方法和系统。根据一个实施例的方法可以包括确定运动障碍影响患者的步态，口腔功能和/或其他功能，以及分别在大脑间裂缝，西尔维亚裂缝或两个裂缝之间施加电刺激。在另一个实施例中，该方法可以包括从由患者依次执行的多个进程中选择至少一个神经过程以引起患者的肌肉运动（例如，计划过程，发起过程和执行过程）并且将电刺激施加到与所述至少一个神经过程相关联的患者脑部的位置。

3. 发明授权

US07353064B2 Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction 有权
标题翻译：用于增强或优化用于治疗运动障碍和/或其他神经功能障碍症状的神经刺激治疗的系统和方法
公开(公告)号：US07353064B2
公开(公告)日：2008-04-01
申请号：US10782526
申请日：2004-02-19
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61N1/0534 , A61N1/36082 , A61N1/36167 , A61N1/36178 , G06F19/00
摘要： In one embodiment, a procedure directed toward enhancing neural stimulation therapy efficacy comprises acquiring coherence and/or silent period measurements to facilitate and/or effectuate determination of neural stimulation parameters corresponding to a treatment program, and/or modification of neural stimulation parameters associated with a treatment program in view of short-term changes in a patient's symptomatic state and/or persistent or lasting changes in a patient's neurofunctional condition.
摘要翻译：在一个实施方案中，针对增强神经刺激疗效的方法包括采集相干性和/或静默期测量以促进和/或实现对应于治疗程序的神经刺激参数的确定，和/或修改与考虑到患者症状状态的短期变化和/或患者神经功能状况的持续或持久变化。

4. 发明申请

US20060253170A1 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of parkinson's disease, other movement disorders, and/or drug side effects 有权
公开(公告)号：US20060253170A1
公开(公告)日：2006-11-09
申请号：US11489074
申请日：2006-07-18
申请人： Allen Wyler , Brad Fowler
发明人： Allen Wyler , Brad Fowler
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.

5. 发明申请

US20060106431A1 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects 有权
公开(公告)号：US20060106431A1
公开(公告)日：2006-05-18
申请号：US10986614
申请日：2004-11-12
申请人： Allen Wyler , Brad Fowler
发明人： Allen Wyler , Brad Fowler
IPC分类号： A61N1/18
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.

6. 发明申请

US20050070971A1 Apparatus and methods for applying neural stimulation to a patient 失效
标题翻译：将神经刺激应用于患者的装置和方法
公开(公告)号：US20050070971A1
公开(公告)日：2005-03-31
申请号：US10910775
申请日：2004-08-02
申请人： Brad Fowler , Bradford Gliner
发明人： Brad Fowler , Bradford Gliner
IPC分类号： A61N20060101 , A61N1/05 , A61N1/18 , A61N1/36
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0539
摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.
摘要翻译：用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。刺激单元可以是可植入脉冲发生器，其包括可以以第一信号极性偏置的第一端子和可以以第二信号极性偏置的第二端子。第一电极组件包括被配置为放置在刺激部位的支撑构件，由支撑构件承载的第一组触点，以及构造成附接到可植入脉冲发生器的第一端子的第一引线，用于偏置表面触点在第一极性。第二组触点与表面电极组件脱离。第二组触点可以是固定到可植入脉冲发生器的一部分或形成部分的一个或多个导电元件，或单独的电极阵列。

7. 发明授权

US08929991B2 Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits 有权
标题翻译：用于建立神经刺激参数的方法，包括通过执行工作记忆任务以及相关工具包
公开(公告)号：US08929991B2
公开(公告)日：2015-01-06
申请号：US11737673
申请日：2007-04-19
申请人： Brad Fowler , Leif R. Sloan , Joleen Borgerding
发明人： Brad Fowler , Leif R. Sloan , Joleen Borgerding
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/36096
摘要： Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits, are disclosed. A method in accordance with one embodiment includes engaging a patient in a function controlled at least in part by a target neural population, and applying electromagnetic signals to the target neural population. A target parameter in accordance with which the electromagnetic signals are applied is adjusted, based at least in part on a characteristic of the patient's performance of the function. Electromagnetic signals are applied to the patient with the adjusted target parameter, and the patient's response to the electromagnetic signals, including the characteristic of the patient's performance, is evaluated. Based at least in part on the evaluation of the patient's response, an embodiment of the method includes determining whether to apply further electromagnetic signals to the patient, establishing a value of the target parameter for applying further electromagnetic signals to the patient, and/or adjusting another target parameter in accordance with which the electromagnetic signals are applied to the patient.
摘要翻译：公开了用于建立神经刺激参数的方法，包括通过执行工作记忆任务以及相关工具包。根据一个实施例的方法包括使患者至少部分地由目标神经群体控制的功能并且向目标神经群体施加电磁信号。至少部分地基于患者对功能的执行的特性来调整施加电磁信号的目标参数。利用调整后的目标参数对病人施加电磁信号，评价病人对电磁信号的反应，包括病人的表现特点。至少部分地基于对患者的反应的评估，该方法的实施例包括确定是否向患者施加进一步的电磁信号，建立用于向患者施加进一步的电磁信号的目标参数的值，和/或调整电磁信号被施加到患者的另一目标参数。

