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1. 发明申请

US20070150024A1 Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 有权
标题翻译：用于向患者推荐用于管理癫痫和其他神经障碍的适当动作的方法和系统
公开(公告)号：US20070150024A1
公开(公告)日：2007-06-28
申请号：US11321897
申请日：2005-12-28
申请人： Kent Leyde , Daniel Dilorenzo
发明人： Kent Leyde , Daniel Dilorenzo
IPC分类号： A61N1/00
CPC分类号： A61B5/4094 , A61B5/0476 , A61B5/048 , A61B5/7264 , A61B5/7275 , A61N1/36082 , A61N1/37247 , A61N1/37258 , G06F19/00
摘要： The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.
摘要翻译：本发明提供了用于治疗诸如癫痫的神经障碍的方法和系统。在一个实施例中，该方法包括测量来自患者的一个或多个信号并处理一个或多个信号以表征患者将来发作的倾向。其特征是缉获倾向之后用于确定管理或治疗预期癫痫发作的适当行动; 并且向患者传达指示适当动作的建议。

2. 发明申请

US20070142862A1 Systems and methods for monitoring a patient's neurological disease state 有权
标题翻译：用于监测患者神经疾病状态的系统和方法
公开(公告)号：US20070142862A1
公开(公告)日：2007-06-21
申请号：US11239653
申请日：2005-09-28
申请人： Daniel Dilorenzo
发明人： Daniel Dilorenzo
IPC分类号： A61N1/18
CPC分类号： A61N1/3605 , A61B5/4082 , A61N1/0529 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： The present invention provides methods and systems for modulating a patient's neurological disease state. In one embodiment, the system comprises one or more sensors that sense at least one signal that comprise a characteristic that is indicative of a neurological disease state. A signal processing assembly is in communication with the one or more sensors and processes the at least one signal to estimate the neurological disease state and to generate a therapy to the patient that is based at least in part on the estimated neurological disease state. A treatment assembly is in communication with the signal processing assembly and delivers the therapy to a nervous system component of the patient.
摘要翻译：本发明提供了调节患者神经疾病状态的方法和系统。在一个实施例中，系统包括感测至少一个信号的一个或多个传感器，该信号包括指示神经疾病状态的特征。信号处理组件与所述一个或多个传感器通信并处理所述至少一个信号以估计所述神经疾病状态，并且至少部分地基于估计的神经疾病状态产生对所述患者的治疗。治疗组件与信号处理组件连通并将治疗递送到患者的神经系统部件。

3. 发明申请

US20060293720A1 Closed-loop feedback-driven neuromodulation 有权
标题翻译：闭环反馈驱动神经调节
公开(公告)号：US20060293720A1
公开(公告)日：2006-12-28
申请号：US11159842
申请日：2005-06-22
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/00
CPC分类号： A61N1/36082 , A61N1/0529 , A61N1/0531 , A61N1/0539
摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) stimulating electrodes and other actuators, in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
摘要翻译：用于调节包括神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。神经系统控制系统根据治疗参数产生通过一个或多个神经调节器递送至神经系统组分的神经调制信号，包括颅内（IC）刺激电极和其它致动器。这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

4. 发明申请

US20070167991A1 Methods and systems for determining subject-specific parameters for a neuromodulation therapy 有权
标题翻译：用于确定神经调节治疗的受试者特异性参数的方法和系统
公开(公告)号：US20070167991A1
公开(公告)日：2007-07-19
申请号：US11647700
申请日：2006-12-29
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/36
CPC分类号： A61B5/4094 , A61B5/04001 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/0816 , A61B5/1101 , A61B5/4082 , A61B5/4839 , A61B5/6852 , A61B5/6864 , A61B5/6868 , A61B5/6882 , A61B5/7203 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36114 , A61N1/36139 , A61N1/372 , A61N1/3787 , G06F19/00
摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
摘要翻译：用于调节包括神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。神经系统控制系统通过一个或多个神经调节器产生递送至神经系统组分的神经调制信号，以控制神经系统状态并预防神经系统症状和体征。这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

5. 发明申请

US20070149952A1 Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser 审中-公开
标题翻译：用于表征患者神经系统事件倾向并与药剂分配器通信的系统和方法
公开(公告)号：US20070149952A1
公开(公告)日：2007-06-28
申请号：US11322150
申请日：2005-12-28
申请人： Mike Bland , Kent Leyde , David Snyder , Daniel Dilorenzo
发明人： Mike Bland , Kent Leyde , David Snyder , Daniel Dilorenzo
IPC分类号： A61K9/22
CPC分类号： G16H50/20 , G06F19/3418 , G06F19/3462 , G06F19/3468
摘要： The present invention provides systems and methods for managing intake of a pharmacological agent. In one method of the present invention, the systems and methods are for controlling intake of an anti-epileptic drug. In such embodiments, one or more signals from a patient are processed to predict an onset of a seizure. Upon the prediction of the seizure, the patient is allowed to access the pharmacological agent in a pharmacological agent dispenser.
摘要翻译：本发明提供了用于管理药理学摄入的系统和方法。在本发明的一种方法中，系统和方法用于控制抗癫痫药物的摄入。在这样的实施例中，来自患者的一个或多个信号被处理以预测癫痫发作。在预测癫痫发作后，允许患者在药剂分配器中进入药理剂。

