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1. 发明申请

US20190195896A1 Antibodies to TTR and Methods of Use 审中-公开
公开(公告)号：US20190195896A1
公开(公告)日：2019-06-27
申请号：US16198965
申请日：2018-11-23
申请人： University Health Network
发明人： Avijit Chakrabartty , Rishi Rakhit , Anita Antoinette Bugyei-Twum
IPC分类号： G01N33/78 , C07K16/26 , C07K14/47 , C07K16/18
CPC分类号： G01N33/78 , C07K14/47 , C07K14/575 , C07K16/18 , C07K16/26 , C07K2317/34 , C07K2317/76 , G01N33/74 , G01N2800/046 , G01N2800/28 , G01N2800/325 , G01N2800/7047
摘要： The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.

2. 发明申请

US20170349951A1 COMPOSITIONS AND METHODS FOR DIAGNOSING THYROID CANCER 审中-公开
公开(公告)号：US20170349951A1
公开(公告)日：2017-12-07
申请号：US15536772
申请日：2015-12-16
申请人： DIAXONHIT
发明人： PASCALE BEURDELEY , MICHAEL BRENNER , ANNE-CHARLOTTE JARRIGE , DIEGO PALLARES
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N2800/046
摘要： The present application relates to methods and compositions for detecting thyroid cancer in mammals, in particular in humans. The invention provides novel biomarkers which, in combination, allow effective, specific and sensitive detection of thyroid cancer, particularly to assist in the diagnosis of thyroid lesions in human subjects. The invention further relates to tools and/or kits (such as reagents, probes, primers, chips or arrays) suitable for implementing said methods, and the preparation and uses thereof.

3. 发明申请

US20170319526A1 COMPOSITIONS AND METHODS OF PROVIDING THYROID HORMONE OR ANALOGS THEREOF 审中-公开
公开(公告)号：US20170319526A1
公开(公告)日：2017-11-09
申请号：US15583695
申请日：2017-05-01
申请人： Spectrix Therapeutics, LLC
发明人： Mark Tengler
IPC分类号： A61K31/197 , A61K9/20 , A61K9/00 , G01N33/78
CPC分类号： A61K31/197 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/198 , G01N33/78 , G01N2800/046 , G01N2800/52
摘要： The present invention includes a pharmaceutical composition, and methods of making and using, a pharmaceutical composition comprising one or more thyroid hormone(s) or analogs thereof, wherein a first portion of thyroid hormone(s) is formulated for immediate release and a second portion of thyroid hormone(s) is formulated of modified release, e.g., by forming a drug-resin particle with an ion exchange resin.

4. 发明申请

US20170176452A1 THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY 有权
公开(公告)号：US20170176452A1
公开(公告)日：2017-06-22
申请号：US15443805
申请日：2017-02-27
申请人： Quest Diagnostics Investments Incorporated
发明人： Yanni Zhang , Nigel J. Clarke , Richard E. Reitz
IPC分类号： G01N33/68 , C12Q1/37
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

5. 发明授权

US09580740B2 Thyroglobulin quantitation by mass spectroscopy 有权
标题翻译：通过质谱法测定甲状腺球蛋白定量
公开(公告)号：US09580740B2
公开(公告)日：2017-02-28
申请号：US14689542
申请日：2015-04-17
申请人： Quest Diagnostics Investments Incorporated
发明人： Yanni Zhang , Nigel J. Clarke , Richard E. Reitz
IPC分类号： C12Q1/37 , G01N33/68 , G01N33/78
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
摘要翻译：提供了使用各种纯化步骤随后进行质谱法测定样品中甲状腺球蛋白量的方法。所述方法通常涉及在测试样品中纯化甲状腺球蛋白，消化甲状腺球蛋白以形成肽T129，纯化肽T129，电离肽T129，检测产生的肽T129离子的量，并将肽T129离子的量与原始存在的甲状腺球蛋白量相关联在样品中。

6. 发明授权

US09304136B2 Means and methods for assessing increased peroxisomal proliferation 有权
标题翻译：评估增加的过氧化物酶体增殖的方法和方法
公开(公告)号：US09304136B2
公开(公告)日：2016-04-05
申请号：US14152411
申请日：2014-01-10
申请人： BASF SE
发明人： Bennard van Ravenzwaay , Werner Mellert , Eric Fabian , Volker Strauss , Tilmann B. Walk , Ralf Looser , Edgar Leibold , Hennicke Kamp , Georgia Coelho Palermo Cunha , Michael Manfred Herold , Jan C. Wiemer , Alexandre Prokoudine
IPC分类号： G01N33/92 , G01N33/68 , G01N33/50 , G01N33/82
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection including characteristic values of at least five metabolites, a data storage medium including data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及诊断增加的过氧化物酶体增殖的方法。它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

7. 发明申请

US20160053297A1 THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY 有权
标题翻译：通过大量光谱测定的THYROGLOBULIN量子
公开(公告)号：US20160053297A1
公开(公告)日：2016-02-25
申请号：US14689542
申请日：2015-04-17
申请人： Quest Diagnostics Investments Incorporated
发明人： Yanni Zhang , Nigel J. Clarke , Richard E. Reitz
IPC分类号： C12Q1/37
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
摘要翻译：提供了使用各种纯化步骤随后进行质谱法测定样品中甲状腺球蛋白量的方法。所述方法通常涉及在测试样品中纯化甲状腺球蛋白，消化甲状腺球蛋白以形成肽T129，纯化肽T129，电离肽T129，检测产生的肽T129离子的量，并将肽T129离子的量与原始存在的甲状腺球蛋白量相关联在样品中。

