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1. 发明申请

US20080020475A1 METHODS AND KITS FOR THE DIAGNOSIS OF HYPOTHYROIDISM 审中-公开
标题翻译：用于诊断血友病的方法和工具
公开(公告)号：US20080020475A1
公开(公告)日：2008-01-24
申请号：US11744723
申请日：2007-05-04
申请人： Jim Mapes , Michael Spain , Ralph McDade , Kenneth Pass
发明人： Jim Mapes , Michael Spain , Ralph McDade , Kenneth Pass
IPC分类号： G01N33/53 , G06F15/18
CPC分类号： G01N33/6893 , G01N2800/046
摘要： Provided are methods for the detection and diagnosis of Hypothyroidism. The methods are based on the discovery that altered levels of selected analytes in sample fluid, typically blood samples, of patients are supportive of a diagnosis of Hypothyroidism. At least twenty-four new biomarkers for hypothyroidism are thus disclosed (singly or in any combination), Thyroid Stimulating Hormone, Interleukin-12p40, Tumor Necrosis Factor Alpha, Tissue Factor, Interleukin-15, Insulin, Immunoglobulin E, Growth Stimulating Hormone, Calcitonin, Prostate-Specific Antigen, Interleukin-4, Granulocyte Macrophage Colony Stimulating Factor, Matrix Metalloproteinase 9, Lymphotactin, Fatty Acid Binding Protein, Alpha Fetoprotein, Alpha-2 Macroglobulin, Serum Glutamic Oxaloacetic Transaminase, Matrix Metalloproteinase 3, Cancer Antigen 125, Mumps Antibody, Double Stranded DNA Antibody, Proliferating Cell Nuclear Antigen Antibody, Smith Antibody, or Herpes Simplex Virus 1 Glycoprotein D Antibody. Altogether the concentrations of one or more of these analytes, as well as Thyroid Stimulating Hormone, or any combination thereof, provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from Hypothyroidism. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了检测和诊断甲状腺功能减退症的方法。这些方法基于以下发现：患者样品液体（通常为血液样本）中所选择的分析物水平的改变支持甲状腺功能减退症的诊断。因此，至少二十四种用于甲状腺功能减退的新生物标志物（单独或以任何组合），甲状腺刺激激素，白细胞介素-12p40，肿瘤坏死因子α，组织因子，白介素-15，胰岛素，免疫球蛋白E，生长刺激激素，降钙素，前列腺特异性抗原，白介素-4，粒细胞巨噬细胞集落刺激因子，基质金属蛋白酶9，淋巴细胞趋化因子，脂肪酸结合蛋白，甲胎蛋白，α-2巨球蛋白，血清谷氨酸氧乙酸转氨酶，基质金属蛋白酶3，癌症抗原125，腮腺炎抗体，双链DNA抗体，增殖细胞核抗原抗体，史密斯抗体或单纯疱疹病毒1糖蛋白D抗体。这些分析物中的一种或多种，以及甲状腺刺激激素或其任何组合的浓度总共提供了患者状况的敏感和选择性图像，即患者是否患有甲状腺功能减退。还描述了含有辅助分析流体样品的试剂的试剂盒。

2. 发明申请

US20080261253A1 Methods and kits for the diagnosis of galactosemia 审中-公开
标题翻译：用于诊断半乳糖血症的方法和试剂盒
公开(公告)号：US20080261253A1
公开(公告)日：2008-10-23
申请号：US12007500
申请日：2008-01-11
申请人： Michael Spain , James P. Mapes , Ralph McDade , Kenneth Pass
发明人： Michael Spain , James P. Mapes , Ralph McDade , Kenneth Pass
IPC分类号： G01N33/543
CPC分类号： G01N33/6863 , G01N2800/042
摘要： Provided are methods for the detection and diagnosis of galactosemia. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of galactosemia. At least two new biomarkers for galactosemia are thus disclosed, Eotaxin and MCP-1. Altogether the concentrations these markers, individually, or in combinations with any of Alpha-2 Macroglobulin, Apolipoprotein H, Cancer Antigen 125, Leptin, TNF RII, Alpha-Fetoprotein, IgM, MIP-1 alpha, Ferritin, and IgE provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from galactosemia. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了检测和诊断半乳糖血症的方法。这些方法是基于以下发现：患有风险的患者的样品液体（通常为血液样本）中所选分析物的异常水平支持半乳糖血症诊断。因此，公开了至少两种用于半乳糖血症的新生物标志物，即嗜酸性粒细胞趋化因子和MCP-1。总的来说，这些标记物，单独或与任何α-2巨球蛋白，载脂蛋白H，癌症抗原125，瘦素，TNF RII，α-甲胎蛋白，IgM，MIP-1α，铁蛋白和IgE组合的浓度提供了敏感和患者状况的选择性图片，即患者是否患有半乳糖血症。还描述了含有辅助分析流体样品的试剂的试剂盒。

3. 发明申请

US20080255766A1 Methods and kits for the diagnosis of sickle cell 审中-公开
标题翻译：用于诊断镰状细胞的方法和试剂盒
公开(公告)号：US20080255766A1
公开(公告)日：2008-10-16
申请号：US12068518
申请日：2008-02-07
申请人： Michael Spain , James P. Mapes , Ralph L. McDade , Kenneth Pass
发明人： Michael Spain , James P. Mapes , Ralph L. McDade , Kenneth Pass
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/6863 , G01N2333/52 , G01N2800/22
摘要： Provided are methods for the detection and diagnosis of sickle cell. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of sickle cell. At least two new biomarkers for sickle cell are thus disclosed, Eotaxin and Monocyte Chemotactic Protein-1. Altogether the concentrations of eleven analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from sickle cell. Other important biomarkers for sickle cell are described, including but not limited to IL-12p40, SHBG, MMP-9, Adiponectin, Haptoglobin, FGF basic, IgM, Growth Hormone, Factor VII. Kits containing reagents to assist in the analysis of fluid samples are also described.
摘要翻译：提供了镰状细胞的检测和诊断方法。这些方法是基于以下发现：患有风险的患者的样本液体（通常为血液样本）中所选分析物的异常水平支持镰状细胞的诊断。因此公开了至少两种镰状细胞的新生物标志物，即嗜酸细胞活化趋化因子和单核细胞趋化蛋白-1。总共11种分析物的浓度提供了对患者状况的敏感和选择性图像，即患者是否患有镰状细胞。描述了镰状细胞的其他重要生物标志物，包括但不限于IL-12p40，SHBG，MMP-9，脂连蛋白，海藻球蛋白，FGF碱性，IgM，生长激素，因子VII。还描述了含有辅助分析流体样品的试剂的试剂盒。

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