6. 发明申请

US20070162086A1 Monitoring efficacy of neural modulation therapy 有权
标题翻译：监测神经调节疗法的疗效
公开(公告)号：US20070162086A1
公开(公告)日：2007-07-12
申请号：US11647900
申请日：2006-12-29
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/32
CPC分类号： A61B5/4094 , A61B5/04001 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/0816 , A61B5/1101 , A61B5/4082 , A61B5/4839 , A61B5/6852 , A61B5/6864 , A61B5/6868 , A61B5/6882 , A61B5/7203 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36114 , A61N1/36139 , A61N1/372 , A61N1/3787 , G06F19/00
摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
摘要翻译：用于调节包括神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。神经系统控制系统通过一个或多个神经调节器产生递送至神经系统组分的神经调制信号，以控制神经系统状态并预防神经系统症状和体征。这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

7. 发明申请

US20060167498A1 Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease 审中-公开
标题翻译：用于治疗疾病的自主神经调节的方法，装置和手术技术
公开(公告)号：US20060167498A1
公开(公告)日：2006-07-27
申请号：US11151816
申请日：2005-06-13
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/08 , A61N1/362 , A61N1/34 , A61N1/05
CPC分类号： A61N1/36007 , A61B17/3468 , A61N1/0551 , A61N1/36071 , A61N1/36082 , A61N1/36114
摘要： The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.
摘要翻译：本发明教导了一种用于生理调节的方法和装置，包括神经和胃肠调节，用于治疗包括肥胖症，抑郁症，癫痫和糖尿病在内的几种疾病。这包括长期植入的神经和神经肌肉调节剂，用于调节交感神经系统的传入神经元以诱导饱腹感。此外，这包括对胃的神经肌肉刺激以实现基线和间歇性平滑肌收缩以增加胃管腔内压力，其诱导饱腹感，并且刺激交感神经传入纤维，包括交感神经干，内脏神经和胃弯曲更大的交感神经纤维，增加饱腹感。

8. 发明申请

US20060116736A1 Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity 审中-公开
标题翻译：用于治疗肥胖症的自主神经调节的方法，装置和手术技术
公开(公告)号：US20060116736A1
公开(公告)日：2006-06-01
申请号：US11317099
申请日：2005-12-22
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/08
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/36007 , A61N1/36082 , A61N1/36114 , A61N2/00 , A61N5/00 , A61N7/00
摘要： The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.
摘要翻译：本发明教导了一种用于生理调节的方法和装置，包括神经和胃肠调节，用于治疗包括肥胖症，抑郁症，癫痫和糖尿病在内的几种疾病。这包括长期植入的神经和神经肌肉调节剂，用于调节交感神经系统的传入神经元以诱导饱腹感。此外，这包括对胃的神经肌肉刺激以实现基线和间歇性平滑肌收缩以增加胃管腔内压力，其诱导饱腹感，并且刺激交感神经传入纤维，包括交感神经干，内脏神经和胃弯曲更大的交感神经纤维，增加饱腹感。

9. 发明申请

US20050240242A1 Closed-loop feedback-driven neuromodulation 有权
标题翻译：闭环反馈驱动神经调节
公开(公告)号：US20050240242A1
公开(公告)日：2005-10-27
申请号：US10889844
申请日：2004-07-12
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/18
CPC分类号： A61N1/3605 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
摘要翻译：用于调节包括神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。神经系统控制系统通过一个或多个神经调节器产生递送至神经系统组分的神经调制信号，以控制神经系统状态并预防神经系统症状和体征。这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

10. 发明申请

US20050222626A1 Cloosed-loop feedback-driven neuromodulation 有权
标题翻译：闭环反馈驱动神经调节
公开(公告)号：US20050222626A1
公开(公告)日：2005-10-06
申请号：US11138621
申请日：2005-05-25
申请人： Daniel DiLorenzo
发明人： Daniel DiLorenzo
IPC分类号： A61N1/08 , A61N1/36 , H03C3/06
CPC分类号： A61N1/3605 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082
摘要： A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators, comprising intracranial (IC) stimulating electrodes and other actuators, in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
摘要翻译：用于调节包括神经系统的全部或部分或与其接合的任何结构的任何组件或结构的活性的神经控制系统，在本文中通常称为“神经系统组分”。神经系统控制系统根据治疗参数产生通过一个或多个神经调节器递送至神经系统组分的神经调制信号，包括颅内（IC）刺激电极和其它致动器。这样的治疗参数可以从对由一个或多个传感器感测到的先前传递的神经调制信号的神经反应导出，每个传感器被配置为感测指示神经系统或精神病状态的特定特征。

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