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1. 发明申请

US20100197510A1 METHODS FOR RAPID DISEASE SCREENING 审中-公开
标题翻译：快速筛查筛查方法
公开(公告)号：US20100197510A1
公开(公告)日：2010-08-05
申请号：US12529840
申请日：2008-03-07
申请人： Michael Spain , Craig Benson , James P. Mapes , Ralph L. McDade
发明人： Michael Spain , Craig Benson , James P. Mapes , Ralph L. McDade
IPC分类号： C40B30/00
CPC分类号： G01N33/6803
摘要： Methods are provided for screening for the necessity for further diagnosis of one or more diseases or conditions in a subject, which methods are based on the discovery that abnormal levels of selected analytes in a sample fluid from a subject can be correlated with specific diseases or conditions. Further provided are criteria, and methods for the determine thereof, for selected analytes with respect to selected diseases or conditions. Thus, a variety of diseases or conditions can be screened in a rapid, cost-effective composite assay. The methods are useful for screening of newborn humans for a variety of diseases and conditions, whereby additional diagnostic procedures need only be conducted for those diseases or conditions indicated by the methods of the invention.
摘要翻译：提供了筛选用于进一步诊断受试者中一种或多种疾病或病症的必要性的方法，该方法基于以下发现：来自受试者的样品液体中的选定分析物的异常水平可与特定疾病或病症相关。关于所选择的疾病或病症，进一步提供了用于确定所选分析物的标准和方法。因此，可以以快速，成本有效的复合测定法筛选各种疾病或病症。该方法可用于筛选各种疾病和病症的新生儿，由此仅需对本发明方法所指出的那些疾病或病症进行额外的诊断程序。

2. 发明申请

US20080255766A1 Methods and kits for the diagnosis of sickle cell 审中-公开
标题翻译：用于诊断镰状细胞的方法和试剂盒
公开(公告)号：US20080255766A1
公开(公告)日：2008-10-16
申请号：US12068518
申请日：2008-02-07
申请人： Michael Spain , James P. Mapes , Ralph L. McDade , Kenneth Pass
发明人： Michael Spain , James P. Mapes , Ralph L. McDade , Kenneth Pass
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/6863 , G01N2333/52 , G01N2800/22
摘要： Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein-1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了镰状细胞的检测和诊断方法。这些方法是基于以下发现：患有风险的患者的样本液体（通常为血液样本）中所选分析物的异常水平支持镰状细胞的诊断。因此公开了至少两种镰状细胞的新生物标志物，即嗜酸细胞活化趋化因子和单核细胞趋化蛋白-1。总共11种分析物的浓度提供了对患者状况的敏感和选择性图像，即患者是否患有镰状细胞。描述了镰状细胞的其他重要生物标志物，包括但不限于IL-12p40，SHBG，MMP-9，脂连蛋白，海藻球蛋白，FGF碱性，IgM，生长激素，因子VII。还描述了含有辅助分析流体样品的试剂的试剂盒。

3. 发明申请

US20080261253A1 Methods and kits for the diagnosis of galactosemia 审中-公开
标题翻译：用于诊断半乳糖血症的方法和试剂盒
公开(公告)号：US20080261253A1
公开(公告)日：2008-10-23
申请号：US12007500
申请日：2008-01-11
申请人： Michael Spain , James P. Mapes , Ralph McDade , Kenneth Pass
发明人： Michael Spain , James P. Mapes , Ralph McDade , Kenneth Pass
IPC分类号： G01N33/543
CPC分类号： G01N33/6863 , G01N2800/042
摘要： Provided are methods for the detection and diagnosis of galactosemia. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of galactosemia. At least two new biomarkers for galactosemia are thus disclosed, Eotaxin and MCP-1. Altogether the concentrations these markers, individually, or in combinations with any of Alpha-2 Macroglobulin, Apolipoprotein H, Cancer Antigen 125, Leptin, TNF RII, Alpha-Fetoprotein, IgM, MIP-1 alpha, Ferritin, and IgE provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from galactosemia. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了检测和诊断半乳糖血症的方法。这些方法是基于以下发现：患有风险的患者的样品液体（通常为血液样本）中所选分析物的异常水平支持半乳糖血症诊断。因此，公开了至少两种用于半乳糖血症的新生物标志物，即嗜酸性粒细胞趋化因子和MCP-1。总的来说，这些标记物，单独或与任何α-2巨球蛋白，载脂蛋白H，癌症抗原125，瘦素，TNF RII，α-甲胎蛋白，IgM，MIP-1α，铁蛋白和IgE组合的浓度提供了敏感和患者状况的选择性图片，即患者是否患有半乳糖血症。还描述了含有辅助分析流体样品的试剂的试剂盒。