8. 发明申请

US20120078327A1 MICRODEVICE-BASED ELECTRODE ASSEMBLIES AND ASSOCIATED NEURAL STIMULATION SYSTEMS, DEVICES, AND METHODS 审中-公开
标题翻译：基于微阵列的电极组件和相关的神经刺激系统，设备和方法
公开(公告)号：US20120078327A1
公开(公告)日：2012-03-29
申请号：US13308931
申请日：2011-12-01
申请人： Leif R. Sloan , Brad Fowler
发明人： Leif R. Sloan , Brad Fowler
IPC分类号： A61N1/375
CPC分类号： A61N1/0529 , A61B5/4064 , A61B5/6882 , A61B2562/028 , A61M5/14276 , A61M5/172 , A61M2205/054 , A61N1/36096 , A61N1/37205 , A61N1/37288 , A61N1/3756
摘要： Microdevice-based electrode assemblies and associated neurostimulation systems, devices and methods are disclosed. A system in accordance with a particular embodiment includes a microdevice positioned to send signals or fluids to the patient, and/or to receive signals or fluids from the patient. The microdevice can include a housing having an external surface, and a signal/fluid transmitter/receiver positioned within the housing and coupled to a terminal carried by the housing. The system can further include a patient-implantable, flexible support member attached to the external surface of the housing and carrying the housing. The system can still further include an interface carried by the support member and connected to the terminal, with the interface being positioned to direct signals or fluids into patient tissue, and/or receive signals or fluids from the patient tissue.
摘要翻译：公开了基于微装置的电极组件和相关的神经刺激系统，装置和方法。根据特定实施例的系统包括定位成向患者发送信号或流体和/或从患者接收信号或流体的微型装置。微型装置可以包括具有外表面的壳体和位于壳体内的信号/流体发射器/接收器，并且耦合到由壳体承载的端子。该系统还可以包括附接到壳体的外表面并承载壳体的患者可植入的柔性支撑构件。系统还可以进一步包括由支撑构件承载并连接到终端的界面，其中界面被定位成将信号或流体引导到患者组织中，和/或从患者组织接收信号或流体。

9. 发明申请

US20110213440A1 ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：由神经元功能丧失，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递
公开(公告)号：US20110213440A1
公开(公告)日：2011-09-01
申请号：US13104802
申请日：2011-05-10
申请人： Brad Fowler , Bradford E. Gliner , David Himes
发明人： Brad Fowler , Bradford E. Gliner , David Himes
IPC分类号： A61N1/36
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

10. 发明授权

US07917225B2 Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of parkinson's disease, other movement disorders, and/or drug side effects 有权
标题翻译：用于选择刺激部位和应用治疗的系统和方法，包括治疗帕金森病症状，其他运动障碍和/或药物副作用
公开(公告)号：US07917225B2
公开(公告)日：2011-03-29
申请号：US11489074
申请日：2006-07-18
申请人： Allen Wyler , Brad Fowler
发明人： Allen Wyler , Brad Fowler
IPC分类号： A61N1/18
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.
摘要翻译：公开了用于治疗运动障碍的方法和系统。根据一个实施例的方法可以包括确定运动障碍影响患者的步态，口腔功能和/或其他功能，以及分别在大脑间裂缝，西尔维亚裂缝或两个裂缝之间施加电刺激。在另一个实施例中，该方法可以包括从由患者依次执行的多个进程中选择至少一个神经过程以引起患者的肌肉运动（例如，计划过程，发起过程和执行过程）并且将电刺激施加到与所述至少一个神经过程相关联的患者脑部的位置。

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