8. 发明申请

US20150233914A1 Compositions and Methods for Detecting Autoantibodies 审中-公开
标题翻译：用于检测自身抗体的组合物和方法
公开(公告)号：US20150233914A1
公开(公告)日：2015-08-20
申请号：US14625086
申请日：2015-02-18
申请人： Quidel Corporation
发明人： Yunsheng Li , Paul D. Olivo , Hannah Jaekyung Kim
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N33/566 , G01N33/76 , G01N2333/723 , G01N2333/726 , G01N2800/046
摘要： The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated with the presence of TBI and/or TSI, for monitoring the progress of disease and/or treatment regimens, therapeutics, vaccines, etc., and for assisting clinicians in making treatment decisions.
摘要翻译：本发明提供了用于检测甲状腺激素阻断免疫球蛋白（TBI）的组合物和方法。本发明的方法对TBI敏感且特异，可用于双重检测TBI和TSI。本发明的组合物和方法可用于诊断与TBI和/或TSI的存在相关的疾病，用于监测疾病和/或治疗方案，治疗剂，疫苗等的进展，并用于协助临床医生制造治疗决定。

9. 发明申请

US20150118155A1 COMPOSITIONS AND METHODS FOR DIAGNOSING AND MONITORING HYPERTHYROIDISM IN A FELINE 审中-公开
标题翻译：用于诊断和监测氟尿嘧啶的组合物和方法
公开(公告)号：US20150118155A1
公开(公告)日：2015-04-30
申请号：US14125981
申请日：2012-06-14
申请人： Samer Al-Murrani , Xiangming Gao
发明人： Samer Al-Murrani , Xiangming Gao
IPC分类号： C12Q1/68 , A23L1/29 , G01N33/68
CPC分类号： C12Q1/6883 , A23L33/30 , A23V2002/00 , C12Q2600/158 , G01N33/6893 , G01N2800/046 , G01N2800/50
摘要： The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.
摘要翻译：本发明提供一种诊断猫科动物中甲状腺功能亢进的存在或风险的方法，其包括测量选自以下的一种或多种生物标志物的表达水平：IYD，TG，SLC5A5，NIS，TPO，TSHR，DUOX1，来自猫科动物的生物样品中的DUOX2（ThOX），TGFB1，CSTD，DCN和SEPP1及其表达产物，其中样品中一种或多种生物标志物的表达升高相对于来自正常的猫科动物或猫科动物群体，或猫科动物的基线值，表明甲状腺功能亢进的存在或风险; 一种治疗如此诊断的猫科动物的方法; 以及用于执行指定方法的组合物，试剂和试剂盒。

10. 发明申请

US20150017738A1 MEANS AND METHODS OF MEASURING PARATHYROID HORMONE IN PATIENTS SUFFERING FROM OXIDATIVE STRESS 审中-公开
标题翻译：在氧化应激患者中测量PARATHYROID HORMONE的方法和方法
公开(公告)号：US20150017738A1
公开(公告)日：2015-01-15
申请号：US14380147
申请日：2013-02-22
申请人： IMMUNDIAGNOSTIK AG
发明人： Franz Paul Armbruster , Berthold Hocher , Hans Juergen Groen , Heinz Juergen Roth
IPC分类号： G01N33/78 , C07K16/26
CPC分类号： G01N33/78 , C07K16/26 , C07K2317/30 , C07K2317/34 , G01N33/6848 , G01N33/6854 , G01N33/6893 , G01N2333/635 , G01N2500/00 , G01N2800/046 , G01N2800/347 , G01N2800/7009
摘要： Method for obtaining an antibody or antibody fragment to a conformational epitope specific for oxidized, inactive human parathyroid hormone and fragments thereof; a method for removal of oxidized, inactive human parathyroid hormone from a sample of body fluid; methods of determining the concentration of active parathyroid hormone in a sample, and an in vitro method of diagnosis of renal failure or secondary hyperthyroidism in patients on dialysis. The antibody is obtained by immunizing an animal with an immunogen containing parathyroid hormone or fragment thereof oxidized at methionines at positions 8, 18 or both; and a recovering of antibodies; whereby the complementary determining region of the antibody or antibody fragment or single chain antibody specifically recognizes a conformational epitope (antigenic determinant) which is a tertiary structure and only present on oxidized parathyroid hormone and fragments thereof only but not regular bioactive human parathyroid hormone, while the binding surface to the complementary binding region does not include any one of the oxidized methionines of human parathyroid hormone.
摘要翻译：获得针对氧化的，无活性的人甲状旁腺激素及其片段特异的构象表位的抗体或抗体片段的方法; 从体液样品中去除氧化的，无活性的人甲状旁腺激素的方法; 确定样品中活性甲状旁腺激素浓度的方法，以及透析患者肾衰竭或继发性甲状腺功能亢进的体外诊断方法。抗体是通过用含有甲状旁腺激素或其片段的蛋白质在8,18或两者氧化的免疫原免疫动物获得的; 和抗体的回收; 由此抗体或抗体片段或单链抗体的互补决定区域特异性识别作为三级结构的构象表位（抗原决定簇），仅存在于氧化的甲状旁腺激素及其片段但不存在于规则的生物活性人甲状旁腺激素上，而与互补结合区的结合表面不包括人甲状旁腺激素的氧化甲硫氨酸中的任一种。

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