4. 发明申请

US20050079099A1 Generation of biochemical images and methods of use 审中-公开
标题翻译：生成生化图像和使用方法
公开(公告)号：US20050079099A1
公开(公告)日：2005-04-14
申请号：US10961145
申请日：2004-10-12
申请人： Michael Spain , Craig Benson , Mark Chandler , James Mapes , Ralph McDade
发明人： Michael Spain , Craig Benson , Mark Chandler , James Mapes , Ralph McDade
IPC分类号： G01N33/50 , G06F19/20 , G06F19/26 , G06F19/28 , G06T7/00 , G01N33/48
CPC分类号： G06T7/0012 , G01N33/50 , G16B25/00 , G16B45/00 , G16B50/00
摘要： A biochemical image is derived from specimens, preferably obtained from a statistically relevant sample of a subject population sharing a common characteristic. The biochemical images for one or more conditions present in the subject population and/or one or more test subjects are determined and made available for computer implemented diagnostic evaluations and medical research. In addition to using the information for general research purposes, information from the images may be used to classify diseases and disease states.
摘要翻译：生物化学图像来自标本，优选从具有共同特征的对象群体的统计学相关样品获得。确定主题群体和/或一个或多个测试对象中存在的一个或多个条件的生化图像，并且可用于计算机实施的诊断评估和医学研究。除了将信息用于一般研究目的之外，来自图像的信息可以用于对疾病和疾病状态进行分类。

5. 发明申请

US20050221363A1 Universal shotgun assay 审中-公开
标题翻译：通用霰弹枪测定
公开(公告)号：US20050221363A1
公开(公告)日：2005-10-06
申请号：US11094366
申请日：2005-03-31
申请人： Michael Spain , Mark Chandler
发明人： Michael Spain , Mark Chandler
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/536 , G01N33/541 , G01N33/543 , G06F19/00
CPC分类号： G01N33/536 , C12Q1/6816 , G01N33/541 , G01N33/54333 , G16H50/50 , G16H50/70 , Y02A90/26 , C12Q2563/137
摘要： A method for the multiplexed diagnosis of a plurality of different biomolecules in a fluid sample substantially simultaneously is provided. In accordance with a method of the invention, a substantial fraction of biomolecules in a fluid sample are complexed with a universal label and a secondary labeling reagent. Flow cytometric measurements may be used to identify and quantify, in real-time, by detecting the secondary reagent and universal label present in any of said complexes. The inventive technology enables the simultaneous, and automated, detection and interpretation of multiple biomolecules while also reducing the cost of performing diagnostic and genetic assays.
摘要翻译：提供了基本上同时多次诊断流体样本中的多个不同生物分子的方法。根据本发明的方法，流体样品中的大部分生物分子与通用标记物和次级标记试剂复合。流式细胞术测量可用于通过检测存在于任何所述复合物中的次级试剂和通用标记来实时鉴定和定量。本发明的技术使得能够同时和自动化地检测和解释多种生物分子，同时也降低了进行诊断和遗传测定的成本。

6. 发明申请

US20070003981A1 Methods and kits for the diagnosis of acute coronary syndrome 审中-公开
标题翻译：用于诊断急性冠状动脉综合征的方法和试剂盒
公开(公告)号：US20070003981A1
公开(公告)日：2007-01-04
申请号：US11475249
申请日：2006-06-27
申请人： Mark Chandler , Michael Spain , James Mapes , George Rodgers
发明人： Mark Chandler , Michael Spain , James Mapes , George Rodgers
IPC分类号： G01N33/53 , C12Q1/37
CPC分类号： C12Q1/48 , C12Q1/37 , G01N33/573 , G01N33/6893 , G01N2333/91188 , G01N2333/96486 , G01N2800/324
摘要： Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new biomarkers for ACS are thus disclosed, MMP-3 and SGOT. Altogether the concentrations of twelve analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering a heart attack. Other important biomarkers for ACS are described, including but not limited to IL-18, Factor VII, ICAM-1, Creatine Kinase-MB, MCP-1, Myoglobin, C Reactive Protein, von Willebrand Factor, TIMP-1, Ferritin, Glutathione S-Transferase, Prostate Specific Antigen (free), IL-3, Tissue Factor, alpha-Fetoprotein, Prostatic Acid Phosphatase, Stem Cell Factor, MIP-1-beta, Carcinoembryonic Antigen, IL-13, TNF-alpha, IgE, Fatty Acid Binding Protein, ENA-78, IL-1-beta, Brain-Derived Nerotrophic Factor, Apolipoprotein A1, Serum Amyloid P, Growth Hormone, Beta-2 microglobulin, Lipoprotein (a), MMP-9, Thyroid Stimulating hormone, alpha-2 Macroglobulin, Complement 3, IL-7, Leptin, and IL-6. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了用于急性冠状动脉综合征或ACS的检测和诊断的方法。这些方法基于以下发现：患有风险的患者的样品液体（通常为血液样本）中所选分析物的异常水平支持ACS的诊断。因此公开了至少两种用于ACS的新生物标志物，MMP-3和SGOT。总共有十二种分析物的浓度可以提供对病人状况的敏感和有选择性的图片，即患者是否患有心脏病发作。描述了ACS的其他重要生物标志物，包括但不限于IL-18，因子VII，ICAM-1，肌酸激酶-MB，MCP-1，肌红蛋白，C反应蛋白，血管性血友病因子，TIMP-1，铁蛋白，谷胱甘肽 S转移酶，前列腺特异性抗原（游离），IL-3，组织因子，α-甲胎蛋白，前列腺酸性磷酸酶，干细胞因子，MIP-1-β，癌胚抗原，IL-13，TNF-α，IgE，脂肪酸结合蛋白，ENA-78，IL-1-β，脑源性神经营养因子，载脂蛋白A1，血清淀粉样蛋白P，生长激素，β-2微球蛋白，脂蛋白（a），MMP-9，甲状腺刺激激素， 2大球蛋白，补体3，IL-7，瘦蛋白和IL-6。还描述了含有辅助分析流体样品的试剂的试剂盒。

7. 发明申请

US20080020475A1 METHODS AND KITS FOR THE DIAGNOSIS OF HYPOTHYROIDISM 审中-公开
标题翻译：用于诊断血友病的方法和工具
公开(公告)号：US20080020475A1
公开(公告)日：2008-01-24
申请号：US11744723
申请日：2007-05-04
申请人： Jim Mapes , Michael Spain , Ralph McDade , Kenneth Pass
发明人： Jim Mapes , Michael Spain , Ralph McDade , Kenneth Pass
IPC分类号： G01N33/53 , G06F15/18
CPC分类号： G01N33/6893 , G01N2800/046
摘要： Provided are methods for the detection and diagnosis of Hypothyroidism. The methods are based on the discovery that altered levels of selected analytes in sample fluid, typically blood samples, of patients are supportive of a diagnosis of Hypothyroidism. At least twenty-four new biomarkers for hypothyroidism are thus disclosed (singly or in any combination), Thyroid Stimulating Hormone, Interleukin-12p40, Tumor Necrosis Factor Alpha, Tissue Factor, Interleukin-15, Insulin, Immunoglobulin E, Growth Stimulating Hormone, Calcitonin, Prostate-Specific Antigen, Interleukin-4, Granulocyte Macrophage Colony Stimulating Factor, Matrix Metalloproteinase 9, Lymphotactin, Fatty Acid Binding Protein, Alpha Fetoprotein, Alpha-2 Macroglobulin, Serum Glutamic Oxaloacetic Transaminase, Matrix Metalloproteinase 3, Cancer Antigen 125, Mumps Antibody, Double Stranded DNA Antibody, Proliferating Cell Nuclear Antigen Antibody, Smith Antibody, or Herpes Simplex Virus 1 Glycoprotein D Antibody. Altogether the concentrations of one or more of these analytes, as well as Thyroid Stimulating Hormone, or any combination thereof, provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from Hypothyroidism. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了检测和诊断甲状腺功能减退症的方法。这些方法基于以下发现：患者样品液体（通常为血液样本）中所选择的分析物水平的改变支持甲状腺功能减退症的诊断。因此，至少二十四种用于甲状腺功能减退的新生物标志物（单独或以任何组合），甲状腺刺激激素，白细胞介素-12p40，肿瘤坏死因子α，组织因子，白介素-15，胰岛素，免疫球蛋白E，生长刺激激素，降钙素，前列腺特异性抗原，白介素-4，粒细胞巨噬细胞集落刺激因子，基质金属蛋白酶9，淋巴细胞趋化因子，脂肪酸结合蛋白，甲胎蛋白，α-2巨球蛋白，血清谷氨酸氧乙酸转氨酶，基质金属蛋白酶3，癌症抗原125，腮腺炎抗体，双链DNA抗体，增殖细胞核抗原抗体，史密斯抗体或单纯疱疹病毒1糖蛋白D抗体。这些分析物中的一种或多种，以及甲状腺刺激激素或其任何组合的浓度总共提供了患者状况的敏感和选择性图像，即患者是否患有甲状腺功能减退。还描述了含有辅助分析流体样品的试剂的试剂盒。

8. 发明申请

US20070141656A1 Method for Characterizing Autoimmune Disorders 有权
标题翻译：表征自身免疫性疾病的方法
公开(公告)号：US20070141656A1
公开(公告)日：2007-06-21
申请号：US11674365
申请日：2007-02-13
申请人： James Mapes , James Jacobson , Harold Baker , Michael Spain
发明人： James Mapes , James Jacobson , Harold Baker , Michael Spain
IPC分类号： G01N33/00
CPC分类号： G01N33/54313 , G01N33/564 , G01N2800/24 , Y10S435/973 , Y10S436/811
摘要： The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. According to another approach the ratio of self-antigen to autoantibody is measured by exposing a sample suspected of containing self-antigen and autoantibody to a bead set associated with monoclonal antibody specific for the self-antigen and a bead set associated with the self-antigen.
摘要翻译：本发明涉及通过使用多重测定系统检测和测量至少一种分析物来表征自身免疫性疾病的方法。根据一个实施例，通过具有不同反应物的不同珠组检测和测量靶。根据另一种方法，通过将怀疑含有自身抗原和自身抗体的样品暴露于与自身抗原特异性的单克隆抗体相关联的珠粒组和与自身抗原相关的珠粒组来测量自身抗原与自身抗体的比例。

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